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Somatosensory evaluation in women with temporomandibular disorders and asymptomatic controls before and after application of a topical anesthetic ointment: a controlled study

Grant number: 13/20236-9
Support Opportunities:Regular Research Grants
Duration: June 01, 2014 - May 31, 2016
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Leonardo Rigoldi Bonjardim
Grantee:Leonardo Rigoldi Bonjardim
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
Associated researchers:Paulo César Rodrigues Conti


The present study aims to evaluate possible changes in somatosensory mechanisms and pain modulation in the masticatory muscles of women with TMD and asymptomatic controls before and after application of a topical anesthetic and a placebo ointment. So, 40 volunteers between 18 and 50 years, presenting with complaints of facial pain in Orofacial Pain Clinic of the Bauru School of Dentistry - USP will be evaluated. Patients must be diagnosed with myofascial pain or arthralgia according to the Research Diagnostic Criteria (RDC / TMD). The sample will be divided into experimental groups - voluntareers with muscular TMD (n=20) and control group (n=20) - volunteers without signs and symptoms of TMD. Individuals will be (baseline) evaluated through (1) self-reported pain intensity, (2) pressure pain threshold, (3) quantitative sensory testing. After this initial evaluation, the subjects will be assessed a second (same day) and a third (the next day) time, although under the effect of an ointment of topical anesthetics (lidocaine 4%) and placebo ointment of the same color, consistency and odor. The order of substances application will be performed randomly and the interval between evaluations will be 24 hours. Each ointment will be applied on masseter and / or anterior temporalis muscle (region of trigger point) and on TMJ region, on a 2 cm2-area. The topical anesthetic and placebo ointment will be applied 60 minutes prior to somatosensory tests. Data analysis will be performed by analysis of variance (ANOVA) for repeated measures or non-parametric matching. A significance level of 5% and a confidence interval of 95% will be adopted in all analyzes. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COSTA, Y. M.; MORITA-NETO, O.; DE ARAUJO-JUNIOR, E. N. S.; SAMPAIO, F. A.; CONTI, P. C. R.; BONJARDIM, L. R.. Test-retest reliability of quantitative sensory testing for mechanical somatosensory and pain modulation assessment of masticatory structures. Journal of Oral Rehabilitation, v. 44, n. 3, p. 197-204, . (15/09913-4, 13/20236-9)

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