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Development of new systems for controlled drug delivery

Grant number: 14/08027-8
Support type:Multi-user Equipment Program
Duration: June 01, 2014 - May 31, 2016
Field of knowledge:Engineering - Chemical Engineering - Chemical Technology
Principal researcher:Amilton Martins dos Santos
Grantee:Amilton Martins dos Santos
Home Institution: Escola de Engenharia de Lorena (EEL). Universidade de São Paulo (USP). Lorena , SP, Brazil
Associated research grant:13/06987-1 - Development of new systems for controlled drug delivery, AP.R
As informações de acesso ao Equipamento Multiusuário são de responsabilidade do Pesquisador responsável
EMU web page: Página do Equipamento Multiusuário não informada
Type of equipment:Processos Físicos - Reatores químicos - Formação de partículas
Processos Físicos - Equipamentos de atmosfera controlada - Sprayer
Manufacturer: Fabricante não informado
Model: Modelo não informado

Abstract

The micro/nanoencapsulation involves a series of techniques that enable the manufacture of functional particles consisting of a carrier material (encapsulating agent) and an active substance distributed in their core. To obtain such systems, which can be used in controlled drug release systems, several methods are described in the literature, all of which depend primarily on the hydrophilic/organophilic properties of all materials involved in the synthesis. In general, these methods are divided into those involving in situ polymerization or the precipitation of a preformed polymer in the presence of the substance to be encapsulated. Among the last ones, spray-drying" technique presents some advantages such as a good control of the dried product properties, possibility of large scale continuous production, production of particles having different morphologies, high encapsulation efficiency and low cost. The choice of the most appropriate method must be based on a number of factors such as the type of polymer and active ingredients, application area, desired particle size etc. The purpose in this project is to synthesize novel biocompatible/biodegradable and stimuli-responsive random and block copolymers and to study different techniques, including spray drying, for the incorporation of hydrophilic and hydrophobic drugs into these polymeric matrices. Moreover, the kinetics of drug release will be evaluated by in vitro assays and cutaneous permeation tests. Thus, the main application in this project is the purchase of a "Nano Spray-dryer" for the encapsulation of different active agents. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FONSECA, JESSICA DE MATOS; MEDEIROS, SIMONE DE FATIMA; ALVES, GIZELDA MARIA; DOS SANTOS, DANILO MARTINS; CAMPANA-FILHO, SERGIO PAULO; DOS SANTOS, AMILTON MARTINS. Chitosan microparticles embedded with multi-responsive poly(N-vinylcaprolactam-co-itaconic acid-co-ethylene-glycol dimethacrylate)-based hydrogel nanoparticles as a new carrier for delivery of hydrophobic drugs. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 175, p. 73-83, . (14/08027-8, 13/06987-1)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.