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Development and implementation of biophysical models to describe the force of contraction in rat cardiac myocyte REASONED dynamics in calcium


Ions involved in the complex functioning of the heart, calcium (Ca2+) is considered the most important being the direct activator of myofilaments that causes contraction. For this reason, its uneven flow in the cardiac myocyte is a major cause of cardiac arrhythmias and contractile dysfunction. Thus, the formulation of new mathematical and computational models of ventricular myocyte mammalian brings important tools for understanding the mechanisms of Ca2+ release and analyze in detail the causes of several types of cardiac arrhythmia. The purpose of this project is to develop and implement for biophysical models of rat cardiac myocyte, in order to reduce the number of degrees of freedom of the system structure provide a simple mathematical and computational for the calculation of the contractile force in cardiac myocyte, based especially Ca2+ dynamics. The project begins with the implementation of the model by Silva et al (2012): inclusion of "buffers" Ca2+, update the parameters used in the modeling, undertaking new simulations and comparison with experimental data so check the robustness of the model in issue and enable the study of blockers and activators that act changer NCX in Ca2+ - ATPase of the sarcoplasmic reticulum or the L - type channels, thus corroborating to a better understanding of the effects of drugs used in the treatment of arrhythmias. Then the model will be structured for the platform OpenCell and with the addition of noise heart rate, allow for simulations for the analysis of heart rate variability, an important tool for the study and prevention of cardiac arrhythmias. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, ROBSON RODRIGUES; DE SOUZA FILHO, OSIAS BAPTISTA; MAGALHAES BASSANI, JOSE WILSON; BASSANI, ROSANA ALMADA. The ForceLAB simulator: Application to the comparison of current models of cardiomyocyte contraction. COMPUTERS IN BIOLOGY AND MEDICINE, v. 131, APR 2021. Web of Science Citations: 0.
DA SILVA, ROBSON RODRIGUES; GOROSO, DANIEL GUSTAVO; BERS, DONALD M.; PUGLISI, JOSE LUIS. MarkoLAB: A simulator to study ionic channel's stochastic behavior. COMPUTERS IN BIOLOGY AND MEDICINE, v. 87, p. 258-270, AUG 1 2017. Web of Science Citations: 0.
DA SILVA, ROBSON RODRIGUES; SILVA BISSACO, MARCIA APARECIDA; GOROSO, DANIEL GUSTAVO. MioLab, a rat cardiac contractile force simulator: Applications to teaching cardiac cell physiology and biophysics. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, v. 122, n. 3, p. 480-490, DEC 2015. Web of Science Citations: 1.

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