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Detection of human herpesvirus in human saliva and gingival fluid of patients with chronic renal failure

Grant number: 13/08242-3
Support type:Regular Research Grants
Duration: May 01, 2014 - April 30, 2016
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal researcher:Débora Pallos
Grantee:Débora Pallos
Home Institution: Universidade de Santo Amaro (UNISA). São Paulo , SP, Brazil
Assoc. researchers:Claudio Sergio Pannuti ; Gilson Fernandes Ruivo ; Paulo Henrique Braz da Silva

Abstract

Patients with chronic renal failure (CRF) present inability of the kidney to maintain normal product of protein metabolism, blood pressure and hematocrit, balance of sodium, water, potassium and acid-base. They have the cellular and humoral immune response and depressed so the existence of any changes in oral health may represent foci of infection. Periodontal disease is an inflammatory disease that affects the destructive periodontal tissues, and studies have shown that the prevalence of this is higher in patients with CKD compared with the general population. The monitoring of opportunistic viruses is an extreme importance, since they are related co morbidities in these individuals. The objective of this study is to analyze the presence of human herpes virus (EBV, CMV, and HHV8 HHV7) in saliva and gingival fluid of patients with CRF. Will be assessed 120 individuals with chronic renal disease divided into 3 groups according to the treatment stage renal disease. Patients will be evaluated clinical indices of periodontal disease such as insertion loss, probing depth, gingival index and plaque. Samples will be evaluated by real time PCR for herpesvirus. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GALHARDO, LUCIANA F.; RUIVO, GILSON F.; SANTOS, FERNANDA O.; FERREIRA, TAMIRES T.; SANTOS, JULIANA; LEAO, MARIELLA V. P.; PALLOS, DEBORA. Impact of Oral Care and Antisepsis on the Prevalence of Ventilator-Associated Pneumonia. ORAL HEALTH & PREVENTIVE DENTISTRY, v. 18, n. 2, p. 331-335, . (13/08242-3)
DE SANTANA SARMENTO, DMITRY JOSE; TOZETTO-MENDOZA, TANIA REGINA; SUMITA, LAURA MASAMI; PIERROTI, LIGIA CAMARA; PALLOS, DEBORA; CALIENTO, RUBENS; PALMIERI, MICHELLE; DE OLIVEIRA MARTINS, VICTOR ADRIANO; GALLOTTINI, MARINA; PANNUTI, CLAUDIO SERGIO; et al. Oral shedding of human herpesviruses in renal transplant recipients. CLINICAL ORAL INVESTIGATIONS, v. 22, n. 2, p. 885-891, . (15/03906-6, 13/08242-3, 12/04223-1)
MARQUES FILHO, JAIME S.; GOBARA JR, JORGE; DA SILVA SALOMAO, GUSTAVO VARGAS; SUMITA, LAURA M.; SHIBLI, JAMIL A.; VIANA, RENATO G.; SCHWARTZ FILHO, HUMBERTO O.; PANNUTI, CLAUDIO SERGIO; BRAZ-SILVA, PAULO HENRIQUE; PALLOS, DEBORA. Cytokine Levels and Human Herpesviruses in Saliva from Clinical Periodontal Healthy Subjects with Peri-Implantitis: A Case-Control Study. Mediators of Inflammation, . (08/07154-5, 13/08242-3)
PALLOS, DEBORA; SOUSA, VANESSA; FERES, MAGDA; RETAMAL-VALDES, BELEN; CHEN, TSUTE; CURTIS, MIKE; BOAVENTURA, RICHARDSON MONDEGO; TANAKA, MARCIA HIROMI; SALOMAO, GUSTAVO VARGAS DA SILVA; ZANELLA, LOUISE; et al. alivary Microbial Dysbiosis Is Associated With Peri-Implantitis: A Case-Control Study in a Brazilian Populatio. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, . (13/08242-3, 15/07727-9)
PALLOS, DEBORA; RUIVO, GILSON F.; FERRARI-JUNIOR, SABINO H.; PANNUTI, CLAUDIO S.; PEROZINI, CAROLINE; SARMENTO, DMITRY J. S.; PALMIERI, MICHELLE; SOUZA, ANA C. M. F.; TOZETTO-MENDOZA, TANIA R.; DOGLIO, ALAIN; et al. Periodontal disease and detection of human herpesviruses in saliva and gingival crevicular fluid of chronic kidney disease patients. Journal of Periodontology, v. 91, n. 9, . (13/08242-3)

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