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Biodiversity of cyanobacteria and their bioactive compounds from under-explored Brazilian habitats

Grant number: 13/50425-8
Support Opportunities:Regular Research Grants
Duration: January 01, 2014 - December 31, 2018
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Convênio/Acordo: AKA
Principal Investigator:Marli de Fátima Fiore
Grantee:Marli de Fátima Fiore
Principal researcher abroad: Kaarina Sivonen
Institution abroad: University of Helsinki, Finland
Host Institution: Centro de Energia Nuclear na Agricultura (CENA). Universidade de São Paulo (USP). Piracicaba , SP, Brazil


Cyanobacteria are interesting ancient diverse organisms with a great future in biotechnology. They produce a large number of biomedically interesting bioactive compounds as well as have good prospects in bioenergy field. In this project, we will investigate molecular and cultivable cyanobacterial biodiversity from diverse habitats in Brazil. We will isolate strains to form a biobank and utilize cyanobacterial strains to screen and identify new bioactive compounds, their biosynthetic genes and enzymes. The Brazilian and Finnish teams have complementary expertise and will join forces to reveal cyanobacterial, bioactive compound and biosynthetic gene diversity in the state of Sao Paolo. The outcomes of the project will be taxonomically new cyanobacteria, information on the biodiversity of cyanobacteria from diverse environments, novel bioactive compounds for drug leads and cell reagents, new biosynthetic pathways and novel enzymes, database products of LC-MS fragmentation patters of the compounds, which can be used to exclude the known compounds and focus novelty in the future research. The biobank of cyanobacteria is a natural resource which could be utilized for the benefit of the country for years to come. One of the major ecosystem services provided by the cyanobacteria is the production of new bioactive compounds, drug leads for combatting serious human diseases. We will map the environments likely to yield to highest diversity of cyanobacteria and their metabolites for benefit of future targeted searches for novel natural products. (AU)

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Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIMA, STELLA T.; FALLON, TIMOTHY R.; CORDOZA, JENNIFER L.; CHEKAN, JONATHAN R.; DELBAJE, ENDREWS; HOPIAVUORI, AUSTIN R.; ALVARENGA, DANILLO O.; WOOD, STEFFANEY M.; LUHAVAYA, HANNA; BAUMGARTNER, JACKSON T.; et al. Biosynthesis of Guanitoxin Enables Global Environmental Detection in Freshwater Cyanobacteria. Journal of the American Chemical Society, v. N/A, p. 8-pg., . (11/08092-6, 13/50425-8, 17/06869-0)
ALVARENGA, DANILLO OLIVEIRA; DINI ANDREOTE, ANA PAULA; ZANINI BRANCO, LUIS HENRIQUE; DELBAJE, ENDREWS; CRUZ, RENATA BEATRIZ; VARANI, ALESSANDRO DE MELLO; FIORE, MARLI FATIMA. Amazonocrinis nigriterrae gen. nov., sp. nov., Atlanticothrix silvestris gen. nov., sp. nov. and Dendronalium phyllosphericum gen. nov., sp. nov., nostocacean cyanobacteria from Brazilian environments. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, v. 71, n. 5, . (13/50425-8, 09/15402-1, 11/08092-6)
GAMA, WATSON ARANTES; RIGONATO, JANAINA; FIORE, MARLI FATIMA; SANT'ANNA, CELIA LEITE. New insights into Chroococcus (Cyanobacteria) and two related genera: Cryptococcum gen. nov. and Inacoccus gen. nov.. European Journal of Phycology, v. 54, n. 3, . (12/16430-1, 13/50425-8)
ALVARENGA, DANILLO O.; FIORE, MARLI F.; VARANI, ALESSANDRO M.. A Metagenomic Approach to Cyanobacterial Genomics. FRONTIERS IN MICROBIOLOGY, v. 8, . (11/08092-6, 13/50425-8, 15/14600-5)
SHISHIDO, TANIA K.; JOKELA, JOUNI; FEWER, DAVID P.; WAHLSTEN, MATTI; FIORE, MARLI F.; SIVONEN, KAARINA. Simultaneous Production of Anabaenopeptins and Namalides by the Cyanobacterium Nostoc sp CENA543. ACS Chemical Biology, v. 12, n. 11, p. 2746-2755, . (13/50425-8)
GENUARIO, DIEGO BONALDO; DINI ANDREOTE, ANA PAULA; MARCAL VIEIRA VAZ, MARCELO GOMES; FIORE, MARLI FATIMA. Heterocyte-forming cyanobacteria from Brazilian saline-alkaline lakes. Molecular Phylogenetics and Evolution, v. 109, p. 105-112, . (10/00321-3, 13/50425-8, 10/18732-0, 14/26131-7, 09/15402-1)
JOKELA, JOUNI; HEINILA, LASSI M. P.; SHISHIDO, TANIA K.; WAHLSTEN, MATTI; FEWER, DAVID P.; FIORE, MARLI F.; WANG, HAO; HAAPANIEMI, ESA; PERMI, PERTTU; SIVONEN, KAARINA. Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp CENA543. FRONTIERS IN MICROBIOLOGY, v. 8, . (13/50425-8)
RIGONATO, JANAINA; GAMA, WATSON ARANTES; ALVARENGA, DANILLO OLIVEIRA; ZANINI BRANCO, LUIS HENRIQUE; BRANDINI, FREDERICO PEREIRA; GENUARIO, DIEGO BONALDO; FIORE, MARLI FATIMA. Aliterella atlantica gen. nov., sp nov., and Aliterella antarctica sp nov., novel members of coccoid Cyanobacteria. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, v. 66, p. 9-pg., . (11/08092-6, 10/00321-3, 12/06850-3, 12/16430-1, 13/50425-8)
HECK, KARINA; ALVARENGA, DANILLO O.; SHISHIDO, TANIA K.; VARANI, ALESSANDRO M.; DORR, FELIPE A.; PINTO, ERNANI; ROUHIAINEN, LEO; JOKELA, JOUNI; SIVONEN, KAARINA; FIORE, MARLI F.. Biosynthesis of microcystin hepatotoxins in the cyanobacterial genus Fischerella. Toxicon, v. 141, p. 43-50, . (14/50420-9, 11/08092-6, 13/50425-8)
ALVARENGA, DANILLO O.; FRANCO, MAIONE W.; SIVONEN, KAARINA; FIORE, MARLI F.; VARANI, ALESSANDRO M.. Evaluating Eucalyptus leaf colonization by Brasilonema octagenarum (Cyanobacteria, Scytonemataceae) using in planta experiments and genomics. PeerJ, v. 8, . (13/50425-8, 15/14600-5, 18/01563-2)
POPIN, RAFAEL VICENTINI; DELBAJE, ENDREWS; DE ABREU, VINICIUS AUGUSTO CARVALHO; RIGONATO, JANAINA; DORR, FELIPE AUGUSTO; PINTO, ERNANI; SIVONEN, KAARINA; FIORE, MARLI FATIMA. Genomic and Metabolomic Analyses of Natural Products in Nodularia spumigena Isolated from a Shrimp Culture Pond. TOXINS, v. 12, n. 3, . (13/50425-8, 14/50420-9)
SHISHIDO, TANIA KEIKO; POPIN, RAFAEL VICENTINI; JOKELA, JOUNI; WAHLSTEN, MATTI; FIORE, MARLI FATIMA; FEWER, DAVID P.; HERFINDAL, LARS; SIVONEN, KAARINA. Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria. TOXINS, v. 12, n. 1, . (13/50425-8)
LIMA, STELLA T.; ALYARENGA, DANILLO.; ETCHEGARAY, AUGUSTO; FEWER, DAVID P.; JOKELA, JOUNI; VARANI, ALESSANDRO M.; SANZ, MIRIAM; DORR, FELIPE A.; PINTO, ERNANI; SIYONEN, KAARINA; et al. Genetic Organization of Anabaenopeptin and Spumigin Biosynthetic Gene Clusters in the Cyanobacterium Sphaerospermopsis torquesreginae ITEP-024. ACS Chemical Biology, v. 12, n. 3, p. 769-778, . (12/25272-0, 14/50420-9, 11/08092-6, 13/50425-8)
RIGONATO, JANAINA; GAMA, WATSON ARANTES; ALVARENGA, DANILLO OLIVEIRA; ZANINI BRANCO, LUIS HENRIQUE; BRANDINI, FREDERICO PEREIRA; GENUARIO, DIEGO BONALDO; FIORE, MARLI FATIMA. Aliterella atlantica gen. nov., sp nov., and Aliterella antarctica sp nov., novel members of coccoid Cyanobacteria. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, v. 66, n. 8, p. 2853-2861, . (12/16430-1, 10/00321-3, 12/06850-3, 13/50425-8, 11/08092-6)
ANDREOTE, ANA P. D.; DINI-ANDREOTE, FRANCISCO; RIGONATO, JANAINA; MACHINESKI, GABRIELA SILVA; SOUZA, BRUNO C. E.; BARBIERO, LAURENT; REZENDE-FILHO, ARY T.; FIORE, MARLI F.. Contrasting the Genetic Patterns of Microbial Communities in Soda Lakes with and without Cyanobacterial Bloom. FRONTIERS IN MICROBIOLOGY, v. 9, . (13/20142-4, 13/09192-0, 13/50425-8)

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