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Effect of fruit juices from Myrtaceae family on postprandial glycemia in individuals with metabolic syndrome and dysglycemia

Grant number: 13/19797-6
Support Opportunities:Regular Research Grants
Duration: May 01, 2014 - July 31, 2016
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Science
Principal Investigator:Maria Ines Genovese Rodriguez
Grantee:Maria Ines Genovese Rodriguez
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Rosa Ferreira dos Santos


Incidence of Metabolic Syndrome (MS) and type 2 diabetes (T2DM) has taken epidemic proportions in recent years, reaching billions of people worldwide, and is continuously growing. Accordingly, innovations in science, capable of preventing and / or treating this disease, become relevant to mitigate their impacts on public health, considering the low adherence to therapy. Studies have shown that bioactive phenolic compounds may be able to influence the metabolism of carbohydrates and is thus an alternative to population with this disease. Some native Brazilian fruit can be considered excellent sources of bioactive compounds of phenolic nature. We highlight, among them the fruits of the Myrtaceae family, such as guava, cambuci, jaboticaba, camu-camu, and cagaita, whose phenolic compounds are able to inhibit the enzymes of carbohydrate metabolism, a-amylase and-aglucosidase in vitro and clarified juices which are capable of reducing postprandial glucose levels by about 20 to 60% in healthy subjects (results in FAPESP 2009/14654-7). The aim of this project is to extend the previous study evaluating the effect of two native Brazilian fruit juices, family Myrtaceae, namely cagaita and cambuci, on postprandial glucose and antioxidant capacity in pre-diabetic human patients after consumption of 25 g of available carbohydrate from white bread (about 50 g), using only commercial fruit plantations, with confirmation of the safety of use by historical consumption by the population.Possible adverse gastrointestinal effects (associated with the use of alpha-glucosidase inhibitors) will be evaluated by a specific questionnaire and monitoring of volunteers within 24 hours of testing. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DONADO-PESTANA, CARLOS M.; BELCHIOR, THIAGO; GENOVESE, MARIA INES. Phenolic compounds from cagaita (Eugenia dysenterica DC.) fruit prevent body weight and fat mass gain induced by a high-fat, high-sucrose diet. Food Research International, v. 77, n. 2, SI, p. 177-185, . (13/19797-6)
DONADO-PESTANA, CARLOS M.; BELCHIOR, THIAGO; FESTUCCIA, WILLIAM T.; GENOVESE, MARIA INES. Phenolic compounds from cambuci (Campomanesia phaea O. Berg) fruit attenuate glucose intolerance and adipose tissue inflammation induced by a high-fat, high-sucrose diet. Food Research International, v. 69, p. 170-178, . (13/50394-5, 13/19797-6)

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