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Study of nerve regeneration in peripheral nerve of SHR rats lineage using plasma Fibrin-Rich: evaluation the best method of treatment acute injuries

Grant number: 13/26878-2
Support Opportunities:Regular Research Grants
Duration: April 01, 2014 - March 31, 2015
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Joao Baptista Gomes dos Santos
Grantee:Joao Baptista Gomes dos Santos
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


The treatment of peripheral nerve injuries have widely varying results. The search for new methods of treating allowed knowledge of Fibrin-Rich Plasma (PRF). It is known that the PRF releases growth factors with great potential for tissue regeneration. Objective: To compare different methods of repair of peripheral nerve injury in the rat sciatic nerve isogenic SHR, using FRP obtained from centrifugation methods. Material and Methods: Will be evaluated 8 different methods of obtaining PRF: obtaining from peripheral blood without spin, spin only (200g and 400g), double centrifugation (200g/200g, 200g/400g, 200g/800g, 400g/400g, 400g/800g). The PRF used in the repair of peripheral nerve is the one with the highest concentration of platelets. Will be performed: direct nerve suture versus nerve suture directly associated with graft versus PRF vein tube filled with PRF versus nerve graft associated with the PRF versus control (without dissection nerve injury). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROTH, FELIPE; FERNANDES, MARCELA; VALENTE, SANDRA G.; SANTOS, JOAO B. G.; FURUKAWA, REBECA BARROS; FERNANDES, CARLOS HENRIQUE; LEITE, VILNEI M.; FALOPPA, FLAVIO. Platelet-Rich Fibrin Conduits as an Alternative to Nerve Autografts for Peripheral Nerve Repair. JOURNAL OF RECONSTRUCTIVE MICROSURGERY, v. 33, n. 8, p. 549-556, . (13/26878-2)

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