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Native and recombinant animal toxins: functional, structural and molecular analysis

Grant number: 11/23236-4
Support type:Research Projects - Thematic Grants
Duration: February 01, 2014 - April 30, 2019
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal researcher:Suely Vilela
Grantee:Suely Vilela
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
( Últimos )
Antonio Cardozo dos Santos ; Eliane Candiani Arantes Braga
Pesquisadores principais:
( Antigos )
Fabíola Attié de Castro ; Maria Cristina Nonato
Assoc. researchers:Antonio José da Costa Filho ; Benedito Barraviera ; Carlos Henrique Tomich de Paula da Silva ; Catarina de Fatima Pereira Teixeira ; Fabiani Gai Frantz ; Fabíola Attié de Castro ; Hamilton Cabral ; José César Rosa ; Lúcia Helena Faccioli ; Luciana Simon Pereira Crott ; Lucilene Delazari dos Santos ; Lusânia Maria Greggi Antunes ; Maria Cristina Nonato ; Maria Regina Torqueti ; Rui Seabra Ferreira Junior ; Sergio Akira Uyemura
Associated grant(s):18/23389-4 - Multi-User Equipment approved in grant 2011/23236-4: prominence chromatography system and accessories, AP.EMU
15/02506-4 - Multi-User Equipment approved in grant 2011/23236-4: automatic sequencing of proteins and peptides, PPSQ-33A model and accessories, AP.EMU
14/20212-5 - Multi-User Equipment approved in grant 2011/23236-4: Labchip GXII touch 24 instrument, AP.EMU
Associated scholarship(s):17/03580-9 - Biochemical, structural and functional evaluation of a phosphodiesterase from Crotalus durissus collilineatus venom, BP.DR
16/04761-4 - Functional and structural characterization and immune response evaluation of a recombinant serine protease from Crotalus durissus collilineatus modified by PEGylation, BP.DD
16/11578-1 - Functional study of a disintegrin from Crotalus durissus collilineatus venom, BP.IC
+ associated scholarships 15/24701-3 - Studies of effects of a snake venom phospholipase A2 on cells from the adipose tissue: Adipogenesis and inflammatory response, BP.PD
16/04079-9 - Anti-inflammatory potential evaluation of crotoxin, a phospholipase A2 isolated from the venom of Crotalus durissus terrificus, in endotoxemia model, BP.IC
15/26901-0 - Immunomodulatory action and epigenetic and transcriptional evaluation of natural killer cells submitted to Bothrops moojeni L-amino acid oxidase enzyme and to Bothrops jararacussu BthTX-I phospholipase, BP.PD
15/26609-7 - Bothrops moojeni snake venomics: application of toxins of biotechnological interest obtained by omics techniques, BP.PD
15/25637-7 - Epigenetic modulation of apoptotic machinery in Bcr-Abl positive cells by BmooLAAO-I and MjTX-I toxins, BP.PD
15/24808-2 - Neuroprotective potential evaluation of a synthetic peptide in neurodegenerative diseases: evaluation of genotoxicity and mutagenicity, BP.PD
15/24010-0 - Structural and biophysical characterization of animal toxins, BP.PD
15/06290-6 - Evaluation of anti-inflammatory potential of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus venom, in a disseminated intravascular coagulation model induced by endotoxemia, BP.PD
15/00740-0 - Therapeutic potential evaluation of L-amino acid oxidases isolated from snake venoms as antitumor: genotoxicity and gene expression studies, BP.PD
15/00847-9 - Evaluation of genotoxic potential of an isolated L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom on human cell lines, BP.IC
14/06170-8 - Biochemical and in vitro evaluation of fibroblast activation and leishmanicidal potential of an L-amino acid oxidase (LAAO) from Crotalus durissus terrificus venom, BP.MS
14/16182-3 - New functional perspectives of a serine protease from Crotalus durissus collilineatus: activity on voltage-gated ion channels, BP.PD
14/19127-3 - Effect of Calloselasma rhodostoma and Bothrops moojeni LAAO on apoptotic machinery of JAK2V617F positive strains of myeloproliferative neoplasms, BP.IC
14/13717-3 - Immunomodulatory potential evaluation of Calloselasma rhodostoma raw venom and L-amino acid oxidase on the complement system, BP.IC
14/11266-4 - Structural and biophysical characterization of animal toxins, BP.PD
12/11963-1 - Effects of a metalloprotease and an acidic phospholipase A2 from Bothrops atrox snake venom on the complement system and the inflammatory process, BP.PD
12/21569-9 - ANTITHROMBOTIC AND TROMBOLYTIC ACTIVITIES OF BATROXASE, A METALLOPROTEINASE PURIFIED FROM THE VENOM OF Bothrops atrox SNAKE, IN EXPERIMENTAL ANIMAL MODELS., BP.PD - associated scholarships

Abstract

Animal venoms constitute a rich source of pharmacologically active substances. Such molecules, named toxins, act either isolated or in synergy through the binding to cell receptors and/or interfering metabolic pathways fundamental to cell viability, inducing local, systemic and even lethal damage to the victim or pray. Exploring the mechanisms of action of toxins has been relevant for providing the molecular basis of their toxicity, as well as by allowing the application of toxins in the development of new therapeutic strategies. In addition, animal toxins represent valuable tools for the elucidation of different metabolic pathways within the biological system. The present proposal aims to contribute to the mapping of new components of different snake venoms by the application of modern approaches for structural and functional characterization, and the study of plasma inhibitors of these animals. Investigating venoms from different snakes our studies will focus the characterization of molecules (proteins and peptides) that present activities on haemostasis, apoptosis, genomic stability and inflammatory processes; as well as involvement on neuroprotective, immunomodulatory, antiparasitic and antitumor effects. The application of very well established biological assays, associated to a complete characterization by the application of molecular biology, biochemical and biophysical tools, will be employed in studies of structure-function relationship, aiming not only to elucidate the toxicity mechanism, but also to explore the therapeutic potential of venom components in the development and production of new drugs. (AU)

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Scientific publications (58)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DANILO L. MENALDO; ANNA L. JACOB-FERREIRA; CAROLINA P. BERNARDES; ADÉLIA C. O. CINTRA; SUELY V. SAMPAIO. Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A 2 fromBothrops atrox snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, p. 0-0, . (12/21569-9, 12/11963-1, 11/23236-4)
WIEZEL, GISELE A.; RUSTIGUEL, JOANE K.; MORGENSTERN, DAVID; ZOCCAL, KARINA E.; FACCIOLI, LUCIA H.; CRISTINA NONATO, M.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C.. Insights into the structure, function and stability of bordonein-L, the first L-amino acid oxidase from Crotalus durissus terrificus snake venom. Biochimie, v. 163, p. 33-49, . (14/03332-7, 11/23236-4, 15/24010-0, 14/23285-3, 14/06170-8, 14/07125-6)
MENALDO, DANILO L.; COSTA, TASSIA R.; RIBEIRO, DIEGO L.; ZAMBUZI, FABIANA A.; ANTUNES, LUSANIA M. G.; CASTRO, FABIOLA A.; FRANTZ, FABIANI G.; SAMPAIO, SUELY V.. Immunomodulatory actions and epigenetic alterations induced by proteases from Bothrops snake venoms in human immune cells. TOXICOLOGY IN VITRO, v. 61, . (11/23236-4)
ALVES BEZERRA, PATRICIA HELOISE; FERREIRA, ISADORA MARQUES; FRANCESCHI, BEATRIZ TINOCO; BIANCHINI, FRANCINE; AMBROSIO, LUCIANA; CINTRA, ADELIA CRISTINA O.; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE; TORQUETI, MARIA REGINA. BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, . (11/23236-4)
DE OLIVEIRA, ISADORA SOUSA; CARDOSO, IARA AIME; FIGUEIREDO BORDON, KARLA DE CASTRO; IMAI CARONE, SANTE EMMANUEL; BOLDRINI-FRANCA, JOHARA; PUCCA, MANUELA BERTO; ZOCCAL, KARMA FURLANI; FACCIOLI, LUCIA HELENA; SAMPAIO, SUELY VILELA; ROSA, JOSE CESAR; et al. Global proteomic and functional analysis of Crotalus durissus collilineatus individual venom variation and its impact on envenoming. JOURNAL OF PROTEOMICS, v. 191, n. SI, p. 153-165, . (14/16182-3, 14/03332-7, 11/23236-4)
PEREIRA-CROTT, LUCIANA SIMON; CASARE-OGASAWARA, TANIA MARA; AMBROSIO, LUCIANA; PRINCI CHAIM, LUIZ FERNANDO; DE MORAIS, FABIANA ROSSETO; OLIVEIRA CINTRA, ADELIA CRISTINA; CANICOBA, NATHALIA CRISTINA; FORTUNATO TUCCI, LUIZ FERNANDO; TORQUETI, MARIA REGINA; SAMPAIO, SUELY VILELA; et al. Bothrops moojeni venom and BmooLAAO-I downmodulate CXCL8/IL-8 and CCL2/MCP-1 production and oxidative burst response, and upregulate CD11b expression in human neutrophils. International Immunopharmacology, v. 80, . (11/23236-4)
COSTA, TASSIA R.; AMSTALDEN, MARTIN K.; RIBEIRO, DIEGO L.; MENALDO, DANILO L.; SARTIM, MARCO A.; AISSA, ALEXANDRE F.; ANTUNES, LUSANIA M. G.; SAMPAIO, V, SUELY. CR-LAAO causes genotoxic damage in HepG2 tumor cells by oxidative stress. Toxicology, v. 404, p. 42-48, . (11/23236-4, 15/00740-0, 15/00847-9)
CEZARETTE, G. N.; SARTIM, M. A.; SAMPAIO, S. V.. Inflammation and coagulation crosstalk induced by BJcuL, a galactose-binding lectin isolated from Bothrops jararacussu snake venom. International Journal of Biological Macromolecules, v. 144, p. 296-304, . (11/23236-4, 15/06290-6, 16/04079-9)
BURIN, SANDRA M.; MENALDO, DANILO L.; SAMPAIO, SUELY V.; FRANTZ, FABIANI G.; CASTRO, FABIOLA A.. An overview of the immune modulating effects of enzymatic toxins from snake venoms. International Journal of Biological Macromolecules, v. 109, p. 664-671, . (11/23236-4, 15/25637-7)
PALACIO, TATIANA Z.; SANTOS-FILHO, NORIVAL A.; ROSA, JOSE CESAR; FERREIRA JUNIOR, RUI S.; BARRAVIERA, BENEDITO; SAMPAIO, SUELY V.. Isolation and characterization of a novel metalloprotease inhibitor from Bothrops alternatus snake serum. International Journal of Biological Macromolecules, v. 98, p. 436-446, . (12/02734-9, 11/23236-4)
BOLDRINI-FRANCA, JOHARA; COLOGNA, CAMILA TAKENO; PUCCA, MANUELA BERTO; FIGUEIREDO BORDON, KARLA DE CASTRO; AMORIM, FERNANDO GOBBI; PINO ANJOLETTE, FERNANDO ANTONIO; CORDEIRO, FRANCIELLE ALMEIDA; WIEZEL, GISELE ADRIANO; CERNI, FELIPE AUGUSTO; PINHEIRO-JUNIOR, ERNESTO LOPES; et al. Minor snake venom proteins: Structure, function and potential applications. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 4, p. 824-838, . (14/06170-8, 11/12317-3, 11/23236-4, 15/16714-8, 12/13590-8, 13/26619-7, 14/15644-3, 12/12954-6, 13/26200-6)
ANDREIA VIEIRA PEREIRA; GUSTAVO DE BARROS; ERIKA GRACIELLE PINTO; ANDRE GUSTAVO TEMPONE; RICARDO DE OLIVEIRA ORSI; LUCILENE DELAZARI DOS SANTOS; SUELI CALVI; RUI SEABRA FERREIRA JR; DANIEL CARVALHO PIMENTA; BENEDITO BARRAVIERA. Melittin induces in vitro death of Leishmania (Leishmania) infantum by triggering the cellular innate immune response. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 22, . (11/23236-4, 09/53846-9)
WIEZEL, GISELE A.; SHIBAO, PRISCILA Y. T.; COLOGNA, CAMILA T.; MORANDI FILHO, ROMUALDO; UEIRA-VIEIRA, CARLOS; DE PAUW, EDWIN; QUINTON, LOIC; ARANTES, ELIANE C.. In-Depth Venome of the Brazilian Rattlesnake Crotalus durissus terrificus: An Integrative Approach Combining Its Venom Gland Transcriptome and Venom Proteome. JOURNAL OF PROTEOME RESEARCH, v. 17, n. 11, p. 3941-3958, . (15/17466-8, 13/26200-6, 11/23236-4, 17/00586-6, 14/15644-3, 15/18432-0)
CEDRO, RAFHAELLA C. A.; MENALDO, DANILO L.; COSTA, TASSIA R.; ZOCCAL, KARINA F.; SARTIM, MARCO A.; SANTOS-FILHO, NORIVAL A.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V.. Cytotoxic and inflammatory potential of a phospholipase A(2) from Bothrops jararaca snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (11/23236-4)
BURIN, SANDRA MARA; GHISLA, SANDRO; OUCHIDA, AMANDA TOMIE; AISSA, ALEXANDRE FERRO; BERZOTI COELHO, MARIA GABRIELA; COSTA, TASSIA RAFAELLA; ZAMBUZI CARDOSO MARSOLA, ANA PAULA; PINTO-SIMOES, BELINDA; GREGGI ANTUNES, LUSANIA MARIA; CURTI, CARLOS; et al. CR-LAAO antileukemic effect against Bcr-Abl(+) cells is mediated by apoptosis and hydrogen peroxide. International Journal of Biological Macromolecules, v. 86, p. 309-320, . (11/23236-4)
COSTA, TASSIA R.; MENALDO, DANILO L.; ZOCCAL, KARINA F.; BURIN, SANDRA M.; AISSA, ALEXANDRE F.; DE CASTRO, FABIOLA A.; FACCIOLI, LUCIA H.; GREGGI ANTUNES, LUSANIA M.; SAMPAIO, SUELY V.. CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma venom, as a potential tool for developing novel immunotherapeutic strategies against cancer. SCIENTIFIC REPORTS, v. 7, . (11/23236-4, 15/00740-0)
BARBIZAN, ROBERTA; CASTRO, MATEUS V.; FERREIRA, JR., RUI SEABRA; BARRAVIERA, BENEDITO; OLIVEIRA, ALEXANDRE L. R.. Long-Term Spinal Ventral Root Reimplantation, but not Bone Marrow Mononuclear Cell Treatment, Positively Influences Ultrastructural Synapse Recovery and Motor Axonal Regrowth. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 15, n. 11, p. 19535-19551, . (11/23236-4, 12/08101-8, 14/06892-3, 09/53846-9)
JACOB-FERREIRA, ANNA L.; MENALDO, DANILO L.; BERNARDES, CAROLINA P.; SARTIM, MARCO A.; DE ANGELIS, CELIO D.; TANUS-SANTOS, JOSE E.; SAMPAIO, SUELY V.. Evaluation of the in vivo thrombolytic activity of a metalloprotease from Bothrops atrox venom using a model of venous thrombosis. Toxicon, v. 109, p. 18-25, . (11/23236-4, 12/21569-9)
LODOVICHO, MARINA E.; COSTA, TASSIA R.; BERNARDES, CAROLINA P.; MENALDO, DANILO L.; ZOCCAL, KARINA F.; CARONE, SANTE E.; ROSA, JOSE C.; PUCCA, MANUELA B.; CERNI, FELIPE A.; ARANTES, ELIANE C.; et al. Investigating possible biological targets of Bj-CRP, the first cysteine-rich secretory protein (CRISP) isolated from Bothrops jararaca snake venom. Toxicology Letters, v. 265, p. 156-169, . (11/23236-4, 12/12954-6, 12/13590-8)
MENALDO, DANILO L.; BERNARDES, CAROLINA P.; ZOCCAL, KARINA F.; JACOB-FERREIRA, ANNA L.; COSTA, TASSIA R.; DEL LAMA, MARIA P. F. M.; NAAL, ROSE M. Z. G.; FRANTZ, FABIANI G.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V.. Immune cells and mediators involved in the inflammatory responses induced by a P-I metalloprotease and a phospholipase A(2) from Bothrops atrox venom. Molecular Immunology, v. 85, p. 238-247, . (11/23236-4, 12/11963-1)
MACHADO, A. R. T.; AISSA, A. F.; RIBEIRO, D. L.; COSTA, T. R.; FERREIRA, JR., R. S.; SAMPAIO, S. V.; ANTUNES, L. M. G.. Cytotoxic, genotoxic, and oxidative stress-inducing effect of an L-amino acid oxidase isolated from Bothrops jararacussu venom in a co-culture model of HepG2 and HUVEC cells. International Journal of Biological Macromolecules, v. 127, p. 425-432, . (11/23236-4)
BERNARDES, CAROLINA P.; SANTOS, NEIFE A. G.; COSTA, TASSIA R.; SISTI, FLAVIA; AMARAL, LILIAN; MENALDO, DANILO L.; AMSTALDEN, MARTIN K.; RIBEIRO, DIEGO L.; ANTUNES, LUSANIA M. G.; SAMPAIO, SUELY VILELA; et al. A Synthetic Snake-Venom-Based Tripeptide Protects PC12 Cells from the Neurotoxicity of Acrolein by Improving Axonal Plasticity and Bioenergetics. NEUROTOXICITY RESEARCH, . (15/24808-2, 11/23236-4)
LEAO, TAINA KEILLER; RIBEIRO, DIEGO LUIS; THOMAZELA MACHADO, ANA RITA; COSTA, TASSIA RAFAELA; SAMPAIO, SUELY VILELA; GREGGI ANTUNES, LUSANIA MARIA. Synephrine and caffeine combination promotes cytotoxicity, DNA damage and transcriptional modulation of apoptosis-related genes in human HepG2 cells. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, v. 868, . (11/23236-4, 15/00740-0, 14/20344-9)
BERNARDES, CAROLINA PETRI; MENALDO, DANILO LUCCAS; ZOCCAL, KARIM FURLANI; BOLDRINI-FRANCA, JOHARA; PEIGNEUR, STEVE; ARANTES, ELIANE CANDIANE; ROSA, JOSE CESAR; FACCIOLI, LUCIA HELENA; TYTGAT, JAN; SAMPAIO, SUELY VILELA. First report on BaltCRP, a cysteine-rich secretory protein (CRISP) from Bothrops alternatus venom: Effects on potassium channels and inflammatory processes. International Journal of Biological Macromolecules, v. 140, p. 556-567, . (11/23236-4)
RAFHAELLA C. A. CEDRO; DANILO L. MENALDO; TÁSSIA R. COSTA; KARINA F. ZOCCAL; MARCO A. SARTIM; NORIVAL A. SANTOS-FILHO; LÚCIA H. FACCIOLI; SUELY V. SAMPAIO. Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (11/23236-4)
SANDRA MARA BURIN; MAIRA DA COSTA CACEMIRO; JUÇARA GASTALDI COMINAL; RONE APARECIDO DE GRANDIS; ANA RITA THOMAZELA MACHADO; FLAVIA SACILOTTO DONAIRES; ADELIA CRISTINA OLIVEIRA CINTRA; LUCIANA AMBROSIO; LUSÂNIA MARIA GREGGI ANTUNES; SUELY VILELA SAMPAIO; et al. Bothrops moojeni L-amino acid oxidase induces apoptosis and epigenetic modulation on Bcr-Abl+ cells. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 26, . (18/01756-5, 15/25637-7, 11/23236-4)
AMORIM, FERNANDA GOBBI; MORANDI-FILHO, ROMUALDO; FUJIMURA, PATRICIA TIEME; UEIRA-VIEIRA, CARLOS; SAMPAIO, SUELY VILELA. New findings from the first transcriptome of the Bothrops moojeni snake venom gland. Toxicon, v. 140, p. 105-117, . (11/23236-4, 15/26609-7, 16/20641-9)
AMORIM, FERNANDA GOBBI; COSTA, TASSIA RAFAELA; BAIWIR, DOMINIQUE; DE PAUW, EDWIN; QUINTON, LOIC; SAMPAIO, SUELY VILELA. Proteopeptidomic, Functional and Immunoreactivity Characterization of Bothrops moojeni Snake Venom: Influence of Snake Gender on Venom Composition. TOXINS, v. 10, n. 5, . (15/00740-0, 15/26609-7, 11/23236-4, 16/20641-9)
DE ANDRADE, CAMILA M.; REY, FERNANDA M.; CINTRA, ADELIA CRISTINA O.; SAMPAIO, SUELY V.; TORQUETI, MARIA REGINA. Effects of crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, on human endothelial cells. International Journal of Biological Macromolecules, v. 134, p. 613-621, . (11/23236-4)
DE ANDRADE, CAMILA M.; REY, FERNANDA M.; BIANCHINI, FRANCINE J.; SAMPAIO, SUELY V.; TORQUETI, MARIA REGINA. Crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, as a potential tool against thrombosis development. International Journal of Biological Macromolecules, v. 134, p. 653-659, . (11/23236-4)
AMORIM, FERNANDA G.; MENALDO, DANILO L.; CARONE, SANTE E. I.; SILVA, THIAGO A.; SARTIM, MARCO A.; DE PAUW, EDWIN; QUINTON, LOIC; SAMPAIO, SUELY V.. New Insights on Moojase, a Thrombin-Like Serine Protease from Bothrops moojeni Snake Venom. TOXINS, v. 10, n. 12, . (11/23236-4, 16/20641-9, 15/26609-7)
CARONE, I, SANTE E.; MENALDO, DANILO L.; SARTIM, MARCO A.; BERNARDES, CAROLINA P.; CAETANO, RENATO C.; DA SILVA, RONIVALDO R.; CABRAL, HAMILTON; BARRAVIERA, BENEDITO; FERREIRA JUNIOR, RUI S.; SAMPAIO, V, SUELY. BjSP, a novel serine protease from Bothrops jararaca snake venom that degrades fibrinogen without forming fibrin clots. Toxicology and Applied Pharmacology, v. 357, p. 50-61, . (11/23236-4)
MENALDO, DANILO L.; BERNARDES, CAROLINA P.; JACOB-FERREIRA, ANNA L.; NOGUEIRA-SANTOS, CINTIA G.; CASARE-OGASAWARA, TANIA M.; PEREIRA-CROTT, LUCIANA S.; SAMPAIO, SUELY V.. Effects of Bothrops atrox venom and two isolated toxins on the human complement system: Modulation of pathways and generation of anaphylatoxins. Molecular Immunology, v. 80, p. 91-100, . (12/11963-1, 11/23236-4)
BURIN, SANDRA MARA; BERZOTI-COELHO, MARIA GABRIELA; COMINAL, JUCARA GASTALDI; AMBROSIO, LUCIANA; TORQUETI, MARIA REGINA; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE. The L-amino acid oxidase from Calloselasma rhodostoma snake venom modulates apoptomiRs expression in Bcr-Abl-positive cell lines. Toxicon, v. 120, p. 9-14, . (15/25637-7, 15/23555-3, 11/23236-4)
AMORIM, FERNANDA GOBBI; LONGHIM, HELOISA TAVONI; COLOGNA, CAMILA TAKENO; DEGUELDRE, MICHEL; DE PAUW, EDWIN; QUINTON, LOIC; ARANTES, ELIANE CANDIANI. Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, . (15/17466-8, 11/23236-4, 14/22959-0, 13/26200-6, 13/26083-0, 14/07824-1, 12/14996-8)
BERNARDES, CAROLINA P.; SANTOS, NEIFE A. G.; SISTI, FLAVIA M.; FERREIRA, RAFAELA SCALCO; SANTOS-FILHO, NORIVAL A.; CINTRA, ADELIA C. O.; CILLI, EDUARDO M.; SAMPAIO, V, SUELY; SANTOS, ANTONIO C.. A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP+ toxicity by activating the NGF-signaling pathway. Peptides, v. 104, p. 24-34, . (11/23236-4, 13/07600-3)
CARONE, SANTE E. I.; COSTA, TASSIA R.; BURIN, SANDRA M.; CINTRA, ADELIA C. O.; ZOCCAL, KARINA F.; BIANCHINI, FRANCINE J.; TUCCI, LUIZ F. F.; FRANCO, JOAO J.; TORQUETI, MARIA R.; FACCIOLI, LUCIA H.; et al. A new L-amino acid oxidase from Bothrops jararacussu snake venom: Isolation, partial characterization, and assessment of pro-apoptotic and antiprotozoal activities. International Journal of Biological Macromolecules, v. 103, p. 25-35, . (11/23236-4, 15/25637-7, 15/00740-0)
SARTIM, MARCO A.; CEZARETTE, GABRIEL N.; JACOB-FERREIRA, ANNA L.; FRANTZ, FABIANI G.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V.. Disseminated intravascular coagulation caused by moojenactivase, a procoagulant snake venom metalloprotease. International Journal of Biological Macromolecules, v. 103, p. 1077-1086, . (11/23236-4, 15/06290-6)
MACHADO, A. R. T.; AISSA, A. F.; RIBEIRO, D. L.; HERNANDES, L. C.; MACHADO, C. S.; BIANCHI, M. L. P.; SAMPAIO, S. V.; ANTUNES, L. M. G.. The toxin BjussuLAAO-II induces oxidative stress and DNA damage, upregulates the inflammatory cytokine genes TNF and IL6, and downregulates the apoptotic-related genes BAX, BCL2 and RELA in human Caco-2 cells. International Journal of Biological Macromolecules, v. 109, p. 212-219, . (11/23236-4)
JACOB-FERREIRA, ANNA L.; MENALDO, DANILO L.; SARTIM, MARCO A.; RIUL, THALITA B.; DIAS-BARUFFI, MARCELO; SAMPAIO, SUELY V.. Antithrombotic activity of Batroxase, a metalloprotease from Bothrops atrox venom, in a model of venous thrombosis. International Journal of Biological Macromolecules, v. 95, p. 263-267, . (11/23236-4, 12/21569-9)
SARTIM, MARCO A.; PINHEIRO, MATHEUS P.; DE PADUA, RICARDO A. P.; SAMPAIO, SUELY V.; CRISTINA NONATO, M.. Structural and binding studies of a C-type galactose-binding lectin from Bothrops jararacussu snake venom. Toxicon, v. 126, p. 59-69, . (14/19127-3, 11/23236-4, 14/11266-4)
MENALDO, DANILO L.; JACOB-FERREIRA, ANNA L.; BERNARDES, CAROLINA P.; CINTRA, ADELIA C. O.; SAMPAIO, SUELY V.. Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A(2) from Bothrops atrox snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, . (11/23236-4, 12/11963-1, 12/21569-9)
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CRISTIANE TAVARES; THAÍS MACIEL; SANDRA BURIN; LUCIANA AMBRÓSIO; SANDRO GHISLA; SUELY SAMPAIO; FABÍOLA CASTRO. l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines. Revista Brasileira de Hematologia e Hemoterapia, v. 38, n. 2, p. 128-134, . (11/23236-4, 14/19127-3)
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CARTAROZZI, LUCIANA P.; SPEJO, ALINE B.; FERREIRA, JR., RUI S.; BARRAVIERA, BENEDITO; DUEK, ELIANA; CARVALHO, JULIANA L.; GOES, ALFREDO M.; OLIVEIRA, ALEXANDRE L. R.. Mesenchymal stem cells engrafted in a fibrin scaffold stimulate Schwann cell reactivity and axonal regeneration following sciatic nerve tubulization. Brain Research Bulletin, v. 112, p. 14-24, . (11/23236-4, 12/08101-8, 14/06892-3, 09/53846-9)
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