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Native and recombinant animal toxins: functional, structural and molecular analysis

Grant number: 11/23236-4
Support Opportunities:Research Projects - Thematic Grants
Duration: February 01, 2014 - April 30, 2019
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal Investigator:Suely Vilela
Grantee:Suely Vilela
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
( Últimos )		Antonio Cardozo dos Santos ; Eliane Candiani Arantes Braga
Pesquisadores principais:
( Antigos )		Fabíola Attié de Castro ; Maria Cristina Nonato
Associated researchers:Antonio José da Costa Filho ; Benedito Barraviera ; Carlos Henrique Tomich de Paula da Silva ; Catarina de Fatima Pereira Teixeira ; Fabiani Gai Frantz ; Fabíola Attié de Castro ; Hamilton Cabral ; José César Rosa ; Lúcia Helena Faccioli ; Luciana Simon Pereira Crott ; Lucilene Delazari dos Santos ; Lusânia Maria Greggi Antunes ; Maria Cristina Nonato ; Maria Regina Torqueti ; Rui Seabra Ferreira Junior ; Sergio Akira Uyemura
Associated grant(s):18/23389-4 - Multi-User Equipment approved in grant 2011/23236-4: prominence chromatography system and accessories, AP.EMU
15/02506-4 - Multi-User Equipment approved in grant 2011/23236-4: automatic sequencing of proteins and peptides, PPSQ-33A model and accessories, AP.EMU
14/20212-5 - Multi-User Equipment approved in grant 2011/23236-4: Labchip GXII touch 24 instrument, AP.EMU
Associated scholarship(s):17/03580-9 - Biochemical, structural and functional evaluation of a phosphodiesterase from Crotalus durissus collilineatus venom, BP.DR
16/04761-4 - Functional and structural characterization and immune response evaluation of a recombinant serine protease from Crotalus durissus collilineatus modified by PEGylation, BP.DD
16/11578-1 - Functional study of a disintegrin from Crotalus durissus collilineatus venom, BP.IC
 + associated scholarships 15/24701-3 - Studies of effects of a snake venom phospholipase A2 on cells from the adipose tissue: Adipogenesis and inflammatory response, BP.PD
16/04079-9 - Anti-inflammatory potential evaluation of crotoxin, a phospholipase A2 isolated from the venom of Crotalus durissus terrificus, in endotoxemia model, BP.IC
15/26901-0 - Immunomodulatory action and epigenetic and transcriptional evaluation of natural killer cells submitted to Bothrops moojeni L-amino acid oxidase enzyme and to Bothrops jararacussu BthTX-I phospholipase, BP.PD
15/26609-7 - Bothrops moojeni snake venomics: application of toxins of biotechnological interest obtained by omics techniques, BP.PD
15/25637-7 - Epigenetic modulation of apoptotic machinery in Bcr-Abl positive cells by BmooLAAO-I and MjTX-I toxins, BP.PD
15/24808-2 - Neuroprotective potential evaluation of a synthetic peptide in neurodegenerative diseases: evaluation of genotoxicity and mutagenicity, BP.PD
15/24010-0 - Structural and biophysical characterization of animal toxins, BP.PD
15/06290-6 - Evaluation of anti-inflammatory potential of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus venom, in a disseminated intravascular coagulation model induced by endotoxemia, BP.PD
15/00740-0 - Therapeutic potential evaluation of L-amino acid oxidases isolated from snake venoms as antitumor: genotoxicity and gene expression studies, BP.PD
15/00847-9 - Evaluation of genotoxic potential of an isolated L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom on human cell lines, BP.IC
14/19127-3 - Effect of Calloselasma rhodostoma and Bothrops moojeni LAAO on apoptotic machinery of JAK2V617F positive strains of myeloproliferative neoplasms, BP.IC
14/06170-8 - Biochemical and in vitro evaluation of fibroblast activation and leishmanicidal potential of an L-amino acid oxidase (LAAO) from Crotalus durissus terrificus venom, BP.MS
14/16182-3 - New functional perspectives of a serine protease from Crotalus durissus collilineatus: activity on voltage-gated ion channels, BP.PD
14/13717-3 - Immunomodulatory potential evaluation of Calloselasma rhodostoma raw venom and L-amino acid oxidase on the complement system, BP.IC
14/11266-4 - Structural and biophysical characterization of animal toxins, BP.PD
12/11963-1 - Effects of a metalloprotease and an acidic phospholipase A2 from Bothrops atrox snake venom on the complement system and the inflammatory process, BP.PD
12/21569-9 - ANTITHROMBOTIC AND TROMBOLYTIC ACTIVITIES OF BATROXASE, A METALLOPROTEINASE PURIFIED FROM THE VENOM OF Bothrops atrox SNAKE, IN EXPERIMENTAL ANIMAL MODELS., BP.PD - associated scholarships

Abstract

Animal venoms constitute a rich source of pharmacologically active substances. Such molecules, named toxins, act either isolated or in synergy through the binding to cell receptors and/or interfering metabolic pathways fundamental to cell viability, inducing local, systemic and even lethal damage to the victim or pray. Exploring the mechanisms of action of toxins has been relevant for providing the molecular basis of their toxicity, as well as by allowing the application of toxins in the development of new therapeutic strategies. In addition, animal toxins represent valuable tools for the elucidation of different metabolic pathways within the biological system. The present proposal aims to contribute to the mapping of new components of different snake venoms by the application of modern approaches for structural and functional characterization, and the study of plasma inhibitors of these animals. Investigating venoms from different snakes our studies will focus the characterization of molecules (proteins and peptides) that present activities on haemostasis, apoptosis, genomic stability and inflammatory processes; as well as involvement on neuroprotective, immunomodulatory, antiparasitic and antitumor effects. The application of very well established biological assays, associated to a complete characterization by the application of molecular biology, biochemical and biophysical tools, will be employed in studies of structure-function relationship, aiming not only to elucidate the toxicity mechanism, but also to explore the therapeutic potential of venom components in the development and production of new drugs. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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VEICULO: TITULO (DATA)
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Scientific publications (85)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RAFHAELLA C. A. CEDRO; DANILO L. MENALDO; TÁSSIA R. COSTA; KARINA F. ZOCCAL; MARCO A. SARTIM; NORIVAL A. SANTOS-FILHO; LÚCIA H. FACCIOLI; SUELY V. SAMPAIO. Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (11/23236-4)
SANDRA MARA BURIN; MAIRA DA COSTA CACEMIRO; JUÇARA GASTALDI COMINAL; RONE APARECIDO DE GRANDIS; ANA RITA THOMAZELA MACHADO; FLAVIA SACILOTTO DONAIRES; ADELIA CRISTINA OLIVEIRA CINTRA; LUCIANA AMBROSIO; LUSÂNIA MARIA GREGGI ANTUNES; SUELY VILELA SAMPAIO; et al. Bothrops moojeni L-amino acid oxidase induces apoptosis and epigenetic modulation on Bcr-Abl+ cells. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 26, . (18/01756-5, 15/25637-7, 11/23236-4)
BISCOLA, NATALIA PERUSSI; CARTAROZZI, LUCIANA POLITTI; FERREIRA JUNIOR, RUI SEABRA; BARRAVIERA, BENEDITO; RODRIGUES DE OLIVEIRA, ALEXANDRE LEITE. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. NEURAL PLASTICITY, . (12/08101-8, 14/06892-3, 11/23377-7, 11/23236-4, 09/53846-9)
BERNARDES, CAROLINA P.; MENALDO, DANILO L.; MAMEDE, CARLA C. N.; ZOCCAL, KARINA F.; CINTRA, ADELIA C. O.; FACCIOLI, LUCIA H.; STANZIOLA, LEONILDA; DE OLIVEIRA, FABIO; SAMPAIO, SUELY V.. Evaluation of the local inflammatory events induced by BpirMP, a metalloproteinase from Bothrops pirajai venom. Molecular Immunology, v. 68, n. 2, B, p. 456-464, . (07/08361-1, 05/54855-0, 11/23236-4)
WIEZEL, GISELE A.; DOS SANTOS, PATTY K.; CORDEIRO, FRANCIELLE A.; BORDON, KARLA C. F.; SELISTRE-DE-ARAUJO, HELOISA S.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C.. Identification of hyaluronidase and phospholipase B in Lachesis muta rhombeata venom. Toxicon, v. 107, n. B, SI, p. 359-368, . (11/23236-4, 10/06199-5)
CARONE, SANTE E. I.; COSTA, TASSIA R.; BURIN, SANDRA M.; CINTRA, ADELIA C. O.; ZOCCAL, KARINA F.; BIANCHINI, FRANCINE J.; TUCCI, LUIZ F. F.; FRANCO, JOAO J.; TORQUETI, MARIA R.; FACCIOLI, LUCIA H.; et al. A new L-amino acid oxidase from Bothrops jararacussu snake venom: Isolation, partial characterization, and assessment of pro-apoptotic and antiprotozoal activities. International Journal of Biological Macromolecules, v. 103, p. 25-35, . (15/00740-0, 11/23236-4, 15/25637-7)
SARTIM, MARCO A.; CEZARETTE, GABRIEL N.; JACOB-FERREIRA, ANNA L.; FRANTZ, FABIANI G.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V.. Disseminated intravascular coagulation caused by moojenactivase, a procoagulant snake venom metalloprotease. International Journal of Biological Macromolecules, v. 103, p. 1077-1086, . (15/06290-6, 11/23236-4)
SANTOS-FILHO, NORIVAL A.; SOUSA, TIAGO S.; BOLDRINI-FRANCA, JOHARA; SANTOS-SILVA, LUDIER K.; MENALDO, DANILO L.; HENRIQUE-SILVA, FLAVIO; CINTRA, ADELIA C. O.; LAURE, HELEN J.; MAMEDE, CARLA C. N.; OLIVEIRA, FABIO; et al. rBaltMIP, a recombinant alpha-type myotoxin inhibitor from Bothrops alternatus (Rhinocerophis alternatus) snake, as a potential candidate to complement the antivenom therapy. Toxicon, v. 124, p. 53-62, . (11/23236-4, 08/10760-4)
BERNARDES, CAROLINA P.; SANTOS, NEIFE A. G.; SISTI, FLAVIA M.; FERREIRA, RAFAELA SCALCO; SANTOS-FILHO, NORIVAL A.; CINTRA, ADELIA C. O.; CILLI, EDUARDO M.; SAMPAIO, V, SUELY; SANTOS, ANTONIO C.. A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP+ toxicity by activating the NGF-signaling pathway. Peptides, v. 104, p. 24-34, . (11/23236-4, 13/07600-3)
AMORIM, FERNANDA G.; MENALDO, DANILO L.; CARONE, SANTE E. I.; SILVA, THIAGO A.; SARTIM, MARCO A.; DE PAUW, EDWIN; QUINTON, LOIC; SAMPAIO, SUELY V.. New Insights on Moojase, a Thrombin-Like Serine Protease from Bothrops moojeni Snake Venom. TOXINS, v. 10, n. 12, . (11/23236-4, 16/20641-9, 15/26609-7)
BERNARDES, CAROLINA P.; MENALDO, DANILO L.; MAMEDE, CARLA C. N.; ZOCCAL, KARINA F.; CINTRA, ADELIA C. O.; FACCIOLI, LUCIA H.; STANZIOLA, LEONILDA; DE OLIVEIRA, FABIO; SAMPAIO, SUELY V.. Evaluation of the local inflammatory events induced by BpirMP, a metalloproteinase from Bothrops pirajai venom. Molecular Immunology, v. 68, n. 2, p. 9-pg., . (11/23236-4, 07/08361-1, 05/54855-0)
DE OLIVEIRA, ISADORA SOUSA; PUCCA, MANUELA BERTO; WIEZEL, GISELE ADRIANO; CARDOSO, IARA AIME; FIGUEIREDO BORDON, KARLA DE CASTRO; SARTIM, MARCO AURELIO; KALOGEROPOULOS, KONSTANTINOS; AHMADI, SHIRIN; BAIWIR, DOMINIQUE; NONATO, MARIA CRISTINA; et al. Unraveling the structure and function of CdcPDE: A novel phosphodiesterase from Crotalus durissus collilineatus snake venom. International Journal of Biological Macromolecules, v. 178, p. 180-192, . (17/00586-6, 17/03580-9, 19/10173-6, 11/23236-4, 18/21233-7)
CEZARETTE, G. N.; SARTIM, M. A.; SAMPAIO, S. V.. Inflammation and coagulation crosstalk induced by BJcuL, a galactose-binding lectin isolated from Bothrops jararacussu snake venom. International Journal of Biological Macromolecules, v. 144, p. 9-pg., . (11/23236-4, 15/06290-6, 16/04079-9)
CASELLA-MARTINS, ANDREA; AYRES, LORENA R.; BURIN, SANDRA M.; MORAIS, FABIANA R.; PEREIRA, JULIANA C.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V.; ARANTES, ELIANE C.; CASTRO, FABIOLA A.; PEREIRA-CROTT, LUCIANA S.. Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, . (11/23236-4)
DA-SILVA-FREITAS, DEBORA; BOLDRINI-FRANCA, JOHARA; ARANTES, ELIANE CANDIANI. PEGylation: A Successful Approach to Improve the Biopharmaceutical Potential of Snake Venom Thrombin-Like Serine Protease. PROTEIN AND PEPTIDE LETTERS, v. 22, n. 12, p. 1133-1139, . (08/11688-5, 11/23236-4)
CARTAROZZI, LUCIANA P.; SPEJO, ALINE B.; FERREIRA, JR., RUI S.; BARRAVIERA, BENEDITO; DUEK, ELIANA; CARVALHO, JULIANA L.; GOES, ALFREDO M.; OLIVEIRA, ALEXANDRE L. R.. Mesenchymal stem cells engrafted in a fibrin scaffold stimulate Schwann cell reactivity and axonal regeneration following sciatic nerve tubulization. Brain Research Bulletin, v. 112, p. 14-24, . (14/06892-3, 12/08101-8, 11/23236-4, 09/53846-9)
BURIN, SANDRA MARA; BERZOTI-COELHO, MARIA GABRIELA; COMINAL, JUCARA GASTALDI; AMBROSIO, LUCIANA; TORQUETI, MARIA REGINA; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE. The L-amino acid oxidase from Calloselasma rhodostoma snake venom modulates apoptomiRs expression in Bcr-Abl-positive cell lines. Toxicon, v. 120, p. 9-14, . (15/23555-3, 15/25637-7, 11/23236-4)
BENATI, ROGERIO BODINI; COSTA, TASSIA RAFAELA; CACEMIRO, MAIRA DA COSTA; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE; BURIN, SANDRA MARA. Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (15/00740-0, 15/25637-7, 11/23236-4, 14/04234-9)
AMORIM, FERNANDA GOBBI; LONGHIM, HELOISA TAVONI; COLOGNA, CAMILA TAKENO; DEGUELDRE, MICHEL; DE PAUW, EDWIN; QUINTON, LOIC; ARANTES, ELIANE CANDIANI. Proteome of fraction from Tityus serrulatus venom reveals new enzymes and toxins. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, . (14/07824-1, 15/17466-8, 12/14996-8, 13/26083-0, 11/23236-4, 14/22959-0, 13/26200-6)
BALDO, MATEUS AMARAL; SIQUEIRA CUNHA, ALEXANDRA OLIMPIO; GODOY, LIVEA DORNELA; LIBERATO, JOSE LUIZ; YONEDA, JULIANA SAKAMOTO; FORNARI-BALDO, ELISA CORREA; CIANCAGLINI, PIETRO; DOS SANTOS, WAGNER FERREIRA; ARANTES, ELIANE CANDIANI. Assessment of neuropharmacological potential of low molecular weight components extracted from Rhinella schneideri toad poison. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, . (11/23236-4, 15/18432-0)
DE ANDRADE, CAMILA M.; REY, FERNANDA M.; CINTRA, ADELIA CRISTINA O.; SAMPAIO, SUELY V.; TORQUETI, MARIA REGINA. Effects of crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, on human endothelial cells. International Journal of Biological Macromolecules, v. 134, p. 613-621, . (11/23236-4)
DE ANDRADE, CAMILA M.; REY, FERNANDA M.; BIANCHINI, FRANCINE J.; SAMPAIO, SUELY V.; TORQUETI, MARIA REGINA. Crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, as a potential tool against thrombosis development. International Journal of Biological Macromolecules, v. 134, p. 653-659, . (11/23236-4)
CARONE, I, SANTE E.; MENALDO, DANILO L.; SARTIM, MARCO A.; BERNARDES, CAROLINA P.; CAETANO, RENATO C.; DA SILVA, RONIVALDO R.; CABRAL, HAMILTON; BARRAVIERA, BENEDITO; FERREIRA JUNIOR, RUI S.; SAMPAIO, V, SUELY. BjSP, a novel serine protease from Bothrops jararaca snake venom that degrades fibrinogen without forming fibrin clots. Toxicology and Applied Pharmacology, v. 357, p. 50-61, . (11/23236-4)
CORDEIRO, FRANCIELLE ALMEIDA; COUTINHO, BARBARA MARQUES; WIEZEL, GISELE ADRIANO; FIGUEIREDO BORDON, KARLA DE CASTRO; BREGGE-SILVA, CRISTIANE; ROSA-GARZON, NATHALIA GONSALES; CABRAL, HAMILTON; UEBERHEIDE, BEATRIX; ARANTES, ELIANE CANDIANI. Purification and enzymatic characterization of a novel metalloprotease from Lachesis muta rhombeata snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (14/23285-3, 11/23236-4)
BRUNA TERADA GIMENEZ; GABRIEL NEVES CEZARETTE; ALINE DE SOUSA BOMFIM; WUELTON MARCELO MONTEIRO; ELISA MARIA DE SOUSA RUSSO; FABIANI GAI FRANTZ; SUELY VILELA SAMPAIO; MARCO AURELIO SARTIM. Role of crotoxin in coagulation: novel insights into anticoagulant mechanisms and impairment of inflammation-induced coagulation. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 26, . (16/04079-9, 11/23236-4, 15/06290-6)
MENALDO, DANILO L.; BERNARDES, CAROLINA P.; JACOB-FERREIRA, ANNA L.; NOGUEIRA-SANTOS, CINTIA G.; CASARE-OGASAWARA, TANIA M.; PEREIRA-CROTT, LUCIANA S.; SAMPAIO, SUELY V.. Effects of Bothrops atrox venom and two isolated toxins on the human complement system: Modulation of pathways and generation of anaphylatoxins. Molecular Immunology, v. 80, p. 91-100, . (12/11963-1, 11/23236-4)
BERNARDES, CAROLINA P.; SANTOS, NEIFE A. G.; COSTA, TASSIA R.; MENALDO, DANILO L.; SISTI, FLAVIA M.; AMSTALDEN, MARTIN K.; RIBEIRO, DIEGO L.; ANTUNES, LUSANIA M. G.; SAMPAIO, SUELY V.; SANTOS, ANTONIO C.. Effects of C-Terminal-Ethyl-Esterification in a Snake-Venom-Based Peptide Against the Neurotoxicity of Acrolein in PC12 Cells. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, v. 29, n. 3, p. 16-pg., . (11/23236-4)
AMORIM, FERNANDA GOBBI; MORANDI-FILHO, ROMUALDO; FUJIMURA, PATRICIA TIEME; UEIRA-VIEIRA, CARLOS; SAMPAIO, SUELY VILELA. New findings from the first transcriptome of the Bothrops moojeni snake venom gland. Toxicon, v. 140, p. 105-117, . (16/20641-9, 15/26609-7, 11/23236-4)
AMORIM, FERNANDA GOBBI; COSTA, TASSIA RAFAELA; BAIWIR, DOMINIQUE; DE PAUW, EDWIN; QUINTON, LOIC; SAMPAIO, SUELY VILELA. Proteopeptidomic, Functional and Immunoreactivity Characterization of Bothrops moojeni Snake Venom: Influence of Snake Gender on Venom Composition. TOXINS, v. 10, n. 5, . (15/26609-7)
JACOB-FERREIRA, ANNA L.; MENALDO, DANILO L.; SARTIM, MARCO A.; RIUL, THALITA B.; DIAS-BARUFFI, MARCELO; SAMPAIO, SUELY V.. Antithrombotic activity of Batroxase, a metalloprotease from Bothrops atrox venom, in a model of venous thrombosis. International Journal of Biological Macromolecules, v. 95, p. 263-267, . (11/23236-4, 12/21569-9)
SARTIM, MARCO A.; PINHEIRO, MATHEUS P.; DE PADUA, RICARDO A. P.; SAMPAIO, SUELY V.; CRISTINA NONATO, M.. Structural and binding studies of a C-type galactose-binding lectin from Bothrops jararacussu snake venom. Toxicon, v. 126, p. 59-69, . (11/23236-4, 14/19127-3, 14/11266-4)
CRISTIANE TAVARES; THAÍS MACIEL; SANDRA BURIN; LUCIANA AMBRÓSIO; SANDRO GHISLA; SUELY SAMPAIO; FABÍOLA CASTRO. l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines. Revista Brasileira de Hematologia e Hemoterapia, v. 38, n. 2, p. 128-134, . (11/23236-4, 14/19127-3)
BURIN, SANDRA MARA; CACEMIRO, MAIRA COSTA; COMINAL, JUCARA GASTALDI; DE GRANDIS, RONE APARECIDO; THOMAZELA MACHADO, ANA RITA; DONAIRES, FLAVIA SACILOTTO; OLIVEIRA CINTRA, ADELIA CRISTINA; AMBROSIO, LUCIANA; GREGGI ANTUNES, LUSANIA MARIA; SAMPAIO, SUELY VILELA; et al. Bothrops moojeni L-amino acid oxidase induces apoptosis and epigenetic modulation on Bcr-Abl plus cells. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 26, . (15/25637-7, 11/23236-4, 18/01756-5)
LEIGUEZ, ELBIO; MOTTA, PRISCILA; MAIA MARQUES, RODRIGO; LOMONTE, BRUNO; SAMPAIO, SUELY VILELA; TEIXEIRA, CATARINA. A Representative GIIA Phospholipase A(2) Activates Preadipocytes to Produce Inflammatory Mediators Implicated in Obesity Development. BIOMOLECULES, v. 10, n. 12, . (11/23236-4, 15/24701-3)
MACHADO, A. R. T.; AISSA, A. F.; RIBEIRO, D. L.; HERNANDES, L. C.; MACHADO, C. S.; BIANCHI, M. L. P.; SAMPAIO, S. V.; ANTUNES, L. M. G.. The toxin BjussuLAAO-II induces oxidative stress and DNA damage, upregulates the inflammatory cytokine genes TNF and IL6, and downregulates the apoptotic-related genes BAX, BCL2 and RELA in human Caco-2 cells. International Journal of Biological Macromolecules, v. 109, p. 212-219, . (11/23236-4)
SARTIM, MARCO A.; COSTA, TASSIA R.; LAURE, HELEN J.; ESPINDOLA, MILENA S.; FRANTZ, FABIANI G.; SORGI, CARLOS A.; CINTRA, ADELIA C. O.; ARANTES, ELIANE C.; FACCIOLI, LUCIA H.; ROSA, JOSE C.; et al. Moojenactivase, a novel pro-coagulant PIIId metalloprotease isolated from Bothrops moojeni snake venom, activates coagulation factors II and X and induces tissue factor up-regulation in leukocytes. ARCHIVES OF TOXICOLOGY, v. 90, n. 5, p. 1261-1278, . (11/23236-4)
SANTOS-FILHO, NORIVAL A.; BOLDRINI-FRANCA, JOHARA; SANTOS-SILVA, LUDIER K.; MENALDO, DANILO L.; HENRIQUE-SILVA, FLAVIO; SOUSA, TIAGO S.; CINTRA, ADELIA C. O.; MAMEDE, CARLA C. N.; OLIVEIRA, FABIO; ARANTES, ELIANE C.; et al. Heterologous expression and biochemical and functional characterization of a recombinant alpha-type myotoxin inhibitor from Bothrops alternatus snake. Biochimie, v. 105, p. 119-128, . (11/23236-4, 08/10760-4)
BORDON, KARLA C. F.; WIEZEL, GISELE A.; CABRAL, HAMILTON; ARANTES, ELIANE C.. Bordonein-L, a new L-amino acid oxidase from Crotalus durissus terrificus snake venom: isolation, preliminary characterization and enzyme stability. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, . (14/06170-8, 11/23236-4)
AYRES, LORENA ROCHA; RECIO, ALEX DOS REIS; BURIN, SANDRA MARA; PEREIRA, JULIANA CAMPOS; MARTINS, ANDREA CASELLA; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE; PEREIRA-CROTT, LUCIANA SIMON. Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, . (11/23236-4)
MENALDO, DANILO L.; JACOB-FERREIRA, ANNA L.; BERNARDES, CAROLINA P.; CINTRA, ADELIA C. O.; SAMPAIO, SUELY V.. Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A(2) from Bothrops atrox snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, . (12/21569-9, 11/23236-4, 12/11963-1)
COSTA, TASSIA R.; MENALDO, DANILO L.; DA SILVA, CASSIO PRINHOLATO; SORRECHIA, RODRIGO; DE ALBUQUERQUE, SERGIO; PIETRO, ROSEMEIRE C. L. R.; GHISLA, SANDRO; ANTUNES, LUSANIA M. GREGGI; SAMPAIO, SUELY V.. Evaluating the microbicidal, antiparasitic and antitumor effects of CR-LAAO from Calloselasma rhodostoma venom. International Journal of Biological Macromolecules, v. 80, p. 489-497, . (11/23236-4, 11/02645-3)
SARTIM, MARCO A.; SAMPAIO, SUELY V.. Snake venom galactoside-binding lectins: a structural and functional overview. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, . (11/23236-4)
SARTIM, MARCO AURELIO; SOUZA, CAMILA O. S.; DINIZ, CASSIANO RICARDO A. F.; DA FONSECA, VANESSA M. B.; SOUSA, LUCAS O.; PETI, ANA PAULA F.; COSTA, TASSIA RAFAELLA; LOURENCO, ALAN G.; BORGES, MARCOS C.; SORGI, CARLOS A.; et al. Crotoxin-Induced Mice Lung Impairment: Role of Nicotinic Acetylcholine Receptors and COX-Derived Prostanoids. BIOMOLECULES, v. 10, n. 5, . (15/06290-6, 11/23236-4)
BOLDRINI-FRANCA, JOHARA; PINHEIRO-JUNIOR, ERNESTO LOPES; PEIGNEUR, STEVE; PUCCA, MANUELA BERTO; CERNI, FELIPE AUGUSTO; BORGES, RAFAEL JUNQUEIRA; COSTA, TASSIA RAFAELLA; IMAI CARONE, SANTE EMMANUEL; DE MATTOS FONTES, MARCOS ROBERTO; SAMPAIO, SUELY VILELA; et al. Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities. SCIENTIFIC REPORTS, v. 10, n. 1, . (15/18432-0, 15/00740-0, 18/14158-9, 16/24191-8, 15/16714-8, 17/13485-3, 11/23236-4, 17/14035-1, 16/04761-4, 14/16182-3, 15/17286-0)
BORDON, KARLA C. F.; WIEZEL, GISELE A.; AMORIM, FERNANDA G.; ARANTES, ELIANE C.. Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, . (11/12317-3, 14/06170-8, 11/23236-4)
DANILO L. MENALDO; ANNA L. JACOB-FERREIRA; CAROLINA P. BERNARDES; ADÉLIA C. O. CINTRA; SUELY V. SAMPAIO. Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A 2 fromBothrops atrox snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 21, p. 0-0, . (12/21569-9, 12/11963-1, 11/23236-4)
DE OLIVEIRA, ISADORA SOUSA; CARDOSO, IARA AIME; FIGUEIREDO BORDON, KARLA DE CASTRO; IMAI CARONE, SANTE EMMANUEL; BOLDRINI-FRANCA, JOHARA; PUCCA, MANUELA BERTO; ZOCCAL, KARMA FURLANI; FACCIOLI, LUCIA HELENA; SAMPAIO, SUELY VILELA; ROSA, JOSE CESAR; et al. Global proteomic and functional analysis of Crotalus durissus collilineatus individual venom variation and its impact on envenoming. JOURNAL OF PROTEOMICS, v. 191, n. SI, p. 153-165, . (14/16182-3, 11/23236-4, 14/03332-7)
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CEZARETTE, G. N.; SARTIM, M. A.; SAMPAIO, S. V.. Inflammation and coagulation crosstalk induced by BJcuL, a galactose-binding lectin isolated from Bothrops jararacussu snake venom. International Journal of Biological Macromolecules, v. 144, p. 296-304, . (11/23236-4, 15/06290-6, 16/04079-9)
BARBIZAN, ROBERTA; CASTRO, MATEUS V.; FERREIRA, JR., RUI SEABRA; BARRAVIERA, BENEDITO; OLIVEIRA, ALEXANDRE L. R.. Long-Term Spinal Ventral Root Reimplantation, but not Bone Marrow Mononuclear Cell Treatment, Positively Influences Ultrastructural Synapse Recovery and Motor Axonal Regrowth. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 15, n. 11, p. 19535-19551, . (14/06892-3, 12/08101-8, 11/23236-4, 09/53846-9)
COSTA, TASSIA R.; BURIN, SANDRA M.; MENALDO, DANILO L.; DE CASTRO, FABIOLA A.; SAMPAIO, SUELY V.. Snake venom L-amino acid oxidases: an overview on their antitumor effects. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 20, . (11/02645-3, 12/11963-1, 11/23236-4)
SARTIM, MARCO A.; NOGUEIRA, RENATO C.; CAVALCANTE, TAVILA T. A.; SOUSA, LUCAS O.; MONTEIRO, WUELTON M.; CINTRA, ADELIA C. O.; NETO-NEVES, EVANDRO M.; SAMPAIO, SUELY V.. Hemodynamic impairment induced by Crotoxin using in vivo and ex vivo approach in a rat model. International Journal of Biological Macromolecules, v. 232, p. 8-pg., . (11/23236-4)
MENALDO, DANILO L.; BERNARDES, CAROLINA P.; ZOCCAL, KARINA F.; JACOB-FERREIRA, ANNA L.; COSTA, TASSIA R.; DEL LAMA, MARIA P. F. M.; NAAL, ROSE M. Z. G.; FRANTZ, FABIANI G.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V.. Immune cells and mediators involved in the inflammatory responses induced by a P-I metalloprotease and a phospholipase A(2) from Bothrops atrox venom. Molecular Immunology, v. 85, p. 238-247, . (11/23236-4, 12/11963-1)
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FERREIRA, ISABELA GOBBO; PUCCA, MANUELA BERTO; CARDOSO, IARA AIME; FIGUEIREDO BORDON, KARLA DE CASTRO; WIEZEL, GISELE ADRIANO; AMORIM, FERNANDA GOBBI; RODRIGUES, RENATA SANTOS; RODRIGUES, VERIDIANA DE MELO; DE CAMPOS BRITES, VERA LUCIA; ROSA, JOSE CESAR; et al. Insights into structure and function of CdcVEGFs, the vascular endothelial growth factor from Crotalus durissus collilineatus snake venom. Biochimie, v. 200, p. 11-pg., . (11/23236-4, 17/00586-6, 19/10173-6)
SARTIM, MARCO AURELIO; MENALDO, DANILO LUCCAS; SAMPAIO, SUELY VILELA. Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (15/06290-6, 11/23236-4)
LODOVICHO, MARINA E.; COSTA, TASSIA R.; BERNARDES, CAROLINA P.; MENALDO, DANILO L.; ZOCCAL, KARINA F.; CARONE, SANTE E.; ROSA, JOSE C.; PUCCA, MANUELA B.; CERNI, FELIPE A.; ARANTES, ELIANE C.; et al. Investigating possible biological targets of Bj-CRP, the first cysteine-rich secretory protein (CRISP) isolated from Bothrops jararaca snake venom. Toxicology Letters, v. 265, p. 156-169, . (12/12954-6, 11/23236-4, 12/13590-8)
JACOB-FERREIRA, ANNA L.; MENALDO, DANILO L.; BERNARDES, CAROLINA P.; SARTIM, MARCO A.; DE ANGELIS, CELIO D.; TANUS-SANTOS, JOSE E.; SAMPAIO, SUELY V.. Evaluation of the in vivo thrombolytic activity of a metalloprotease from Bothrops atrox venom using a model of venous thrombosis. Toxicon, v. 109, p. 18-25, . (11/23236-4, 12/21569-9)
BARBIZAN, ROBERTA; CASTRO, MATEUS V.; FERREIRA, RUI SEABRA, JR.; BARRAVIERA, BENEDITO; OLIVEIRA, ALEXANDRE L. R.. Long-Term Spinal Ventral Root Reimplantation, but not Bone Marrow Mononuclear Cell Treatment, Positively Influences Ultrastructural Synapse Recovery and Motor Axonal Regrowth. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 15, n. 11, p. 17-pg., . (14/06892-3, 09/53846-9, 12/08101-8, 11/23236-4)
DE OLIVEIRA, ISADORA SOUSA; CARDOSO, IARA AIME; FIGUEIREDO BORDON, KARLA DE CASTRO; IMAI CARONE, SANTE EMMANUEL; BOLDRINI-FRANCA, JOHARA; PUCCA, MANUELA BERTO; ZOCCAL, KARMA FURLANI; FACCIOLI, LUCIA HELENA; SAMPAIO, SUELY VILELA; ROSA, JOSE CESAR; et al. Global proteomic and functional analysis of Crotalus durissus collilineatus individual venom variation and its impact on envenoming. JOURNAL OF PROTEOMICS, v. 191, p. 13-pg., . (14/16182-3, 11/23236-4, 14/03332-7)
WIEZEL, GISELE A.; DOS SANTOS, PATTY K.; CORDEIRO, FRANCIELLE A.; BORDON, KARLA C. F.; SELISTRE-DE-ARAUJO, HELOISA S.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C.. Identification of hyaluronidase and phospholipase B in Lachesis muta rhombeata venom. Toxicon, v. 107, p. 10-pg., . (11/23236-4, 10/06199-5)
BISCOLA, NATALIA PERUSSI; CARTAROZZI, LUCIANA POLITTI; FERREIRA JUNIOR, RUI SEABRA; BARRAVIERA, BENEDITO; RODRIGUES DE OLIVEIRA, ALEXANDRE LEITE. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. NEURAL PLASTICITY, v. 2016, p. 19-pg., . (14/06892-3, 09/53846-9, 12/08101-8, 11/23236-4, 11/23377-7)
BERNARDES, CAROLINA PETRI; MENALDO, DANILO LUCCAS; ZOCCAL, KARIM FURLANI; BOLDRINI-FRANCA, JOHARA; PEIGNEUR, STEVE; ARANTES, ELIANE CANDIANE; ROSA, JOSE CESAR; FACCIOLI, LUCIA HELENA; TYTGAT, JAN; SAMPAIO, SUELY VILELA. First report on BaltCRP, a cysteine-rich secretory protein (CRISP) from Bothrops alternatus venom: Effects on potassium channels and inflammatory processes. International Journal of Biological Macromolecules, v. 140, p. 556-567, . (11/23236-4)
THOMAZELA MACHADO, ANA RITA; AISSA, ALEXANDRE FERRO; RIBEIRO, DIEGO LUIS; FERREIRA, JR., RUI SEABRA; SAMPAIO, SUELY VILELA; GREGGI ANTUNES, LUSANIA MARIA. BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, . (11/23236-4)
MACHADO, A. R. T.; AISSA, A. F.; RIBEIRO, D. L.; COSTA, T. R.; FERREIRA, JR., R. S.; SAMPAIO, S. V.; ANTUNES, L. M. G.. Cytotoxic, genotoxic, and oxidative stress-inducing effect of an L-amino acid oxidase isolated from Bothrops jararacussu venom in a co-culture model of HepG2 and HUVEC cells. International Journal of Biological Macromolecules, v. 127, p. 425-432, . (11/23236-4)
COSTA, TASSIA R.; AMSTALDEN, MARTIN K.; RIBEIRO, DIEGO L.; MENALDO, DANILO L.; SARTIM, MARCO A.; AISSA, ALEXANDRE F.; ANTUNES, LUSANIA M. G.; SAMPAIO, V, SUELY. CR-LAAO causes genotoxic damage in HepG2 tumor cells by oxidative stress. Toxicology, v. 404, p. 42-48, . (15/00740-0, 11/23236-4, 15/00847-9)
BURIN, SANDRA M.; MENALDO, DANILO L.; SAMPAIO, SUELY V.; FRANTZ, FABIANI G.; CASTRO, FABIOLA A.. An overview of the immune modulating effects of enzymatic toxins from snake venoms. International Journal of Biological Macromolecules, v. 109, p. 664-671, . (11/23236-4, 15/25637-7)
WIEZEL, GISELE A.; RUSTIGUEL, JOANE K.; MORGENSTERN, DAVID; ZOCCAL, KARINA E.; FACCIOLI, LUCIA H.; CRISTINA NONATO, M.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C.. Insights into the structure, function and stability of bordonein-L, the first L-amino acid oxidase from Crotalus durissus terrificus snake venom. Biochimie, v. 163, p. 33-49, . (14/03332-7, 11/23236-4, 15/24010-0, 14/23285-3, 14/06170-8, 14/07125-6)
DE OLIVEIRA, ISADORA SOUSA; MANZINI, RAFAELLA VARZONI; FERREIRA, ISABELA GOBBO; CARDOSO, IARA AIME; FIGUEIREDO BORDON, KARLA DE CASTRO; THOMAZELA MACHADO, ANA RITA; GREGGI ANTUNES, LUSANIA MARIA; ROSA, JOSE CESAR; ARANTES, ELIANE CANDIANI. Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (16/11578-1, 11/23236-4, 12/14996-8, 17/03580-9)
ALVES BEZERRA, PATRICIA HELOISE; FERREIRA, ISADORA MARQUES; FRANCESCHI, BEATRIZ TINOCO; BIANCHINI, FRANCINE; AMBROSIO, LUCIANA; CINTRA, ADELIA CRISTINA O.; SAMPAIO, SUELY VILELA; DE CASTRO, FABIOLA ATTIE; TORQUETI, MARIA REGINA. BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, . (11/23236-4)
WIEZEL, GISELE A.; BORDON, KARLA C. F.; SILVA, RONIVALDO R.; GOMES, MARIO S. R.; CABRAL, HAMILTON; RODRIGUES, VERIDIANA M.; UEBERHEIDE, BEATRIX; ARANTES, ELIANE C.. Subproteome of Lachesis muta rhombeata venom and preliminary studies on LmrSP-4, a novel snake venom serine proteinase. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, . (10/06199-5, 14/23285-3, 15/18432-0, 11/23236-4)
PEREIRA-CROTT, LUCIANA SIMON; CASARE-OGASAWARA, TANIA MARA; AMBROSIO, LUCIANA; PRINCI CHAIM, LUIZ FERNANDO; DE MORAIS, FABIANA ROSSETO; OLIVEIRA CINTRA, ADELIA CRISTINA; CANICOBA, NATHALIA CRISTINA; FORTUNATO TUCCI, LUIZ FERNANDO; TORQUETI, MARIA REGINA; SAMPAIO, SUELY VILELA; et al. Bothrops moojeni venom and BmooLAAO-I downmodulate CXCL8/IL-8 and CCL2/MCP-1 production and oxidative burst response, and upregulate CD11b expression in human neutrophils. International Immunopharmacology, v. 80, . (11/23236-4)
COSTA, TASSIA R.; MENALDO, DANILO L.; ZOCCAL, KARINA F.; BURIN, SANDRA M.; AISSA, ALEXANDRE F.; DE CASTRO, FABIOLA A.; FACCIOLI, LUCIA H.; GREGGI ANTUNES, LUSANIA M.; SAMPAIO, SUELY V.. CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma venom, as a potential tool for developing novel immunotherapeutic strategies against cancer. SCIENTIFIC REPORTS, v. 7, . (15/00740-0, 11/23236-4)
ANDREIA VIEIRA PEREIRA; GUSTAVO DE BARROS; ERIKA GRACIELLE PINTO; ANDRE GUSTAVO TEMPONE; RICARDO DE OLIVEIRA ORSI; LUCILENE DELAZARI DOS SANTOS; SUELI CALVI; RUI SEABRA FERREIRA JR; DANIEL CARVALHO PIMENTA; BENEDITO BARRAVIERA. Melittin induces in vitro death of Leishmania (Leishmania) infantum by triggering the cellular innate immune response. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 22, . (11/23236-4, 09/53846-9)
PALACIO, TATIANA Z.; SANTOS-FILHO, NORIVAL A.; ROSA, JOSE CESAR; FERREIRA JUNIOR, RUI S.; BARRAVIERA, BENEDITO; SAMPAIO, SUELY V.. Isolation and characterization of a novel metalloprotease inhibitor from Bothrops alternatus snake serum. International Journal of Biological Macromolecules, v. 98, p. 436-446, . (12/02734-9, 11/23236-4)
BOLDRINI-FRANCA, JOHARA; COLOGNA, CAMILA TAKENO; PUCCA, MANUELA BERTO; FIGUEIREDO BORDON, KARLA DE CASTRO; AMORIM, FERNANDO GOBBI; PINO ANJOLETTE, FERNANDO ANTONIO; CORDEIRO, FRANCIELLE ALMEIDA; WIEZEL, GISELE ADRIANO; CERNI, FELIPE AUGUSTO; PINHEIRO-JUNIOR, ERNESTO LOPES; et al. Minor snake venom proteins: Structure, function and potential applications. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, v. 1861, n. 4, p. 824-838, . (14/06170-8, 11/12317-3, 11/23236-4, 15/16714-8, 12/13590-8, 13/26619-7, 14/15644-3, 12/12954-6, 13/26200-6)
BURIN, SANDRA MARA; GHISLA, SANDRO; OUCHIDA, AMANDA TOMIE; AISSA, ALEXANDRE FERRO; BERZOTI COELHO, MARIA GABRIELA; COSTA, TASSIA RAFAELLA; ZAMBUZI CARDOSO MARSOLA, ANA PAULA; PINTO-SIMOES, BELINDA; GREGGI ANTUNES, LUSANIA MARIA; CURTI, CARLOS; et al. CR-LAAO antileukemic effect against Bcr-Abl(+) cells is mediated by apoptosis and hydrogen peroxide. International Journal of Biological Macromolecules, v. 86, p. 309-320, . (11/23236-4)
WIEZEL, GISELE A.; SHIBAO, PRISCILA Y. T.; COLOGNA, CAMILA T.; MORANDI FILHO, ROMUALDO; UEIRA-VIEIRA, CARLOS; DE PAUW, EDWIN; QUINTON, LOIC; ARANTES, ELIANE C.. In-Depth Venome of the Brazilian Rattlesnake Crotalus durissus terrificus: An Integrative Approach Combining Its Venom Gland Transcriptome and Venom Proteome. JOURNAL OF PROTEOME RESEARCH, v. 17, n. 11, p. 3941-3958, . (15/17466-8, 13/26200-6, 11/23236-4, 17/00586-6, 14/15644-3, 15/18432-0)
CEDRO, RAFHAELLA C. A.; MENALDO, DANILO L.; COSTA, TASSIA R.; ZOCCAL, KARINA F.; SARTIM, MARCO A.; SANTOS-FILHO, NORIVAL A.; FACCIOLI, LUCIA H.; SAMPAIO, SUELY V.. Cytotoxic and inflammatory potential of a phospholipase A(2) from Bothrops jararaca snake venom. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (11/23236-4)
DE OLIVEIRA, ISADORA SOUSA; PUCCA, MANUELA BERTO; SAMPAIO, SUELY VILELA; ARANTES, ELIANE CANDIANI. Antivenomic approach of different Crotalus durissus collilineatus venoms. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (11/23236-4, 12/14996-8)
COSTA, TASSIA R.; CARONE, SANTE E. I.; TUCCI, LUIZ F. F.; MENALDO, DANILO L.; ROSA-GARZON, NATHALIA G.; CABRAL, HAMILTON; SAMPAIO, SUELY V.. Kinetic investigations and stability studies of two Bothrops L-amino acid oxidases. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (15/00740-0, 11/23236-4)
MENALDO, DANILO L.; COSTA, TASSIA R.; RIBEIRO, DIEGO L.; ZAMBUZI, FABIANA A.; ANTUNES, LUSANIA M. G.; CASTRO, FABIOLA A.; FRANTZ, FABIANI G.; SAMPAIO, SUELY V.. Immunomodulatory actions and epigenetic alterations induced by proteases from Bothrops snake venoms in human immune cells. TOXICOLOGY IN VITRO, v. 61, . (11/23236-4)
BERNARDES, CAROLINA P.; SANTOS, NEIFE A. G.; COSTA, TASSIA R.; SISTI, FLAVIA; AMARAL, LILIAN; MENALDO, DANILO L.; AMSTALDEN, MARTIN K.; RIBEIRO, DIEGO L.; ANTUNES, LUSANIA M. G.; SAMPAIO, SUELY VILELA; et al. A Synthetic Snake-Venom-Based Tripeptide Protects PC12 Cells from the Neurotoxicity of Acrolein by Improving Axonal Plasticity and Bioenergetics. NEUROTOXICITY RESEARCH, v. 37, n. 1, p. 11-pg., . (11/23236-4, 15/24808-2)
CAROLINA PETRI BERNARDES; ERNESTO LOPES PINHEIRO JUNIOR; ISABELA GOBBO FERREIRA; ISADORA SOUSA DE OLIVEIRA; NEIFE APARECIDA GUINAIM DOS SANTOS; SUELY VILELA SAMPAIO; ELIANE CANDIANI ARANTES; ANTONIO CARDOZO DOS SANTOS. Fraction of C. d. collilineatus venom containing crotapotin protects PC12 cells against MPP + toxicity by activating the NGF-signaling pathway. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 30, . (19/10173-6, 11/23236-4, 20/13176-3)
LEAO, TAINA KEILLER; RIBEIRO, DIEGO LUIS; THOMAZELA MACHADO, ANA RITA; COSTA, TASSIA RAFAELA; SAMPAIO, SUELY VILELA; GREGGI ANTUNES, LUSANIA MARIA. Synephrine and caffeine combination promotes cytotoxicity, DNA damage and transcriptional modulation of apoptosis-related genes in human HepG2 cells. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, v. 868, . (11/23236-4, 15/00740-0, 14/20344-9)

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