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Mansonella ozzardi: a neglected filaria that may modulate the immune response to co-occurring infections

Grant number: 13/12723-7
Support Opportunities:Regular Research Grants
Duration: February 01, 2014 - January 31, 2016
Field of knowledge:Biological Sciences - Parasitology - Helminthology of Parasites
Principal Investigator:Marcelo Urbano Ferreira
Grantee:Marcelo Urbano Ferreira
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Esper Georges Kallás ; Karina Inacio Ladislau de Carvalho

Abstract

Human infections with the filarial parasite Mansonella ozzardi are common in areas of tropical and subtropical Central and South America and often coexist with other endemic tropical diseases, such as malaria. In the Amazonian Basin of Brazil, infections are typically asymptomatic; most of them will remain undiagnosed. These chronic, untreated filarial infections are potentially associated with a regulatory immune environment, dominated by IL-10-producing T-cells, which mediates the suppression of T-cell proliferation in response to filarial and non-related antigens. However, the potential impact of M. ozzardi infections on immune responses to other pathogens, such as Toxoplasma gondii and Plasmodium vivax, remains unknown. Here we aim to investigate whether human M. ozzardi infections induce the expansion of CD4+ T-lymphocyte populations that express molecules with immunoregulatory potential and whether these cell populations are able to inhibit T-cell proliferative responses ex-vivo to unrelated antigens and mitogens. We will also examine plasma levels of several inflammatory and regulatory cytokines and investigate the putative cellular sources of the major immunoregulatory cytokine IL-10 during M. ozzardi infections in naturally exposed subjects living in an endemic area of Amazonas State, Brazil. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, MARCELO U.; CRAINEY, JAMES LEE; LUZ, SERGIO L. B.. Mansonella ozzardi. Trends in Parasitology, v. 37, n. 1, p. 2-pg., . (13/12723-7)
FERREIRA, MARCELO U.; CRAINEY, JAMES LEE; GOBBI, FEDERICO G.. The search for better treatment strategies for mansonellosis: an expert perspective. EXPERT OPINION ON PHARMACOTHERAPY, v. 24, n. 15, p. 8-pg., . (13/12723-7)
LIMA, NATHALIA F.; GONCALVES-LOPES, RAQUEL M.; KRUIZE, YVONNE C. M.; YAZDANBAKHSH, MARIA; FERREIRA, MARCELO U.. CD39 and immune regulation in a chronic helminth infection: The puzzling case of Mansonella ozzardi. PLoS Neglected Tropical Diseases, v. 12, n. 3, . (13/12723-7, 13/26928-0, 16/06970-0)
LIMA, NATHALIA F.; AYBAR, CECILIA A. VEGGIANI; JURI, MARIA J. DANTUR; FERREIRA, MARCELO U.. Mansonella ozzardi: a neglected New World filarial nematode. PATHOGENS AND GLOBAL HEALTH, v. 110, n. 3, p. 97-107, . (13/26928-0, 13/12723-7)
SINHA, AMIT; LI, ZHIRU; POOLE, CATHERINE B.; ETTWILLER, LAURENCE; LIMA, NATHALIA F.; FERREIRA, MARCELO U.; FOMBAD, FANNY F.; WANJI, SAMUEL; CARLOW, CLOTILDE K. S.. Multiple Lineages of Nematode-Wolbachia Symbiosis in Supergroup F and Convergent Loss of Bacterioferritin in Filarial Wolbachia. GENOME BIOLOGY AND EVOLUTION, v. 15, n. 5, p. 21-pg., . (13/12723-7, 13/26928-0)

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