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Sensory and motor conduction velocity in spontaneously hypertensive rats

Grant number: 13/01111-0
Support Opportunities:Regular Research Grants
Duration: February 01, 2014 - January 31, 2016
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal Investigator:Valéria Paula Sassoli Fazan
Grantee:Valéria Paula Sassoli Fazan
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Previous results from our laboratory show morphological and morphometric alterations in small and large myelinated fibers in adult SHR peripheral nerves. Nevertheless, the functional correlates of these alterations need further investigation. Thus, we aim to evaluate the sensory and motor electrophysiological parameters of the sciatic nerves in male and female SHR in 4 different ages: 5, 8, 20 and 40 weeks. Male and female normotensive Wistar-Kyoto rats will be used as controls. Systolic arterial pressure will be measured by means of tail cuff pletismography one day before the experiments. On the experimental day, animals will be anesthetized and sensory and motor electroneuromyographic conduction studies performed on the right hind paw, using subdermal needle electrodes (Dantec-Medtronic® electromyograph instrument, Keypoint® 4 model). The motor and sensory conduction velocities will be investigated. At the end of the physiological study, the animals will be killed and their sural nerves will be prepared for light microscopy morphology and morphometry. Additional experimental groups, with animals aged 5, 8 and 20 weeks will also have their sural nerves morphologically investigated, in order to compare with the results obtained with the 40 weeks old animals. In this way, we will be able to associate the eventual morphological alterations with those function related findings. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LETÍCIA OLIVEIRA NERI; MILENA MENEZES DE AMORIM; STELLA ANDRADE RODRIGUES CAMPOS; LUCIANA SAYURI SANADA; VALÉRIA PAULA SASSOLI FAZAN. Hind Limb Sensory Innervation in Rats: Comparison between Sural and Saphenous Nerve Morphometry. INTERNATIONAL JOURNAL OF MORPHOLOGY, v. 33, n. 2, p. 743-750, . (13/01111-0, 13/20549-7)
DO CARMO, ELISABETE DE CASSIA; SANADA, LUCIANA SAYURI; BERTO MACHADO, NATHALIA LEILANE; SASSOLI FAZAN, VALERIA PAULA. Does Pain in the Neonatal Period Influence Motor and Sensory Functions in a Similar Way for Males and Females During Post-Natal Development in Rats?. PAIN MEDICINE, v. 17, n. 8, p. 1520-1529, . (09/07265-4, 13/01111-0, 10/04116-5, 12/00231-0)
RODRIGUES DA SILVA, GREICE ANNE; DE AGUIAR MENDES, VANIA ALICE; GENARI, ADRIANA BORGES; CASTANIA, JACI AYRTON; SALGADO, HELIO CESAR; SASSOLI FAZAN, VALERIA PAULA. Recurrent Laryngeal Nerve Alterations in Developing Spontaneously Hypertensive Rats. LARYNGOSCOPE, v. 126, n. 1, p. E40-E47, . (13/01111-0, 13/20549-7)
SILVA, L. E. V.; SENRA FILHO, A. C. S.; FAZAN, V. P. S.; FELIPE, J. C.; MURTA JUNIOR, L. O.. Two-dimensional sample entropy: assessing image texture through irregularity. BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, v. 2, n. 4, . (13/15445-8, 13/01111-0)
SANADA, LUCIANA SAYURI; TAVARES, MARCELO RODRIGO; SATO, KARINA LAURENTI; FERREIRA, RENATA DA SILVA; MAIA NEUBERN, MILENA CARDOSO; CASTANIA, JACI AYRTON; SALGADO, HELIO CESAR; SASSOLI FAZAN, VALERIA PAULA. Association of chronic diabetes and hypertension in sural nerve morphometry: an experimental study. DIABETOLOGY & METABOLIC SYNDROME, v. 7, . (13/01111-0, 13/20549-7, 09/16748-9)
FONTANESI, LUCAS B.; FAZAN, FREDERICO S.; DIAS, FERNANDO J.; SCHIAVONI, MARIA CRISTINA L.; MARQUES JR, WILSON; SASSOLI FAZAN, VALERIA PAULA. Sensory and Motor Conduction Velocity in Spontaneously Hypertensive Rats: Sex and Aging Investigation. FRONTIERS IN SYSTEMS NEUROSCIENCE, v. 13, . (13/01111-0)

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