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Bioactive components from by-products of food processing used in a symbiotic approach for improving human health and well-being (BioSyn)


By-products in food processing have a significant nutritive value, containing fiber and bioactive substances, and should be, therefore, utilized to improve value addition in food sector and to enhance human health. The project develops a strategy of effective utilization of food by-products, by generating novel functional products for human consumption. The by-products of concern are peel from tropical Brazilian fruits, for example, citrus, orange and mango, besides peel and starches from potato Processing. The by-products will be converted into multifunctional symbiotic carriers for colon-specific delivery of probiotic lactobacilli and bifidobacteria. Prebiotic potential of the food by-products, such as supporting growth of probiotics, adhesion to intestinal cells and immunomodulation will be investigated using in vitro mammalian cell models. The hypothesis that prebiotics and symbiotic can beneficially modulate the gut microbiota will be tested by in vitro gastrointestinal models using microbiota profiling techniques and next generation DNA sequencing. Microbiota studies will focus on the metabolic diseases, such as obesity. The bioactive carbohydrate epitopes related to prebiotic action and their dynamic in intestinal environment will be determined by chromatography and carbohydrate microarrays. The multivariate statistical models will be developed to link the bioactive structures in the symbiotic products with their functionality and prebiotic capacity for prediction of the health benefits. Finally, BioSyn will design, develop and produce a symbiotic dietary formulation based on the food by-products. The outcome of BioSyn will include a new knowledge of combined potential of symbiotic ingredients for improvement of human health and the tools to generate valuable symbiotic formulations from the food by-products. (AU)

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Scientific publications (15)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAVALCANTI DE ALBUQUERQUE, MARCELA ALBUQUERQUE; BEDANI, RAQUEL; SILVA VIEIRA, ANTONIO DIOGO; LEBLANC, JEAN GUY; ISAY SAAD, SUSANA MARTA. Supplementation with fruit and okara soybean by-products and amaranth flour increases the folate production by starter and probiotic cultures. International Journal of Food Microbiology, v. 236, p. 26-32, . (13/50506-8)
BIANCHI, FERNANDA; LARSEN, NADJA; TIEGHI, THATIANA DE MELLO; ADORNO, MARIA ANGELA T.; SAAD, I, SUSANA M.; JESPERSEN, LENE; SIVIERI, KATIA. In vitro modulation of human gut microbiota composition and metabolites by Bifidobacterium longum BB-46 and a citric pectin. Food Research International, v. 120, p. 595-602, . (15/13965-0, 15/08228-6, 13/50506-8, 16/20336-1)
BIANCHI, FERNANDA; LOPES, NATALIA PONTIN; TALLARICO ADORNO, MARIA ANGELA; SAKAMOTO, ISABEL KIMIKO; GENOVESE, MARIA INES; ISAY SAAD, SUSANA MARTA; SIVIERI, KATIA. Impact of combining acerola by-product with a probiotic strain on a gut microbiome model. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, v. 70, n. 2, p. 182-194, . (15/13965-0, 13/50506-8, 15/08228-6)
BIANCHI, FERNANDA; ROCHA FARIA DUQUE, ANA LUIZA; ISAY SAAD, SUSANA MARTA; SIVIERI, KATIA. Gut microbiome approaches to treat obesity in humans. Applied Microbiology and Biotechnology, v. 103, n. 3, p. 1081-1094, . (15/13965-0, 13/50506-8, 15/08228-6)
LARSEN, NADJA; CAHU, THIAGO BARBOSA; ISAY SAAD, SUSANA MARTA; BLENNOW, ANDREAS; JESPERSEN, LENE. The effect of pectins on survival of probiotic Lactobacillus spp. in gastrointestinal juices is related to their structure and physical properties. FOOD MICROBIOLOGY, v. 74, p. 11-20, . (13/50506-8)
BIANCHI, FERNANDA; LARSEN, NADJA; TIEGHI, THATIANA DE MELLO; TALLARICO ADORNO, MARIA ANGELA; KOT, WITOLD; ISAY SAAD, SUSANA MARTA; JESPERSEN, LENE; SIVIERI, KATIA. Modulation of gut microbiota from obese individuals by in vitro fermentation of citrus pectin in combination with Bifidobacterium longum BB-46. Applied Microbiology and Biotechnology, v. 102, n. 20, p. 8827-8840, . (15/13965-0, 16/20336-1, 13/50506-8, 15/08228-6)
SILVA VIEIRA, ANTONIO DIOGO; BISCOLA, VANESSA; CAVALCANTI DE ALBUQUERQUE, MARCELA ALBUQUERQUE; BEDANI, RAQUEL; ISAY SAAD, SUSANA MARTA. Impact of Acerola (Malpighia emarginata DC) Byproduct and Probiotic Strains on Technological and Sensory Features of Fermented Soy Beverages. Journal of Food Science, v. 84, n. 12, p. 3726-3734, . (13/19346-4, 13/50506-8)
SILVA VIEIRA, ANTONIO DIOGO; DE SOUZA, CARLOTA BUSSOLO; PADILHA, MARINA; ZOETENDAL, ERWIN GERARD; SMIDT, HAUKE; ISAY SAAD, SUSANA MARTA; VENEMA, KOEN. Impact of a fermented soy beverage supplemented with acerola by-product on the gut microbiota from lean and obese subjects using an in vitro model of the human colon. Applied Microbiology and Biotechnology, v. 105, n. 9, p. 3771-3785, . (13/26435-3, 13/19346-4, 13/50506-8, 16/07940-7)
SILVA VIEIRA, ANTONIO DIOGO; BEDANI, RAQUEL; ALBUQUERQUE, M. A. C.; BISCOLA, VANESSA; ISAY SAAD, SUSANA MARTA. The impact of fruit and soybean by-products and amaranth on the growth of probiotic and starter microorganisms. Food Research International, v. 97, p. 356-363, . (13/19346-4, 13/50506-8)
CAVALCANTI ALBUQUERQUE, MARCELA ALBUQUERQUE; BEDANI, RAQUEL; GUY LEBLANC, JEAN; ISAY SAAD, SUSANA MARTA. Passion fruit by-product and fructooligosaccharides stimulate the growth and folate production by starter and probiotic cultures in fermented soymilk. International Journal of Food Microbiology, v. 261, p. 35-41, . (13/50506-8, 13/07914-8)
MATIAS, NATALIA SILVA; PADILHA, MARINA; BEDANI, RAQUEL; ISAY SAAD, SUSANA MARTA. In vitro gastrointestinal resistance of Lactobacillus acidophilus La-5 and Bifidobacterium animalis Bb-12 in soy and/or milk-based synbiotic apple ice creams. International Journal of Food Microbiology, v. 234, p. 83-93, . (11/12981-0, 13/50506-8)
SILVA VIEIRA, ANTONIO DIOGO; BATTISTINI, CAROLINA; BEDANI, RAQUEL; ISAY SAAD, SUSANA MARTA. cerola by-product may improve the in vitro gastrointestinal resistance of probiotic strains in a plant-based fermented beverag. LWT-FOOD SCIENCE AND TECHNOLOGY, v. 141, . (13/19346-4, 13/50506-8)
CAVALCANTI DE ALBUQUERQUE, MARCELA ALBUQUERQUE; LEVIT, ROMINA; BERES, CAROLINA; BEDANI, RAQUEL; DE MORENO DE LEBLANC, ALEJANDRA; SAAD, SUSANA MARTA ISAY; GUY LEBLANC, JEAN. Tropical fruit by-products water extracts as sources of soluble fibres and phenolic compounds with potential antioxidant, anti-inflammatory, and functional properties. Journal of Functional Foods, v. 52, p. 724-733, . (13/50506-8, 16/50480-7)
RUIZ MARTINEZ, RAFAEL CHACON; BEDANI, RAQUEL; ISAY SAAD, SUSANA MARTA. Scientific evidence for health effects attributed to the consumption of probiotics and prebiotics: an update for current perspectives and future challenges. BRITISH JOURNAL OF NUTRITION, v. 114, n. 12, p. 1993-2015, . (13/50506-8)

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