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Gene expression changes of neuropeptides and proinflammatory factors of the hypothalamus and brainstem nucleus involved with cardiovascular regulation in diet-induced obesity animals

Grant number: 13/06206-0
Support type:Regular Research Grants
Duration: December 01, 2013 - November 30, 2016
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal researcher:Vagner Roberto Antunes
Grantee:Vagner Roberto Antunes
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Obesity has reached epidemic proportions globally and it is a major risk factor for other diseases including diabetes, cancer and cardiovascular disorders, especially hypertension. Although several studies in this area, little is known about the mechanisms by which the excessive accumulation of fat results in hypertension. There are several experimental evidences linking obesity with sympathetic overactivity to different territories of the body, a phenotype that could be involved in the genesis and maintenance of hypertension associated with obesity. Obesity is generally characterized by a low-intensity chronic inflammation that occurs not only systemically but also centrally, for example in the hypothalamus, an important region involved in the control of autonomic outflow and blood pressure. Moreover, there is evidence in the literature showing that activation of proinflammatory pathways at the hypothalamic level caused by high fat diet may be directly associated with hypertension. However, there is no evidence that high fats diet could affect similarly the neuronal integration of autonomic nuclei of the brainstem and the interplay beetween hypothalamic-brainstem circuitry, which in turn is regulating the sympathetic activity and blood pressure levels associated with obesity. Thus, in this project, we will investigate the hypothesis that, similarly to the hypothalamus, the induction of obesity by high-fat diet rich in saturated fatty acids is associated with an inflammatory process at the brainstem nuclei level and hypothalamic-brainstem circuitry that control blood pressure and sympathetic outflow. (AU)

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RAMOS RIBEIRO, IZABELA MARTINA; ANTUNES, VAGNER ROBERTO. The role of insulin at brain-liver axis in the control of glucose production. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, v. 315, n. 4, p. G538-G543, . (13/06206-0, 09/13047-0)
FERREIRA-NETO, H. C.; RIBEIRO, I. M. R.; MOREIRA, T. S.; YAO, S. T.; ANTUNES, V. R.. PURINERGIC P2 RECEPTORS IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS ARE INVOLVED IN HYPEROSMOTIC-INDUCED SYMPATHOEXCITATION. Neuroscience, v. 349, p. 253-263, . (10/05037-1, 13/06206-0, 16/21991-3, 10/17997-0)
CHAAR, LAIALI J.; COELHO, ALINE; SILVA, NATALIA M.; FESTUCCIA, WILLIAM L.; ANTUNES, VAGNER R.. High-fat diet-induced hypertension and autonomic imbalance are associated with an upregulation of CART in the dorsomedial hypothalamus of mice. PHYSIOLOGICAL REPORTS, v. 4, n. 11, . (13/06206-0, 11/13563-8, 09/15354-7, 10/19018-9, 15/19530-5)
GOMES, PAULA MAGALHAES; MARTINS SA, RENATO WILLIAN; AGUIAR, GIOVANA LOPES; SARAIVA PAES, MILEDE HANNER; ALZAMORA, ANDREIA CARVALHO; LIMA, WANDERSON GERALDO; DE OLIVEIRA, LISANDRA BRANDINO; STOCKER, SEAN DAVID; ANTUNES, VAGNER ROBERTO; CARDOSO, LEONARDO M.. Chronic high-sodium diet intake after weaning lead to neurogenic hypertension in adult Wistar rats. SCIENTIFIC REPORTS, v. 7, . (13/06206-0)
RIBEIRO, IZABELA MARTINA R.; FERREIRA-NETO, HILDEBRANDO C.; ANTUNES, VAGNER R.. Subdiaphragmatic vagus nerve activity and hepatic venous glucose are differentially regulated by the central actions of insulin in Wistar and SHR. PHYSIOLOGICAL REPORTS, v. 3, n. 5, . (13/06206-0, 10/05037-1, 07/04085-0, 09/13047-0)
BUTTLER, L.; RIBEIRO, I. M.; FERREIRA-NETO, H. C.; ANTUNES, V. R.. Angiotensin II acting on PVN induces sympathoexcitation and pressor responses via the PI3K-dependent pathway. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v. 198, p. 54-58, . (09/01827-0, 10/17997-0, 13/06206-0, 10/05037-1)
RIBEIRO, NATALIA; PANIZZA, HELENA DO NASCIMENTO; DOS SANTOS, KAROLINE MARTINS; FERREIRA-NETO, HILDEBRANDO C.; ANTUNES, VAGNER ROBERTO. Salt-induced sympathoexcitation involves vasopressin V-1a receptor activation in the paraventricular nucleus of the hypothalamus. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 309, n. 11, p. R1369-R1379, . (13/06206-0, 10/17997-0, 10/05037-1, 09/13047-0)
RIBEIRO, NATALIA; MARTINS SA, RENATO W.; ANTUNES, VAGNER R.. Depletion of C1 neurons attenuates the salt-induced hypertension in unanesthetized rats. Brain Research, v. 1748, . (16/21991-3, 13/06206-0)
ROMEU, DEBORAH DE PAULA; RIBEIRO, LUCIENE MARIA; ANTUNES, VAGNER ROBERTO. Central action of CART induces neuronal activation in the paraventricular and dorsomedial hypothalamus of diet-induced obese and lean mice. Neuroscience Letters, v. 686, p. 175-180, . (15/07944-0, 16/21991-3, 13/06206-0)

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