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Multifunctional molecules from Lonomia obliqua caterpillar: designing of new chemical entities and interrelationship with cellular mechanisms

Grant number: 13/06892-0
Support Opportunities:Regular Research Grants
Duration: December 01, 2013 - May 31, 2016
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Ana Marisa Chudzinski-Tavassi
Grantee:Ana Marisa Chudzinski-Tavassi
Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated researchers:Kerly Fernanda Mesquita Pasqualoto


Animal venoms and secretions have in their composition a quite promising amount of potentially pharmacological molecules capable of overcoming several biochemical responses into the host's system. In our research group, new exogenous molecules as well as some synthetic peptide derivatives targeting the haemostatic system have been investigated as promising drug candidates, and they are already in different phases of the development process. Beyond haemostasis, these molecules can also modulate other biological systems like the immune system, survival or death pathways, and even tissue regeneration. However, the biological sense related to the presence of such molecules in those animals and why these molecules are multifunctional regarding the human tissues, with more binding affinity for some biological systems, remain still unknown. Herein, the efforts will be converged to the molecules extracted from the Lonomia obliqua caterpillar bristle, Lopap and Losac, as well as their derivative peptides. Three different proposals will be considered: (I) study of action mechanism of the multifunctional molecules on cellular homeostasis, (II) in silico studies to predict novel bioactive derivatives from those proteins, and (III) evaluation of the proteins' effect in the treatment of inducing injuries and those caused by Bothrops jararaca and Loxosceles gaucho venomous in vitro and in vivo. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SATO, ANA CLAUDIA; BOSCH, ROSEMARY VIOLA; ALVES WILL, SONIA ELISABETE; ALVAREZ-FLORES, MIRYAM PAOLA; GOLDFEDER, MAURICIO BARBUGIANI; MESQUITA PASQUALOTO, KERLY FERNANDA; VAZ GALVAO DA SILVA, BRBARA ATHAYDE; DE ANDRADE, SONIA APARECIDA; CHUDZINSKI-TAVASSI, ANA MARISA. Exploring the in vivo wound healing effects of a recombinant hemolin from the caterpillar Lonomia obliqua. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 22, . (13/07467-1, 13/06892-0)
BOSCH, ROSEMARY VIOLA; ALVAREZ-FLORES, MIRYAM PAOLA; MARIA, DURVANEI AUGUSTO; CHUDZINSKI-TAVASSI, ANA MARISA. Hemolin triggers cell survival on fibroblasts in response to serum deprivation by inhibition of apoptosis. BIOMEDICINE & PHARMACOTHERAPY, v. 82, p. 537-546, . (13/07467-1, 15/50040-4, 13/06892-0)

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