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Evaluation of the capacity of bacteriophage 933W to transduce the Stx gene to host cells in vivo: impacts on the development of vaccines against hemolytic uremic syndrome

Grant number: 13/20635-0
Support Opportunities:Research Grants - Visiting Researcher Grant - International
Duration: February 02, 2014 - April 01, 2014
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:Luis Carlos de Souza Ferreira
Grantee:Luis Carlos de Souza Ferreira
Visiting researcher: Leticia Veronica Bentancor
Visiting researcher institution: Universidad Nacional de Quilmes (UNQ), Argentina
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

We want to evaluate if the bacteriophage 933W is able to transduce host cells in vivo. These results could impact on the STEC-HUS comprehension, since local eukaryotic cells transduced with and/or infected by bacteriophage encoding Stx2, could be an alternative source to produce Stx2 and should be helpful to design a new vaccine approach against the bacteriophage implicated in Stx production. (AU)

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