Advanced search
Start date
Betweenand
Related content

The extracellular matrix in aging, exercise and in the tumor microenvironment

Grant number: 13/00798-2
Support Opportunities:Research Projects - Thematic Grants
Duration: January 01, 2014 - December 31, 2018
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Heloisa Sobreiro Selistre de Araújo
Grantee:Heloisa Sobreiro Selistre de Araújo
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Pesquisadores principais:
Stela Márcia Mattiello
Associated researchers:Helena Bonciani Nader ; Keico Okino Nonaka ; Lucimar Retto da Silva de Avó ; Marcelo Andrade de Lima ; Márcia Regina Cominetti ; Priscila Maria de Andrade Borra ; Ricardo Carneiro Borra ; Sergio Eduardo de Andrade Perez ; Stela Márcia Mattiello ; Uliana Sbeguen Stotzer ; Wanessa Fernanda Altei
Associated grant(s):16/50346-9 - The effects of different exercise protocols and different delivery methods on the progression of knee osteoarthritis, AP.R SPRINT
16/17768-7 - DNA Repair: Tumor Development and Therapeutic Response, AR.EXT
Associated scholarship(s):18/08405-3 - Plasticity and remodeling of the muscular extracellular matrix in aging and strength training, BP.TT
17/10248-0 - Effects of strength training on lower limbs in obese rats with knee osteoarthritis, BE.PQ
17/22025-6 - Evaluation of hyperphagia and its relation with bone metabolism, body composition and serum leptin in rats with osteoporosis, BP.IC
 + associated scholarships 16/22741-0 - Effect of integrin ±v²3 blocking on interaction of exosomes with osteoblasts extracellular matrix, BP.IC
16/19021-6 - Segmentation of visceral and subcutaneous fat tissues in computed tomography images using finite mixture models, BP.IC
16/05047-3 - INFLUENCE OF A CIRCUIT TRAINING PROTOCOL IN INTERMUSCULAR ADIPOSE TISSUE OF PATIENTS WITH KNEE OSTEOARTHRITIS: A RANDOMIZED CONTROLLED TRIAL, BP.DR
16/12367-4 - Cartilaginous and bone extracellular matrix: effect of collagen supplementation in animal model of osteoarthritis, BP.IC
16/08630-1 - Effect of an Acetogenin, extracted from the Annona mucosa, on breast tumor cells, BP.IC
16/07043-5 - Use of DisBa-01, a recombinant disintegrin from Bothrops alternatus, to study the role of alphavbeta3 integrin on the beta-estradiol in vitro effects in breast tumor cells, BP.IC
15/19232-4 - The influence of intermuscular fat and body composition in postural control in patients with knee osteoarthritis, BP.DD
14/18747-8 - Tumor breast cell exosomes and their role in cell adhesion during metastasis, BP.PD
15/08854-4 - Analysis of the expression of MMP-7 in intra epithelial high staged squamous lesions in the cervix, BP.IC
15/08760-0 - Expression analysis of extracellular matrix molecules by fibroblasts treated with DisBa-01, a recombinant RGD disintegrin, BP.IC
14/17651-7 - The alfa2beta1 integrin in breast tumor progression: the role in tumor microenvironment and metastasis, BP.DR
14/08015-0 - The extracellular matrix in aging, exercise and in the tumor microenvironment, BP.PD
14/07820-6 - The extracellular matrix in aging, exercise and in the tumor microenvironment, BP.PD
14/05137-7 - The extracellular matrix (ECM) is the structural scaffold for body tissues, and it is formed by a complex network of macromolecules such as collagens, glycosaminoglycans and proteoglycans, BP.IC
14/02173-2 - Silenced tumor cells gene expression profile of alfaVbeta3 integrin, BP.IC - associated scholarships

Abstract

The extracellular matrix (ECM) is the structural scaffold for body tissues, and it is formed by a complex network of macromolecules such as collagens, glycosaminoglycans and proteoglycans. The ECM supports tissue volume, size and strength, and it is the basis for cell growth, division, and migration. However, ECM function is beyond structural and mechanical support. The ECM actively modulates cell behavior, polarity, differentiation, proliferation and survival, providing signals that are transmitted to the cytoskeleton and determining cell fate. Many studies have demonstrated the key role of ECM and its interaction with the cells in a number of physiological and pathological processes. Drug design targeting the cell interaction with the ECM represents a new area in the frontier of knowledge. Therefore, in the present project we combined a team of experienced researchers in the ECM field in order to collectively contribute for the knowledge of the ECM roles in the context of aging, in exercise as a form of prevention from the deleterious effects of aging, and in cancer, due to the evident importance of these two areas (exercise and cancer) for human longevity. In vitro (cell culture), in vivo (in humans and in animal models) and ex vivo (human and animal tissues) will be used for gene expression analysis by different techniques in a small- and medium-scale basis. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
TITULO 
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (32)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MILENE NÓBREGA DE OLIVEIRA MORITZ; LÍVIA MARA SANTOS EUSTÁQUIO; KELLI CRISTINA MICOCCI; ANA CAROLINA CAETANO NUNES; PATTY KARINA DOS SANTOS; TAMIRES DE CASTRO VIEIRA; HELOÍSA SOBREIRO SELISTRE-DE-ARAUJO. Alternagin-C binding to α2β1 integrin controls matrix metalloprotease-9 and matrix metalloprotease-2 in breast tumor cells and endothelial cells. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (14/17651-7, 13/00798-2)
DE ALMEIDA, ALINE CASTILHO; PEDROSO, MARIA GABRIELA; AILY, JESSICA BIANCA; GONCALVES, GLAUCIA HELENA; PASTRE, CARLOS MARCELO; MATTIELLO, STELA MARCIA. Influence of a periodized circuit training protocol on intermuscular adipose tissue of patients with knee osteoarthritis: protocol for a randomized controlled trial. BMC MUSCULOSKELETAL DISORDERS, v. 19, . (16/05047-3, 13/00798-2)
STOTZER, ULIANA SBEGUEN; DERIGGI PISANI, GRAZIELE FERNANDA; RIGO CANEVAZZI, GUSTAVO HENRIQUE; SHIGUEMOTO, GILBERTO EIJI; DE OLIVEIRA DUARTE, ANA CLAUDIA GARCIA; DE ANDRADE PEREZ, SERGIO EDUARDO; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO. Benefits of resistance training on body composition and glucose clearance are inhibited by long-term low carbohydrate diet in rats. PLoS One, v. 13, n. 12, . (13/00798-2)
DE FARIAS JUNIOR, GONCALO CARREIRO; NETO, IVO VIEIRA DE SOUSA; GUZZONI, VINICIUS; PISANI, GRAZIELE DERIGGI; ROYER, CARINE; DE LIMA, CAROLINE LOURENCO; NEVES, FRANCISCO DE ASSIS ROCHA; BOGNI, FABIO HENRIQUE; NONAKA, KEICO OKINO; DURIGAN, JOAO LUIZ QUAGLIOTTI; et al. Remodeling process in bone of aged rats in response to resistance training. Life Sciences, v. 256, . (10/19390-5, 11/11229-3, 13/00798-2)
BRESSANI LINO, RAFAEL LUIS; DOS SANTOS, PATTY KARINA; DERIGGI PISANI, GRAZIELE FERNANDA; ALTEI, WANESSA FERNANDA; COMINETTI, MARCIA REGINA; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO. Alphavbeta3 integrin blocking inhibits apoptosis and induces autophagy in murine breast tumor cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1866, n. 12, . (13/00798-2)
COMINETTI, MARCIA R.; ALTEI, WANESSA F.; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO. Metastasis inhibition in breast cancer by targeting cancer cell extravasation. BREAST CANCER-TARGETS AND THERAPY, v. 11, p. 165-178, . (15/24940-8, 13/00798-2)
POPOLIN, CECILIA P.; COMINETTI, MARCIA R.. A Review of Ruthenium Complexes Activities on Breast Cancer Cells. MINI-REVIEWS IN MEDICINAL CHEMISTRY, v. 17, n. 15, p. 1435-1441, . (13/00798-2)
MARTIN, ANA CAROLINA B. M.; FUZER, ANGELINA M.; BECCENERI, AMANDA B.; DA SILVA, JAMES ALMADA; TOMASIN, REBEKA; DENOYER, DELPHINE; KIM, SOO-HYUN; MCINTYRE, KATHERINE A.; PEARSON, HELEN B.; YEO, BELINDA; et al. [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo. ONCOTARGET, v. 8, n. 42, p. 72260-72271, . (12/03771-5, 13/00798-2, 15/24940-8, 12/18908-6)
MARIA, ROBERTA M.; ALTEI, WANESSA F.; SELISTRE-DE-ARAUJO, HELOISA S.; COLNAGO, LUIZ A.. Effects of Doxorubicin, Cisplatin, and Tamoxifen on the Metabolic Profile of Human Breast Cancer MCF-7 Cells As Determined by H-1 High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance. BIOCHEMISTRY, v. 56, n. 16, p. 2219-2224, . (13/00798-2, 13/05128-5)
MONTENEGRO, CYNTIA F.; CASALI, BRUNA C.; LINO, RAFAEL L. B.; PACHANE, BIANCA C.; SANTOS, PATTY K.; HORWITZ, ALAN R.; SELISTRE-DE-ARAUJO, HELOISA S.; LAMERS, MARCELO L.. Inhibition of alpha(v)beta(3) integrin induces loss of cell directionality of oral squamous carcinoma cells (OSCC). PLoS One, v. 12, n. 4, . (13/00798-2)
CURY RODRIGUES, MARIA FERNANDA; FERREIRA, FABIANO CANDIDO; SILVA-MAGOSSO, NATALIA SANTANIELO; BARBOSA, MARINA RODRIGUES; CAMPOS SOUZA, MARKUS VINICIUS; DOMINGOS, MATEUS MORAES; RIGO CANEVAZZI, GUSTAVO HENRIQUE; STOTZER, ULIANA SBEGUEN; PEVIANI, SABRINA MESSA; DE LIRA, FABIO SANTOS; et al. Effects of resistance training and estrogen replacement on adipose tissue inflammation in ovariectomized rats. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, v. 42, n. 6, p. 605-612, . (13/00798-2)
MONTEIRO, DIANA AMARAL; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO; TAVARES, DRIELE; FERNANDES, MARISA NARCISO; KALININ, ANA LUCIA; RANTIN, FRANCISCO TADEU. Alternagin-C (ALT-C), a Disintegrin-Like Cys-Rich Protein Isolated from the Venom of the Snake Rhinocerophis alternatus, Stimulates Angiogenesis and Antioxidant Defenses in the Liver of Freshwater Fish, Hoplias malabaricus. TOXINS, v. 9, n. 10, . (13/00798-2, 12/10993-4)
MONTEIRO, D. A.; KALININ, A. L.; SELISTRE-DE-ARAUJO, H. S.; VASCONCELOS, E. S.; RANTIN, F. T.. Alternagin-C (ALT-C), a disintegrin-like protein from Rhinocerophis alternatus snake venom promotes positive inotropism and chronotropism in fish heart. Toxicon, v. 110, p. 1-11, . (13/00798-2, 12/10993-4)
GUZZONI, VINICIUS; RIBEIRO, MANOEL B. T.; LOPES, GISELE N.; MARQUETI, RITA DE CASSIA; DE ANDRADE, ROSANGELA V.; SELISTRE-DE-ARAUJO, HELOISA S.; DURIGAN, JOAO L. Q.. Effect of Resistance Training on Extracellular Matrix Adaptations in Skeletal Muscle of Older Rats. FRONTIERS IN PHYSIOLOGY, v. 9, . (11/11229-3, 13/00798-2)
MARQUETI, RITA C.; DURIGAN, JOAO L. Q.; OLIVEIRA, ANDERSON JOSE S.; MEKARO, MARCELO SHINYU; GUZZONI, VINICIUS; ARO, ANDREA A.; PIMENTEL, EDSON ROSA; SELISTRE-DE-ARAUJO, HELOISA S.. Effects of aging and resistance training in rat tendon remodeling. FASEB JOURNAL, v. 32, n. 1, p. 353-368, . (10/19390-5, 11/11229-3, 13/00798-2)
CAROLINA VAN DE VELDE, ANDREA; CAROLINA GAY, CLAUDIA; DE OLIVEIRA MORITZ, MILENE NOBREGA; DOS SANTOS, PATTY KARINA; BUSTILLO, SOLEDAD; PABLO RODRIGUEZ, JUAN; CRISTINA ACOSTA, OFELIA; JOSEFA BISCOGLIO, MIRTHA; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO; CRISTINA LEIVA, LAURA. Purification of a fragment obtained by autolysis of a PIIIb-SVMP from Bothrops alternatus venom. International Journal of Biological Macromolecules, v. 113, p. 205-211, . (13/00798-2)
MORITZ, MILENE N. O.; MERKEL, ALYSSA R.; FELDMAN, EAN G.; SELISTRE-DE-ARAUJO, HELOISA S.; RHOADES (STERLING), JULIE A.. Biphasic alpha 2 beta 1 Integrin Expression in Breast Cancer Metastasis to Bone. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 13, . (13/00798-2, 19/11437-7, 17/23094-1)
DE ALMEIDA, ALINE CASTILHO; AILY, JESSICA BIANCA; PEDROSO, MARIA GABRIELA; GONCALVES, GLAUCIA HELENA; FELINTO, JONAS DE CARVALHO; FERRARI, RICARDO JOSE; PASTRE, CARLOS MARCELO; MATTIELLO, STELA MARCIA. A periodized training attenuates thigh intermuscular fat and improves muscle quality in patients with knee osteoarthritis: results from a randomized controlled trial. CLINICAL RHEUMATOLOGY, v. 39, n. 4, p. 1265-1275, . (16/05047-3, 13/00798-2)
MONTEIRO, DIANA AMARAL; KALININ, ANA LUCIA; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO; RANTIN, FRANCISCO TADEU. ormetic-like dose-response induced by alternagin-C, a protein isolated from urutu snake (Rhinocerophis alternatus) venom, in fish (Hoplias malabaricus) cardiac contractilit. Toxicon, v. 205, p. 67-70, . (13/00798-2, 12/10993-4)
DE SOUSA NETO, IVO VIEIRA; QUAGLIOTI DURIGAN, JOAO LUIZ; DE FARIAS JUNIOR, GONCALO CARREIRO; BOGNI, FABIO HENRIQUE; RUIVO, AMANDA LIMA; DE ARAUJO, JULIANA OLIVEIRA; NONAKA, KEICO OKINO; SELISTRE-DE-ARAUJO, HELOISA; MARQUETI, RITA DE CASSIA. Resistance Training Modulates the Matrix Metalloproteinase-2 Activity in Different Trabecular Bones in Aged Rats. CLINICAL INTERVENTIONS IN AGING, v. 16, p. 71-81, . (11/11229-3, 13/00798-2)
MONTEIRO, D. A.; KALININ, A. L.; SELISTRE-DE-ARAUJO, H. S.; NOGUEIRA, L. A. N.; BELETTI, M. E.; FERNANDES, M. N.; RANTIN, F. T.. Cardioprotective effects of alternagin-C (ALT-C), a disintegrin-like protein from Rhinocerophis alternatus snake venom, on hypoxia-reoxygenation-induced injury in fish. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v. 215, p. 67-75, . (12/10993-4, 13/00798-2)
NAVES, MARINA A.; GRAMINHA, ANGELICA E.; VEGAS, LEGNA C.; LUNA-DULCEY, LIANY; HONORATO, JOAO; MENEZES, ANTONIO C. S.; BATISTA, ALZIR A.; COMINETTI, MARCIA R.. Transport of the Ruthenium Complex [Ru(GA)(dppe)(2)]PF6 into Triple-Negative Breast Cancer Cells Is Facilitated by Transferrin Receptors. MOLECULAR PHARMACEUTICS, v. 16, n. 3, p. 1167-1183, . (16/16312-0, 15/24940-8, 13/00798-2)
DANILUCCI, TAIS M.; SANTOS, PATTY K.; PACHANE, BIANCA C.; PISANI, GRAZIELE F. D.; LINO, RAFAEL L. B.; CASALI, BRUNA C.; ALTEI, WANESSA F.; SELISTRE-DE-ARAUJO, HELOISA S.. Recombinant RGD-disintegrin DisBa-01 blocks integrin alpha(v)beta(3) and impairs VEGF signaling in endothelial cells. CELL COMMUNICATION AND SIGNALING, v. 17, . (13/00798-2, 14/18747-8)
DE OLIVEIRA MORITZ, MILENE NOBREGA; SANTOS EUSTAQUIO, LIVIA MARA; MICOCCI, KELLI CRISTINA; CAETANO NUNES, ANA CAROLINA; DOS SANTOS, PATTY KARINA; VIEIRA, TAMIRES DE CASTRO; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO. Alternagin-C binding to a(2)beta(1) integrin controls matrix metalloprotease-9 and matrix metalloprotease-2 in breast tumor cells and endothelial cells. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (14/17651-7, 13/00798-2)
FUZER, ANGELINA M.; MARTIN, ANA C. B. M.; BECCENERI, AMANDA B.; DA SILVA, JAMES A.; VIEIRA, PAULO C.; COMINETTI, MARCIA R.. [10]-Gingerol Affects Multiple Metastatic Processes and Induces Apoptosis in MDA-MB-231 Breast Tumor Cells. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 19, n. 5, p. 645-654, . (13/00798-2, 16/23202-6, 15/24940-8)
BECCENERI, AMANDA BLANQUE; POPOLIN, CECILIA PATRICIA; MARIA PLUTIN, ANA; MAISTRO, EDSON LUIS; CASTELLANO, EDUARDO ERNESTO; BATISTA, ALZIR AZEVEDO; COMINETTI, MARCIA REGINA. The trans-[Ru(PPh3)(2)(N,N-dimethyl-N `-thiophenylthioureato-k(2)O,S)(bipy)] PF6 complex has pro-apoptotic effects on triple negative breast cancer cells and presents low toxicity in vivo. Journal of Inorganic Biochemistry, v. 186, p. 70-84, . (13/00798-2, 15/24940-8, 14/25121-8)
DE ALMEIDA, ALINE CASTILHO; AILY, JESSICA BIANCA; PEDROSO, MARIA GABRIELA; GONCALVES, GLAUCIA HELENA; PASTRE, CARLOS MARCELO; MATTIELLO, STELA MARCIA. Reductions of cardiovascular and metabolic risk factors after a 14-week periodized training model in patients with knee osteoarthritis: a randomized controlled trial. CLINICAL RHEUMATOLOGY, v. 40, n. 1, . (13/00798-2, 16/05047-3)
GUZZONI, VINICIUS; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO; MARQUETI, RITA DE CASSIA. Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging. CELLS, v. 7, n. 12, . (14/50938-8, 13/00798-2)
POPOLIN, CECILIA P.; REIS, JOAO P. B.; BECCENERI, AMANDA B.; GRAMINHA, ANGELICA E.; ALMEIDA, MARCIO A. P.; CORREA, RODRIGO S.; COLINA-VEGAS, LEGNA A.; ELLENA, JAVIER; BATISTA, ALZIR A.; COMINETTI, MARCIA R.. Cytotoxicity and anti-tumor effects of new ruthenium complexes on triple negative breast cancer cells. PLoS One, v. 12, n. 9, . (13/00798-2, 15/24940-8)
GUZZONI, VINICIUS; MARQUETI, RITA DE CASSIA; QUAGLIOTTI DURIGAN, JOAO LUIZ; DE CARVALHO, HERNANDES FAUSTINO; BRESSANI LINO, RAFAEL LUIS; MEKARO, MARCELO S.; COSTA SANTOS, TAYNA OLIVEIRA; MECAWI, ANDRE SOUZA; RODRIGUES, JOSE ANTUNES; HORD, JEFFREY M.; et al. Reduced collagen accumulation and augmented MMP-2 activity in left ventricle of old rats submitted to high-intensity resistance training. Journal of Applied Physiology, v. 123, n. 3, p. 655-663, . (13/00798-2, 14/50938-8)
FUZER, ANGELINA M.; LEE, SUN-YOUNG; MOTT, JONI D.; COMINETTI, MARCIA R.. [10]-Gingerol Reverts Malignant Phenotype of Breast Cancer Cells in 3D Culture. Journal of Cellular Biochemistry, v. 118, n. 9, p. 2693-2699, . (13/00798-2, 15/08146-0, 12/18908-6)
MARIA, ROBERTA M.; ALTEI, WANESSA F.; SELISTRE-DE-ARAUJO, HELOISA S.; COLNAGO, LUIZ A.. Impact of chemotherapy on metabolic reprogramming: Characterization of the metabolic profile of breast cancer MDA-MB-231 cells using H-1 HR-MAS NMR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis, v. 146, p. 324-328, . (13/00798-2, 13/05128-5)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.