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Cognitive profile in tobacco smokers: relationship with respiratory parameters and oxidative stress

Grant number: 13/10985-4
Support Opportunities:Regular Research Grants
Duration: October 01, 2013 - September 30, 2015
Field of knowledge:Humanities - Psychology - Physiological Psychology
Principal Investigator:Sabine Pompéia
Grantee:Sabine Pompéia
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Smoking tobacco affects the central nervous system in several ways, among which decreased brain oxygen supply and alterated metabolism of gasotransmissors as nitric oxide and carbon monoxide. However, the relationship of these effects with the cognitive damage of smoking are largely unknown and will be explored in this project through a cross-sectional study with 80 subjects. The main purpose is to characterize the cognitive impairment of smokers and to determine how this injury is related to respiratory parameters / oxidative stress in young adults with high and low cognitive stimulation (schooling level / purchasing power), since the latter affects both smoking and cognition. This study has the potential to better understanding of the effects of smoking on cognition, considering different levels of cognitive stimulation (schooling / socioeconomic status), and to establish possible correlations between physiological and biochemical alterations (respiratory parameters and oxidative stress) with cognitive changes attributed to this habit. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEREIRA DA SILVA, VICTOR HUGO; DE LUNA ANTONIO, RAQUEL; POMPEIA, SABINE; RIBEIRO, DANIEL ARAKI. Cytogenetic Biomonitoring in Buccal Mucosa Cells from Young Smokers. ACTA CYTOLOGICA, v. 59, n. 6, p. 474-478, . (12/20664-8, 13/10985-4)

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