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Evaluation of the effectiveness of the Mindfulness-Based Relapse Prevention (MBRP) program as adjunct to tobacco dependence treatment

Grant number: 13/02316-5
Support Opportunities:Regular Research Grants
Duration: October 01, 2013 - March 31, 2016
Field of knowledge:Humanities - Psychology - Cognitive Psychology
Principal Investigator:Ana Regina Noto
Grantee:Ana Regina Noto
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated researchers:Elisa Harumi Kozasa ; Telmo Mota Ronzani


Tobacco dependence is one of the main predictable causes of death around the world. The treatment based on cognitive-behavioral therapy, including relapse prevention, has become a standard for the treatment of tobacco dependence. However, scientific advances are still necessary. The emotional and behavioral regulation after smoking cessation seems to be a risk factor to relapses, and therefore requires therapeutic models that stimulate the ability of the individual to respond to negative affects. In this sense, the program Mindfulness-Based Relapse Prevention (MBRP) as an adjunct treatment has been presenting promising results. The objective of this project is to evaluate the effectiveness of the de MBRP program as an adjunct treatment to smoking cessation created by Ministry of Health through the Instituto Nacional de Câncer (National Institute of Cancer - INCA).Methodology. It will be a randomized clinical trial, with random allocation, stratified by gender, education and dependence level. Sixty patients under standard treatment at the INCA will participate in the study. They will be randomly allocated to two groups: the Experimental Group (EG), which will be submitted to eight sessions of MBRP; and the Control Group (CG), which will be submitted to eight sessions of the traditional model of Relapse Prevention. Patients with a diagnosis of nicotine dependence who are in withdrawal will also be included. All the patients will be evaluated at (T0) and at four other moments: 1 (T1), 3 (T2), 6 (T3) and 12 months (T4) after the beginning of treatment. They will also undergo the maintenance evaluations of the INCA protocol. We will use a screening instrument of non-psychotic mental disorders (Self Reporting Questionnaire - SRQ-20) and instruments that measure craving (Questionnaire of Smoking Urges - QSU); anxiety (Hamilton-Anxiety - HAM-A); depression (Center for Epidemiologic Studies Depression Scale - CES-D); mindfulness (Five Facet Mindfulness Questionnaire - FFMQ); withdrawal (Smokerlyser - CO measure), tobacco dependence (The Fagerstrom Test for Nicotine Dependence - FTND), and positive and negative affects (Positive and Negative Affect Schedule - PANAS). The Analysis of Variance for Repeated Measures and the Longitudinal Logistic Regression will be used for us to evaluate the evolution of comorbidities and withdrawal of the patients. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, ISABEL WEISS; KOZASA, ELISA HARUMI; RABELLO, LUANE A.; MATTOZO, BEATRIZ; BOWEN, SARAH; RICHTER, KIMBER P.; ANDREOLI SARTES, LAISA MARCORELA; NOTO, ANA REGINA. Dispositional mindfulness, affect and tobacco dependence among treatment naive cigarette smokers in Brazil. TOBACCO INDUCED DISEASES, v. 17, . (13/02316-5)
WEISS DE SOUZA, ISABEL CRISTINA; KOZASA, ELISA HARUMI; BOWEN, SARAH; RICHTER, KIMBER P.; ANDREOLI SARTES, LAISA MARCORELA; BASILE COLUGNATI, FERNANDO ANTONIO; NOTO, ANA REGINA. Effectiveness of Mindfulness-Based Relapse Prevention Program as an Adjunct to the Standard Treatment for Smoking: A Pragmatic Design Pilot Study. NICOTINE & TOBACCO RESEARCH, v. 22, n. 9, p. 1605-1613, . (13/02316-5)

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