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Assessment of biochemical and antioxidant parameters in rats exposed to Lentinula edodes (shiitake) and its possible use in metabolic disturbances

Grant number: 13/05765-5
Support Opportunities:Regular Research Grants
Duration: October 01, 2013 - September 30, 2015
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Denise Grotto
Grantee:Denise Grotto
Host Institution: Pró-Reitoria Acadêmica. Universidade de Sorocaba (UNISO). Sorocaba , SP, Brazil
Associated researchers:Marli Gerenutti


The incidence of overweight and obesity have been increasing worldwide, decreasing the quality of life and increasing the public spending with patients since overweight and obesity are closely linked to chronic diseases such as diabetes, dyslipidemias, and cardiac diseases. One of the main mechanisms involved in obesity pathogenesis is the oxidative stress. The excess of nutrients (glucose, fatty acids) triggers, among others cellular effects, the overproduction of reactive species, which are unstable and can damage cellular structure to react with lipids, proteins and DNA. The organism has antioxidants defenses, as reduced glutathione, catalase, glutathione peroxidase, metallothionein. However exogenous antioxidants gotten from food are frequently required, such as vitamins, minerals, and phytochemicals. Edible mushrooms are food with excellent nutritional properties since they are low in calories, are source of proteins, vitamins and selenium. Researches have showed that phytochemicals from edible mushrooms have many pharmacological effects, among them cholesterol reducing, hypoglycemic, and antioxidant. Nevertheless in vivo studies evaluating these effects are important. Thus this study intends evaluate biochemical and antioxidant effects from the daily intake of Lentinula edodes (Shiitake) in normal rats and in rat with metabolic disturbance by the high caloric diet ingestion. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GROTTO, DENISE; ROSA BUENO, DAIANE CRISTOVAM; DE ALMEIDA RAMOS, GABRIELA KARINE; DA COSTA, SUSI ROSA; VIEIRA SPIM, SARA ROSICLER; GERENUTTI, MARLI. Assessment of the Safety of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), in Rats: Biochemical, Hematological, and Antioxidative Parameters. International Journal of Medicinal Mushrooms, v. 18, n. 10, p. 861-870, . (13/05765-5)
CAETANO, ERIKA LEAO AJALA; VIROEL, FABIA JUDICE MARQUES; LAURINO, LETICIA FAVARA; CAMARGO, ISABELLA FERREIRA; CASTRO, RAQUEL DE MENDONCA ROSA; PICKLER, THAISA BORIM; JOZALA, ANGELA FAUSTINO; GROTTO, DENISE; GERENUTTI, MARLI. Royal Sun Culinary-Medicinal Mushroom Agaricus brasiliensis (Agaricomycetes) as a Functional Food in Gestational Diabetes Mellitus Before and After Fetus Implantation. International Journal of Medicinal Mushrooms, v. 23, n. 9, p. 15-27, . (15/24566-9, 13/05765-5)
MASCHIO, BIANCA HESSEL; GENTIL, BIANCA CARVALHO; AJALA CAETANO, ERIKA LEAO; RODRIGUES, LUCAS SILVA; LAURINO, LETICIA FAVARA; VIEIRA SPIM, SARA ROSICLER; JOZALA, ANGELA FAUSTINO; DOS SANTOS, CAROLINA ALVES; GROTTO, DENISE; GERENUTTI, MARLI. Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats. International Journal of Medicinal Mushrooms, v. 19, n. 11, p. 991-1000, . (15/24566-9, 13/05765-5)
LAURINO, LETICIA F.; VIROEL, FABIA J. M.; CAETANO, ERIKA; SPIM, SARA; PICKLER, THAISA B.; ROSA-CASTRO, RAQUEL M.; VASCONCELOS, EDILMA ALBUQUERQUE; JOZALA, ANGELA F.; HATAKA, ALESSANDRE; GROTTO, DENISE; et al. Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus. NUTRIENTS, v. 11, n. 11, . (15/24566-9, 13/05765-5)
VIEIRA SPIM, SARA ROSICLER; CORREA CHRISPIM DE OLIVEIRA, BRUNA GIOVANNA; LEITE, FERNANDA GOMES; GERENUTTI, MARLI; GROTTO, DENISE. Effects of Lentinula edodes consumption on biochemical, hematologic and oxidative stress parameters in rats receiving high-fat diet. EUROPEAN JOURNAL OF NUTRITION, v. 56, n. 7, p. 2255-2264, . (13/05765-5)
GROTTO, D.; GERENUTTI, M.; SOUZA, V. C. O.; BARBOSA, JR., F.. Deficiency of macro- and micronutrients induced by Lentinula edodes. TOXICOLOGY REPORTS, v. 2, p. 401-404, . (13/05765-5)

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