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Systemic metronidazole and amoxicillin as adjuncts to scaling and root planing in the treatment of chronic periodontitis in type 2 diabetic subjects: clinical, glycemic and microbiological evaluations

Grant number: 13/01072-5
Support Opportunities:Regular Research Grants
Duration: October 01, 2013 - September 30, 2014
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Poliana Mendes Duarte
Grantee:Poliana Mendes Duarte
Host Institution: Universidade de Guarulhos (UNG). Campus Guarulhos-Centro. Guarulhos , SP, Brazil


The aim of this double-blinded, prospective, randomized, placebo-controlled clinical trial will be to evaluate, at 3 and 12 months, the clinical, glycemic and microbiological effects of systemic metronidazol and amoxicillin as adjunctive to scaling and root planing (SRP) in uncontrolled type 2 diabetic subjects with chronic periodontitis. Fifty subjects with chronic periodontitis and type 2 diabetes will be assigned into one of the following therapeutic groups: Control (n=25) SRP + placebo; Test (n=25): RAR + systemic metronidazole (400mg) + amoxicillin (500mg), 3x/day for 14 days. The following clinical parameters will be evaluated: probing depth (PD), clinical attachment level (CAL), visible plaque accumulation, bleeding on probing, marginal bleeding and suppuration. Six subgingival biofilm samples will be collected per subjects (3 samples PD < 5 mm e 3 samples PD e 5 mm) for the evaluation by quantitative PCR of the following bacterial species: Prevotella intermedia, Porphyromonas gingivalis, Tanerella forsythia, Eubacterium nodatum, Parvimona micra and Fusobacterium nucleatum e Treponema denticola. Clinical and microbiological parameters and the levels of glycated hemoglobin and fasting plasma glucose will be assessed before and at 3 and 12 months post-therapies. Intra-group comparisons (before and after treatment) will be performed by Friedman test or repeated measured ANOVA, according to data normality. Inter-group comparisons (control/test) within each time-point will be performed by Mann-Whitney test and t-test. The level of significance will be set at 5%. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DIAS GONCALVES, TIAGO EDUARDO; SANTOS ZIMMERMANN, GLAUCIA; CRISTINA FIGUEIREDO, LUCIENE; DE CARVALHO SOUZA, MONIQUE; FERREIRA DA CRUZ, DANIELE; FERREIRA BASTOS, MARTA; PEREIRA DA SILVA, HELIO DOYLE; MENDES DUARTE, POLIANA. Local and serum levels of adipokines in patients with obesity after periodontal therapy: one-year follow-up. Journal of Clinical Periodontology, v. 42, n. 5, p. 431-439, . (11/14875-3, 13/01072-5)
DUARTE, POLIANA MENDES; FERES, MAGDA; SMEILI YASSINE, LINA LAMEH; SILVA SOARES, GEISLA MARY; MIRANDA, TAMIRES SZEREMESKE; FAVERI, MARCELO; RETAMAL-VALDES, BELEN; FIGUEIREDO, LUCIENE CRISTINA. Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study. JOURNAL OF CLINICAL PERIODONTOLOGY, v. 45, n. 11, p. 1326-1335, . (11/14872-4, 13/01072-5)
MIRANDA, TAMIRES SZEREMESKE; FERES, MAGDA; RETAMAL-VALDES, BELEN; PEREZ-CHAPARRO, PAULA JULIANA; MACIEL, SUELLEN SILVA; DUARTE, POLIANA MENDES. Influence of glycemic control on the levels of subgingival periodontal pathogens in patients with generalized chronic periodontitis and type 2 diabetes. Journal of Applied Oral Science, v. 25, n. 1, p. 82-89, . (11/14872-4, 13/01072-5)
TAMASHIRO, N. S.; DUARTE, P. M.; MIRANDA, T. S.; MACIEL, S. S.; FIGUEIREDO, L. C.; FAVERI, M.; FERES, M.. Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial. JOURNAL OF DENTAL RESEARCH, v. 95, n. 7, p. 829-836, . (11/14872-4, 13/01072-5)
MIRANDA, TAMIRES SZEREMESKE; FERES, MAGDA; PEREZ-CHAPARRO, PAULA JULIANA; FAVERI, MARCELO; FIGUEIREDO, LUCIENE CRISTINA; TAMASHIRO, NEILA SUMIE; BASTOS, MARTA FERREIRA; DUARTE, POLIANA MENDES. Metronidazole and amoxicillin as adjuncts to scaling and root planing for the treatment of type 2 diabetic subjects with periodontitis: 1-year outcomes of a randomized placebo-controlled clinical trial. Journal of Clinical Periodontology, v. 41, n. 9, p. 890-899, . (11/14872-4, 13/01072-5)

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