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Phytochemistry study and evaluation of the cytotoxicity and lipoxygenase inhibitory activity from Cerrado plants

Abstract

This project intents on realize the bioassay-guide chemistry study from species of the genus Styrax, Arrabidaea and Anacardium with potential use as lipoxygenase (LO) inhibitors. The phytochemical research will be guided by LO inhibitory activity, using the 5-LO enzyme inhibition in vitro assay. The analysis methodologies to be used, will involve chromatographic separation techniques (CC, TLC, GC-MS, HPLC-DAD). The structural characterization of the isolated compounds will be performed using spectroscopic methods such as experiments of 1D and 2D NMR, IR, UV and MS. Thus, the main goal of this proposal will be identifying natural compounds with lipoxygenase inhibitory activity, also evaluating the cytotoxic properties from the species: S. ferrugineus, S. camporum, S. pohlii, Arrabidaea pulchra and Anacardium othonianum and others that are eventually collected during the project. This project will contribute to the ongoing natural products research in the GPNUF laboratory (Grupo de Pesquisa em Produtos Naturais UNIFRAN), to the human resource formation, and with the UNIFRAN M.D.and Ph.D. Program in Science (Capes, score 5). (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVARENGA, TAVANE A.; DE OLIVEIRA, POLLYANNA F.; DE SOUZA, JULIA M.; TAVARES, DENISE C.; ANDRADE E SILVA, MARCIO L.; CUNHA, WILSON R.; GROPPO, MILTON; JANUARIO, ANA H.; MAGALHAES, LIZANDRA G.; PAULETTI, PATRICIA M.. Schistosomicidal Activity of Alkyl-phenols from the Cashew Anacardium occidentale against Schistosoma mansoni Adult Worms. Journal of Agricultural and Food Chemistry, v. 64, n. 46, p. 8821-8827, . (13/20280-8, 13/09280-6)
GIMENEZ, VALERIA M. M.; ALVARENGA, TAVANE A.; GROPPO, MILTON; A E SILVA, MARCIO L.; CUNHA, WILSON R.; JANUARIO, ANA H.; SMILKSTEIN, MARTIN J.; RISCOE, MICHAEL K.; PAULETTI, PATRICIA M.. Antiplasmodial evaluation of Anacardium occidentale and alkyl-phenols. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 29, n. 1, p. 36-39, . (13/09280-6, 16/06260-2, 16/10313-4, 13/20280-8)
ALVARENGA, TAVANE A.; BERTANHA, CAMILA S.; DE OLIVEIRA, POLLYANNA F.; TAVARES, DENISE C.; GIMENEZ, VALERIA M. M.; SILVA, MARCIO L. A.; CUNHA, WILSON R.; JANUARIO, ANA H.; PAULETTI, PATRICIA M.. Lipoxygenase inhibitory activity of Cuspidaria pulchra and isolated compounds. NATURAL PRODUCT RESEARCH, v. 29, n. 11, p. 1083-1086, . (13/09280-6, 11/01139-7)
BERTANHA, CAMILA S.; GIMENEZ, VALERIA M. M.; FURTADO, RICARDO A.; TAVARES, DENISE C.; CUNHA, WILSON R.; A E SILVA, MARCIO L.; JANUARIO, ANA H.; BORGES, ALEXANDRE; KAWANO, DANIEL F.; PARREIRA, RENATO L. T.; et al. Isolation, in vitro and in silico Evaluation of Phenylethanoid Glycoside from Arrabidaea brachypoda as Lipoxygenase Inhibitor. Journal of the Brazilian Chemical Society, v. 31, n. 4, p. 849-855, . (13/09280-6)
MILANI, REINALDO R.; ALVES, OSVAINE J. A.; BERTANHA, CAMILA S.; GIMENEZ, VALERIA M. M.; SQUARISI, IARA S.; NICOLELLA, HELOIZA D.; PAGOTTI, MARIANA C.; TAVARES, DENISE C.; E SILVA, MARCIO L. A.; CUNHA, WILSON R.; et al. ANTIPROMASTIGOTE AND CYTOTOXIC ACTIVITIES OF FLAVONOIDS FROM Fridericia speciosa LEAVES. Química Nova, v. 43, n. 10, p. 1404-1407, . (15/04999-8, 16/10313-4, 13/09280-6, 17/24860-0)
BERTANHA, CAMILA SPERETA; JANUARIO, ANA HELENA; ALVARENGA, TAVANE APARECIDA; PIMENTA, LETICIA PEREIRA; ANDRADE E SILVA, MARCIO LUIS; CUNHA, WILSON ROBERTO; PAULETTI, PATRICIA MENDONCA. Quinone and Hydroquinone Metabolites from the Ascidians of the Genus Aplidium. MARINE DRUGS, v. 12, n. 6, p. 3608-3633, . (13/09280-6)
CAMILA SPERETA BERTANHA; SUSANE HELLEN UTRERA; VALÉRIA MARIA MELLEIRO GIMENEZ; MILTON GROPPO; MÁRCIO LUIS ANDRADE E SILVA; WILSON ROBERTO CUNHA; CARLOS HENRIQUE GOMES MARTINS; ANA HELENA JANUÁRIO; PATRÍCIA MENDONÇA PAULETTI. Antibacterial evaluation of Styrax pohlii and isolated compounds. Brazilian Journal of Pharmaceutical Sciences, v. 49, n. 4, p. 653-658, . (09/02535-3, 08/10283-1, 08/01268-9, 13/09280-6)

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