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Ecology and etiology of fibropapillomatosis in Chelonia mydas (Testudines, Cheloniidae) populations: structure of populations and the role of polychlorinated biphenyls and toxic potentially metals for the development of diseases

Grant number: 12/14319-6
Support Opportunities:Regular Research Grants
Duration: August 01, 2013 - July 31, 2016
Field of knowledge:Biological Sciences - Ecology - Applied Ecology
Principal Investigator:Eliana Reiko Matushima
Grantee:Eliana Reiko Matushima
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Angelica Maria Sanchez Sarmiento ; Silmara Rossi


The green turtle (Chelonia mydas) feeds and nests on the Brazilian coast and have been affected by fibropapillomatosis, wich is characterized of benign skin tumors and is one of the greatest threats to the survival of this species. Studies suggest virus associated with population, genetics and environmental factors. At this study, we will have access to green turtle populations from various Brazilian coast spots and (will be) determined haplotype of C. mydas populations with and without fibropapillomas from feeding areas. We will collect biometry data from green turtles, quantity and distribution of the tumors and associated with population haplotypes, CFPHV (Chelonid fibropapilloma-associated herpesvirus) detected, polychlorinated biphenyls (PCBs) and toxic potentially metals concentrations (Pb, Cd, Zn e Cu). The general aim is to elucidate the relations between C. mydas population and the role of population structure, CFPHV and environmental pollutants in the development of disease. The specifics aims are: 1- to assess the leukocytes function by flow cytometry; 2- to investigate the PCBs presence in blood samples and solid tissues by gas chromatograph; 3- to establish correlations between cell function and PCBs concentrations; 4- to investigate the metals presence and how they interfere in the sanity and development of disease; 5- to detect and to characterize the herpesvirus genic sequence associated with fibropapillomatosis (CFPHV) by moleculars methods and classic methods of virologic and hystopathologic diagnosis 7- to determine the structure of C. mydas populations from feeding areas and associate with (virus) CFPHV detected, toxic potentially metals presence (Pb, Cd, Zn e Cu) and severity and development of disease. The aims of present study enlarge the understood about the ecology and etiopathogeny of fibropapillomatosis, enabling procedures for future control of the disease in Brazilian areas and the preparation of management strategies for conservation of this species. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANCHEZ-SARMIENTO, ANGELICA MARIA; ROSSI, SILMARA; VILCA, FRANZ ZIRENA; THIJL VANSTREELS, RALPH ERIC; MONTEIRO, SERGIO HENRIQUE; VALE, LUIZ AMERICO S.; DOS SANTOS, ROBSON GUIMARAES; MARIGO, JULIANA; BERTOZZI, CAROLINA PACHECO; HILDEBRAND GRISI FILHO, JOSE HENRIQUE; et al. Organochlorine pesticides in green sea turtles (Chelonia mydas) with and without fibropapillomatosis caught at three feeding areas off Brazil. Journal of the Marine Biological Association of the United Kingdom, v. 97, n. 1, p. 215-223, . (11/04565-7, 10/01781-8, 12/14319-6, 09/53956-9)
ZIRENA VILCA, FRANZ; ROSSI, SILMARA; DE OLINDA, RICARDO ALVES; SANCHEZ-SARMIENTO, ANGELICA MARIA; SETIM PRIOSTE, FABIOLA ELOISA; MATUSHIMA, ELIANA REIKO; TORNISIELO, VALDEMAR LUIZ. Concentrations of polycyclic aromatic hydrocarbons in liver samples of juvenile green sea turtles from Brazil: Can these compounds play a role in the development of fibropapillomatosis?. Marine Pollution Bulletin, v. 130, p. 215-222, . (11/04565-7, 12/14319-6, 12/13683-6)
ZAMANA, ROBERTA RAMBLAS; GATTAMORTA, MARCO AURELIO; CRUZ OCHOA, PABLO FELIPE; NAVAS-SUAREZ, PEDRO ENRIQUE; SACRISTAN, CARLOS; ROSSI, SILMARA; HILDEBRAND GRISI-FILHO, JOSE HENRIQUE; SILVA, ISABELA SANTOS; MATUSHIMA, ELIANA REIKO. igh Occurrence of Chelonid Alphaherpesvirus 5 (ChHV5) in Green Sea Turtles Chelonia mydas with and without Fibropapillomatosis in Feeding Areas of the Sao Paulo Coast, Brazi. JOURNAL OF AQUATIC ANIMAL HEALTH, v. 33, n. 4, . (18/25069-7, 12/14319-6)
ROSSI, SILMARA; DE QUEIROZ HAZARBASSANOV, NICOLLE G. T.; SANCHEZ-SARMIENTO, ANGELICA MARIA; SETIM PRIOSTE, FABIOLA ELOISA; MATUSHIMA, ELIANA REIKO. Immune Response of Green Sea Turtles with and without Fibropapillomatosis: Evaluating Oxidative Burst and Phagocytosis via Flow Cytometry. CHELONIAN CONSERVATION AND BIOLOGY, v. 15, n. 2, p. 273-278, . (11/04565-7, 10/01781-8, 12/14319-6)
ROSSI, SILMARA; SANCHEZ-SARMIENTO, ANGELICA MARIA; THIJL VANSTREELS, RALPH ERIC; DOS SANTOS, ROBSON GUIMARAES; SETIM PRIOSTE, FABIOLA ELOISA; GATTAMORTA, MARCO AURELIO; HILDEBRAND GRISI-FILHO, JOSE HENRIQUE; MATUSHIMA, ELIANA REIKO. Challenges in Evaluating the Severity of Fibropapillomatosis: A Proposal for Objective Index and Score System for Green Sea Turtles (Chelonia mydas) in Brazil. PLoS One, v. 11, n. 12, . (11/04565-7, 10/01781-8, 12/14319-6, 09/53956-9)
ROSSI, SILMARA; SANCHEZ-SARMIENTO, ANGELICA MARIA; DOS SANTOS, ROBSON GUIMARAES; ZAMANA, ROBERTA RAMBLAS; SETIM PRIOSTE, FABIOLA ELOISA; GATTAMORTA, MARCO AURELIO; CRUZ OCHOA, PABLO FELIPE; HILDEBRAND GRISI-FILHO, JOSE HENRIQUE; MATUSHIMA, ELIANA REIKO. Monitoring green sea turtles in Brazilian feeding areas: relating body condition index to fibropapillomatosis prevalence. Journal of the Marine Biological Association of the United Kingdom, v. 99, n. 8, p. 1879-1887, . (11/04565-7, 10/01781-8, 12/14319-6)

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