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Influence of VEGF-C and lymphatic vessel density on regional metastasis and prognosis of patients with oral squamous cell carcinoma

Grant number: 05/04577-4
Support Opportunities:Regular Research Grants
Duration: April 01, 2006 - March 31, 2008
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal Investigator:Denise Tostes Oliveira
Grantee:Denise Tostes Oliveira
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


The metastatic dissemination of head and neck squamous cell carcinoma (SCC) to neck lymph nodes occurs rather through the lymphatic system. Furthermore, it has long been established that the presence of lymph node metastasis (N+), verified through histopathological analysis, is the most important prognostic factor to the patients with SCC. Recent studies reported that the vascular endothelial growth factor C (VEGF-C) may directly induce lymphangiogenesis and dilatation of lymphatic vessels in solid tumors of different sites. However, the VEGF-C as a prognostic factor to the oral squamous cell carcinoma has not been frequently studied. The aim of this study is to investigate the influence of VEGF-C and the lymphatic microvessel density on regional metastasis and the prognosis of patients with oral squamous cell carcinoma. A total of 117 cases of surgically excised primary oral squamous cell carcinoma with clinical stages I and II (located in tongue and floor of the mouth) from the files of Head and Neck Surgery and Otohinolaryngology Department of the A. C. Camargo Cancer Hospital, São Paulo, Brazil, will be analysed. Clinical information regarding the gender, age, race, tobacco and alcohol abuse, localization, stage by the TNM-UICC, treatment, lymph nodes involvement, local and cervical recurrences, distant metastasis and second primary tumors will be obtained from the patients files. In addition, the immunohistochemical study will be performed on paraffin sections of SCC with policlonal VEGF-C and monoclonal podoplanin (specific for lymphatic vessel) using a standard streptavidin-biotin-peroxidase technique... (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALMEIDA, AROLDO DOS SANTOS; OLIVEIRA, DENISE TOSTES; PEREIRA, MICHELE CONCEICAO; SITA FAUSTINO, SIMONE ELOIZA; NONOGAKI, SUELY; CARVALHO, ANDRE LOPES; KOWALSKI, LUIZ PAULO. Podoplanin and VEGF-C Immunoexpression in Oral Squamous Cell Carcinomas: Prognostic Significance. ANTICANCER RESEARCH, v. 33, n. 9, p. 3969-3976, . (05/04577-4, 07/04907-0)
FAUSTINO, S. E. S.; OLIVEIRA, D. T.; NONOGAKI, S.; LANDMAN, G.; CARVALHO, A. L.; KOWALSKI, L. P.. Expression of vascular endothelian growth factor-C does not predict occult lymphnode metastasis in early oral squamous cell carcinoma. International Journal of Oral and Maxillofacial Surgery, v. 37, n. 4, p. 372-378, . (05/04577-4)
CAETANO, ADRIANA DOS SANTOS; TJIOE, KELLEN CRISTINE; SITA FAUSTINO, SIMONE ELOIZA; COSTA HANEMANN, JOAO ADOLFO; FERNANDES BELONE, ANDREA DE FARIA; SOARES, CLEVERSON TEIXEIRA; OLIVEIRA, DENISE TOSTES. Immunolocalization of podoplanin in benign odontogenic tumours with and without ectomesenchyme. ARCHIVES OF ORAL BIOLOGY, v. 58, n. 4, p. 408-415, . (05/04577-4, 07/04907-0)
FAUSTINO, SIMONE E. S.; TJIOE, KELLEN C.; ASSAO, AGNES; PEREIRA, MICHELE C.; CARVALHO, ANDRE L.; KOWALSKI, LUIZ P.; OLIVEIRA, DENISE T.. Association of lymph vessel density with occult lymph node metastasis and prognosis in oral squamous cell carcinoma. BMC ORAL HEALTH, v. 21, n. 1, . (05/04577-4, 07/04907-0)

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