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Cellular and functional bases of exercise in cardiovascular diseases

Grant number: 10/50048-1
Support Opportunities:Research Projects - Thematic Grants
Duration: August 01, 2010 - January 31, 2016
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Carlos Eduardo Negrão
Grantee:Carlos Eduardo Negrão
Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Pesquisadores principais:
Antonio Carlos Pereira-Barretto ; Edilamar Menezes de Oliveira ; Luciana Venturini Rossoni ; Maria Urbana Pinto Brandão Rondon ; Patricia Chakur Brum
Associated grant(s):14/22335-7 - Study of perivascular innervation in arteries from post-myocardial infarction rats: effect of physical training, AV.EXT
Associated scholarship(s):14/13690-8 - Role of exercise training on prevention of cardiotoxicity provoked by doxorubicin, BP.PD
13/10472-7 - Swimming exercise training in vascular remodeling of coronary arteries of spontaneously hypertensive rats: effects on the expression of microRNAs and perspective of identifying therapeutic targets., BP.PD

Abstract

Accumulated evidences show that exercise training plays an important role in cardiovascular disease. The present study will focus on the effects that exercise training may have on muscle mechanoreflex and metaboreflex controls of sympathetic nerve activity in patients with heart failure. In addition, we will investigate the cellular mechanisms involved in these controls. At a vascular level, we will study the effects of exercise training on miRNA expression involved in the cardiac angiogenesis in spontaneously hypertensive rats. Also, we will investigate the influence of exercise training on pro-inflammation, oxidative stress and antioxidant enzymes in endothelial cells of the human femoral artery, and on the vascular morphology and function of animals with heart failure. The final section will be dedicated to the investigation of the effects of exercise training on cardiac remodeling and skeletal myopathy in heart failure. To accomplish this goal, we will study the effects of exercise training on cardiac calcineurine pathway and skeletal muscle protein synthesis and degradation with two different approaches: heart failure patients submitted to cardiac resynchronization therapy and heart failure patients undergoing testosterone therapy. Furthermore, we will study the role of angiotensin II on the amelioration of muscle myopathy provoked by exercise training. Finally, we close this section investigating if the improvement of cardiac and skeletal myopathy in heart failure is associated with exercise training intensity. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
El sensor del corazón 
The heart's sensor 
Articles published in Agência FAPESP Newsletter about the research grant:
TITULO 
Articles published in other media outlets (0 total):
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (50)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BRAGA, VIVIANE A. V. N.; COUTO, GISELE K.; LAZZARIN, MARIANA C.; ROSSONI, LUCIANA V.; MEDEIROS, ALESSANDRA. Aerobic Exercise Training Prevents the Onset of Endothelial Dysfunction via Increased Nitric Oxide Bioavailability and Reduced Reactive Oxygen Species in an Experimental Model of Menopause. PLoS One, v. 10, n. 4, . (12/17709-0, 10/50048-1)
NEGRAO, CARLOS E.; MIDDLEKAUFF, HOLLY R.; GOMES-SANTOS, IGOR L.; ANTUNES-CORREA, LIGIA M.. Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 308, n. 8, p. H792-H802, . (10/50048-1, 13/15651-7, 14/13690-8)
SOARES MELO, STEPHANO FREITAS; BARAUNA, VALERIO GARRONE; CARNEIRO JUNIOR, MIGUEL ARAUJO; MARCHESI BOZI, LUIZ HENRIQUE; DRUMMOND, LUCAS RIOS; NATALI, ANTONIO JOSE; DE OLIVEIRA, EDILAMAR MENEZES. Resistance Training Regulates Cardiac Function through Modulation of miRNA-214. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 16, n. 4, p. 6855-6867, . (10/50048-1, 10/09438-0, 09/18370-3)
GROEHS, RAPHAELA V.; TOSCHI-DIAS, EDGAR; ANTUNES-CORREA, LIGIA M.; TREVIZAN, PATRICIA F.; RONDON, MARIA URBANA P. B.; OLIVEIRA, PATRICIA; ALVES, MARIA J. N. N.; ALMEIDA, DIRCEU R.; MIDDLEKAUFF, HOLLY R.; NEGRAO, CARLOS E.. Exercise training prevents the deterioration in the arterial baroreflex control of sympathetic nerve activity in chronic heart failure patients. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 308, n. 9, p. H1096-H1102, . (10/50048-1, 13/15651-7, 13/07651-7)
NOBRE, T. S.; GROEHS, R. V.; AZEVEDO, L. F.; ANTUNES-CORREA, L. M.; MARTINEZ, D. G.; ALVES, M. J. N. N.; NEGRAO, C. E.. Post-Exercise Neurovascular Control in Chronic Heart Failure Patients. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 37, n. 13, p. 1073-1079, . (10/50048-1)
FERNANDES, TIAGO; BARRETTI, DIEGO LOPES; PHILLIPS, M. IAN; OLIVEIRA, EDILAMAR MENEZES. Exercise training prevents obesity-associated disorders: Role of miRNA-208a and MED13. Molecular and Cellular Endocrinology, v. 476, p. 148-154, . (14/50673-4, 10/50048-1, 15/17275-8, 09/18370-3)
ANTUNES-CORREA, LIGIA M.; NOBRE, THAIS S.; GROEHS, RAPHAELA V.; ALVES, MARIA JANIEIRE N. N.; FERNANDES, TIAGO; COUTO, GISELE K.; RONDON, MARIA URBANA P. B.; OLIVEIRA, PATRICIA; LIMA, MARTA; MATHIAS, WILSON; et al. Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 307, n. 11, p. H1655-H1666, . (10/50048-1)
TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; DIAS DA SILVA, VALDO JOSE; MAKI-NUNES, CRISTIANE; ALVES, MARIA JANIEIRE N. N.; ANGELO, LUCIANA F.; CEPEDA, FELIPE X.; MARTINEZ, DANIEL G.; NEGRAO, CARLOS EDUARDO; RONDON, MARIA URBANA P. B.. Symptoms of anxiety and mood disturbance alter cardiac and peripheral autonomic control in patients with metabolic syndrome. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 113, n. 3, p. 671-679, . (08/03714-6, 10/50048-1)
FERNANDES, TIAGO; MAGALHAES, FLAVIO DE CASTRO; DO CARMO, EVERTON CRIVOI; DE OLIVEIRA, EDILAMAR MENEZES. O treinamento físico aeróbio inibe a sinalização apoptótica muscular esquelética mediada por VEGF-VEGR2 em ratos espontaneamente hipertensos. Revista Brasileira de Medicina do Esporte, v. 18, n. 6, p. 412-418, . (10/50048-1)
FERNANDES, TIAGO; ROQUE, FERNANDA ROBERTA; MAGALHAES, FLAVIO DE CASTRO; DO CARMO, EVERTON CRIVOI; DE OLIVEIRA, EDILAMAR MENEZES. O treinamento físico aeróbio corrige a rarefação capilar e as alterações nas proporções dos tipos de fibra muscular esquelética em ratos espontaneamente hipertensos. Revista Brasileira de Medicina do Esporte, v. 18, n. 4, p. 267-272, . (10/50048-1, 09/18370-3)
DOS SANTOS, MARCELO RODRIGUES; CARRARI SAYEGH, ANA LUIZA; RAMALHO GROEHS, RAPHAELA VILAR; FONSECA, GUILHERME; TROMBETTA, IVANI CREDIDIO; PEREIRA BARRETTO, ANTONIO CARLOS; ARAP, MARCO ANTONIO; NEGRAO, CARLOS EDUARDO; MIDDLEKAUFF, HOLLY R.; NUNES ALVES, MARIA-JANIEIRE DE NAZARE. Deficiência de Testosterona Aumenta Readmissão Hospitalar e Mortalidade em Pacientes do Sexo Masculino com Insuficiência Cardíaca. Arquivos Brasileiros de Cardiologia, v. 105, n. 3, p. 256-264, . (10/50048-1)
BOUCHARD, CLAUDE; ANTUNES-CORREA, LIGIA M.; ASHLEY, EUAN A.; FRANKLIN, NINA; HWANG, PAUL M.; MATTSSON, C. MIKAEL; NEGRAO, CARLOS E.; PHILLIPS, SHANE A.; SARZYNSKI, MARK A.; WANG, PING-YUAN; et al. Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventionse. PROGRESS IN CARDIOVASCULAR DISEASES, v. 57, n. 4, p. 337-346, . (10/50048-1, 13/15651-7, 13/07607-8)
VANZELLI, ANDREA S.; MEDEIROS, ALESSANDRA; ROLIM, NATALE; BARTHOLOMEU, JAN B.; CUNHA, TELMA F.; BECHARA, LUIZ G.; GOMES, ENEAS R. M.; MATTOS, KATT C.; SIRVENTE, RAQUEL; SALEMI, VERA; et al. Integrative Effect of Carvedilol and Aerobic Exercise Training Therapies on Improving Cardiac Contractility and Remodeling in Heart Failure Mice. PLoS One, v. 8, n. 5, . (10/50048-1)
SOARES MELO, STEPHANO FREITAS; BARAUNA, VALERIO GARRONE; NEVES, VANDER JOSE; FERNANDES, TIAGO; LARA, LUCIENNE DA SILVA; MAZZOTTI, DIEGO ROBLES; OLIVEIRA, EDILAMAR MENEZES. Exercise training restores the cardiac microRNA-1 and-214 levels regulating Ca2+ handling after myocardial infarction. BMC CARDIOVASCULAR DISORDERS, v. 15, . (10/50048-1, 10/09438-0, 12/04104-2, 09/18370-3)
FERREIRA-SANTOS, LARISSA; MARTINEZ, DANIEL G.; NICOLAU, JOSE CARLOS; MOREIRA, HUMBERTO G.; ALVES, MARIA JANIEIRE; PEREIRA, ALEXANDRE C.; TROMBETTA, IVANI C.; NEGRAO, CARLOS EDUARDO; RONDON, MARIA URBANA P. B.. Neurovascular control during exercise in acute coronary syndrome patients with Gln27Glu polymorphism of beta(2)-adrenergic receptor. PLoS One, v. 12, n. 2, . (10/50048-1, 05/59740-7)
COUTO, GISELE K.; PAULA, SULIANA M.; GOMES-SANTOS, IGOR L.; NEGRAO, CARLOS EDUARDO; ROSSONI, V, LUCIANA. Exercise training induces eNOS coupling and restores relaxation in coronary arteries of heart failure rats. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 314, n. 4, p. H878-H887, . (10/50048-1)
GABRIEL-COSTA, DANIELE; DA CUNHA, TELMA FATIMA; GRASSMANN BECHARA, LUIZ ROBERTO; FORTUNATO, RODRIGO SOARES; MARCHESI BOZI, LUIZ HENRIQUE; COELHO, MARCELE DE ALMEIDA; BARRETO-CHAVES, MARIA LUIZA; BRUM, PATRICIA CHAKUR. Lactate Up-Regulates the Expression of Lactate Oxidation Complex-Related Genes in Left Ventricular Cardiac Tissue of Rats. PLoS One, v. 10, n. 5, . (10/50048-1)
BECHARA, LUIZ R. G.; MOREIRA, JOSE B. N.; JANNIG, PAULO R.; VOLTARELLI, VANESSA A.; DOURADO, PAULO M.; VASCONCELOS, ANDREA R.; SCAVONE, CRISTOFORO; RAMIRES, PAULO R.; BRUM, PATRICIA C.. NADPH oxidase hyperactivity induces plantaris atrophy in heart failure rats. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 175, n. 3, p. 499-507, . (10/50048-1)
VOLTARELLI, VANESSA A.; BECHARA, LUIZ R. G.; BACURAU, ALINE V. N.; MATTOS, KATT C.; DOURADO, PAULO M. M.; BUENO, JR., CARLOS R.; CASARINI, DULCE E.; NEGRAO, CARLOS E.; BRUM, PATRICIA C.. Lack of beta(2)-adrenoceptors aggravates heart failure-induced skeletal muscle myopathy in mice. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 18, n. 6, p. 1087-1097, . (10/50048-1, 08/56483-1)
DOS SANTOS, MARCELO R.; SAYEGH, ANA L. C.; BACURAU, ALINE V. N.; ARAP, MARCO A.; BRUM, PATRICIA C.; PEREIRA, ROSA M. R.; TAKAYAMA, LILIAM; BARRETTO, ANTONIO C. P.; NEGRAO, CARLOS E.; DE NAZARE NUNES ALVES, MARIA JANIEIRE. Effect of Exercise Training and Testosterone Replacement on Skeletal Muscle Wasting in Patients With Heart Failure With Testosterone Deficiency. MAYO CLINIC PROCEEDINGS, v. 91, n. 5, p. 575-586, . (10/50048-1)
NOBRE, THAIS S.; ANTUNES-CORREA, LIGIA M.; GROEHS, RAPHAELA V.; ALVES, MARIA JANIEIRE N. N.; SARMENTO, ADRIANA O.; BACURAU, ALINE V.; URIAS, URSULA; ALVES, GUILHERME B.; RONDON, MARIA URBANA P. B.; BRUM, PATRICIA C.; et al. Exercise training improves neurovascular control and calcium cycling gene expression in patients with heart failure with cardiac resynchronization therapy. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 311, n. 5, p. H1180-H1188, . (10/50048-1)
LOBO, DENISE M. L.; TREVIZAN, PATRICIA F.; TOSCHI-DIAS, EDGAR; OLIVEIRA, PATRICIA A.; PIVETA, RAFAEL B.; ALMEIDA, DIRCEU R.; MADY, CHARLES; BOCCHI, EDIMAR A.; LORENZI-FILHO, GERALDO; MIDDLEKAUFF, HOLLY R.; et al. Sleep-Disordered Breathing Exacerbates Muscle Vasoconstriction and Sympathetic Neural Activation in Patients with Systolic Heart Failure. Circulation-Heart Failure, v. 9, n. 11, . (10/50048-1, 13/07651-7)
BOZI, LUIZ H. M.; JANNIG, PAULO R.; ROLIM, NATALE; VOLTARELLI, VANESSA A.; DOURADO, PAULO M. M.; WISLOFF, ULRIK; BRUM, PATRICIA C.. Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 20, n. 11, p. 2208-2212, . (10/50048-1, 14/23703-0)
MELO, STEPHANO F. S.; FERNANDES, TIAGO; BARAUNA, VALERIO G.; MATOS, KATT C.; SANTOS, ALEXANDRA A. S.; TUCCI, PAULO J. F.; OLIVEIRA, EDILAMAR M.. Expression of MicroRNA-29 and Collagen in Cardiac Muscle after Swimming Training in Myocardial-Infarcted Rats. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 33, n. 3, p. 657-669, . (10/50048-1, 10/09438-0, 09/18370-3)
COUTO, GISELE K.; BRITT, LUIZ ROBERTO G.; MILL, JOSE G.; ROSSONI, LUCIANA V.. Enhanced nitric oxide bioavailability in coronary arteries prevents the onset of heart failure in rats with myocardial infarction. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, v. 86, p. 110-120, . (10/50048-1)
TOSCHI-DIAS, EDGAR; TROMBETTA, IVANI C.; SILVA, VALDO J. D.; MAKI-NUNES, CRISTIANE; CEPEDA, FELIPE X.; ALVES, MARIA JANIEIRE N. N.; CARVALHO, GLAUCE L.; DRAGER, LUCIANO F.; LORENZI-FILHO, GERALDO; NEGRAO, CARLOS E.; et al. Diet associated with exercise improves baroreflex control of sympathetic nerve activity in metabolic syndrome and sleep apnea patients. Sleep and Breathing, v. 23, n. 1, p. 143-151, . (08/03714-6, 12/02953-2, 16/16831-7, 13/07651-7, 11/17533-6, 10/50048-1)
DARDI, PATRIZIA; PERAZZA, LAIS ROSSI; COUTO, GISELE KRUGER; CAMPOS, GIANNE PAUL; AGGUM CAPETTINI, LUCIANO DOS SANTOS; ROSSONI, LUCIANA VENTURINI. ena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stres. Clinical Science, v. 135, n. 23, p. 2625-2641, . (10/50048-1)
GRAZIELA AMARO-VICENTE; MATEUS C. LATERZA; DANIEL G. MARTINEZ; MARIA JANIEIRE N. N. ALVES; IVANI C. TROMBETTA; ANA MARIA F. W. BRAGA; EDGAR TOSCHI-DIAS; MARIA URBANA P. B. RONDON. Exercise Training Improves Heart Rate Recovery after Exercise in Hypertension. Motriz: rev. educ. fis., v. 25, n. 1, . (10/50048-1)
TOSCHI-DIAS, EDGAR; MONTANO, NICOLA; TOBALDINI, ELEONORA; TREVIZAN, PATRICIA F.; GROEHS, V, RAPHAELA; ANTUNES-CORREA, LIGIA M.; NOBRE, THAIS S.; LOBO, DENISE M.; SALES, ALLAN R. K.; UENO-PARDI, LINDA M.; et al. Oscillatory Pattern of Sympathetic Nerve Bursts Is Associated With Baroreflex Function in Heart Failure Patients With Reduced Ejection Fraction. FRONTIERS IN NEUROSCIENCE, v. 15, . (10/50048-1, 15/17642-0, 13/07651-7, 15/22814-5)
BERNAK-OLIVEIRA, ANGELO; GUIZONI, DANIELE M.; CHIAVEGATTO, SILVANA; DAVEL, ANA P.; V. ROSSONI, LUCIANA. The protective role of neuronal nitric oxide synthase in endothelial vasodilation in chronic beta-adrenoceptor overstimulation. Life Sciences, v. 285, . (10/50048-1, 11/16017-4, 17/06100-8)
JANNIG, PAULO R.; MOREIRA, JOSE B. N.; BECHARA, LUIZ R. G.; BOZI, LUIZ H. M.; BACURAU, ALINE V.; MONTEIRO, ALEX W. A.; DOURADO, PAULO M.; WISLOFF, ULRIK; BRUM, PATRICIA C.. Autophagy Signaling in Skeletal Muscle of Infarcted Rats. PLoS One, v. 9, n. 1, . (10/50048-1, 10/14567-4)
ANTUNES-CORREA, LIGIA M.; UENO-PARDI, LINDA M.; TREVIZAN, PATRICIA F.; SANTOS, MARCELO R.; DA SILVA, CARLOS HENRIQUE P.; FRANCO, FABIO G. M.; ALVES, MARIA JANIEIRE N. N.; RONDON, MARIA URBANA P. B.; NEGRAO, CARLOS E.. The influence of aetiology on the benefits of exercise training in patients with heart failure. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, v. 24, n. 4, p. 365-372, . (10/50048-1, 13/15651-7)
BACURAU, ALINE V. N.; JANNIG, PAULO R.; DE MORAES, WILSON M. A. M.; CUNHA, TELMA F.; MEDEIROS, ALESSANDRA; BARBERI, LAURA; COELHO, MARCELE A.; BACURAU, REURY F. P.; UGRINOWITSCH, CARLOS; MUSARO, ANTONIO; et al. Akt/mTOR pathway contributes to skeletal muscle anti-atrophic effect of aerobic exercise training in heart failure mice. INTERNATIONAL JOURNAL OF CARDIOLOGY, v. 214, p. 137-147, . (14/25957-9, 12/22817-6, 10/50048-1)
FERNANDES, TIAGO; BARAUNA, VALERIO G.; NEGRAO, CARLOS E.; PHILLIPS, M. IAN; OLIVEIRA, EDILAMAR M.. Aerobic exercise training promotes physiological cardiac remodeling involving a set of microRNAs. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 309, n. 4, p. H543-H552, . (14/50673-4, 10/50048-1)
GROEHS, RAPHAELA V.; ANTUNES-CORREA, LIGIA M.; NOBRE, THAIS S.; ALVES, MARIA-JANIEIRE N. N.; RONDON, MARIA URBANA P. B.; PEREIRA BARRETO, ANTONIO CARLOS; NEGRAO, CARLOS E.. Muscle electrical stimulation improves neurovascular control and exercise tolerance in hospitalised advanced heart failure patients. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, v. 23, n. 15, p. 1599-1608, . (10/50048-1, 13/15651-7)
ALMEIDA MONTEIRO DE MORAES, WILSON MAX; MELARA, THAIS PLASTI; MORAES DE SOUZA, PAMELLA RAMONA; GUIMARAES, FABIANA DE SALVI; MARCHESI BOZI, LUIZ HENRIQUE; BRUM, PATRICIA CHAKUR; MEDEIROS, ALESSANDRA. Impact of Leucine Supplementation on Exercise Training Induced Anti-Cardiac Remodeling Effect in Heart Failure Mice. NUTRIENTS, v. 7, n. 5, p. 3751-3766, . (10/50048-1, 09/06830-0)
JORDAO, CAMILA P.; FERNANDES, TIAGO; TANAKA, LEONARDO YUJI; GRASSMANN BECHARA, LUIZ R.; OLIVEIRA DE SOUSA, LUIS GUSTAVO; OLIVEIRA, EDILAMAR M.; RAMIRES, PAULO RIZZO. Aerobic Swim Training Restores Aortic Endothelial Function by Decreasing Superoxide Levels in Spontaneously Hypertensive Rats. Clinics, v. 72, n. 5, p. 310-316, . (10/50048-1)
BACURAU, ALINE V.; CUNHA, TELMA F.; SOUZA, RODRIGO W.; VOLTARELLI, VANESSA A.; GABRIEL-COSTA, DANIELE; BRUM, PATRICIA C.. Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, . (14/25957-9, 10/50048-1)
GOMES-SANTOS, IGOR LUCAS; FERNANDES, TIAGO; COUTO, GISELE KRUGER; AYRES FERREIRA-FILHO, JULIO CESAR; CURY SALEMI, VERA MARIA; FERNANDES, FERNANDA BARRINHA; CASARINI, DULCE ELENA; BRUM, PATRICIA CHAKUR; ROSSONI, LUCIANA VENTURINI; DE OLIVEIRA, EDILAMAR MENEZES; et al. Effects of Exercise Training on Circulating and Skeletal Muscle Renin-Angiotensin System in Chronic Heart Failure Rats. PLoS One, v. 9, n. 5, . (10/50048-1)
ALVES, CLEBER RENE; ALVES, GUILHERME BARRETO; PEREIRA, ALEXANDRE COSTA; TROMBETTA, IVANI CREDIDIO; DIAS, RODRIGO GONCALVES; MOTA, GLORIA F. A.; FERNANDES, TIAGO; KRIEGER, JOSE EDUARDO; NEGRAO, CARLOS EDUARDO; OLIVEIRA, EDILAMAR MENEZES. Vascular reactivity and ACE activity response to exercise training are modulated by the+9/-9 bradykinin B-2 receptor gene functional polymorphism. Physiological Genomics, v. 45, n. 12, p. 487-492, . (10/50048-1)
ZAGLIA, TANIA; MILAN, GIULIA; FRANZOSO, MAURO; BERTAGGIA, ENRICO; PIANCA, NICOLA; PIASENTINI, ELEONORA; VOLTARELLI, VANESSA A.; CHIAVEGATO, DAVID; BRUM, PATRICIA C.; GLASS, DAVID J.; et al. Cardiac sympathetic neurons provide trophic signal to the heart via 2-adrenoceptor-dependent regulation of proteolysis. Cardiovascular Research, v. 97, n. 2, p. 240-250, . (10/50048-1, 08/56483-1)
BLANCO-RIVERO, JAVIER; COUTO, GISELE K.; PAULA, SULIANA M.; FONTES, MILENE T.; ROSSONI, V, LUCIANA. Enhanced sympathetic neurotransduction in the superior mesenteric artery in a rat model of heart failure: role of noradrenaline and ATP. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 320, n. 2, p. H563-H574, . (10/50048-1, 14/20303-0, 14/22335-7)
ALVES, CLEBER RENE; FERNANDES, TIAGO; LEMOS, JR., JOSE RIBEIRO; MAGALHAES, FLAVIO DE CASTRO; TROMBETTA, IVANI CREDIDIO; ALVES, GUILHERME BARRETO; ALVES DA MOTA, GLORIA DE FATIMA; DIAS, RODRIGO GONCALVES; PEREIRA, ALEXANDRE COSTA; KRIEGER, JOSE EDUARDO; et al. Aerobic exercise training differentially affects ACE C- and N-domain activities in humans: Interactions with ACE I/D polymorphism and association with vascular reactivity. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v. 19, n. 2, . (10/50048-1, 09/18370-3)
FERNANDES, TIAGO; CASAES, LILIAN; SOCI, URSULA; SILVEIRA, ANDRE; GOMES, JOAO; BARRETTI, DIEGO; ROQUE, FERNANDA; OLIVEIRA, EDILAMAR. Exercise Training Restores the Cardiac Microrna-16 Levels Preventing Microvascular Rarefaction in Obese Zucker Rats. Obesity Facts, v. 11, n. 1, p. 15-24, . (14/50673-4, 10/50048-1, 15/17275-8, 09/18370-3)
MOREIRA, JOSE B. N.; BECHARA, LUIZ R. G.; BOZI, LUIZ H. M.; JANNIG, PAULO R.; MONTEIRO, ALEX W. A.; DOURADO, PAULO M.; WISLOFF, ULRIK; BRUM, PATRICIA C.. High- versus moderate-intensity aerobic exercise training effects on skeletal muscle of infarcted rats. Journal of Applied Physiology, v. 114, n. 8, p. 1029-1041, . (10/50048-1, 09/12640-9)
SILVEIRA, ANDRE C.; FERNANDES, TIAGO; SOCI, URSULA P. R.; GOMES, JOAO L. P.; BARRETTI, DIEGO L.; MOTA, GLORIA G. F.; NEGRAO, CARLOS EDUARDO; OLIVEIRA, EDILAMAR M.. Exercise Training Restores Cardiac MicroRNA-1 and MicroRNA-29c to Nonpathological Levels in Obese Rats. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, . (10/50048-1, 13/07607-8, 09/18370-3)
RENO SOCI, URSULA PAULA; FERNANDES, TIAGO; BARAUNA, VALERIO GARRONE; HASHIMOTO, NARA YUMI; ALVES MOTA, GLORIA DE FATIMA; ROSA, KALEIZU TEODORO; IRIGOYEN, MARIA CLAUDIA; PHILIPS, MICHAEL IAN; DE OLIVEIRA, EDILAMAR MENEZES. Epigenetic control of exercise training-induced cardiac hypertrophy by miR-208. Clinical Science, v. 130, n. 22, p. 2005-2015, . (14/50673-4, 10/50048-1)
BRUM, P. C.; BACURAU, A. V.; CUNHA, T. F.; BECHARA, L. R. G.; MOREIRA, J. B. N.. Skeletal myopathy in heart failure: effects of aerobic exercise training. Experimental Physiology, v. 99, n. 4, p. 616-620, . (10/50048-1)
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