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Pilot scale production and purification of chicken polyclonal antibodies from egg yolks

Grant number: 05/00705-8
Support Opportunities:Research Grants - Innovative Research in Small Business - PIPE
Duration: March 01, 2007 - October 31, 2010
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Sandro Gomes Soares
Grantee:Sandro Gomes Soares
Host Company:Invent Biotecnologia Ltda. - ME
City: Ribeirão Preto
Associated researchers:Bergson Fogaça de Oliveira


The antibodies are important tool used in both biomedicine and biotechnology areas due its ability of bind to antigens with specificity and affinity. Antibodies-related assays represent 30% of 10 billion dollars of diagnostic industries profit. Monoclonal and polyclonal antibodies are more used, although it has disadvantages as production costs and animal stress during bleeding. Chicken polyclonal antibodies are efficient non-evasive alternative and low costs in view of that IgY, chicken immunoglobulin IgG-like, is concentrated in egg yolk. However, it is necessary develop a purification approach of scale up antibodies to commercial use. The aim of this project is standardize the approach of egg yolks antibodies purification, using chromatograph techniques and uniting efficiency of production with low cost. Lowing costs, we will can produce polyclonal antibodies to diagnostic kits with competitive price in relation to similar imported kits, besides to possibility its use in therapeutics and prophylactics uniting new technologies used in pharmaceutical industries. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Valuable antibodies 
Anticuerpos de gran valía 
Articles published in Agência FAPESP Newsletter about the research grant:
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