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Behavioural effects and neuronal apoptosis alteration induced for the continuous and not continuous treadmill training pós-ischemia cerebral unilateral in Gerbils

Grant number: 05/02607-3
Support Opportunities:Regular Research Grants
Duration: November 01, 2005 - October 31, 2007
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:João Eduardo de Araujo
Grantee:João Eduardo de Araujo
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


In the acute period after cerebral ischemia, it is verified a reduction of the excitability and reduction of the cortical representation of the areas of the paretic muscles. This is associated with the reduction of the motor function and with the damage of neuronais structures. However, the retrain can prevent subsequent injuries in the adjacent cortical areas. The intensity, as well as, the interval of time between the injury and the beginning of the motor rehabilitation, they influence in the recovery of the neural function. The prolonged lack of active movement can lead to the subsequent loss of the function in regions not injured of encephalon. However, the precocious beginning of vigorous rehabilitation of the motor function can be contra productive. It was demonstrated that the forced use of a member, initiating immediately after the experimental cortical injury in rats, resulted in accented increase of the area of neural injury, behavior deficiencies, absence of dendritic growth and sprouting. On the other hand, positive effects are associates to the chronic periods of training of the recovery. Materials and methods- Surgery: They will be used rodents of the Meriones unguiculatus species (Mongolian Gerbil), weighing between 50 and 70g. Each animal will be anaesthetized and submitted to the surgery for the production of the unilateral cerebral ischemia, through the occlusion of the carotid artery external left... (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BUIATTI DE ARAUJO, FERNANDA LOPES; BERTOLINO, GUILHERME; GONCALVES, RENATA BATAGINI; MARINI, LUANA DE CASTRO; COIMBRA, NORBERTO CYSNE; DE ARAUJO, JOAO EDUARDO. Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: Evidence in motor cortex, hippocampal CA1 region and the neostriatum. JOURNAL OF THE NEUROLOGICAL SCIENCES, v. 312, n. 1-2, p. 73-78, . (05/02607-3)
KITABATAKE, TAKAE TAMY; MARINI, LUANA DE CASTRO; GONCALVES, RENATA BATAGINI; BERTOLINO, GUILHERME; DUTRA DE SOUZA, HUGO CELSO; DE ARAUJO, JOAO EDUARDO. Behavioral effects and neural changes induced by continuous and not continuous treadmill training, post bilateral cerebral ischemia in gerbils. Behavioural Brain Research, v. 291, p. 20-25, . (05/02607-3)
CASSIANO SILVEIRA, ANA PAULA; KITABATAKE, TAKAE TAMY; PANTALEO, VIVIAN MOZOL; ZANGROSSI JUNIOR, HELLO; BERTOLINO, GUILHERME; DE OLIVEIRA GUIRRO, ELAINE CALDEIRA; DUTRA DE SOUZA, HUGO CELSO; DE ARAUJO, JOAO EDUARDO. Continuous and not continuous 2-week treadmill training enhances the performance in the passive avoidance test in ischemic gerbils. Neuroscience Letters, v. 665, p. 170-175, . (05/02607-3, 15/07730-0, 07/03077-3)

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