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Thiamin and riboflavin in blood and severity of illness in children admitted in a pediatric intensive care unit

Grant number: 05/01559-5
Support Opportunities:Regular Research Grants
Duration: November 01, 2005 - April 30, 2008
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Heitor Pons Leite
Grantee:Heitor Pons Leite
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


The vitamin status assessment has been subject to increasing recognition in the context of adult patients receiving artificial nutrition support, in which factors such as increased consumption due to increased metabolic rate, insufficient supply, impaired intestinal nutrients' absorption, loss of water-soluble micronutrients (diarrhea, tubes, fistula, dialysis), drugs administration and later, during the anabolism phase put them at risk of developing a deficiency state Prevalence and incidence of thiamine and riboflavin deficiencies in seriously ill children are not known. Despite most adult patients admitted to ICU may initially have normal status of these micronutrients, this assumption can not be applicable for a Pediatric ICU with a high prevalence of malnutrition. Clinical anthropometric and dietary history are not reliable predictors of deficiency states. Given that more research is needed to determine the requirements of thiamine and riboflavin in critically ill pediatric patients and those pediatric studies on this subject are scarce, we will conduct a study aiming at: 1) To determine the incidence of thiamine and riboflavin deficiencies in pediatric patients admitted in a pediatric intensive care unit; 2) To identify factors associated with deficiencies of these vitamins and to construct a model to predict these nutritional disturbances in critically ill pediatric patients. This will be a prospective, cohort study. The setting for the study will be a 9-bed Pediatric ICU at a tertiary care university hospital, which has approximately 200 admissions every year, with a prevalence of malnutrition at admission higher than 50%. The mean occupation coefficient is 80%; mean length of hospital stay 11.8 days, and mortality rate 12,6%... (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEITE, HEITOR PONS; PEIXOTO DE LIMA, LUCIO FLAVIO; TADDEI, JOSE AUGUSTO DE A. C.; PAES, ANGELA TAVARES. Effect of blood thiamine concentrations on mortality: Influence of nutritional status. NUTRITION, v. 48, p. 105-110, . (05/01559-5)

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