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Functional immunome of Aedes aegypti saliva


Two recent revolutions changed the history of Aedes aegypti mosquito research. The first occurred with the publication of the species' "sialomes". These catalogs, representing the proteins and messenger RNAs present in the salivary gland of this vector, increased the knowledge on the salivary constituents in more than twenty times. The second revolution came through the sequencing of its genome, creating a unique perspective for comparative studies and development of genomic tools for transcriptome analysis and reverse genetics. The current project aims to become a third revolution in the field by establishing the functional "immunome" of Ae. aegypti saliva. In this way, classic biochemical approaches (microfiltration, chromatographic separation, Edman's degradation, mass spectometry) and post genomic biochemical approaches (bioinformatic analysis, genetic cloning, protein expression, peptide synthesis) will be explored side by side in high-throughput immunopharmacological screenings, with the purpose of producing a map of the immunomodulatory activities from the proteins present in the saliva of this mosquito. This project will set up a new research line in the Department of Immunology from Institute of Biomedical Sciences - USP, where the work will be performed. Considering the impact of this vector and the diseases transmitted by it in the public health and in the worldwide economy, specially in developing countries, the knowledge generated by this project may lead to the discovery of new molecules with important biological activities and therapeutic potential, vaccine development against the pathogens transmitted by the mosquito and new approaches for vector control. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LARA, PRISCILA G.; ESTEVES, ELIANE; SALES-CAMPOS, HELIOSWILTON; ASSIS, JOSIANE B.; HENRIQUE, MARESSA O.; BARROS, MICHELE S.; NETO, LEILA S.; SILVA, PEDRO, I; MARTINS, JOILSON O.; CARDOSO, CRISTINA R. B.; et al. AeMOPE-1, a Novel Salivary Peptide From Aedes aegypti, Selectively Modulates Activation of Murine Macrophages and Ameliorates Experimental Colitis. FRONTIERS IN IMMUNOLOGY, v. 12, p. 15-pg., . (20/03175-0, 13/00740-4, 09/09892-6, 15/22934-0, 13/07467-1)
ASSIS, JOSIANE B.; COGLIATI, BRUNO; ESTEVES, ELIANE; CAPURRO, MARGARETH L.; FONSECA, DENISE M.; SA-NUNES, ANDERSON. Aedes aegypti mosquito saliva ameliorates acetaminophen-induced liver injury in mice. PLoS One, v. 16, n. 2, . (16/11523-2, 09/09892-6)
MACIEL, CERES; FUJITA, ANDRE; GUERONI, DANIELE I.; RAMOS, ANDERSON D.; CAPURRO, MARGARETH L.; SA-NUNES, ANDERSON. Evans Blue as a Simple Method to Discriminate Mosquitoes' Feeding Choice on Small Laboratory Animals. PLoS One, v. 9, n. 10, . (09/53637-0, 10/18216-1, 09/09892-6, 11/22669-4)
BARROS, MICHELE S.; GOMES, ELIANE; GUERONI, DANIELE I.; RAMOS, ANDERSON D.; MIROTTI, LUCIANA; FLORSHEIM, ESTHER; BIZZARRO, BRUNA; LINO, CIRO N. R.; MACIEL, CERES; LINO-DOS-SANTOS-FRANCO, ADRIANA; et al. Exposure to iBites Induces a Mixed-Type Allergic Response following Salivary Antigens Challenge in Mice. PLoS One, v. 11, n. 5, . (11/15569-3, 10/18216-1, 09/09892-6, 09/07208-0, 09/12247-5, 11/22669-4)
BREIJO, MARTIN; ESTEVES, ELIANE; BIZZARRO, BRUNA; LARA, PRISCILA G.; ASSIS, JOSIANE B.; ROCHA, SERGIO; PASTRO, LUCIA; FERNANDEZ, CECILIA; MEIKLE, ANA; SA-NUNES, ANDERSON. Hematobin is a novel immunomodulatory protein from the saliva of the horn fly Haematobia irritans that inhibits the inflammatory response in murine macrophages. PARASITES & VECTORS, v. 11, . (09/09892-6)
SALES-CAMPOS, HELIOSWILTON; DE SOUZA, PATRICIA REIS; BASSO, PAULO JOSE; RAMOS, ANDERSON DANIEL; NARDINI, VIVIANI; LAZO CHICA, JAVIER EMILIO; CAPURRO, MARGARETH LARA; SA-NUNES, ANDERSON; DE BARROS CARDOSO, CRISTINA RIBEIRO. Aedes aegypti salivary gland extract ameliorates experimental inflammatory bowel disease. International Immunopharmacology, v. 26, n. 1, p. 13-22, . (09/09892-6, 10/20162-7)
HENRIQUE, MARESSA O.; NETO, LEILA S.; ASSIS, JOSIANE B.; BARROS, MICHELE S.; CAPURRO, MARGARETH L.; LEPIQUE, ANA P.; FONSECA, DENISE M.; SA-NUNES, ANDERSON. Evaluation of inflammatory skin infiltrate following Aedes aegypti bites in sensitized and non-sensitized mice reveals saliva-dependent and immune-dependent phenotypes. IMMUNOLOGY, v. 158, n. 1, p. 47-59, . (09/09892-6, 15/25364-0)
BIZZARRO, BRUNA; BARROS, MICHELE S.; MACIEL, CERES; GUERONI, DANIELE I.; LINO, CIRO N.; CAMPOPIANO, JULIA; KOTSYFAKIS, MICHALIS; AMARANTE-MENDES, GUSTAVO P.; CALVO, ERIC; CAPURRO, MARGARETH L.; et al. Effects of Aedes aegypti salivary components on dendritic cell and lymphocyte biology. PARASITES & VECTORS, v. 6, . (09/53637-0, 11/15569-3, 10/18216-1, 09/09892-6, 09/12247-5)

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