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Study of the immunopathological mechanisms involved in pregnancy-associated malaria

Grant number: 09/53889-0
Support Opportunities:Research Grants - Young Investigators Grants
Duration: March 01, 2010 - August 31, 2014
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Principal Investigator:Cláudio Romero Farias Marinho
Grantee:Cláudio Romero Farias Marinho
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):13/00981-1 - Characterization of the role of dendritic cells in the recrudescence of malaria in pregnancy, BP.DD
12/04755-3 - Association of gestational malaria with intrauterine growth restriction and low birth weight in the far-western Brazilian Amazon, BP.DD
11/19048-8 - Role of Inflamassoma in the immunopathogenesis of Placental Malaria, BP.DR
11/20921-8 - Malaria in Pregnancy: a Study of Plasmodium vivax Infections on Pregnant Women from the Westernmost Region of the Brazilian Amazon, BP.PD
11/17880-8 - Toll-like receptors and NOD-like receptors in pregnancy-associated malaria pathogenesis: effects and mechanisms, BP.PD

Abstract

Every year at least 50 millions pregnant women are exposed to malaria infection. This high incidence is a result of the life threatening conditions of the mother and the developing fetus. Pregnancy-associated malaria (PAM) is characterized by the parasite sequestration in the maternal placenta with consequent maternal anemia, uterine growth retardation and decreased of the fetal viability. The high number of risk factors involved in PAM together with the inherent difficulties to study this disease in humans, are the main reasons why the molecular bases of this pathologic dysfunction are still poorly understood. This project aims to use a multiparametric approach in order to identify the cellular and molecular components of the innate and acquired immunity that contribute to the development of P AM, in mouse models. The knowledge of the innate immune response will bring an important contribution to the understanding of placental malaria. Moreover, makes it possible to address the development of new methodology studies, for PAM treatment. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COSTA, FABIO T. M.; LOPES, STEFANIE C. P.; ALBRECHT, LETUSA; ATAIDE, RICARDO; SIQUEIRA, ANDRE M.; SOUZA, RODRIGO M.; RUSSELL, BRUCE; RENIA, LAURENT; MARINHO, CLAUDIO R. F.; LACERDA, MARCUS V. G.. On the pathogenesis of Plasmodium vivax malaria: Perspectives from the Brazilian field. International Journal for Parasitology, v. 42, n. 12, SI, p. 1099-1105, . (09/53889-0)
LIMA, FLAVIA A.; GOMEZ-CONDE, IVAN; VIDEIRA, PAULA A.; MARINHO, CLAUDIO R. F.; OLIVIERI, DAVID N.; TADOKORO, CARLOS E.. Intravital microscopy technique to study parasite dynamics in the labyrinth layer of the mouse placenta. Parasitology International, v. 63, n. 1, p. 254-259, . (09/53889-0)
BARBOZA, RENATO; REIS, ARAMYS SILVA; DA SILVA, LEANDRO GUSTAVO; HASENKAMP, LUTERO; BENEVIDES PEREIRA, KEITTY RAQUEL; SARAIVA CAMARA, NIELS OLSEN; MARANHAO COSTA, FABIO TRINDADE; D'IMPERIO LIMA, MARIA REGINA; ALVAREZ, JOSE MARIA; BOSCARDIN, SILVIA BEATRIZ; et al. MyD88 Signaling Is Directly Involved in the Development of Murine Placental Malaria. Infection and Immunity, v. 82, n. 2, p. 830-838, . (09/53256-7, 11/17880-8, 12/02270-2, 09/53889-0)
MEDEIROS, MARCIA M.; DA SILVA, HENRIQUE B.; REIS, ARAMYS S.; BARBOZA, RENATO; THOMPSON, JOANNE; D'IMPERIO LIMA, MARIA REGINA; MARINHO, CLAUDIO R. F.; TADOKORO, CARLOS E.. Liver Accumulation of Plasmodium chabaudi-Infected Red Blood Cells and Modulation of Regulatory T Cell and Dendritic Cell Responses. PLoS One, v. 8, n. 11, . (09/53889-0)
SERCUNDES, MICHELLE K.; ORTOLAN, LUANA S.; DEBONE, DANIELA; SOEIRO-PEREIRA, PAULO V.; GOMES, ELIANE; AITKEN, ELIZABETH H.; NETO, ANTONIO CONDINO; RUSSO, MOMTCHILO; D' IMPERIO LIMA, MARIA R.; ALVAREZ, JOSE M.; et al. Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice. PLOS PATHOGENS, v. 12, n. 12, . (09/53256-7, 13/20718-3, 11/19525-0, 10/11925-7, 09/53889-0, 10/19439-4)
BARBOZA, RENATO; LIMA, FLAVIA AFONSO; REIS, ARAMYS SILVA; MURILLO, OSCAR JAVIER; MACHADO PEIXOTO, ERIKA PAULA; BANDEIRA, CARLA LETICIA; FOTORAN, WESLEY LUZETTI; SARDINHA, LUIS ROBERTO; WUNDERLICH, GERHARD; BEVILACQUA, ESTELA; et al. TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria. SCIENTIFIC REPORTS, v. 7, . (12/16525-2, 11/17880-8, 14/20451-0, 14/09964-5, 15/06106-0, 13/00981-1, 11/19048-8, 13/16417-8, 09/53889-0)
ATAIDE, RICARDO; MURILLO, OSCAR; DOMBROWSKI, JAMILLE G.; SOUZA, RODRIGO M.; LIMA, FLAVIA A.; LIMA, GISELLE F. M. C.; HRISTOV, ANGELICA D.; VALLE, SUIANE C. N.; DI SANTI, SILVIA M.; EPIPHANIO, SABRINA; et al. Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta. PLoS Neglected Tropical Diseases, v. 9, n. 6, . (12/04755-3, 09/53256-7, 09/53889-0, 11/20921-8)
AITKEN, ELIZABETH H.; NEGRI, ELNARA M.; BARBOZA, RENATO; LIMA, MARIA RI; ALVAREZ, JOSE M.; MARINHO, CLAUDIO R. F.; CALDINI, ELIA G.; EPIPHANIO, SABRINA. Ultrastructure of the lung in a murine model of malaria-associated acute lung injury/acute respiratory distress syndrome. Malaria Journal, v. 13, . (09/53256-7, 09/53889-0)
ORTOLAN, LUANA S.; SERCUNDES, MICHELLE K.; BARBOZA, RENATO; DEBONE, DANIELA; MURILLO, OSCAR; HAGEN, STEFANO C. F.; RUSSO, MOMTCHILO; D' IMPERIO LIMA, MARIA REGINA; ALVAREZ, JOSE M.; AMAKU, MARCOS; et al. Predictive Criteria to Study the Pathogenesis of Malaria-Associated ALI/ARDS in Mice. Mediators of Inflammation, v. 2014, p. 12-pg., . (09/53256-7, 09/53889-0)
ORTOLAN, LUANA S.; SERCUNDES, MICHELLE K.; BARBOZA, RENATO; DEBONE, DANIELA; MURILLO, OSCAR; HAGEN, STEFANO C. F.; RUSSO, MOMTCHILO; D' IMPERIO LIMA, MARIA REGINA; ALVAREZ, JOSE M.; AMAKU, MARCOS; et al. Predictive Criteria to Study the Pathogenesis of Malaria-Associated ALI/ARDS in Mice. Mediators of Inflammation, . (09/53256-7, 09/53889-0)
DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; LIMA, FLAVIA AFONSO; BANDEIRA, CARLA LETICIA; MURILLO, OSCAR; COSTA, DOUGLAS DE SOUSA; MACHADO PEIXOTO, ERIKA PAULA; CUNHA, MARIELTON DOS PASSOS; DE ANDRADE ZANOTTO, PAOLO MARINHO; BEVILACQUA, ESTELA; et al. Association of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon. JAMA NETWORK OPEN, v. 2, n. 5, . (14/17766-9, 18/20468-0, 12/04755-3, 13/21728-2, 14/20451-0, 14/09964-5, 15/06106-0, 13/00981-1, 16/08204-2, 13/16417-8, 09/53889-0)
DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; MENDES SILVA, NATERCIA REGINA; BARATEIRO, ANDRE; EPIPHANIO, SABRINA; GONCALVES, LIGIA ANTUNES; FARIAS MARINHO, CLAUDIO ROMERO. Malaria during pregnancy and newborn outcome in an unstable transmission area in Brazil: A population-based record linkage study. PLoS One, v. 13, n. 6, . (15/06106-0, 17/03939-7, 12/04755-3, 14/20451-0, 14/09964-5, 09/53889-0)
BARBOZA, RENATO; HASENKAMP, LUTERO; BARATEIRO, ANDRE; MURILLO, OSCAR; MACHADO PEIXOTO, ERIKA PAULA; LIMA, FLAVIA AFONSO; REIS, ARAMYS SILVA; GONCALVES, LIGIA ANTUNES; EPIPHANIO, SABRINA; MARINHO, CLAUDIO R. F.. Fetal-Derived MyD88 Signaling Contributes to Poor Pregnancy Outcomes During Gestational Malaria. FRONTIERS IN MICROBIOLOGY, v. 10, . (11/17880-8, 15/10892-1, 09/53256-7, 12/14715-9, 16/07030-0, 15/06106-0, 17/03939-7, 11/19048-8, 13/16417-8, 09/53889-0)
RIBEIRO, BRUNO DE PAULO; CASSIANO, GUSTAVO CAPATTI; DE SOUZA, RODRIGO MEDEIROS; CYSNE, DALILA NUNES; GRIGOLIN GRISOTTO, MARCOS AUGUSTO; SILVA DE AZEVEDO DOS SANTOS, ANA PAULA; FARIAS MARINHO, CLAUDIO ROMERO; DANTAS MACHADO, RICARDO LUIZ; FERNANDES NASCIMENTO, FLAVIA RAQUEL. Polymorphisms in Plasmodium vivax Circumsporozoite Protein (CSP) Influence Parasite Burden and Cytokine Balance in a Pre-Amazon Endemic Area from Brazil. PLoS Neglected Tropical Diseases, v. 10, n. 3, . (09/53889-0)

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