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Functional anatomy evaluation of the defensive behavior of tonic immobility in guinea pigs

Abstract

Tonic immobility is an inborn defensive behavior characterized by a temporary state of profound and reversible motor inhibition elicited by some forms of physical restraint. It is a component of antipredatory behavior and is the last resource used by the prey to reduce the probability of continued attack on the part of the predator, thus being of adaptative value. The study of neural substrate involved in the TI modulation has been investigated in several studies by means of brain sectioning techniques (Arch. Ital. Biol., 109:15-26, 1971), or by peripherical (Behav. Pharmacol., 13:261-69, 2002) or central drug administration (Braz. J. Med. Biol. Res., 23: 723-27, 1990; Physiol. Behav., 67:717-24, 1999; Brain Res. Bull., 58:13-19, 2002; Brain Res. Bull., 50:201-08, 1999), in order to activate different neurotransmissors systems. The functional anatomy of neural circuitry that is activated during TI is, however, only poorly understood. In addition, there is a growing interest to correlate the TI model with catatonia (Psychol. Rev., 111: 984-1002, 2004), depression state in human (Brist. J. Med. Psychol., 71: 417-45,1998; Psychol. Med., 28: 585-98, 1998), or yet as a model for ansiolitic or anxiogenic drugs (Behav. Pharmacol., 13: 261-69, 2002). Therefore it is necessary to understand better the neural substrate involved in the modulation of the defensive behavior of TI in animals. Previous studies of our group demonstrated the involvement of diverse brain structures, such as: parabrachial lateral area (Behav. Brain Res., 56: 127-132, 1993), periaqueductal gray matter (Brain Res. Bull., 50: 201-208, 1999), hypothalamic areas (Neuroreport, 8: 3489-93, 1997), and amygdaloid nuclei (Physiol. Behav., 67: 717-724, 1999) in the TI modulation in guinea pigs... (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VIEIRA-RASTELI, EVELINE BIS; DE PAULA, BRUNA BALBINO; DE PAIVA, YARA BEZERRA; COIMBRA, NORBERTO CYSNE; ANDRADE LEITE-PANISSI, CHRISTIE RAMOS. Restricted lesions of the ventrolateral or dorsal columns of the periaqueductal gray promotes distinct effects on tonic immobility and defensive analgesia in guinea pigs. Physiology & Behavior, v. 194, p. 538-544, OCT 1 2018. Web of Science Citations: 3.
CARVALHO, PRISCILA G.; BRANCO, LUIZ G. S.; ANDRADE LEITE-PANISSI, CHRISTIE RAMOS. Involvement of the heme oxygenase-carbon monoxide-cGMP pathway in the nociception induced by acute painful stimulus in rats. Brain Research, v. 1385, p. 107-113, APR 18 2011. Web of Science Citations: 12.
VIEIRA, EVELINE BIS; MENESCAL-DE-OLIVEIRA, LEDA; ANDRADE LEITE-PANISSI, CHRISTIE RAMOS. Functional mapping of the periaqueductal gray matter involved in organizing tonic immobility behavior in guinea pigs. Behavioural Brain Research, v. 216, n. 1, p. 94-99, JAN 1 2011. Web of Science Citations: 18.
DONATTI, ALBERTO FERREIRA; ANDRADE LEITE-PANISSI, CHRISTIE RAMOS. GABAergic antagonist blocks the reduction of tonic immobility behavior induced by activation of 5-HT2 receptors in the basolateral nucleus of the amygdala in guinea pigs. Brain Research Bulletin, v. 79, n. 6, p. 358-364, AUG 14 2009. Web of Science Citations: 10.

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