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CRID - Center for Research in Inflammatory Diseases

Grant number: 13/08216-2
Support type:Research Grants - Research, Innovation and Dissemination Centers - RIDC
Duration: August 01, 2013 - July 31, 2024
Field of knowledge:Biological Sciences - Pharmacology
Principal researcher:Fernando de Queiroz Cunha
Grantee:Fernando de Queiroz Cunha
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
( Atuais )
Helder Takashi Imoto Nakaya ; João Santana da Silva ; José Carlos Farias Alves Filho ; Paulo Louzada Junior ; Rita de Cassia Aleixo Tostes Passaglia ; Thiago Mattar Cunha
Pesquisadores principais:
( Anteriores )
Carlos Henrique Tomich de Paula da Silva ; Dario Simões Zamboni
Assoc. researchers:Ana Maria Ferreira Roselino ; Ana Paula de Carvalho Panzeri Carlotti ; Anibal Basile Filho ; Antônio Pazin Filho ; Beatriz Rossetti Ferreira ; Cacilda da Silva Souza ; Carlos Henrique Tomich de Paula da Silva ; Claudio Miguel da Costa Neto ; Dario Simões Zamboni ; Doralina Guimarães Brum Souza ; Eduardo Antônio Donadi ; Eduardo Barbosa Coelho ; Elcio dos Santos Oliveira Vianna ; Flavio da Silva Emery ; Francisco José Albuquerque de Paula ; Geraldo Aleixo da Silva Passos Júnior ; Helder Takashi Imoto Nakaya ; João Santana da Silva ; José Carlos Farias Alves Filho ; Jose Marcos Chaves Ribeiro ; Luiz Osório Silveira Leiria ; Marcello Henrique Nogueira Barbosa ; Marcos Antonio Rossi ; Marcos de Carvalho Borges ; Renê Donizeti Ribeiro de Oliveira ; Ronaldo de Albuquerque Ribeiro ; Roque Pacheco de Almeida ; Sandra Yasuyo Fukada Alves ; Sérgio Henrique Ferreira ; Thiago Mattar Cunha ; Vanessa Carregaro Pereira ; Vânia Luiza Deperon Bonato ; Virginia Paes Leme Ferriani ; Waldiceu Aparecido Verri Junior
Associated grant(s):21/08865-7 - Multi-user equipment approved in grant 2013/08216-2: QuantStudio 5 Real Time PCR System Applied Biosystems, AP.EMU
20/05211-3 - Evaluation of Amphiregulin as a prognostic biomarker of severity and its participation in the pathophysiology of COVID-19, AP.R
20/04860-8 - Global genome screening with CRISPRko libraries to identify essential factors in SARS-CoV2 infection and replication, AP.R
+ associated grants 20/05601-6 - Neutrophil extracelular traps (NETs): role in the pathophysiology and potential as a therapeutic target on COVID-19, AP.R
19/21482-0 - Multi-User Equipment approved in grant 2013/08216-2: chromium" 10x genomics, controller & accessory kit, 12 mo. warranty, AP.EMU
19/08265-0 - Multi-User Equipment approved in grant 2013/08216-2: analyzer measures oxygen consumption rate, AP.EMU
18/15235-7 - Macrophage metabolism as a target for cancer therapy, AP.R SPRINT
18/15192-6 - Contribution of endothelial dysfunction in progression of aortic aneurysm, AP.R SPRINT
17/23826-2 - Rheumatoid arthritis and periodontal disease: association between microbiome and disease-modifying drugs, AV.BR
17/20347-6 - Multi-user equipment approved in grant 13/08216-2: flow cytometer, AP.EMU
17/10255-7 - Molecular mechanisms underlying the resistance to the immunosupression development in neonatal sepsis, AV.EXT
15/01055-9 - Multi-User Equipment approved in grant 2013/08216-2: sistema de alta performance por imagem, AP.EMU
14/50268-2 - Deciphering the interactions between Legionella longbeachae and eukaryotic host cells, AP.R - associated grants
Associated scholarship(s):22/04864-9 - Systems Immunology of Inflammatory Diseases, BP.MS
22/10198-1 - Learning of procedures for obtaining mouse embryos., BP.TT
22/09144-4 - Implementation, experimental standardization and analysis of multiparametric flow cytometry, BP.TT
+ associated scholarships 22/08052-9 - Participation of NETs as a biomarker of autoimmune rheumatic diseases, BP.PD
21/10494-7 - Importance of IL-33 in the development of Wallerian degeneration and its actions on immune cells, BP.DR
22/02651-8 - The importance of STING signaling pathway on the differentiation and function of T regulatory cells, BP.DD
22/05647-1 - Genotyping of conditionally deficient animals using the Cre/loxP system, BP.TT
22/04846-0 - Contribution of endothelin-1 in perivascular adipose tissue dysfunction in obese mice: involvement of transcriptional factor Nrf2 and kinase GSK-3B, BP.IC
22/02605-6 - Systems Biology Applied to Transcriptomic Analysis of Inflammatory Diseases, BP.PD
21/00840-5 - Cellular and molecular characterization and origin of the leukocytes accumulated in the leptomeninges of the dorsal roots of neuropathic animals, BP.PD
22/04449-1 - The importance of iron metabolism in the differentiation, stability, function and pathogenicity of Th17 lymphocytes and its implication in autoimmunity, BP.PD
21/09854-9 - Role of cytoplasmic DNA sensor, STING, in cisplatin-induced peripheral neuropathic pain development, BP.DR
22/00951-4 - Scientific diffusion contextualized in health sciences, BP.TT
21/08847-9 - Contribution of autophagic processes in perivascular adipose tissue hyperinflammation associated with metabolic syndrome, BP.PD
21/13400-3 - Manipulation and genotyping of transgenic animal Cre-lox, BP.TT
21/11728-1 - Generation and genotyping of transgenic animals (Cre-Lox System) for use in experimental models, BP.TT
21/08843-3 - The role of gamma delta T cells in the acute Sepsis, BP.IC
21/10650-9 - Morphological and functional characterization of sensory neurons expressing neurotensin (NTS), BP.IC
21/08754-0 - Importance of NFR2 on osteoclastogenis and its impact on bone metabolism, BP.PD
21/06771-5 - Characterization of resistance and susceptibility genes in Visceral Leishmaniasis, BP.PD
21/08330-6 - Crosstalk between innate immune cells and thermogenic adipocytes in the regulation of energetic metabolism, BP.PD
21/08425-7 - Immunopathogenesis of post-Sepsis immunosuppression, BP.PD
21/08434-6 - Identification and validation of drugs for the treatment of Leishmaniasis, BP.PD
20/11339-2 - Trimethylamine N-oxide (TMAO) as a link among gut dysbiosis, immune system activation and vascular dysfunction induced by ethanol consumption, BP.PD
21/03525-3 - Tissue processing for histopathological analysis in experimental models., BP.TT
21/03420-7 - Role of kinase inhibition of G 2 protein-coupled receptors (GRK2) in the treatment of Sepsis, BP.IC
21/03506-9 - Contextualized scientific dissemination in health education, BP.TT
21/04378-4 - ROLE OF O-GLUCONACILATION IN THE ACTIVITY OF THE FOXO1 TRANSCRIPTION FACTOR: VASCULAR ENDOTHELIAL CELL PHYSIOLOGY IN HYPERGLYCEMIA, BP.IC
21/02049-3 - DDX41 protein study on the differentiation and function of regulatory T cells (Tregs), BP.IC
21/02047-0 - Determination of the metabolic profile in real time of cells of the immune system, BP.TT
21/02934-7 - Gene knokouts generation and validation using CRISPR/Cas9 in vitro, BP.TT
21/00696-1 - Manipulation and genotyping of transgenic animal expressing human ACE2 for COVID-19 studies, BP.TT
21/02053-0 - Evaluation of leishmanicidal activity of drugs in macrophages infected by L. amazonensis, BP.TT
21/01213-4 - Identification of therapeutic targets from transcriptomic analysis of the sensory system cells after peripheral nerve injury, BP.IC
20/11372-0 - Importance of ERK5 in the differentiation and function of regulatory T cells, BP.DR
19/24921-4 - Role of resistin via CAP1 in perivascular adipose tissue and vascular dysfunction in an experimental Arthritis model, BP.DR
20/13742-9 - Structural studies and molecular screening for the development of PKM2 and related proteins inhibitors, BP.PD
20/05446-0 - Origin, dynamics and transcriptional profile of dorsal root ganglion and sciatic nerve macrophages in homeostasis and during neuropathic pain, BP.DD
20/04170-1 - The role of reduced folate carrier (SLC19a1) on the differentiation, stability and function of regulatory T lymphocytes, BP.DR
20/08109-5 - Molecular mechanisms involved in the desensibilization of ± adrenergic receptors during Sepsis: potential for the treatment of Vasoplegia, BP.PD
19/20692-0 - Involvement of the NLRP3 inflammasome in cardiac dysfunction associated with supraphysiological levels of testosterone, BP.DR
18/17542-4 - The role of the STING signaling pathway in the regulation of Th17 cell pathogenicity and its implication for autoimmunity, BP.DR
20/02642-3 - Characterization of the TIGIT+ T regulatory cell subset in response to therapy with disease-modifying anti-rheumatic drugs in patients with Rheumatoid Arthritis, BP.PD
20/00382-4 - Sting signaling pathway study on the differentiation and function of Regulatory T cells (Tregs), BP.IC
19/15070-0 - Determination of molecular and cellular mechanisms associated with Sepsis outcome using single cell RNA sequencing, BP.DR
20/02899-4 - Role of NETs in the pathogenesis of psoriasis, BP.TT
20/04393-0 - The use of High-content to evaluate the leishmanicidal activity of drugs., BP.TT
19/25305-5 - Involvement of O-GlcNAcylation in astrocyte activation during development of experimental autoimmune encephalomyelitis, BP.IC
19/22579-7 - Systems biology applied to transcriptomic analysis of inflammatory diseases, BP.PD
19/25622-0 - Generation and genotyping of transgenic animals (Cre-Lox system) for use in experimental models, BP.TT
19/25586-4 - Contribution of tyrosin phosfatase protein DUSP1 in endothelial disfunction induced by lysophosfatidilcolina and participation in the formation of atherosclerosis plaque, BP.IC
19/19190-0 - Role of NETs as osteoclastogenesis modulators in Rheumatoid Arthritis , BP.DR
19/15063-4 - Characterization of the role of the sensory fibers a (TRKb+) and fibers C (galanin+/neurotensin+) in nociceptive and pathological pain, BP.DR
19/14285-3 - Role of succinate/SUCNR1 signalling pathway in sensory neurons in neuropathic pain development, BP.DR
19/19555-9 - Development of a transgenic line, with the conditioned expression of Cre recombinase protein to the activation Sucnr1/Gpr91 endogenous promoter., BP.PD
19/13829-0 - Role of O-GlcNAcylation in the neuroinflammatory functions of astrocytes, BP.DR
19/18645-4 - Understanding the immune response to Leishmania infantum, BP.PD
19/10473-0 - Chemical library screening and structural and biochemical characterization of ligands of novel molecular targets for the treatment of inflammatory diseases., BP.PD
19/04888-2 - Awareness and inflammation: the diffusion of topics related to inflammation and inflammatory diseases, BP.TT
19/08177-3 - The generation of astrocytes derived from human induced pluripotent stem cells (hiPSC): a powerful tool for the neuroinflammation study, BP.IC
18/24063-5 - Role of CCL-2/MCP-1 produced by peripheral sensorial neurons in the development of neuropathic pain, BP.DR
18/23910-6 - Role of PFKFB-3 enzyme in regulatory t cells, BP.MS
18/23168-8 - Importance of AMP-activated protein kinase (AMPK) in the regulation of TGF-beta pathway and T regulatory cells differentiation, BP.DR
18/22802-5 - Origin, dynamics and transcriptional profile of macrophages of the sensory ganglia of the dorsal roots and sciatic nerve, BP.MS
18/20130-0 - Function, mechanisms of activation and regulation of PI3K delta and PI3K gamma signaling pathway in the control of Trypanosoma cruzi infection., BP.PD
18/19312-6 - Role of S100A9/TLR4 pathway in the metabolic and functional modulation of keratinocytes and activation of dendritic cells: implications on the Psoriasis pathogenesis, BP.DR
17/26095-9 - Expression and activity of NRF2 in aorta of mice with insulin resistance submitted to the caloric restriction, BP.IC
18/05102-0 - Cellular metabolite profile analysis in neuropathic pain, BP.PD
17/25308-9 - Role of lactic acid in the resistance to checkpoint inhibitors (anti-PD-1/PD-L1) used in cancer immunotherapy, BP.PD
18/10444-7 - Evaluation of Naip receptors in NLRC4 inflammasome activation in response to L. amazonensis infection, BP.IC
18/09509-7 - Proteomic approach for the evaluation of pathways related to the control of Leishmania major infection dependent on nitric oxide (NO), BP.IC
17/21926-0 - Influence of the neutrophil infection upon the virulence factors of the Leishmania mexicana and Leishmania major parasites, BE.PQ
17/24669-8 - Unraveling the molecular bases of the early protein secretory pathway in humans using biophysical techniques, BP.PD
18/04782-7 - Awareness and inflammation: the dissemination of themes concerning inflammation and inflammatory diseases, BP.TT
17/12487-2 - Studying Juvenile Idiopathic Arthritis through a network Medicine approach, BP.DD
18/02587-2 - Histological processing in bone tissue, BP.TT
17/20692-5 - Regulation and function of O-GlcNAcylation in TAM macrophage differentiation and tumor progression, BP.DR
17/18264-5 - Biased agonists for the Gq protein pathway in the a1-adrenoceptor subtypes in Septic Vasoplegia treatment, BP.PD
17/04347-6 - Cooperation between TLR4 and IL-1R signaling pathways in the regulation of immune response during human and murine L. infantum infection, BP.PD
17/19040-3 - Use of high-content screening to evaluate drug leishmanicidal activity in macrophages, BP.PD
17/13353-0 - Association between inflammation and use of cannabis (Cannabis sativa) in patients in first psychotic episode, BP.IC
17/11270-0 - Awareness and inflammation: the dissemination of themes concerning inflammation and inflammatory diseases, BP.TT
17/01714-8 - PKM2 contribution to neutrophils' activation in experimental systemic lupus erythematosus onset, BP.PD
17/03203-0 - Planning of new candidates for anti-inflammatory drugs, BP.PD
17/06007-8 - Role of methotrexate and pro-resolving mediators in rheumatoid arthritis and in inflammatory response resolution process, BP.PD
17/04200-5 - NEDD4L protein role in the differentiation regulation of TGF-²-induced Treg lymphocytes , BP.PD
17/03491-6 - RIDCs: Research, Innovation and Dissemination Centers, BP.PD
17/04936-1 - Evaluating the in vivo effect of potential drugs for the treatment of Arthritis, BP.PD
17/03775-4 - Control of Sepsis-induced vital organs damage through glycolysis pathway modulation, BP.PD
17/03211-3 - The role of the H2S donor, ATB-346, in the evolution of experimental sepsis, BP.IC
16/24155-1 - Biased agonists for the Gq protein pathway in the a1-adrenoceptor subtypes in Septic Vasoplegia treatment, BP.PD
16/24049-7 - Role of interleukin-17 in the pathogenesis of Legionella longbeachae infection in vivo, BP.IC
16/24050-5 - Evaluation of caspase-8 activity regulation by caspase-1 in response to Legionella pneumophila infection, BP.IC
16/18357-0 - Phenotypic and transcriptome evaluation of murine and human leukocytes in Leishmania infantum infection, BP.PD
16/10280-9 - Involvement of the enzyme pyruvate kinase M2 (PKM2) in the differentiation of Th17 lymphocytes and pathogenesis of experimental autoimmune encephalomyelitis, BP.MS
16/11405-0 - Immuno-molecular mechanisms involved in the resistance to the development of immunosuppression in neonatal sepsis, BP.DR
16/17773-0 - Validation of new pharmacological hits for the treatment of inflammatory diseases and pain, BP.PD
16/16207-1 - Center for Research on Inflammatory Diseases - CRID, BP.PD
16/14188-0 - Relationship of endoplasmic reticulum stress, autophagy, inflammasome and nitric oxide production in inflammatory infectious processes, BP.PD
16/13154-4 - Synthesis and biological evaluation of lysine specific demethylase 1 (LSD-1), BP.IC
16/07602-4 - Role of Dectin-1 and Syk kinase evaluation in Nlrp3 inflammasome activation in murine macrophages infected with L. amazonensis, BP.IC
16/10867-0 - Development of HaCaT keratinocyte cell line knockouts for PKM2 enzyme, BP.IC
16/05377-3 - Role of Erk5 pathway on Th17 and Treg cells differentiation and on experimental autoimmune encephalomyelitis, BP.DR
16/07492-4 - New molecular targets cloning and expression for inflammatory diseases treatment and functional assays validation for selective binders identification, BP.PD
14/24162-2 - Analyses of the regulatory transcriptional mechanisms mediated by miRNAs in metabolic syndrome, BP.DD
15/25289-9 - Identification and validation of essential genes responsible for the immune response induction in patients with visceral leishmaniasis, BP.DR
15/25825-8 - Analysis of metabolic regulatory networks in inflammation, BP.PD
14/18566-3 - Center for Research in Inflammatory Diseases, BP.PD
15/03620-5 - Ubiquitination process and autophagic activity evaluation during macrophages infection with Leishmania spp., BP.IC
14/17740-0 - Planning, development and pharmacological evaluation of new aryl hydrocarbon receptors (AhR) antagonists that are candidates for atheroprotective drugs, BP.PD
14/11009-1 - Planning of new candidates for anti-inflammatory drugs design, BP.PD
14/16630-6 - Characterization of a luciferase expression assay induced by aryl hydrocarbon receptor activation, BP.IC
13/15994-1 - The role of NOD1 and NOD2 receptors in the control of Leishmania (L.) major infection, BP.PD
13/00579-9 - Role of inflammasomes and IL-1 in experimental infection by Trypanosoma cruzi, BP.PD
12/23846-0 - Role of succinate/GPR91 signaling in the physiopathology of neuropathic pain, BP.PD
12/08240-8 - Role of Blimp-1 in differentiation and function of Th9 cells., BP.PD
12/10100-0 - The role of ectonucleotidases and adenosine in the establishment of sepsis-induced immunosuppression, BP.PD
12/02438-0 - Role of the induced miRNAs after the aryl hydrocarbon receptor (AhR) activation and their functions in the pathogenesis of rheumatoid arthritis, BP.PD - associated scholarships

Abstract

Inflammatory diseases are a complex and heterogeneous group of diseases that affect more than 10% of the word population. The current options for the treatment of these diseases are still limited and in some cases, inefficient due to limited understanding of the mechanisms underlying these diseases. The development of translational research by a center that can generate scientific knowledge and also identify new therapeutic targets of inflammatory diseases is imperative. The Center for research in inflammatory diseases (CPDI) will be created with this goal. The general objective of the CPDI will be to perform integrative and translational research to identify, validate and target known and novel biological pathways involved with the induction and resolution of inflammation. As a result, we expect the development of innovative therapeutic strategies and drugs that effectively target inflammatory diseases. The project will involve high-throughput genetic screenings, in vivo and in vitro models of diseases, modeling and chemical synthesis, as well as the discovery of new natural molecules from plants and saliva from arthropods. After selecting the potential drugs and bio-drugs, CPDI will protect the intellectual property and, after partnerships with private companies, coordinate pre-clinical toxicological studies and early clinical trials. The CPDI will also dedicate intense efforts to disseminate knowledge to the general public, in order to fulfill the societal objective of spreading education and generating an enthusiasm for science. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (247)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOUREIRO, CAMILA MARCELINO; FACHIM, HELENE APARECIDA; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; JOCA, SAMIA; MENEZES, PAULO ROSSI; DALTON, CAROLINE F.; DEL-BEN, CRISTINA MARTA; LOUZADA-JUNIOR, PAULO; REYNOLDS, GAVIN P.. Epigenetic-mediated N-methyl-D-aspartate receptor changes in the brain of isolated reared rats. Epigenomics, v. 12, n. 22, . (13/08216-2, 16/12195-9, 12/05178-0, 13/11167-3, 12/17626-7, 15/02948-7, 19/13229-2, 17/00624-5)
PRADO, MORGANA K. B.; FONTANARI, CAROLINE; SOUZA, CAMILA O. S.; GARDINASSI, LUIZ G.; ZOCCAL, KARINA F.; DE PAULA-SILVA, FRANCISCO W. G.; PETI, ANA P. F.; SORGI, CARLOS A.; MEIRELLES, ALYNE F. G.; RAMOS, SIMONE G.; et al. IL-22 Promotes IFN-gamma-Mediated Immunity against Histoplasma capsulatum Infection. BIOMOLECULES, v. 10, n. 6, . (13/08216-2, 14/07125-6, 15/00658-1)
CARLOS, DANIELA; PEREZ, MALENA M.; LEITE, JEFFERSON A.; ROCHA, FERNANDA A.; MARTINS, LARISSA M. S.; PEREIRA, CAMILA A.; FRAGA-SILVA, THAIS F. C.; PUCCI, TAIS A.; RAMOS, SIMONE G.; CAMARA, NIELS O. S.; et al. NOD2 Deficiency Promotes Intestinal CD4+T Lymphocyte Imbalance, Metainflammation, and Aggravates Type 2 Diabetes in Murine Model. FRONTIERS IN IMMUNOLOGY, v. 11, . (12/10395-0, 13/08216-2)
SILVA, CASSIA R.; MELO, BRUNO M. S.; SILVA, JAQUELINE R.; LOPES, ALEXANDRE H.; PEREIRA, JANAINA A.; CECILIO, NERRY T.; BERLINK, JONILSON; SOUZA, GIOVANI G.; LUCAS, GUILHERME; VOGL, THOMAS; et al. S100A9 plays a pivotal role in a mouse model of herpetic neuralgia via TLR4/TNF pathway. BRAIN BEHAVIOR AND IMMUNITY, v. 88, p. 353-362, . (13/08216-2, 11/19670-0)
WANDERLEY, CARLOS W.; COLON, DAVID F.; LUIZ, JOAO PAULO M.; OLIVEIRA, FRANCISCO F.; VIACAVA, PAULA R.; LEITE, CAIO A.; PEREIRA, JANAINA A.; SILVA, CAMILA M.; SILVA, CASSIA R.; SILVA, RANGEL L.; et al. Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner. Cancer Research, v. 78, n. 20, p. 5891-5900, . (13/08216-2)
SARAIVA, ANDRE L.; VERAS, FLAVIO P.; PERES, RAPHAEL S.; TALBOT, JHIMMY; DE LIMA, KALIL A.; LUIZ, JOAO P.; CARBALLIDO, JOSE M.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; RYFFEL, BERNHARD; et al. Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of T(h)17 cells in the lymph nodes. FASEB JOURNAL, v. 32, n. 12, p. 6550-6558, . (13/08216-2, 11/19670-0)
MANCHOPE, MARILIA F.; ARTERO, NAYARA A.; FATTORI, VICTOR; MIZOKAMI, SANDRA S.; PITOL, DIMITRIUS L.; ISSA, JOAO P. M.; FUKADA, SANDRA Y.; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C.; CUNHA, FERNANDO Q.; et al. Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NF kappa B. Inflammation Research, v. 67, n. 11-12, p. 997-1012, . (13/08216-2, 11/19670-0)
DE LIMA, KALIL ALVES; DONATE, PAULA BARBIM; TALBOT, JHIMMY; DAVOLI-FERREIRA, MARCELA; PERES, RAPHAEL SANCHES; CUNHA, THIAGO MATTAR; ALVES-FILHO, JOSE CARLOS; CUNHA, FERNANDO QUEIROZ. TGF beta 1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of T(H)17 cells by an AHR-independent mechanism. CELL DEATH & DISEASE, v. 9, . (13/08216-2, 16/05013-1, 13/04942-0)
BERTOLINI, THAIS B.; PINEROS, ANNIE R.; PRADO, RAFAEL Q.; GEMBRE, ANA FLAVIA; RAMALHO, LEANDRA N. Z.; ALVES-FILHO, JOSE CARLOS; BONATO, VANIA L. D.. CCR4-dependent reduction in the number and suppressor function of CD4(+)Foxp3(+) cells augments IFN-gamma-mediated pulmonary inflammation and aggravates tuberculosis pathogenesis. CELL DEATH & DISEASE, v. 10, . (13/08216-2, 11/09702-2)
DE CARVALHO, RENAN V. H.; ANDRADE, WARRISON A.; LIMA-JUNIOR, DJALMA S.; DILUCCA, MARISA; DE OLIVEIRA, V, CAROLINE; WANG, KUN; NOGUEIRA, PAULA M.; RUGANI, JERONIMO N.; SOARES, RODRIGO P.; BEVERLEY, STEPHEN M.; et al. Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome. CELL REPORTS, v. 26, n. 2, p. 429+, . (13/08216-2, 14/04684-4)
CORSI-ZUELLI, FABIANA; FACHIM, HELENE APARECIDA; LOUREIRO, CAMILA MARCELINO; SHUHAMA, ROSANA; BERTOZI, GIULIANO; JOCA, SAMIA REGIANE LOURENGO; MENEZES, PAULO ROSSI; LOUZADA-JUNIOR, PAULO; DEL-BEN, CRISTINA MARTA. Prolonged Periods of Social Isolation From Weaning Reduce the Anti-inflammatory Cytokine IL-10 in Blood and Brain. FRONTIERS IN NEUROSCIENCE, v. 12, . (13/11167-3, 13/08216-2, 17/00624-5, 16/12195-9, 15/02948-7, 17/17480-6, 12/05178-0)
FACHIM, HELENE A.; LOUREIRO, CAMILA M.; CORSI-ZUELLI, FABIANA; SHUHAMA, ROSANA; LOUZADA, JR., PAULO; MENEZES, PAULO ROSSI; DALTON, CAROLINE F.; DEL-BEN, CRISTINA MARTA; REYNOLDS, GAVIN P.. GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function. Epigenomics, v. 11, n. 4, p. 401-410, . (16/12195-9, 15/02948-7, 17/17480-6, 12/17626-7, 13/08216-2, 12/05178-0, 13/11167-3)
DA COSTA, RAFAEL M.; RODRIGUES, DANIEL; PEREIRA, CAMILA A.; SILVA, JOSIANE F.; ALVES, JULIANO V.; LOBATO, NUBIA S.; TOSTES, RITA C.. Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases. FRONTIERS IN PHARMACOLOGY, v. 10, . (13/08216-2)
NASCIMENTO, MANUELA S. L.; FERREIRA, MARCELA D.; QUIRINO, GUSTAVO F. S.; MARUYAMA, SANDRA R.; KRISHNASWAMY, JAYENDRA K.; LIU, DONG; BERLINK, JONILSON; FONSECA, DENISE M.; ZAMBONI, DARIO S.; CARREGARO, VANESSA; et al. NOD2-RIP2-Mediated Signaling Helps Shape Adaptive Immunity in Visceral Leishmaniasis. Journal of Infectious Diseases, v. 214, n. 11, p. 1647-1657, . (13/08216-2)
BASSI, GABRIEL SHIMIZU; ULLOA, LUIS; SANTOS, VICTOR RODRIGUES; DEL VECCHIO, FLAVIO; DELFINO-PEREIRA, POLIANNA; RODRIGUES, GERSON JHONATAN; CASTANIA, JACI AIRTON; CUNHA, FERNANDO DE QUEIROZ; SALGADO, HELIO CESAR; CUNHA, THIAGO MATTAR; et al. Cortical stimulation in conscious rats controls joint inflammation. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 84, n. A, p. 201-213, . (11/20343-4, 13/20549-7, 13/08216-2, 12/04237-2)
KANASHIRO, ALEXANDRE; FRANCHIN, MARCELO; BASSI, GABRIEL SHIMIZU; REIS SANTANA, DENIS AUGUSTO; CUNHA, THIAGO MATTAR; CUNHA, FERNANDO QUEIROZ; ULLOA, LUIS; RODRIGUES, GERSON JONATHAN. Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation. FUNDAMENTAL & CLINICAL PHARMACOLOGY, v. 32, n. 2, p. 155-162, . (13/08216-2, 12/04237-2, 11/20343-4)
MASSAFERA TRISTAO, FABRINE SALES; ROCHA, FERNANDA AGOSTINI; CARLOS, DANIELA; KETELUT-CARNEIRO, NATALIA; SILVA SOUZA, CAMILA OLIVEIRA; MILANEZI, CRISTIANE MARIA; SILVA, JOAO SANTANA. Th17-inducing cytokines IL-6 and IL-23 are crucial for granuloma Formation during experimental Paracoccidioidomycosis. FRONTIERS IN IMMUNOLOGY, v. 8, . (13/08216-2)
SILVA, MARIA CLAUDIA; BONFIM CARBONE, DEBORA CARDOZO; DINIZ, PEDRO FERNANDO; FERNANDES, FABRICIO FREITAS; FUZO, CARLOS ALESSANDRO; PEREIRA CARDOSO TRINDADE, CAROLINA SANTOS; CHANG, MARILENE RODRIGUES; SILVA, JOAO SANTANA. Modulation of ERG Genes Expression in Clinical Isolates of Candida tropicalis Susceptible and Resistant to Fluconazole and Itraconazole. Mycopathologia, v. 185, n. 4, . (13/08216-2)
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