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CEGH-CEL - Human Genome and Stem Cell Research Center

Grant number: 13/08028-1
Support type:Research Grants - Research, Innovation and Dissemination Centers - RIDC
Duration: July 01, 2013 - June 30, 2024
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal researcher:Mayana Zatz
Grantee:Mayana Zatz
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
( Atuais )
Ana Cristina Victorino Krepischi ; Eliana Maria Beluzzo Dessen ; Ésper Abrão Cavalheiro ; Maria Rita dos Santos e Passos Bueno ; Mariz Vainzof ; Merari de Fátima Ramires Ferrari ; Oswaldo Keith Okamoto ; Regina Célia Mingroni Netto
Pesquisadores principais:
( Anteriores )
Angela Maria Vianna Morgante ; Carla Rosenberg ; Celia Priszkulnik Koiffmann ; Peter Lees Pearson
Assoc. researchers:Ana Cristina Victorino Krepischi ; Angela Maria Vianna Morgante ; Carlos Frederico Martins Menck ; Celia Priszkulnik Koiffmann ; David Schlesinger ; Débora Romeo Bertola ; Edson Amaro Junior ; Fernando Kok ; Joao Paulo Fumio Whitaker Kitajima ; Jorge Elias Kalil Filho ; Luciana Amaral Haddad ; Luis Eduardo Soares Netto ; Maria Dulcetti Vibranovski ; Maria Lúcia Lebrão ; Merari de Fátima Ramires Ferrari ; Miguel Mitne Neto ; Nivaldo Alonso ; Peter Lees Pearson ; Rita de Cássia Mingroni Pavanello ; Tatiana Teixeira Torres ; Valdemir Melechco Carvalho ; Venancio Avancini Ferreira Alves ; Verônica Porto Carreiro de Vasconcellos Coelho ; Yeda Aparecida de Oliveira Duarte
Associated grant(s):22/03787-0 - EMU granted in FAPESP process 13/ 08028-1 - Mayana Zatz: BD FACSymphony" Flow Cytometer, AP.EMU
22/04037-5 - Multi-user equipment approved in grant 13/08028-1: single cell analysis chromiun, AP.EMU
20/05949-2 - Rapid, low-cost and efficient molecular diagnostics and large-scale population testing strategies for COVID-19 management, AP.R
+ associated grants 19/05654-5 - Investigation of alphoid satellite DNA loss in centromeric regions in general population and in pediatric tumors, AV.EXT
16/50021-2 - Cancer stem cell interactome mapping, AP.R SPRINT
14/20796-7 - Synaptopathies in neurodevelopmental disorders: SHANK mutations as a window into synaptic function, AR.EXT - associated grants
Associated scholarship(s):22/04953-1 - Implementation and management of a solution for bioinformatics applications in Docker: monitoring users, costs and flows, BP.TT
22/03577-6 - Implementation of pipelines/workflows in the cloud for bioinformatics analysis of genomic data from the Center for Human Genome and Stem Cell Studies (CEGH-CEL), BP.TT
22/02463-7 - Analysis of dysferlin and the formation of its protein tricomplex FAM65b-HDAC6-DYSF during the different phases of muscle differentiation, BP.IC
+ associated scholarships 22/02649-3 - Analysis of the expression of different forms of myosin in vitro in myogenesis process in cellular models for neuromuscular diseases, BP.IC
22/01953-0 - Bioinformatics pipelines implementation to analyze human whole-genome and transcriptome sequencing, BP.TT
21/04323-5 - Evaluation of EZH2 expression and activity as factors of cellular susceptibility to Zika Virus infection in embryonic central nervous system tumors, BP.PD
21/00689-5 - Development of a chimeric antigen receptor for application on glioblastoma treatment, BP.MS
20/11495-4 - Risk variants investigation in patients with Autism Spectrum Disorder, BP.IC
20/08189-9 - In vitro characterization of the redox state and TCOF1 expression during human craniofacial development, BP.IC
19/21290-3 - Database development of genetic variants (Desbravar: Sequence Repository of Brazilian Variants), BP.TT
19/19998-8 - Development of pipeline for copy number variation (CNVs) analysis, BP.TT
19/20768-7 - Development and implementation of NGS data processing tools and database for analysis and storage and genetic variants, BP.TT
19/18469-1 - Development of universal hepatic organoids produced from IPS cells, BP.PD
18/08486-3 - Genetic bases of Syndromic Obesity and molecular mechanisms involved in its physiopathology, BP.DR
18/20373-0 - Characterization of the proteic interactoma of the pluripotency factor L1TD1 in central nervous system tumour stem cells and neural stem cells, BP.IC
18/05961-2 - Identification of genetic variants related to cancer predisposition in cohort of patients with embryonal tumors or pediatric tumors and additional clinical signs, BP.PD
16/14517-3 - Search for "protective" modifying variants/mechanisms in asymptomatic or very mildly affected individuals with pathogenic mutation in SPAST gene, BP.PD
17/16283-2 - Development of tissue bioengineering techniques for the functional reconstruction of ex vivo iPSC cell livers, BP.PD
17/11430-7 - Interaction of genetic and epigenetic factors in response to inflammation for the predisposition to cleft lip-palate, BP.PD
17/05824-2 - Investigation of parents de novo risk variants in Autism Spectrum Disorder (ASD), BP.DR
16/23648-4 - Investigation of the etiological relevance of novel candidate genes to orofacial clefts, BP.PD
16/24188-7 - Modelling Richieri-Costa-Pereira Syndrome with the use of induced pluripotent stem cells, BP.PD
16/17392-7 - ASSOCIATION STUDY OF RARE VARIANTS IN CANDIDATE GENES FOR OROFACIAL CLEFTS IN THE BRAZILIAN POPULATION, BP.DR
15/18914-4 - Study of the regenerative potential of satellite cells in centronuclear myopathy and myogenic capacity of its released microvesicles, BP.DR
15/19435-2 - Therapeutic analysis of human immunoglobulin G in a mouse model for Duchenne Muscular Dystrophy, BP.IC
15/14821-1 - Development of functional hepatic by-pass using iPSCs-derived cells, BP.DR
15/18130-3 - Analysis of the autophagic pathway in the dystrophic muscle., BP.MS
14/23043-0 - Identification of miRNAs with critical function in neurogenesis and oncogenesis, BP.PD
15/08563-0 - DYRK1A regulation by microRNAs in cultured neurons from the hippocampus of mice models of human trisomy 21 and its relation with Alzheimer's Disease, BP.IC
15/06786-1 - Stress of endoplasmic reticulum and expression of VAPB and Rab1 in cultured motor neurons from a mouse model of Amyotrophic Lateral Sclerosis, BP.IC
14/24541-3 - Use of GFP fusions to analyze the mechanisms of toxicity of human VAPB expressed in Saccharomyces cerevisiae, BP.IC
14/17132-0 - Use of Next Generation Sequencing to study karyotypes with different number of X chromosome, BP.PD
14/13056-7 - Characterization of INDELs and small CNVs in patients with autism spectrum disorder, BP.MS
14/10519-6 - HIPPO SIGNALING PATHWAY AND ASYMMETRIC DIVISION OF CANCER STEM CELLS DERIVED FROM HUMAN MEDULLOBLASTOMA, BP.PD
13/14996-0 - Detection of fetal genetic disorders through non-invasive prenatal testing using next-generation sequencing, BP.DR
12/09950-9 - Evolution of HLA genes: population differentiation and signatures of recent selection in native and admixed populations from Brazil, BP.PD
12/50154-1 - Identification of connexin 26 binding proteins, BP.PD
11/50856-3 - Role of cellular microenvironment in molecular mechanisms of resistance to chemotherapy in a human mammary carcinoma model, BP.PD - associated scholarships

Abstract

The Human Genome Research Center (HGRC-CEPID I) was initiated in 2000 with the main goal of increasing our basic knowledge and diagnosis of prevalent genetic diseases in the Brazilian population. The HGRC concentrated largely on Mendelian disorders, mainly neuromuscular, craniofacial, and mental disability. The scope was expanded in 2005 by incorporating stem-cell research, both as a tool to understand gene expression and differentiation in genetic disorders and to evaluate its potential in disease therapy. Our research has allowed us to address questions on the genetic regulation of particular complex disorders such as autism and various neurodegenerative diseases. However, the unanticipated complexity of the transcriptional mechanisms regulating gene expression in humans that emerged from the Human Genome Project, and the modest advances in improving the effectiveness of genetic health care have opened new fields of investigation. In this CEPID 11 application, we have expanded the scientific breadth to include ageing and degeneration and how factors such as genome instability contribute to the aging process; the role of imprinting mechanisms on disease manifestation; which factors determine differences in the rate of brain degeneration between individuals, which constitutes a rapidly increasing health care burdon as the average life-span of the world population rises; what determines phenotypic variability between individuals carrying the same mutation. To address these questions we will use up to date approaches, particularly the use of second generation sequencing and sophisticated cell sorting, incorporate a much broader base of scientific expertise, optimize inter-group synergy as well as national and international research collaboration. The plan also contributes to translational medicine mainly in the application of stem-cells in preclinical studies and therapeutic trials for particular genetic disorders. The great number of patients with different genetic disorders that have been ascertained and registered in our center, the largest one in Latin America, and the ethnic variability of the Brazilian population provides an extremely rich foundation for the proposed studies. We are positive that the knowledge gained from CEPID 11 will have an important impact on genetic health care in Brazil. However, such an ambitious and integrated program can only be expedited by the flexibility and long term security offered by CEPID funding. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
La tijera de los genes 
El zika contra el cáncer 
Una inmersión en las enfermedades genéticas 
Zika against cancer 
One mutation, several defects 
Una mutación, varios defectos 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (151)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KAID, CAROLINI; ASSONI, AMANDA; MARCOLA, MARINA; SEMEDO-KURIKI, PATRICIA; BORTOLIN, RAUL HERNANDES; CARVALHO, VALDEMIR MELECHCO; OKAMOTO, OSWALDO KEITH. Proteome and miRNome profiling of microvesicles derived from medulloblastoma cell lines with stem-like properties reveals biomarkers of poor prognosis. Brain Research, v. 1730, . (13/08028-1)
FERNANDES, STEPHANIE A.; ALMEIDA, CAMILA F.; SOUZA, LUCAS S.; LAZAR, MONIZE; ONOFRE-OLIVEIRA, PAULA; YAMAMOTO, GUILHERME L.; NOGUEIRA, LETICIA; TASAKI, LETICIA Y.; CARDOSO, RAFAELA R.; PAVANELLO, RITA C. M.; et al. Altered in vitro muscle differentiation in X-linked myopathy with excessive autophagy. Disease Models & Mechanisms, v. 13, n. 2, SI, . (15/18130-3, 13/08028-1)
GUERRA, JOAO V. S.; OLIVEIRA-SANTOS, JOSE; OLIVEIRA, DANYLLO F.; LEAL, GABRIELA F.; OLIVEIRA, JOAO RICARDO M.; COSTA, SILVIA S.; KREPISCHI, V, ANA C.; VIANNA-MORGANTE, ANGELA M.; MASCHIETTO, MARIANA. DNA methylation fingerprint of monozygotic twins and their singleton sibling with intellectual disability carrying a novel KDM5C mutation. EUROPEAN JOURNAL OF MEDICAL GENETICS, v. 63, n. 3, . (15/22758-8, 13/08028-1, 15/06281-7)
NASLAVSKY, MICHEL S.; SCLIAR, MARILIA O.; NUNES, KELLY; WANG, JAQUELINE Y. T.; YAMAMOTO, GUILHERME L.; GUIO, HEINNER; TARAZONA-SANTOS, EDUARDO; DUARTE, YEDA A. O.; PASSOS-BUENO, MARIA RITA; MEYER, DIOGO; et al. Biased pathogenic assertions of loss of function variants challenge molecular diagnosis of admixed individuals. AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS, v. 187, n. 3, SI, p. 357-363, . (13/08028-1, 14/50649-6, 14/50931-3)
ALI, TACCYANNA M.; LINNENKAMP, BIANCA D. W.; YAMAMOTO, GUILHERME L.; HONJO, RACHEL S.; DE MENEZES FILHO, HAMILTON CABRAL; KIM, CHONG AE; BERTOLA, DEBORA R.. The recurrent homozygous translation start site variant in CCDC134 in an individual with severe osteogenesis imperfecta of non-Morrocan ancestry. AMERICAN JOURNAL OF MEDICAL GENETICS PART A, . (13/08028-1)
GRIESI-OLIVEIRA, K.; FOGO, M. S.; PINTO, B. G. G.; ALVES, A. Y.; SUZUKI, A. M.; MORALES, A. G.; EZQUINA, S.; SOSA, O. J.; SUTTON, G. J.; SUNAGA-FRANZE, D. Y.; et al. Transcriptome of iPSC-derived neuronal cells reveals a module of co-expressed genes consistently associated with autism spectrum disorder. MOLECULAR PSYCHIATRY, v. 26, n. 5, p. 1589-1605, . (13/08028-1, 16/50324-5, 14/10068-4)
RAEISOSSADATI, REZA; FERRARI, MERARI F. R.. Mitochondria-ER Tethering in Neurodegenerative Diseases. Cellular and Molecular Neurobiology, . (13/08028-1, 18/07592-4, 19/01290-9)
SOUZA, LUCAS SANTOS; ALMEIDA, CAMILA FREITAS; YAMAMOTO, GUILHERME LOPES; MINGRONI PAVANELLO, RITA DE CASSIA; GURGEL-GIANNETTI, JULIANA; DA COSTA, SILVIA SOUZA; ANEQUINI, ISABELA PESSA; DO CARMO, SILVANA AMANDA; WANG, JAQUELINE YU TING; SCLIAR, MARILIA DE OLIVEIRA; et al. Manifesting carriers of X-linked myotubular myopathy Genetic modifiers modulating the phenotype. NEUROLOGY-GENETICS, v. 6, n. 5, . (13/08028-1)
FLORENTINO, V, PILAR T.; MENDES, DAVI; VITORINO, FRANCISCA NATHALIA L.; MARTINS, DAVI J.; CUNHA, JULIA P. C.; MORTARA, RENATO A.; MENCK, CARLOS F. M.. NA damage and oxidative stress in human cells infected by Trypanosoma cruz. PLOS PATHOGENS, v. 17, n. 4, . (19/19435-3, 13/08028-1, 17/01760-0)
LEITE NOBREGA, JULIA CRISTINA; MEDEIROS, JULIANA BARBOSA; DE MELO SANTOS, TACILA THAMIRES; VIEIRA ALVES, SAIONARA ACUCENA; GOMES DA SILVA FREITAS, JAVANNA LACERDA; SILVA, JAIZA M. M.; MARIZ SIMOES, RAISA FERNANDES; BRITO, ALLISSON DE LIMA; WELLER, MATHIAS; DE FERREIRA SANTOS, JAIR LICIO; et al. ocioeconomic Factors and Health Status Disparities Associated with Difficulty in ADLs and IADLs among Long-Lived Populations in Brazil: A Cross-Sectional Stud. INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING, v. 58, . (13/08028-1, 14/50931-3, 09/53778-3, 05/54947-2)
KAID, CAROLINI; JORDAN, DIONE; DE SIQUEIRA BUENOS, HELOISA MARIA; SILVA ARAUJO, BRUNO HENRIQUE; ASSONI, AMANDA; OKAMOTO, OSWALDO KEITH. miR-367 as a therapeutic target in stem-like cells from embryonal central nervous system tumors. MOLECULAR ONCOLOGY, v. 13, n. 12, . (13/08028-1, 13/02983-1, 16/09707-8, 14/08049-1)
LUIZ GUSTAVO DUFNER-ALMEIDA; DAYANE BERNARDINO DA CRUZ; REGINA CÉLIA MINGRONI NETTO; ANA CARLA BATISSOCO; JEANNE OITICICA; RODRIGO SALAZAR-SILVA. Terapia com células-tronco para perda auditiva: já chegamos lá?. Brazilian Journal of Otorhinolaryngology, v. 85, n. 4, p. 520-529, . (09/09473-3, 13/08028-1)
KOBAYASHI, GERSON SHIGERU; BRITO, LUCIANO ABREU; MOREIRA, DANIELLE DE PAULA; SUZUKI, ANGELA MAY; PING HSIA, GABRIELLA SHIH; PIMENTEL, LYLYAN FRAGOSO; BARRETO DE PAIVA, ANA PAULA; DIAS, CAROLINA REGOLI; VILACA LOURENCO, NAILA CRISTINA; OLIVEIRA, BEATRIZ ARAUJO; et al. A Novel Saliva RT-LAMP Workflow for Rapid Identification of COVID-19 Cases and Restraining Viral Spread. DIAGNOSTICS, v. 11, n. 8, . (13/08028-1, 20/05949-2)
MARQUES AGUIAR, TALITA FERREIRA; RIVAS, MARIA PRATES; COSTA, SILVIA; MASCHIETTO, MARIANA; RODRIGUES, TATIANE; DE BARROS, JULIANA SOBRAL; BARBOSA, ANNE CAROLINE; VALIERIS, RENAN; FERNANDES, GUSTAVO R.; BERTOLA, DEBORA R.; et al. Insights Into the Somatic Mutation Burden of Hepatoblastomas From Brazilian Patients. FRONTIERS IN ONCOLOGY, v. 10, . (13/08028-1, 18/05961-2, 16/04785-0, 17/11212-0, 16/23462-8, 18/21047-9)
BRIDE, LAIS; NASLAVSKY, MICHEL; YAMAMOTO, GUILHERME LOPES; SCLIAR, MARILIA; PIMASSONI, LUCIA H. S.; AGUIAR, PAOLA SOSSAI; DE PAULA, FLAVIA; WANG, JAQUELINE; DUARTE, YEDA; PASSOS-BUENO, MARIA RITA; et al. TCF7L2 rs7903146 polymorphism association with diabetes and obesity in an elderly cohort from Brazil. PeerJ, v. 9, . (13/08028-1, 14/50931-3)
BATISSOCO, A. C.; LEZIROVITZ, K.; ZANATTA, D. B.; HEMZA, C. R. M. L.; VASQUES, L. R.; STRAUSS, B. E.; MINGRONI-NETTO, R. C.; HADDAD, L. A.; BENTO, R. F.; OITICICA, J.. Cochlea cell-specific marker expression upon in vitro Hes1 knockdown. Brazilian Journal of Medical and Biological Research, v. 54, n. 7, . (09/09473-3, 13/08028-1, 08/00458-9)
BERTOLA, DEBORA R.; CASTRO, MATHEUS A. A.; YAMAMOTO, GUILHERME L.; HONJO, RACHEL S.; CERONI, JOSE RICARDO; BUSCARILLI, MICHELE M.; FREITAS, AMANDA B.; MALAQUIAS, ALEXSANDRA C.; PEREIRA, ALEXANDRE C.; JORGE, ALEXANDER A. L.; et al. Phenotype-genotype analysis of 242 individuals with RASopathies: 18-year experience of a tertiary center in Brazil. AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS, v. 184, n. 4, SI, p. 896-911, . (13/08028-1, 11/17299-3)
REILY ROCHA, CLARISSA RIBEIRO; ROCHA, ALEXANDRE REILY; SILVA, MATHEUS MOLINA; GOMES, LUCIANA RODRIGUES; LATANCIA, MARCELA TEATIN; TOMAZ, MARINA ANDRADE; DE SOUZA, IZADORA; SEREGNI MONTEIRO, LINDA KAROLYNNE; MARTINS MENCK, CARLOS FREDERICO. Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries. CELLS, v. 9, n. 12, . (13/08028-1, 19/19435-3, 19/21745-0, 15/25016-2)
DOS SANTOS CARDOSO, FABRIZIO; DOS SANTOS, JULIO CESAR CLAUDINO; GONZALEZ-LIMA, FRANCISCO; ARAUJO, BRUNO HENRIQUE SILVA; LOPES-MARTINS, RODRIGO ALVARO BRANDAO; GOMES DA SILVA, SERGIO. Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Brain Metabolomics of Young and Aged Rats. Molecular Neurobiology, v. 58, n. 5, . (13/08028-1, 17/16443-0)
QUINTERO-RUIZ, NATHALIA; CORRADI, CAMILA; MORENO, NATALIA CESTARI; DE SOUZA, TIAGO ANTONIO; PEREIRA CASTRO, LIGIA; ROCHA, CLARISSA RIBEIRO REILY; MENCK, CARLOS FREDERICO MARTINS. Mutagenicity Profile Induced by UVB Light in Human Xeroderma Pigmentosum Group C Cells(dagger). Photochemistry and Photobiology, . (13/08028-1, 19/19435-3)
FIGUEIREDO, THALITA; MENDES, ANA P. D.; MOREIRA, DANIELLE P.; GOULART, ERNESTO; OLIVEIRA, DANYLLO; KOBAYASHI, GERSON S.; STERN, SHANI; KOK, FERNANDO; MARCHETTO, MARIA C.; SANTOS, RENATA; et al. Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. MOLECULAR PSYCHIATRY, v. 26, n. 7, p. 3558-3571, . (16/09618-5, 17/19877-0, 13/08028-1, 19/18469-1, 14/50931-3)
YEH, ERIKA; ATIQUE, RODRIGO; FANGANIELLO, ROBERTO DALTO; SUNAGA, DANIELE YUMI; ANDRE ISHIY, FELIPE AUGUSTO; PASSOS-BUENO, MARIA RITA. Cell Type-Dependent Nonspecific Fibroblast Growth Factor Signaling in Apert Syndrome. STEM CELLS AND DEVELOPMENT, v. 25, n. 16, p. 1249-1260, . (13/08028-1)
GONCALVES DA SILVA, PATRICIA BENITES; RODINI, CAROLINA OLIVEIRA; KAID, CAROLINI; NAKAHATA, ADRIANA MITI; LEITE PEREIRA, MARCIA CRISTINA; MATUSHITA, HAMILTON; DA COSTA, SILVIA SOUZA; OKAMOTO, OSWALDO KEITH. Establishment of a novel human medulloblastoma cell line characterized by highly aggressive stem-like cells. Cytotechnology, v. 68, n. 4, p. 1545-1560, . (13/08028-1, 10/52686-5)
LIMA, SHIRLEY O. A.; FARIAS, ALLYSSON A.; ALBINO, VICTOR A.; MARQUES-ALVES, YANNA K.; OLINDA, RICARDO; SANTOS-SILVA, TAIS A.; ALVES, LEANDRO U.; ZATZ, MAYANA; SANTOS, SILVANA. A population-based study of inter-generational attitudes towards consanguineous marriages in north-eastern Brazil. JOURNAL OF BIOSOCIAL SCIENCE, v. 51, n. 5, p. 683-697, . (13/08028-1, 14/50931-3)
CERONI, JOSE R. M.; YAMAMOTO, GUILHERME L.; HONJO, RACHEL S.; KIM, CHONG A.; PASSOS-BUENO, MARIA R.; BERTOLA, DEBORA R.. Large deletion in PIGL: a common mutational mechanism in CHIME syndrome?. GENETICS AND MOLECULAR BIOLOGY, v. 41, n. 1, p. 85-91, . (13/08028-1)
GUIMARAES MARQUES, MARCIA J.; REYES-GARCIA, SELVIN Z.; MARQUES-CARNEIRO, JOSE E.; LOPES-SILVA, LEONARDO B.; ANDERSEN, MONICA L.; CAVALHEIRO, ESPER A.; SCORZA, FULVIO A.; SCORZA, CARLA A.. Long-term Potentiation Decay and Poor Long-lasting Memory Process in the Wild Rodents Proechimys from Brazil's Amazon Rainforest. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, v. 12, . (13/08028-1)
YAGURA, TEITI; SCHUCH, ANDRE PASSAGLIA; MACHADO GARCIA, CAMILA CARRIAO; REILY ROCHA, CLARISSA RIBEIRO; MORENO, NATALIA CESTARI; FRIEDMANN ANGELI, JOSE PEDRO; MENDES, DAVI; SEVERINO, DIVINOMAR; SANCHEZ, ANGELICA BIANCHINI; DI MASCIO, PAOLO; et al. Direct participation of DNA in the formation of singlet oxygen and base damage under UVA irradiation. Free Radical Biology and Medicine, v. 108, p. 86-93, . (12/12663-1, 13/07937-8, 14/15982-6, 13/08028-1)
NASLAVSKY, MICHEL SATYA; YAMAMOTO, GUILHERME LOPES; DE ALMEIDA, TATIANA FERREIRA; EZQUINA, SUZANA A. M.; SUNAGA, DANIELE YUMI; PHO, NAM; BOZOKLIAN, DANIEL; MILKEWITZ SANDBERG, TATIANA ORLI; BRITO, LUCIANO ABREU; LAZAR, MONIZE; et al. Exomic variants of an elderly cohort of Brazilians in the ABraOM database. Human mutation, v. 38, n. 7, p. 751-763, . (98/14254-2, 08/57899-7, 13/08028-1, 11/17428-8)
LEE, CHAE SYNG; FU, HE; BARATANG, NISSAN; ROUSSEAU, JUSTINE; KUMRA, HEENA; SUTTON, V. REID; NICETA, MARCELLO; CIOLFI, ANDREA; YAMAMOTO, GUILHERME; BERTOLA, DEBORA; et al. Mutations in Fibronectin Cause a Subtype of Spondylometaphyseal Dysplasia with ``Corner Fractures''. American Journal of Human Genetics, v. 101, n. 5, p. 815-823, . (13/08028-1, 15/21783-9)
GOMES, JULIANA P. A.; ASSONI, AMANDA F.; PELATTI, MAYRA; COATTI, GIULIANA; OKAMOTO, OSWALDO KEITH; ZATZ, MAYANA. Deepening a Simple Question: Can MSCs Be Used to Treat Cancer?. ANTICANCER RESEARCH, v. 37, n. 9, p. 4747-4758, . (08/57899-7, 13/08028-1)
RIBEIRO, ALINE LOPES; KAID, CAROLINI; SILVA, PATRICIA B. G.; CORTEZ, BEATRIZ A.; OKAMOTO, OSWALDO KEITH. Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes. STEM CELLS INTERNATIONAL, . (13/08028-1)
MILLER, EMILY E.; KOBAYASHI, GERSON S.; MUSSO, CAMILA M.; ALLEN, MIRANDA; ISHIY, FELIPE A. A.; DE CAIRES, JR., LUIZ CARLOS; GOULART, ERNESTO; GRIESI-OLIVEIRA, KARINA; ZECHI-CEIDE, ROSELI M.; RICHIERI-COSTA, ANTONIO; et al. EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome. Human Molecular Genetics, v. 26, n. 12, p. 2177-2191, . (13/08028-1)
NUNES, KELLY; PIOVEZAN, BRUNO; TORRES, MARGARETH A.; PONTES, GERLANDIA N.; KIMURA, LILIAN; CARNAVALLI, JULIANA E. P.; MINGRONI NETTO, REGINA CELIA; MORAES, MARIA ELISA; MEYER, DIOGO. Population variation of HLA genes in rural communities in Brazil, the Quilombos from the Vale do Ribeira, Sao Paulo - Brazil. HUMAN IMMUNOLOGY, v. 77, n. 6, p. 447-448, . (12/09950-9, 13/08028-1, 12/18010-0)
MOREIRA, DANIELLE P.; GRIESI-OLIVEIRA, KARINA; BOSSOLANI-MARTINS, ANA L.; LOURENCO, NAILA C. V.; TAKAHASHI, VANESSA N. O.; DA ROCHA, KATIA M.; MOREIRA, ELOISA S.; VADASZ, ESTEVAO; CASTRO MEIRA, JOANNA GOES; BERTOLA, DEBORA; et al. Investigation of 15q11-q13, 16p11.2 and 22q13 CNVs in Autism Spectrum Disorder Brazilian Individuals with and without Epilepsy. PLoS One, v. 9, n. 9, . (08/57899-7, 13/08028-1)
VICTORINO KREPISCHI, ANA CRISTINA; CAPELLI, LEONARDO PIRES; SILVA, AMANDA GONCALVES; SOUZA DE ARAUJO, ERICA SARA; PEARSON, PETER LEES; HECK, BENJAMIN; LIMA DA COSTA, CECILIA MARIA; DE CAMARGO, BEATRIZ; ROSENBERG, CARLA. Large germline copy number variations as predisposing factor in childhood neoplasms. FUTURE ONCOLOGY, v. 10, n. 9, p. 1627-1633, . (09/02058-0, 08/57887-9, 13/08028-1, 09/00898-1)
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Filed patent(s) as a result of this research project

MÉTODO DE PROGNÓSTICO DA AGRESSIVIDADE DE TUMORES E KIT BR1020140155775 - Universidade de São Paulo (USP) . Carolina de Oliveira Rodini; Gabriela Furukawa; Oswaldo Keith Okamoto; Patrícia Benites Gonçalves da Silva - June 2014, 17

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020150030169 - Universidade de São Paulo (USP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - February 2015, 11

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020180081942 - Universidade de São Paulo (USP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - April 2018, 24