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CIBFar - Center for Innovation in Biodiversity and Drug Discovery

Grant number: 13/07600-3
Support type:Research Grants - Research, Innovation and Dissemination Centers - RIDC
Duration: July 01, 2013 - June 30, 2024
Field of knowledge:Biological Sciences - Biophysics
Principal researcher:Glaucius Oliva
Grantee:Glaucius Oliva
Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Pesquisadores principais:
Adriano Defini Andricopulo ; Carlos Roque Duarte Correia ; Fernando Antonio Santos Coelho ; Leila Maria Beltramini ; Luiz Carlos Dias ; Maysa Furlan ; Paulo Cézar Vieira ; Vanderlan da Silva Bolzani
Assoc. researchers:Alberto José Cavalheiro ; Andre Luis Berteli Ambrosio ; Angela Regina Araújo ; Arlene Gonçalves Corrêa ; Dulce Helena Siqueira Silva ; Eduardo Maffud Cilli ; Fabio Cardoso Cruz ; Ian Castro-Gamboa ; Ilana Lopes Baratella da Cunha Camargo ; Marcia Nasser Lopes ; Márcia Regina Cominetti ; Mônica Tallarico Pupo ; Nelma Regina Segnini Bossolan ; Rafael Victorio Carvalho Guido
Associated grant(s):22/04089-5 - Multi-user Equipment approved in grant 2013/07600-3: Vitrobot e ELSA cryo-transfer holder, AP.EMU
22/03494-3 - Multi-user Equipment approved in grant 2013/07600-3: citometer, AP.EMU
21/13118-6 - Multi-user equipment approved in grant 2013/07600-3: High Performance Liquid Chromatograph, AP.EMU
+ associated grants 20/04602-9 - Development of antivirals for the treatment of COVID-19, AP.R
19/13911-8 - 47th IUPAC World Chemistry Congress - 2019, AR.EXT
19/07606-8 - Multi-User Equipment approved in grant 13/07600-3: Omnilog phenotypic microarray, AP.EMU
19/07457-2 - Multi-User Equipment conceived in grant 2013/07600-3 "ROCKIMAGER 1000", AP.EMU
17/17920-6 - 10th European Conference on Marine Natural Products - ECMNP 2017, AR.EXT
16/23279-9 - 5th Annual Conference of AnalytiX-2017, AR.EXT
16/13884-2 - Multi-User Equipment approved in grant 2013/07600-3: MicroScale Thermophoresis (MST), AP.EMU
16/50009-2 - Greening sample preparation of complex matrices by using natural deep eutectic solvents (NADES) together with porous polymeric adsorbents for subsequent analyses by liquid chromatography (LC) and nuclear magnetic resonance (NMR), AP.R SPRINT
15/08181-0 - American Society of Pharmacognosy 2015 Annual Meeting, AR.EXT
15/14968-2 - American Society of Pharmacognosy 2015 Annual Meeting, AR.EXT
15/06751-3 - Antitrypanosomal acetylene fatty acid derivatives from the seeds of Porcelia macrocarpa (Annonaceae), PUB.ART
14/50304-9 - Stereochemical characterization of cyclotides from Cerrado species using Raman optical activity, AP.R
14/15579-7 - 55th Annual American Society of Pharmacognosy Meeting & 14th Annual Oxford International Conference on the Science of Botanicals, AR.EXT
13/21599-8 - Multicomponent organocatalytic strategies to anticancer natural products, AV.EXT
13/18375-0 - 61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), AR.EXT - associated grants
Associated scholarship(s):21/03977-1 - Discovery of inhibitors from Brazilian Savana plants as lead compound candidates for Malaria, BP.DR
21/05646-2 - Metabolic engineering applied to the elucidation of the biosynthetic pathway and sustainable production of quinonemethide triterpenes via heterologous expression in Saccharomyces cerevisiae, BP.DR
21/13544-5 - Design, synthesis and biological evaluation of new antiparasitic agents having 1,2,4-oxadiazole motif in their structures, BP.DD
+ associated scholarships 21/14209-5 - Pharmacokinetic and Biological Properties Evaluation of Drug Candidates, BP.PD
21/06317-2 - Investigation of quinazoline derivatives with anticancer properties, BP.IC
21/06054-1 - Search for antiviral drugs, targeting RNA-dependent RNA polymerases (RdRp) from the Alphavirus Chikungunya (NSP4) and Beta-Coronavirus SARS-CoV-2 (NSP12), BP.PD
21/02777-9 - Drug discovery for Chagas Disease, BP.PD
21/05629-0 - Center for Innovation in Biodiversity and Drug Discovery (CIBFar), BP.TT
21/01706-0 - Screening of compounds for the identification of drugs against the Chikungunya virus using a subgenomic replicon system, BP.IC
21/01686-0 - Screening of compounds for the identification of drugs against the Zika virus using a subgenomic replicon system, BP.IC
20/16787-3 - Chemical study of endophytic microorganisms isolated from Malouetia tamaquarina (Apocynaceae) active against Neglected Tropical Diseases, BP.IC
19/27790-8 - Development of machine learning-based tools for the discovery of new Malaria drug candidates, BP.PD
19/23175-7 - Formulations based on extracts and fractions from Casearia sylvestris for controlling cariogenic biofilm, BP.DR
19/24971-1 - Synthesis, characterization and activity of peptide analogues of the (p-BthTX-I), BP.IC
19/26679-6 - Evaluation of activity of natural products and other compounds against multidrug resistant bacteria and their biofilms, BP.TT
19/12632-8 - Sorocea bompladii: plant model for the isolation of endophytes, aiming at the rational exploitation of their molecular diversity, BP.IC
18/24344-4 - Optimization of lead compounds for treatment of tropical parasitic diseases in collaboration with the Drugs for Neglected Diseases Initiative (DNDi), BP.DR
19/09067-7 - Discovering the potential of the secondary metabolites from Malouetia tamaquarina (Apocynaceae) and its endophytes against neglected tropical diseases, BP.PD
18/25289-7 - Discovery of new bioactive ligands with anticancer properties, BP.DR
18/14153-7 - Investigation of molecular changes in small selectively activated neural groups (neuronal ensembles) of the nucleus acumbens, which mediate the incubation of the fissure to cocaine induced by the environment, BP.DR
18/25600-4 - Discovery and development of antiviral candidates against Yellow Fever virus based on the structure of the NS2B-NS3 protease complex, BP.DD
19/07603-9 - Rational exploration of Colletotrichum gloeosporiodes, aiming at the production and isolation of bioactive metabolites and scale-up processes, BP.IC
19/06587-0 - Center for Innovation in Biodiversity and Drug Discovery (CIBFar), BP.TT
19/05967-3 - Understanding the biological function of Natural Products' scaffolds from Databases for the design of active compounds for the treatment of infectious diseases, BP.PD
18/23946-0 - Predictive models for the phases from structure factors of centric reflections in protein crystallography by machine learning, BP.IC
18/25773-6 - Antiviral candidates discovery based on the structure of the yellow fever NS5 RNA-dependent RNA polymerase enzyme, BP.MS
19/06034-0 - Pharmacokinetic and Biological Properties Evaluation of Drug Candidates, BP.PD
19/01762-8 - Natural and synthetic compounds screening targeting proteins from arboviruses, BP.TT
19/04788-8 - Evaluation of activity of natural products and other compounds against multidrug resistant bacteria and their biofilms, BP.TT
18/23675-7 - Multiparametric analysis of the phase problem in protein crystallography by deep learning, BP.IC
18/17095-8 - Structural characterization of the Chikungunya Virus NSP4 RNA-dependent RNA polymerase and search for antiviral agents, BP.DR
18/15887-4 - Optimization and elucidation of cationic peptides antibacterial activity in multidrug-resistant pathogens, BP.DD
18/19574-0 - Structural biology and drug development against the protein NS5 Zika Virus, BP.DD
18/07287-7 - Discovery of Acridine and Marinoquinoline Derivatives as Plasmodium falciparum Inhibitors, BP.DR
18/05130-3 - Construction and characterization of a ZIKV sub-genomic replicon system for the discovery of antiviral agents., BP.PD
18/04896-2 - Bioguided study of Talisia esculenta for the identification of secondary metabolites inhibitors of advanced glycation, BP.IC
17/26679-0 - 4-Quinolone derivatives as antimalarial drug candidates: Antiplasmodial activity characterization in vitro, in vivo and of the mode of action, BP.MS
17/16772-3 - Structural and functional studies of the NS5 RNA-dependent RNA polymerase enzyme from yellow fever virus, BP.IC
17/23778-8 - Chemoinformatics strategies for a series of antichagasic compounds, BP.IC
17/22661-0 - Structural and functional studies of the NS2B-NS3 protease complex from yellow fever, BP.IC
17/17098-4 - Application of MALDI Imaging (MSI) on non-nodulated and nodulated leaves of Psychotria and Hybanthus: Localization, analysis of cyclotides and its relationship with endosymbionts bacteria, BP.PD
17/07229-4 - Structural characterization of Chikungunya Virus proteins and the search for antiviral agents, BP.PD
17/15682-0 - Amides from Piperaceae species: metabolomic studies in complex matrices for bioprospecting antimicrobial compounds, BP.IC
17/12326-9 - Orbitides from Croton antisyphiliticus and C. sphaerogynus (Euphorbiaceae), chemical-biological characterization and synthesis: rational prospection of low molecular weight peptides with antitumor potential, BP.MS
17/01287-2 - Screening of candidates to new antitumoral drugs by three-dimensional cell culture, BP.PD
17/04070-4 - Discovery of 4-quinolinones derivatives as lead compound candidates for the development of new antimalarials, BP.IC
16/24714-0 - Structuring of a metabolic database for Casearia sylvestris using LC-DAD-CAD-MS, BP.IC
16/24969-9 - Evaluation of compounds in multidrug resistant bacterial pathogens as part of the Center for Innovation in Biodiversity and Drug Discovery (CIBFar), BP.IC
16/19712-9 - Structural characterization of Zika virus proteins and search for antiviral agents, BP.PD
16/17153-2 - Structural biology and drug development against the protein NS5 Zika virus, BP.DD
16/09235-9 - Metabolic fingerprinting (chromatographic profile) by LC-DAD-MS for quality control of Erythrina species herbal drugs: development and method validation, BP.MS
16/09772-4 - Structural biology and medicinal chemistry studies toward the discovery of new Plasmodium falciparum enolase inhibitors, BP.MS
16/06499-5 - Crystallographic studies of the enzyme cruzain from T.cruzi in complex with inhibitors, BP.IC
16/04004-9 - Exploration of the chemical potential and biotransformation from fungus Rhinocladiella similis aimed biological compounds, BP.IC
15/23244-8 - Development of new peptides and bioconjugates against Zika virus infection, BP.DR
15/19495-5 - Compounds synthesis for the treatment of Chagas Disease at RIDCs/FAPESP/DNDi, BP.PD
15/25175-3 - Cloning and characterization of cytochrome P450 oxidoreductase type from Maytenus ilicifolia and their effect on increasing the production of quinonamethide triterpenes by heterologous expression in Saccharomyces ceravisiae, BP.PD
15/18192-9 - Discovery and development of Antimalarial Drugs: Structural Biology, Medicinal Chemistry and Parasitology, BP.PD
15/23095-2 - Synthesis and characterization of bioconjugates containing peptides with antitumor activity, BP.IC
15/21272-4 - Computational studies on N-myristoyltransferase enzyme from Plasmodium falciparum and its inhibitors as antimalarial agents, BP.MS
15/09533-7 - Cyclopeptides of Extreme Environments Plants (Caatinga Biome): Characterization, Function, Synthesis and Evaluation of Anti-tumor and Immunosuppressive Activities, BP.PD
15/11339-4 - Comparative analysis of alkyl resorcinols in sugarcane cultivars and evaluation of possible protective effect against fungal pathogens, BP.IC
14/26313-8 - Discovery and design of Plasmodium falciparum enolase inhibitors as new antimalarial candidates., BP.PD
14/15145-7 - Structural studies of mitochondrial topoisomerase II from trypanosomatids, BP.PD
14/19362-2 - Application of biotechnology to evaluate plant-microorganism interaction during production of secondary metabolites in Peritassa campestris and its endophytes, BP.PD
14/21567-1 - Study of selected microorganisms from Senna spectabilis's rhizosphere aiming the detection of biologically active molecules, BP.IC
14/05538-1 - Synthesis, characterization, study of action mechanism and analysis of different release methods of pBthTX-I, in its monomeric and dimeric forms, BP.PD
14/14067-2 - Prospecting the Quinanomethide derivatives biossynthesis enzymes among biogeografical diverse sampling of Maytenus spp. (Celastraceae), BP.PD
14/02282-6 - Structure-activity relationship studies about of Pilocarpus microphyllus (Rutaceae) alkaloid derivatives against Schistosoma mansoni, BP.PD
14/05935-0 - Co-culture of microorganisms isolated from the rhizosphere of Senna spectabilis aiming to produce new bioactive metabolites, BP.DD
14/02738-0 - Chemical documentation of species from Casearia genus (Salicaceae) of ecological, economical and medicinal relevance, BP.IC
13/15306-8 - Studies concerning the biosynthesis of quinonemethides triterpenes by metabolic engineering: evaluation of the micro- and macromolecular metabolic flow of heterologous system by proteomics and metabolomics techniques., BP.PD
13/25658-9 - Design and Development of Drug Candidates for Chagas Disease, BP.PD
13/24952-0 - Patterns of emergence of multidrug resistant enterococci and staphylococci in Brazil and search for new drugs, BP.PD
14/00326-6 - Chemical characterization of Ficus guaranitica (Moraceae): prospection of compounds of economic interest and evaluation of biological activities with therapeutic interest, BP.IC
13/15086-8 - Application of metabolomics and proteomics in searching for new biologically active compounds in Malpighiaceae plant species, BP.PD
13/10933-4 - Application of biotechnological tools in Streptomyces olindensis to obtain new natural products with pharmaceutical potential, BP.PD
13/03493-8 - Potential of crude extracts, essential oil and pure compounds obtained from Tagetes patula L. (Asteraceae) as botanical biopesticide against Rhipicephalus (Boophilus) microplus, Haemonchus contortus and Cimex lectularis, BP.PD
11/01544-9 - Proteomic analysis focused on the enzyme P450 oxidoreductase in roots of young plants and adult Maytenus ilicifolia (Celastraceae), BP.PD
11/10379-1 - CLONING AND CHARACTERIZATION OF OXIDOSQUALENE CYCLASES FROM Maytenus ilicifolia Mart. ex Reissek, BP.PD
11/01003-8 - Proteomic studies in Peperomia obtusifolia (Piperaceae), BP.PD
11/03017-6 - Natural products from plants of Cerrado and Atlantic Forest, potential models and useful for identifying prototypes with oxidizing action on neutrophils and myeloperoxidase (MPO) enzyme, BP.PD - associated scholarships

Abstract

The Center for Innovation in Biodiversity and Drug Discovery (CIBFar) is a joint initiative resulting from existing collaborative research projects, including the Physics Institute of São Carlos (IFSC) and the School of Pharmaceutical Sciences of Ribeirão Preto at the University of São Paulo (USP), the Institute of Chemistry at the State University of São Paulo (UNESP), the Institute of Chemistry at the State University of Campinas (UNICAMP), and the Department of Chemistry at the Federal University of São Carlos (UFSCar). The major goals of this Center are to perform basic and applied science and to develop technologies, such as in vitro and in vivo biological and pharmacological evaluations, for all areas of biodiversity and drug discovery that rely on state-of-the-art methods in medicinal chemistry, natural products chemistry, synthetic organic chemistry, and molecular and structural biology. Strategic partnerships with the private sector are always sought, particularly with national and international pharmaceutical companies and research institutes within the health sector. The ultimate goals are the development of clinical candidates for tropical infectious diseases, cancer and central nervous system disorders and the development of new synthetic routes to generic drugs. On the educational front, the Center also relies on the considerable experience that has been acquired over the last eleven years from our previous CEPID-FAPESP. Intensive work has been done on outreach programs focused on science education from elementary school to high school. CIBFar has the benefit of joining research groups in a modern multidisciplinary setting while also providing access to a well-established infrastructure with extensive experience in the areas of technical, financial, educational, technological and executive management. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
An agenda for forgotten diseases 
Promising structures 
Estructuras prometedoras 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (282)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, THIAGO S.; COELHO, FERNANDO. Methodologies for the synthesis of quaternary carbon centers via hydroalkylation of unactivated olefins: twenty years of advances. Beilstein Journal of Organic Chemistry, v. 17, p. 1565-1590, . (13/07600-3, 18/02611-0)
ALTEI, WANESSA F.; PACHANE, BIANCA C.; MARTINS, LUCIMARA J.; GOMES, RALPH C.; SANTOS, RICARDO N.; FERNANDES, DANIARA C.; SELISTRE-DE-ARAUJO, HELOISA S.; COELHO, FERNANDO; ANDRICOPULO, ADRIANO D.. Synthetic Spirocyclohexadienones as New Anti-Migratory Compounds in Triple-Negative Breast Cancer Cell Migration. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, v. 21, n. 14, p. 1901-1910, . (13/07600-3, 19/11437-7, 10/06741-4)
FERNANDES, FABIO S.; SANTOS, HUGO; LIMA, SAMIA R.; CONTI, CAROLINE; RODRIGUES JR, MANOEL T.; ZEOLY, LUCAS A.; FERREIRA, LEONARDO L. G.; KROGH, RENATA; ANDRICOPULO, ADRIANO D.; COELHO, FERNANDO. Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 201, . (18/02611-0, 13/07600-3, 16/23005-6, 15/09205-0)
BECCENERI, AMANDA B.; FUZER, ANGELINA M.; PLUTIN, ANA M.; BATISTA, ALZIR A.; LELIEVRE, SOPHIE A.; COMINETTI, MARCIA R.. Three-dimensional cell culture models for metallodrug testing: induction of apoptosis and phenotypic reversion of breast cancer cells by the trans-[Ru(PPh3)(2)(N,N-dimethyl-N-thiophenyl-thioureato-k(2)O,S)(bipy) ]PF6 complex. INORGANIC CHEMISTRY FRONTIERS, v. 7, n. 16, p. 2909-2919, . (17/20055-5, 13/07600-3, 15/24940-8, 18/19342-2, 14/25121-8, 17/01287-2)
SANCHES POLITI, FLAVIO AUGUSTO; FANTATTO, RAFAELA REGINA; DA SILVA, ALEXANDER ALVES; MORO, ISABELA JACOB; SAMPIERI, BRUNO RODRIGUES; CAMARGO-MATHIAS, MARIA IZABEL; FIGUEIREDO, AMANDA; DE SOUZA CHAGAS, ANA CAROLINA; FURLAN, MAYSA. Evaluation of Tagetes patula (Asteraceae) as an ecological alternative in the search for natural control of the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae). Experimental and Applied Acarology, v. 77, n. 4, p. 601-618, . (13/07600-3, 13/03493-8)
CHAGAS, FERNANDA O.; RUZZINI, ANTONIO C.; BACHA, V, LARISSA; SAMBORSKYY, MARKYIAN; CONTI, RAPHAEL; PESSOTTI, RITA C.; DE OLIVEIRA, LUCIANA G.; CLARDY, JON; PUPO, MONICA T.. Genome Sequence of Streptomyces sp. Strain RTd22, an Endophyte of the Mexican Sunflower. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 4, n. 4, . (13/07600-3, 08/09540-0, 13/50954-0, 09/17695-6, 08/00812-7, 11/06209-3, 11/12910-6, 11/11703-7)
FERNANDES, DANIARA C.; SIMONI, DEBORAH DE ALENCAR; RODRIGUES, JR., MANUEL T.; SANTOS, MARILIA S.; COELHO, FERNANDO. Crystal structure of 3-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydrocyclopenta[b]indole-2-car boxylic acid. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, v. 71, n. 6, p. O395-U248, . (13/07600-3, 09/51602-5)
ALVES, THAIS B.; SOUZA-MOREIRA, TATIANA M.; VALENTINI, SANDRO R.; ZANELLI, CLESLEI E.; FURLAN, MAYSA. Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms. Molecules, v. 23, n. 3, . (11/10379-1, 14/03819-3, 13/07600-3)
BERNARDES, CAROLINA P.; SANTOS, NEIFE A. G.; SISTI, FLAVIA M.; FERREIRA, RAFAELA SCALCO; SANTOS-FILHO, NORIVAL A.; CINTRA, ADELIA C. O.; CILLI, EDUARDO M.; SAMPAIO, V, SUELY; SANTOS, ANTONIO C.. A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP+ toxicity by activating the NGF-signaling pathway. Peptides, v. 104, p. 24-34, . (11/23236-4, 13/07600-3)
SUTTON, ADAM T.; FRAIGE, KARINA; LEME, GABRIEL MAZZI; BOLZANI, VANDERLAN DA SILVA; HILDER, EMILY F.; CAVALHEIRO, ALBERTO J.; ARRUA, R. DARIO; FUNARI, CRISTIANO SOLEO. Natural deep eutectic solvents as the major mobile phase components in high-performance liquid chromatography-searching for alternatives to organic solvents. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 410, n. 16, p. 3705-3713, . (13/07600-3, 13/15086-8, 16/50009-2)
MARTINEZ, PABLO D. G.; KRAKE, SUSANN H.; POGGI, MAITIA L.; CAMPBELL, SIMON F.; WILLIS, PAUL A.; DIAS, LUIZ C.. 2,3,8-Trisubstituted Quinolines with Antimalarial Activity. Anais da Academia Brasileira de Ciências, v. 90, n. 2, p. 1215-1231, . (15/50655-9, 13/07600-3)
BERNARDINO, K.; PINTO, M. E. F.; BOLZANI, V. S.; DE MOURA, A. F.; BATISTA JUNIOR, J. M.. Pinpointing disulfide connectivities in cysteine-rich proteins. CHEMICAL COMMUNICATIONS, v. 53, n. 53, p. 7337-7340, . (15/07089-2, 13/07296-2, 14/50304-9, 12/15147-4, 13/07600-3, 14/25222-9)
LORENZON, ESTEBAN N.; PICCOLI, JULIA P.; SANTOS-FILHO, NORIVAL A.; CILLI, EDUARDO M.. Dimerizatiori of Antimicrobial Peptides: A Promising Strategy to Enhance Antimicrobial Peptide Activity. PROTEIN AND PEPTIDE LETTERS, v. 26, n. 2, p. 98-107, . (12/15346-7, 13/07600-3)
FERREIRA, VINICIUS G.; LEME, GABRIEL M.; CAVALHEIRO, ALBERTO J.; FUNARI, CRISTIANO S.. Online Extraction Coupled to Liquid Chromatography Analysis (OLELC): Eliminating Traditional Sample Preparation Steps in the Investigation of Solid Complex Matrices. Analytical Chemistry, v. 88, n. 17, p. 8421-8427, . (10/18840-7, 13/07600-3)
GUBIANI, JULIANA R.; NOGUEIRA, CLAUDIO R.; PEREIRA, MARCOS D. P.; YOUNG, MARIA C. M.; FERREIRA, PAULO M. P.; DE MORAES, MANOEL O.; PESSOA, CLAUDIA; BOLZANI, VANDERLAN S.; ARAUJO, ANGELA R.. Rearranged Sesquiterpenes and Branched Polyketides Produced by the Endophyte Camarops sp.. PHYTOCHEMISTRY LETTERS, v. 17, p. 251-257, . (13/07600-3)
CONTI, RAPHAEL; CHAGAS, FERNANDA OLIVEIRA; CARABALLO-RODRIGUEZ, ANDRES MAURICIO; DA PAIXAO MELO, WEILAN GOMES; DO NASCIMENTO, ANDREA MENDES; CAVALCANTI, BRUNO COELHO; DE MORAES, MANOEL ODORICO; PESSOA, CLAUDIA; COSTA-LOTUFO, LETICIA VERAS; KROGH, RENATA; et al. Endophytic Actinobacteria from the Brazilian Medicinal Plant Lychnophora ericoides Mart. and the Biological Potential of Their Secondary Metabolites. CHEMISTRY & BIODIVERSITY, v. 13, n. 6, p. 727-736, . (08/00812-7, 08/09540-0, 15/01001-6, 12/21803-1, 13/07600-3, 09/17695-6)
FERREIRA, LEONARDO G.; OLIVA, GLAUCIUS; ANDRICOPULO, ADRIANO D.. Target-based molecular modeling strategies for schistosomiasis drug discovery. Future Medicinal Chemistry, v. 7, n. 6, p. 753-764, . (13/25658-9, 13/07600-3)
ZEOLY, LUCAS A.; BARCELOS, ROSIMEIRE C.; RODRIGUES, JR., MANOEL T.; GOMES, RALPH C.; COELHO, FERNANDO. An improved method for the regioselective synthesis of highly substituted quinolines from Morita-Baylis-Hillman adducts. Tetrahedron Letters, v. 56, n. 22, p. 2871-2874, . (12/24783-1, 13/07600-3)
CORNELIO, VIVIAN E.; MALUF, FERNANDO V.; FERNANDES, JOAO B.; DA SILVA, MARIA FATIMA G. F.; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.; VIEIRA, PAULO C.. Isolation of Tiliroside from Spiranthera odoratissima as Inhibitor of Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase by Using Bioactivity-Guided Fractionation. Journal of the Brazilian Chemical Society, v. 28, n. 3, SI, p. 512-519, . (09/17538-8, 13/07600-3)
JULIANA R. GUBIANI; HELDER L. TELES; GERALDO H. SILVA; MARIA CLÁUDIA M. YOUNG; JOSÉ O. PEREIRA; VANDERLAN S. BOLZANI; ANGELA R. ARAUJO. CYCLO-(TRP-PHE) DIKETOPIPERAZINES FROM THE ENDOPHYTIC FUNGUS Aspergillus versicolor ISOLATED FROM Piper aduncum#. Química Nova, v. 40, n. 2, p. 138-142, . (13/07600-3)
GOMES, RALPH C.; BARCELOS, ROSIMEIRE C.; RODRIGUES, JR., MANOEL T.; SANTOS, HUGO; COELHO, FERNANDO. Intermolecular Stetter Reactions on Morita-Baylis-Hillman Adducts: an Approach to Highly Functionalized 1,4-Dicarbonyl Compounds. CHEMISTRYSELECT, v. 2, n. 3, p. 926-930, . (15/09205-0, 13/07600-3, 13/10449-5)
PARACATU, LUANA C.; ZERAIK, MARIA L.; BERTOZO, LUIZA DE CARVALHO; BARTOLOMEU, ALOISIO DE ANDRADE; DA SILVA FILHO, LUIZ C.; DA FONSECA, LUIZ M.; XIMENES, VALDECIR F.. Synthesis, Antioxidant and Anti-inflammatory Properties of an Apocynin- Derived Dihydrocoumarin. Medicinal Chemistry, v. 13, n. 1, p. 93-100, . (13/08784-0, 13/07600-3)
FERREIRA, LEONARDO G.; DOS SANTOS, RICARDO N.; OLIVA, GLAUCIUS; ANDRICOPULO, ADRIANO D.. Molecular Docking and Structure-Based Drug Design Strategies. Molecules, v. 20, n. 7, p. 13384-13421, . (13/25658-9, 13/07600-3)
NIVEA O. CALIXTO; MERI EMILI F. PINTO; SUELEM D. RAMALHO; MARCELA C. M. BURGER; ANTONIO F. BOBEY; MARIA CLAUDIA MARX YOUNG; VANDERLAN S. BOLZANI; ANGELO C. PINTO. The Genus Psychotria: Phytochemistry, Chemotaxonomy, Ethnopharmacology and Biological Properties. Journal of the Brazilian Chemical Society, v. 27, n. 8, p. 1355-1378, . (15/09533-7, 13/07600-3)
DE LIMA BATISTA, ANA P.; COELHO, FERNANDO; BRAGA, ATAUALPA A. C.. DFT exploration of mechanistic pathways of an aza-Morita-Baylis-Hillman reaction. THEORETICAL CHEMISTRY ACCOUNTS, v. 135, n. 8, . (13/07600-3, 15/01491-3, 13/22235-0, 13/10449-5)
LORENZON, ESTEBAN N.; SANTOS-FILHO, NORIVAL A.; RAMOS, MATHEUS A. S.; BAUAB, TAIS M.; CAMARGO, ILANA L. B. C.; CILLI, EDUARDO M.. C-terminal Lysine-Linked Magainin 2 with Increased Activity Against Multidrug-Resistant Bacteria. PROTEIN AND PEPTIDE LETTERS, v. 23, n. 8, p. 738-747, . (12/15346-7, 13/07600-3)
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Filed patent(s) as a result of this research project

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020180719149 - Universidade Estadual Paulista (UNESP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - October 2018, 24

METHOD FOR EXTRACTING AND ISOLATING ACTIVE SUBSTANCES FROM UMBU PULP, ACTIVE SUBSTANCES, NUTRACEUTICAL AND/OR FUNCTIONAL FOODS COMPRISING SAID ACTIVE SUBSTANCES AND USES THEREOF PCT/BR2015/050172 - Universidade Estadual Paulista (UNESP) . Maria Luiza Zeraik; Emerson Ferreira Queiroz; Ian Castro-Gamboa; Dulce Helena Siqueira Silva; Muriel Cuendet; Laurence Marcourt; Olivier Ciclet; Vanderlan da Silva Bolzani; Jean-Luc Wolfender - October 2015, 07

METHOD FOR EXTRACTING AND ISOLATING ACTIVE SUBSTANCES FROM UMBU PULP, NUTRACEUTICAL AND/OR FUNCTIONAL FOODS AND COSMETICS COMPRISING SAID ACTIVE SUBSTANCES AND USES THEREOF PCT/BR2015/050173 - Universidade Estadual Paulista (UNESP) . Maria Luiza Zeraik; Emerson Ferreira Queiroz; Ian Castro-Gamboa; Dulce Helena Siqueira Silva; Muriel Cuendet; Vanderlan da Silva Bolzani; Jean-Luc Wolfender - October 2015, 07