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BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology

Grant number: 13/07559-3
Support Opportunities:Research Grants - Research, Innovation and Dissemination Centers - RIDC
Duration: July 01, 2013 - June 30, 2025
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Fernando Cendes
Grantee:Fernando Cendes
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Pesquisadores principais:
( Atuais )
Fernando José von Zuben ; Gabriela Castellano ; Iscia Teresinha Lopes Cendes ; Li Li Min ; Lília Freire Rodrigues de Souza Li ; Marcio Luiz Figueredo Balthazar ; Marcondes Cavalcante Franca Junior ; Ricardo Ribeiro Gudwin ; Roberto José Maria Covolan ; Simone Appenzeller
Pesquisadores principais:
( Anteriores )
Alan Stewart Hazell ; João Bosco Pesquero ; Marilisa Mantovani Guerreiro ; Roberto de Alencar Lotufo
Associated researchers:Abrahão Fontes Baptista ; Alessandra Marques Pereira ; Alexandre Fonseca Brandão ; Alexandre Hideki Okano ; Alexandre Moreira ; Alexandre Rosa Franco ; Alfredo Damasceno ; Ana Carolina Coan ; André Kazuo Takahata ; Andre Schwambach Vieira ; Andréa Alessio Vieira Alves ; Anelyssa Cysne Frota D'Abreu ; Arnaldo Fim Neto ; Benilton de Sá Carvalho ; Brunno Machado de Campos ; Carlos Alberto Vogt ; Clarissa Lin Yasuda ; Cláudia Vianna Maurer Morelli ; Cristiane de Souza Rocha ; Danilo Rodrigues Pereira ; Danyella Barbosa Dogini ; Edgard Morya ; Eduardo Tavares Costa ; Eliane Gomes Guimarães ; Elvis Lira da Silva ; Enrico Ghizoni ; Eric Rohmer ; Esther Luna Colombini ; Fabio Nauras Akhras ; Fábio Rogério ; Fábio Rossi Torres ; Felipe Paulo Guazzi Bergo ; Felix Rosenow ; Fernando José von Zuben ; Guilherme Côco Beltramini ; Guy A. Rouleau ; Ingmar Blümcke ; Jaíra Ferreira de Vasconcellos ; Jean-Claude Dreher ; Jorge Vicente Lopes da Silva ; José Raimundo de Oliveira ; Jose Remo Ferreira Brega ; LAURA SILVEIRA MORIYAMA ; Leonardo Abdala Elias ; Letícia Franceschet Ribeiro ; Leticia Rittner ; Licio Augusto Velloso ; Louis Lemieux ; Luciana Ramalho Pimentel da Silva ; Luiz Eduardo Gomes Garcia Betting ; Marcelo de Paiva Guimarães ; Marcia Elisabete Morita ; Marcio Luiz Figueredo Balthazar ; Marcondes Cavalcante Franca Junior ; Maria Augusta Santos Montenegro ; Marina Koutsodontis Machado Alvim ; Mateus Henrique Nogueira ; Matthias Koeep ; Norberto Luiz Cabral ; Paulo Henrique Condeixa de França ; Rachel Paes Guimarães ; Raphael Fernandes Casseb ; Ricardo Suyama ; Rickson Coelho Mesquita ; Roberto de Alencar Lotufo ; Roberto Ricardo Panepucci ; Rodrigo Secolin ; Romis Ribeiro de Faissol Attux ; Sara Regina Meira Almeida ; Sarah Negreiros de Carvalho Leite ; Saulo Finco ; Sergio Luiz Novi Junior ; Tamires Araujo Zanão Mariano ; Tátila Martins Lopes ; Thiago Junqueira Ribeiro de Rezende ; Thomas Beltrame ; Vera Regina Toledo Camargo ; Wagner Mauad Avelar ; William Javier Garcia Herrera ; Wu Shin-Ting
Associated grant(s):23/00936-8 - American ACademy of Neurology - 75th Annual Meeting, AR.EXT
22/15882-8 - SPIE Medical Imaging 2023, AR.EXT
22/10175-1 - 17th International Child Neurology Congress - ICNC 2022, AR.EXT
+ associated grants 22/03894-1 - Identifying novel MRI biomarkers of post-stroke epileptogenesis using artificial intelligence., AP.R
22/00597-6 - International harmonisation of clinical and magnetic resonance imaging studies of cognitive impairment in Systemic lupus erythematosus (SLE), AP.R SPRINT
21/12956-8 - Multi-user Equipment approved in grant 2013/07559-3: conversion of achieva 3.0T SmartPath MRI equipment to dStream, including Quasar Dual and PowerSave gradients, AP.EMU
21/02909-2 - Multi-user Equipment approved in grant 2013/07559-3: Bundle Chromium Controller & Next GEM Accessory Kit (Chromium 1000202bundle-10x), AP.EMU
20/13293-0 - Multi-user Equipment approved in grant 2013/07559-3: VICON Motion Capture 3D System, AP.EMU
19/24733-3 - Multi-User Equipment approved in grant 2013/07559-3: Digital PCR machine, AP.EMU
19/23211-3 - Multi-User Equipment approved in grant 2013/07559-3: 4200 TapeStation system, AP.EMU
19/13090-4 - Multi-User Equipment approved in grant 2013/07559-3 -Slide scanner Leica Aperio, AP.EMU
19/09090-9 - Modeling mosaicism in focal cortical dysplasia using cortical organoids, AP.R SPRINT
18/24912-2 - Bridging machine learning and information theory, AP.R SPRINT
17/50404-1 - Modeling focal cortical dysplasia using cortical organoids: looking for new epilepsy therapies, AP.R SPRINT
17/25170-7 - SPIE Medical Imaging 2018, AR.EXT
17/19794-8 - 71st American Epilepsy Society Annual Meeting, AR.EXT
17/06385-2 - Alzheimer's Association International Conference 2017, AR.EXT
16/50486-5 - Brazilian-German collaboration on molecular and histopathological studies on focal cortical dysplasia, AP.R SPRINT
15/23986-4 - SPIE Medical Imaging 2016, AR.EXT
15/18814-0 - 69th American Epilepsy society Annual Meeting, AR.EXT
15/18054-5 - V Eccomas Thematic Conference on Computational Vision and Medical Image Processing, AR.EXT
15/03032-6 - 21st Annual Meeting of the Organization for Human Brain Mapping, AR.EXT
14/14329-7 - SIBGRAPI 2014 - Conference on Graphics, Patterns and Images, AR.BR
13/12481-3 - XXI World Congress of Neurology, AR.EXT - associated grants
Associated scholarship(s):23/16061-0 - Identifying susceptibility loci for mesial temporal epilepsy using an integration of data from ancestry-adjusted genome-wide association and transcriptomics, BP.TT
23/12422-9 - Method for finding low-variability EEG channels for motor imagery detection, BP.PD
23/08802-0 - Neuromodulation combined with other neurotechnologies and evaluation of the somatosensory functionality, BP.PD
+ associated scholarships 23/11024-0 - Functional connectivity changes in neurological patients, BP.DR
23/08579-0 - FUNCTIONAL CHARACTERIZATION OF SODIUM CHANNEL MUTATIONS ASSOCIATED WITH EPILEPSY, BP.TT
23/08705-5 - Molecular and cellular evaluation in antibody-mediated autoimmune encephalitis, BP.TT
23/08470-8 - Clinical and functional evaluation of stroke patients undergoing motor rehabilitation, BP.TT
23/02157-6 - High-field structural and diffusion-weighted MRI in the Pilocarpine Model of Temporal Lobe Epilepsy, BP.PD
23/00983-6 - Use of EEG to investigate the functional connectivity of meditation practitioners, BP.IC
23/02025-2 - Analysis of the structural integrity of temporal structures and the thalamus using T2 magnetic resonance relaxometry in patients with juvenile myoclonic epilepsy, BP.IC
23/02705-3 - Investigation of EEG signals generated using imagined speech for application in BCIs, BP.IC
23/02078-9 - Evaluation of cortical magnetic resonance morphometry in patients with Psychogenic Nonepileptic Seizures, BP.IC
22/14853-4 - Investigation of brain changes in neurological patients with varying degrees of loss of consciousness, BP.MS
22/16477-0 - Investigation of the relationship between adaptive immune response profile and neurological manifestations in patients with SARS-COV-2 infection, BP.TT
22/15274-8 - TECHNICAL TRAINING IN NEXT-GENERATION SEQUENCE EXPERIMENTS, BP.TT
22/11740-4 - CORRELATION BETWEEN HYPOTHALAMUS RELAXOMETRY ALTERATIONS AND FATIGUE AND OTHER SYMPTOMS IN POST-COVID PATIENTS, BP.IC
22/11786-4 - Long COVID: phenotyping and characterization of the functional and structural connectivity in patients with cognitive sequelae from COVID-19, BP.DD
22/12731-9 - Relationship between aura subtypes and areas of extrahippocampal cortical and subcortical atrophy in patients with temporal lobe epilepsy associated with hippocampal sclerosis, BP.IC
21/13725-0 - Mesial Temporal Lobe Epilepsy: A Connectivity Analysis Between Two Distinct Surgical Approaches, BP.IC
22/06777-6 - Effect of resistance training and detraining on cognition, functional and physical performance, and brain parameters in elderly people with mild cognitive impairment., BP.DR
22/08057-0 - Neuromodulation combined with other neurotechnologies for application in the motor rehabilitation of Stroke patients, BP.PD
22/09331-9 - Analysis of seizure frequency over the years in patients with Mesial Temporal Lobe Epilepsy associated with Hippocampal Sclerosis, BP.DD
22/04701-2 - Evaluation of white matter changes in patients with hippocampal sclerosis and correlation with postoperative outcome using diffusion tensor imaging (DTI), BP.MS
22/07393-7 - Neurotechnologies applied to motor rehabilitation of stroke patients, BP.TT
22/04232-2 - The impacts of post-COVID neuropsychiatric symptoms on survivors' workability, BP.IC
22/04970-3 - Relationship between hemodynamic response by EEG coupled to functional magnetic resonance imaging, surgical lacuna and surgical outcome in extratemporal Epilepsies, BP.IC
21/00414-6 - Evaluation of Epilepsy in patients with syndromic craniostenosis, BP.IC
22/02547-6 - Technical Training in Technologies for Isolation of Extracellular Vesicles in Plasma, BP.TT
22/01656-6 - Computational biology applied to neurosciences, BP.TT
21/07050-0 - A motivation-based incremental learning framework for robotics, BP.DR
22/01658-9 - Computational biology applied to multiomics analysis., BP.TT
21/11820-5 - Evaluation of the Effects of Aerobic Physical Exercise Program in Default Mode Network and Hippocampal Connectivity in People with Temporal Lobe Epilepsy and its Relation with Pulmonary Function, BP.IC
21/06289-9 - Relation between interictal epileptiform activity and dynamic functional connectivity in patients with Epilepsy, BP.IC
21/09230-5 - Correlation between white and gray matter changes and Anxiety and Depression symptoms in post-covid-19 patients, BP.IC
21/09724-8 - Bioinformatics applied to multi-omics analyses in the epilepsies, BP.TT
21/06397-6 - Investigation of the stability of functional brain networks obtained from electroencephalography data for application in brain-computer interfaces, BP.MS
21/05173-7 - Statistical considerations about the brain rest state hemodynamics with functional near-infrared spectroscopy, BP.IC
21/04451-3 - Technical training in metabolomic analysis: searching for biomarkers in neurological diseases, BP.TT
21/02300-8 - Patterns of structural neural network abnormalities in children with epileptic encephalopathies, with or without Autism Spectrum disorder symptoms, BP.IC
21/04441-8 - Analysis of molecular biomarkers in patients with stroke., BP.TT
20/16571-0 - Investigation of brain changes in neurological patients undergoing different rehabilitation treatments, BP.DR
21/01017-0 - Multiomics analysis in Neuroscience, BP.PD
20/15666-8 - Unsupervised machine learning applied to decomposition of high-density myoelectric signals, BP.DR
21/00975-8 - Computation biology applied to Neuroscience, BP.PD
20/16800-0 - Integration of a virtual reality scenario with a BCI based on motor imagery for application to rehabilitation of neurological patients, BP.IC
20/10644-6 - Neuromodulation combined with other neurotechnologies for application in motor rehabilitation of stroke patients, BP.PD
20/12651-0 - Histopathological evaluation of glial cells of the white matter and correlation with neuroimaging findings from patients submitted to surgical treatment of Epilepsy in a Brazilian hospital, BP.IC
20/08099-0 - New technologies contribution to the development of executive functions, BP.PD
20/13694-4 - Computation Biology in Genomic Medicine, BP.TT
20/06168-4 - Studying the role of genomic cis-regulatory elements in the mechanisms underlying Mesial Temporal Lobe Epilepsy, BP.DR
20/11184-9 - Development of virtual reality scenarios for upper limbs rehabilitation using a robotic glove and functional electrical stimulation, BP.IC
19/25948-3 - Analysis of synaptosomes isolated from hippocampus tissue of patients with Mesial Temporal Lobe Epilepsy using proteomics and metabolomics, BP.PD
20/04780-4 - Unraveling the molecular mechanisms underlying parasite-host interaction in Taenia solium Neurocysticercosis, BP.PD
19/21964-4 - Lung diseases and COVID diagnosis from computed tomography images using explainable deep learning, BP.DR
20/00019-7 - Advanced analysis of MR imaging in epilepsy to predict surgery outcome: a machine learning approach, BP.PD
20/04032-8 - Gray matter alterations in patients with Huntington Disease and Hintington-Like disease, BP.IC
19/23316-0 - Evaluation of the impact of surgical treatment on motor performance and quality of life of epilepsy patients, BP.IC
19/25281-9 - Obtaining optical and dynamic properties of biological tissues with diffuse optical spectroscopy, BP.DR
19/21962-1 - Investigation of neuroplasticity in the human brain with near-infrared spectroscopy, BP.DD
19/24610-9 - Neuroplasticity after ischemic stroke: a cross-sectional analysis over time, BP.IC
19/14217-8 - Contribution to the study of focused ultrasound transcranial neuromodulation, BP.DR
19/13512-6 - Study of EEG signal processing and analysis and application to epilepsy patients data, BP.IC
19/20953-9 - Technical training in RNA-sequencing for transcriptome studies, BP.TT
19/09512-0 - Nonlinear dynamic functional connectivity analysis via recurrence quantification and its application to brain computer-interfaces, BE.PQ
19/11457-8 - Multifactorial analysis of anxiety disorders and depression in patients with epilepsy and caregivers, BP.MS
19/10653-8 - Development of a haptic feedback device based on electromyography signals and an Arduino, BP.IC
19/12881-8 - Evaluation of motor performance in patients with epilepsy, BP.IC
19/08526-8 - Ancestral genomic architecture evaluation in patients with focal and generalized epilepsy, BP.TT
19/12284-0 - Development of a smart lower limb exoskeleton with innovative human machine interface and simulation in the loop for safe gait generation and foot pose planning, BP.DR
19/00213-0 - Metabolomic analysis from plasma of patients with mesial temporal lobe epilepsy: searching for drug resistant biomarkers, BP.IC
19/01113-0 - Construction and validation of an optical system for brain activity measurements in natural environments, BP.MS
19/08390-9 - MRI quantification of amygdala T2 signal and volume in patients with mesial temporal lobe epilepsy and in patients with depression, BP.IC
19/00048-0 - Metabolic profile of patients with ischemic strokes: research for biomarkers, BP.IC
17/26167-0 - Detection of methylated circulating DNA as a non-invasive biomarker for the identification of patients with mesial temporal lobe epilepsy and ischemic stroke, BP.PD
18/14285-0 - Spectral differences of local field potentials recorded in bilateral subthalamic nuclei of patients with Parkinson's Disease, BP.IC
16/22116-9 - Investigation of the neurofeedback technique using MRI, BP.DR
17/13906-9 - Predictors of functional and structural neuroimaging in conversion of mild cognitive impairment to dementia of Alzheimer's Disease according to AT(N) classification, BP.DR
18/00186-0 - Deep learning for hippocampus segmentation, BP.MS
18/05232-0 - Cerebellar atrophy in neuromyelitis optica spectrum disease (NMOSD) patients, BP.IC
18/03254-7 - Using expression quantitative-trait association studies (eGWAS) to identify loci for mesial temporal lobe epilepsy, BP.PD
17/01900-6 - Identification of the distribution of HLA alleles in the Brazilian population and in neurological phenotypes possibly associated with autoimmunity, BP.PD
18/04100-3 - Deep learning and brain-computer interfaces, BP.MS
17/23954-0 - Methylation pattern of Genomic DNA in mesial temporal lobe epilepsy associated with hippocampal sclerosis, BP.MS
18/00142-3 - Characterization of the intestinal microbiome in patients with different forms of epilepsy and autoimmune encephalitis by metagenomic analysis, BP.DR
18/00151-2 - Assessment of astrogliosis in the hippocampus of Wistar rats with spontaneous ventriculomegaly found by magnetic resonance, BP.IC
15/03695-5 - Application and development of virtual reality tools to complement conventional therapy of stroke patients and evaluation of recovery using brain connectivity through fMRI, BP.PD
17/21174-8 - Enumerative algorithms for biclustering: expanding and exploring their potential in bioinformatics and neuroscience, BP.PD
17/13102-7 - Characterization and Comparison of Bayesian and Deep Learning based Methods for Cerebellar Segmentation, BP.PD
17/13220-0 - Modeling focal cortical dysplasia using cortical organoids: looking for new epilepsy therapies, BP.PD
16/25683-1 - Adjuvant effect of rehabilitation using virtual reality in patients after ischemic stroke, BP.MS
17/10550-9 - To tell or not to tell? Perceptions about the stigma of patients with epilepsy in different situations, BP.IC
17/07267-3 - Voxel based morphometry as technic to improve the detection of focal cortical dysplasia in children with phamacoresistant, BP.IC
17/09451-6 - Investigation of EEG signals generated using motor imagery for application in BCIs, BP.IC
17/10341-0 - Investigation of the neurofeedback technique using MRI, BP.DR
17/04891-8 - Investigating the genetic component of drug resistance in mesial temporal lobe epilepsy: an international multicenter study, BP.PD
16/26172-0 - Searching for blood-based biomarkers to improve the current epilepsy diagnosis, BP.MS
17/00648-1 - Investigating a polygenic effect in genomic data of patients with childhood epileptic encephalopathies (CEE), BP.DR
16/26173-7 - Applications of computational biology advanced techniques for genomic data analysis, BP.PD
17/03186-9 - Neurovascular coupling during functional activation with fNIRS and EEG multimodal approach , BP.IC
15/19768-1 - Searching for mutations associated with focal cortical dysplasia using genomic strategies, BP.DR
16/22990-0 - Assessment of neuroplasticity in the human brain with near-infrared spectroscopy, BP.DD
16/19080-2 - Optimization of epileptic seizure detectors through machine learning techniques, BP.MS
16/10812-0 - Evaluation of individual patterns of functional and structural neural networks in patients with focal epilepsy, BP.MS
16/16355-0 - Topiramate impairs language in patients with epilepsy and migraine: cognitive and functional magnetic resonance assessment, BP.IC
16/19484-6 - Quantitative proteomic analysis of neuronal tissue obtained from patients and animal models of epilepsy, BP.PD
16/04204-8 - Development and optimization of bioinformatics protocols and tools through high-performance computing techniques for use in processing large scale biological data, BP.DR
16/18314-0 - Application and characterization of neural probes, BP.PD
16/10433-0 - Study of functional and structural connectivity and its relationship with memory deficits in patients with mesial temporal lobe epilepsy, BP.DR
15/24233-0 - Relation between the Mental Model and Brain Function measured by Functional Neuroimaging, BP.DR
16/03307-8 - Evaluation of the functional connectivity in brain networks through graph theory analysis and investigation of anxiety and depression in patients with idiopathic generalized epilepsy controlled and refractory to drug treatment, BP.MS
15/25607-0 - Identification of Rare Genomic Variants and microRNAs expression patterns in stroke patients, BP.DR
16/05985-3 - Voxel-based diffusion tensor imaging in patients with focal epilepsies: comparative analyses of microstructural damage and anatomical connectivity between benign and refractory mesial temporal lobe epilepsy and frontal lobe epilepsy, BP.DD
15/19388-4 - T2 relaxometry analysis in contralateral hippocampus after temporal lobe surgery: immediate and long-term evaluation, BP.IC
16/03896-3 - Functional characterization of sodium channel mutations associated with epilepsy, BP.DD
15/23830-4 - Use of virtual reality on stroke patients rehabilitation and evaluation using cerebral connectivity, BP.TT
14/25358-8 - 3T-MRI analysis of temporal lobe after transsylvian approach for the epilepsy surgical treatment, BP.IC
15/09075-9 - Longitudinal Structural and Functional connectivity analyzes in Parkinson' Disease, BP.PD
15/10228-4 - Multimodal evaluation of grey and white matter in patients with generalized epilepsy according to seizure control, BP.IC
15/12960-4 - Proteomic analysis of hippocampal tissues obtained from patients and animal model of Mesial Temporal Lobe Epilepsy: a comparative study, BP.DR
15/11338-8 - Implementation of a 3D method for computing texture parameters originated from the cooccurrence matrix in MR images, BP.IC
15/10331-0 - DTI analysis and visual perimetry after surgery for temporal lobe Epilepsy, BP.IC
15/06163-4 - The relationship of cerebral and cognitive reserves in the connectivity of neurofunctional networks in Alzheimer's Disease patients, considering the APOE 4 allele and cerebrospinal fluid biomarkers, BP.PD
15/14994-3 - Development of a brain-computer interface based in motor imagery using OpenViBE, BP.IC
15/17066-0 - Relationship between inflammatory markers and hippocampal and extra-hippocampal atrophy patterns in patients with temporal lobe epilepsy, BP.DD
15/07868-1 - Epileptic encephalopathies, BP.IC
15/10369-7 - Volumetric analysis of contralateral hippocampus after temporal lobe surgery: short-term and long-term evaluation, BP.IC
14/25486-6 - Construction and evaluation of a frequency-domain diffuse optical spectroscopy device for brain monitoring in the clinic, BP.DR
15/00576-5 - Structure and dynamics of near-infrared spectroscopy data during the basal state with complex networks, BP.IC
13/26353-7 - Relation between the organization method of 5S and brain activation measured by magnetic resonance imaging, BP.MS
14/11125-1 - Co-clustering in ensembles of collaborative filters, BP.MS
14/10911-3 - Healthcare delivery for stroke, BE.PQ
14/01187-0 - Treatment gap in Epilepsy: new insight from analysis of diagnosis gap, BP.IC
13/24932-0 - Identifying Copy Number Variations (CNVs) and Epigenetic Changes in Patients with Stroke, BP.MS
13/25782-1 - Molecular Studies of mTOR and Tau pathways in Focal Cortical Dysplasia, BP.MS
13/19151-9 - EXPLORING DIFFERENT THERAPEUTIC APPROACHES FOR SEIZURE SUPPRESSION USING THE ZEBRAFISH MODEL, BP.DR
13/19524-0 - Genetic association studies in mesial temporal lobe epilepsy and stroke, BP.PD
13/06381-6 - Study of the variation of the GABA neurotransmitter during visual stimulation using functional magnetic resonance spectroscopy, BP.IC
13/18775-9 - Use of zebrafish as an animal model for the study of genetic epilepsies, BP.PD
13/16273-6 - Characterization of texture parameters in MR brain images of healthy individuals, BP.IC
13/21265-2 - Comparison of prevalence of neurocysticercotic calcifications on CT scan in patients with epilepsy and patients with headache, BP.IC
13/23482-0 - Development of a feedback interface for brain computer interface systems based on motor imagery, BP.IC
13/18734-0 - Investigation of the combined use of the techniques electroencephalography and optical spectroscopy for application in brain-computer interface systems, BP.IC
13/00099-7 - EEG-fMRI in the pre-operatory evaluation of patients with focal refractory epilepsies, BP.PD
11/09113-7 - Environments for supporting the navigation of assistive mobile robots, BP.PD
09/17130-9 - Diffusion tensor images segmentation in the context of mathematical morphology, BP.PD - associated scholarships

Abstract

The central biological questions of our RIDC is the investigation of basic mechanisms that lead to epilepsy and stroke and the injury mechanisms that follow the disease onset and progression, and are related to prevention, treatment and rehabilitation. Our goals are to develop new methods and techniques to improve the understanding of mechanisms of damage, plasticity and repair in epilepsy and stroke, and to apply these results to improve diagnosis, prevention and treatment. The main motivation of this project carne from the necessity of approaching these relevant and complex biological problems by combining the expertise of research groups with distinct and complementary backgrounds. One of the multiple aspects revealing the characteristic complexity associated with research on epilepsy and stroke is the fact that such conditions are not uniquely defined, i.e.it cannot be related to a single disease or a unique syndrome. Such a multiplicity of biological factors related to the etiology, symptomatology, prevention and treatment of epilepsy and stroke indicate the need of collaborative research in different areas of expertise. These are the main motivations for the organization of the present RIDC. Moreover, this initiative foresees the creation of a new environment for scientific and technological development, new clinical applications, education and interaction with the business sector. Our proposal will be driven by strong and relevant hypotheses, not only by advances in technology (i.e., it will not be only a method in search of a problem). The research for the development of new technology and improvement of current technology will be driven by solid scientific grounds and social needs in order to provide relevant application in the real world. This research proposal is outstanding as it is clinically important, realistic and scientifically highly original, combining genetics, neurobiology, pharmacology, neuroimaging, computer sciences, robotics, physics and engineering. Results will benefit patients with epilepsy, stroke and other prevalent diseases, and contribute substantially to ongoing scientific discussions within neurology, psychiatry, and cognitive neuroscience. The proposed collaborations between our RIDC and other major neuroscience centers outlined in the list of external collaborators will further advance knowledge directly relevant to all people suffering from devastating neurological conditions. (AU)

Articles published in Pesquisa FAPESP Magazine about the research grant:
Epilepsia <em>in vitro</em> 
Epilepsy <em>in vitro</em> 
Las marcas de la epilepsia 
Signs of Epilepsy 
Persistent minds 
Mentes que persisten 
Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
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VEICULO: TITULO (DATA)

Scientific publications (253)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
S.R.M. ALMEIDA; C.A. STEFANO FILHO; J. VICENTINI; S.L. NOVI; R.C. MESQUITA; G. CASTELLANO; L.M. LI. Modeling functional network topology following stroke through graph theory: functional reorganization and motor recovery prediction. Brazilian Journal of Medical and Biological Research, v. 55, . (16/22116-9, 17/10341-0, 13/07559-3)
LOPES-RAMOS, C. M.; PEREIRA, T. C.; DOGINI, D. B.; GILIOLI, R.; LOPES-CENDES, I.. Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease. Brazilian Journal of Medical and Biological Research, v. 49, n. 12, . (13/07559-3)
DAMASCENO, ALFREDO; DAMASCENO, BENITO PEREIRA; CENDES, FERNANDO. The Clinical Impact of Cerebellar Grey Matter Pathology in Multiple Sclerosis. PLoS One, v. 9, n. 5, . (13/07559-3, 10/00885-4)
CAMPOS, BRUNNO M.; COAN, ANA C.; BELTRAMINI, GUILHERME C.; LIU, MIN; YASSUDA, CLARISSA L.; GHIZONI, ENRICO; BEAULIEU, CHRISTIAN; GROSS, DONALD W.; CENDES, FERNANDO. White matter abnormalities associate with type and localization of focal epileptogenic lesions. Epilepsia, v. 56, n. 1, p. 125-132, . (13/07559-3, 13/00099-7)
BOMBINI, MARIANA FRESCHI; PERES, FERNANDO AUGUSTO; LAPA, ALINE TAMIRES; SINICATO, NAILU ANGELICA; QUENTAL, BEATRIZ RICATO; MELO PINCELLI, AGATHA DE SOUZA; AMARAL, TIAGO NARDI; GOMES, CAROLINE CRISTINA; DEL RIO, ANA PAULA; MARQUES-NETO, JOAO FRANCISCO; et al. Olfactory function in systemic lupus erythematosus and systemic sclerosis. A longitudinal study and review of the literature. AUTOIMMUNITY REVIEWS, v. 17, n. 4, p. 405-412, . (11/03788-2, 08/02917-0, 13/07559-3)
DE OLIVEIRA, SUELEN ROSA; CABRAL DE PAULA MACHADO, ANA CAROLINA; DE PAULA, JONAS JARDIM; PAIVA DE MORAES, PAULO HENRIQUE; SILVERIO NAHIN, MARIA JULIANA; MAGALHAES, LIVIA DE CASTRO; NOVI, SERGIO L.; MESQUITA, RICKSON C.; DE MIRANDA, DEBORA MARQUES; FERRAREZ BOUZADA, MARIA CANDIDA. Association between hemodynamic activity and motor performance in six-month-old full-term and preterm infants: a functional near-infrared spectroscopy study. NEUROPHOTONICS, v. 5, n. 1, . (12/02500-8, 13/07559-3)
SILVA, DANILO S.; AVELAR, WAGNER M.; DE CAMPOS, BRUNNO M.; LINO, ANA PAULA B. L.; BALTHAZAR, MARCIO L. F.; FIGUEIREDO, MARCIO J. O.; CENDES, FERNANDO; COAN, ANA CAROLINA. Default Mode Network Disruption in Stroke-Free Patients with Atrial Fibrillation. CEREBROVASCULAR DISEASES, v. 45, n. 1-2, p. 78-84, . (13/00099-7, 13/07559-3)
DOGINI, DANYELLA B.; AVANSINI, SIMONI H.; VIEIRA, ANDRE S.; LOPES-CENDES, ISCIA. MicroRNA regulation and dysregulation in epilepsy. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 7, . (13/07559-3)
BENTO, MARIANA; DE SOUZA, ROBERTO; LOTUFO, ROBERTO; FRAYNE, RICHARD; RITTNER, LETICIA; CRIMI, A; BAKAS, S; KUIJF, H; MENZE, B; REYES, M. WMH Segmentation Challenge: A Texture-Based Classification Approach. BRAINLESION: GLIOMA, MULTIPLE SCLEROSIS, STROKE AND TRAUMATIC BRAIN INJURIES, BRAINLES 2017, v. 10670, p. 12-pg., . (13/07559-3, 12/21826-1)
PINHEIRO, GUSTAVO R.; COVER, GIOVANA S.; BENTO, MARIANA P.; RITTNER, LETICIA; GIMI, B; KROL, A. Automatic Callosal Fiber Convergence Plane Computation through DTI-based Divergence Map. MEDICAL IMAGING 2018: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING, v. 10578, p. 9-pg., . (13/07559-3)
SANTOS, RENATO O.; SECOLIN, RODRIGO; BARBALHO, PATRICIA G.; SILVA-ALVES, MARIANA S.; ALVIM, MARINA K. M.; YASUDA, CLARISSA L.; ROGERIO, FABIO; VELASCO, TONICARLO R.; SAKAMOTO, AMERICO C.; TEIXEIRA, ANTONIO L.; et al. Multidimensional Approach Assessing the Role of Interleukin 1 Beta in Mesial Temporal Lobe. FRONTIERS IN NEUROLOGY, v. 12, . (19/08526-8, 13/07559-3)
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DISPOSITIVO PARA O CONTROLE DE QUALIDADE DE IMAGENS DO TENSOR DE DIFUSÃO, DE IMAGENS PONDERADAS POR DIFUSÃO PARA RECONSTRUÇÃO DE IMAGENS DE TRATOS E FIBRAS E DE OUTROS PARÂMETROS EM RESSONÂNCIA MAGNÉTICA BR1020170191214 - Universidade Estadual de Campinas (UNICAMP) . Edna Marina De Souza ; Gabriela Castellano ; Eduardo Tavares Costa - September 2017, 06

SISTEMA DE CONTROLE DE PRÓTESE E MÉTODO DE FUNCIONAMENTO DO MESMO BR1020180677500 - Universidade Estadual de Campinas (UNICAMP) . ERIC ROHMER / DANDARA THAMILYS GUEDES DE ANDRADE - September 2018, 04

inCCsight BR512021000281-4 - Universidade Estadual de Campinas (UNICAMP) . Leticia Rittne ; Thais de Oliveira Caldeira ; Simone Appenzeller ; Paulo Rogério Julio ; Renan Bazuco Frittoli - February 2021, 19

APLICATIVO ADOLESCENTES BR512021001141-4 - Sociedade Campineira de de Educação e Instrução ; Universidade Estadual de Campinas (UNICAMP) . Lilia Freire Rodrigues de Souza Li ; Ricardo Rodrigues Nunes ; Sérgio Lourenço Polo Filho ; Thaís Tawil ; Letícia Mansano de Souza - May 2021, 28