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Effects of cholecalciferol on modulation of expression of toll-like receptors (TLR-7 e TLR-9) and IL-6 e INF-gamma production in the b cells in uremia

Grant number: 12/21345-3
Support Opportunities:Regular Research Grants
Duration: May 01, 2013 - April 30, 2015
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Miguel Cendoroglo Neto
Grantee:Miguel Cendoroglo Neto
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


mortality and morbidity, respectively among patients with chronic kidney disease (CKD).Previous studies have reported several alterations in immune cells, which contribute toincrease incidence of CV and infectious diseases observed in this population.Biocompatibility of dialysis membrane and uremic toxins are the main factorsassociated with immune dysfunction in uremia. Furthermore, the Vitamin D deficiency isalso associated with immunologic co-morbidities that are present in CKD. Vitamin Ddeficiency is highly prevalent among patients with all stages of CKD, but it is greater inperitoneal dialysis (PD) patients than the hemodialysis (HD) and pre-dialysis CKD patients.As the vitamin D receptor is expressed in the immune cells (B cells, T cells and others),and these cells are able to synthesizing the active vitamin D metabolite, many studieshave investigated the role of vitamin D in the immune system. In this regard, previousstudies have reported that vitamin D inhibits the TLR-induced cytokines production,including IFN- and IL-6. Thus, the purpose or this study is evaluate the effect ofcholecalciferol treatment therapy on apoptosis, IFN- and IL-6 production, TLR-7 and TLR-9 expression in lymphocytes B in vitro and in vivo. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GIFFONI DE CARVALHO, JOSE TARCISIO; SCHNEIDER, MARION; CUPPARI, LILIAN; GRABULOSA, CAREN CRISTINA; CENDOROGLO, MIGUEL; DALBONI, MARIA APARECIDA. Cholecalciferol Supplementation Did Not Change Interleukin-7 and B cell-Activating Factor Levels and CD95 Expression in B lymphocytes in Patients on Dialysis: A Randomized Pilot-Controlled Trial. JOURNAL OF RENAL NUTRITION, v. 29, n. 5, p. 454-461, . (12/21345-3, 12/19314-2)
CARVALHO, JOSE TARCISIO G.; SCHNEIDER, MARION; CUPPARI, LILIAN; GRABULOSA, CAREN C.; AOIKE, DANILO T.; REDUBLO, BEATA MARIE Q.; BATISTA, MARCELO C.; CENDOROGLO, MIGUEL; MOYSES, ROSA MARIA; DALBONI, MARIA APARECIDA. Cholecalciferol decreases inflammation and improves vitamin D regulatory enzymes in lymphocytes in the uremic environment: A randomized controlled pilot trial. PLoS One, v. 12, n. 6, . (12/21345-3, 12/19314-2)

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