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Effect of nutritional intervention and resistance training in ovariectomized rats and/or in rats subjected to an intense workout protocol

Grant number: 12/21087-4
Support Opportunities:Regular Research Grants
Duration: May 01, 2013 - October 31, 2015
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Julio Orlando Tirapegui Toledo
Grantee:Julio Orlando Tirapegui Toledo
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Gilberto Eiji Shiguemoto


It is well known that regular moderate exercise brings benefit to health. Thus, the RE is an effective intervention for menopausal women, given the fact that these women have increased body fat and inflammatory indicators that can lead to insulin resistance, osteoporosis and development of other chronic diseases.However, the practice of excessive exercise or training with high intensity and volume, with limited recovery periods (overreaching) can damage health. In these situations occur severe muscular injuries, and chronic systemic inflammation that can reduce performance, compromising the athlete's health and lead to the development of the syndrome of super training.Thus, we note that the practice of RE is related both to the improvement of health and quality of life, and in the same subject, this depends on the shape and intensity in which it is practiced. Thus, nutritional intervention is an ally of paramount importance for the practitioner to exercise, because the choice of an appropriate diet and mainly promotes a balanced improvement in their physiological response and performance. Therefore, this project aims to evaluate both the effect of nutritional intervention through caloric restriction in ovariectomized rats practitioners resistance training, as nutritional intervention through supplementation of L-glutamine in rats subjected to intense resistance training. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COQUEIRO, AUDREY YULE; RAIZEL, RAQUEL; BONVINI, ANDREA; GODOIS, ALLAN DA MATA; HYPOLITO, THAIS MENEZES; ROCHA PEREIRA, JESSICA RAMOS; ROGERO, MARCELO MACEDO; TIRAPEGUI, JULIO. Effects of Glutamine and Alanine Supplementation on Adiposity, Plasma Lipid Profile, and Adipokines of Rats Submitted to Resistance Training. JOURNAL OF DIETARY SUPPLEMENTS, v. 16, n. 6, p. 13-pg., . (12/21087-4)
RAIZEL, RAQUEL; MOREIRA LEITE, JAQUELINE SANTOS; HYPOLITO, THAIS MENEZES; COQUEIRO, AUDREY YULE; NEWSHOLME, PHILIP; CRUZAT, VINICIUS FERNANDES; TIRAPEGUI, JULIO. Determination of the anti-inflammatory and cytoprotective effects of L-glutamine and L-alanine, or dipeptide, supplementation in rats submitted to resistance exercise. BRITISH JOURNAL OF NUTRITION, v. 116, n. 3, p. 470-479, . (12/21087-4, 15/00446-4)
DE SOUZA LINO, ANDERSON DIOGO; VIANNA, DAIANA; OISHI, JORGE CAMARGO; CAMPOS SOUZA, MARKUS VINICIUS; RUFFONI, LEANDRO DIAS; MARIN, CECILIA TARDIVO; DA SILVA DE AVO, LUCIMAR RETTO; DE ANDRADE PEREZ, SERGIO EDUARDO; RODRIGUES, GERSON JHONATAN; TIRAPEGUI, JULIO; et al. Resistance training and caloric restriction prevent systolic blood pressure rise by improving the nitric oxide effect on smooth muscle and morphological changes in the aorta of ovariectomized rats. PLoS One, v. 13, n. 8, . (12/21087-4)
TIRAPEGUI, JULIO; RAIZEL, RAQUEL; COQUEIRO, AUDREY; BONVINI, ANDREA; HYPOLITO, THAIS; GARCIA, AMANDA; LARA, RAFAEL. L-glutamine and L-alanine Improve Energy Status and Skeletal Muscle Cytoprotection in Rats Submitted to Heavy Resistance Exercise. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 50, n. 5, p. 1-pg., . (12/21087-4)
COQUEIRO, AUDREY Y.; RAIZEL, RAQUEL; BONVINI, ANDREA; TIRAPEGUI, JULIO; ROGERO, MARCELO M.. Probiotics for inflammatory bowel diseases: a promising adjuvant treatment. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, v. 70, n. 1, p. 20-29, . (12/21087-4)
MOREIRA LEITE, JAQUELINE SANTOS; RAIZEL, RAQUEL; HYPOLITO, THAIS MENEZES; ROSA, THIAGO DOS SANTOS; CRUZAT, VINICIUS FERNANDES; TIRAPEGUI, JULIO. L-glutamine and L-alanine supplementation increase glutamine-glutathione axis and muscle HSP-27 in rats trained using a progressive high-intensity resistance exercise. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM, v. 41, n. 8, p. 842-849, . (12/21087-4, 15/00446-4)
AUDREY YULE COQUEIRO; RAQUEL RAIZEL; THAÍS MENEZES HYPÓLITO; JULIO TIRAPEGUI. Efeitos da suplementação com L-glutamina e L-alanina na composição corporal de ratos submetidos ao exercício resistido. Rev. Bras. Ciênc. Esporte, v. 39, n. 4, p. 417-423, . (12/21087-4)

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