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Machine learning for molecular systems biology (MLMSB) application on synthetic lethality, conditionally essential genes and cooperative transcription

Grant number: 13/02018-4
Support Opportunities:Regular Research Grants
Duration: April 01, 2013 - March 31, 2015
Field of knowledge:Biological Sciences - Biophysics - Biophysics of Processes and Systems
Principal Investigator:Ney Lemke
Grantee:Ney Lemke
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated researchers:Jose Luiz Rybarczyk Filho


The development of high-throughput techniques in biology is transforming biology in a data-rich discipline. We will consider in this project integrated biological networks: these networks deal with all the gene interactions mediated by metabolism, regulation and protein-protein interactions. We will deploy machine learning tools that will use topological data from these graphs, expression data, genomic organization and cellular localization to extract relevant biological information such as detection of drug target genes, morbid genes for humans or essential genes for bacteria. In this project we will use these information to investigate the influence of topological properties on synthetic lethality and conditionally essential genes. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KANDOI, GAURAV; ACENCIO, MARCIO L.; LEMKE, NEY. Prediction of Druggable Proteins Using Machine Learning and Systems Biology: A Mini-Review. FRONTIERS IN PHYSIOLOGY, v. 6, . (13/02018-4)
ACENCIO, MARCIO LUIS; BOVOLENTA, LUIZ AUGUSTO; CAMILO, ESTHER; LEMKE, NEY. Prediction of Oncogenic Interactions and Cancer-Related Signaling Networks Based on Network Topology. PLoS One, v. 8, n. 10, . (13/02018-4, 12/00741-8, 10/20684-3, 12/13450-1)
FERNANDES DE SOUZA, RAFAEL TOLEDO; LEWCZUK GERHARDT, GUENTHER JOHANNES; SCHOENWALD, SUZANA VEIGA; RYBARCZYK-FILHO, JOSE LUIZ; LEMKE, NEY. Synchronization and Propagation of Global Sleep Spindles. PLoS One, v. 11, n. 3, . (13/02018-4, 12/22413-2)
POLLO-OLIVEIRA, LETICIA; POST, HARM; ACENCIO, MARCIO LUIS; LEMKE, NEY; VAN DEN TOORN, HENK; TRAGANTE, VINICIUS; HECK, ALBERT J. R.; ALTELAAR, A. F. MAARTEN; YATSUDA, ANA PATRICIA. Unravelling the Neospora caninum secretome through the secreted fraction (ESA) and quantification of the discharged tachyzoite using high-resolution mass spectrometry-based proteomics. PARASITES & VECTORS, v. 6, . (13/02018-4, 10/20684-3)
VALENTE, GUILHERME T.; ACENCIO, MARCIO L.; MARTINS, CESAR; LEMKE, NEY. The Development of a Universal In Silico Predictor of Protein-Protein Interactions. PLoS One, v. 8, n. 5, . (13/02018-4, 09/05234-4)
ZHANG, XUE; ACENCIO, MARCIO LUIS; LEMKE, NEY. Predicting Essential Genes and Proteins Based on Machine Learning and Network Topological Features: A Comprehensive Review. FRONTIERS IN PHYSIOLOGY, v. 7, . (13/02018-4)
CAMILO, ESTHER; BOVOLENTA, LUIZ A.; ACENCIO, MARCIO L.; RYBARCZYK-FILHO, JOSE L.; CASTRO, MAURO A. A.; MOREIRA, JOSE C. F.; LEMKE, NEY. GALANT: a Cytoscape plugin for visualizing data as functional landscapes projected onto biological networks. Bioinformatics, v. 29, n. 19, p. 2505-2506, . (13/02018-4, 12/00741-8, 10/20684-3, 12/13450-1)

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