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Sodium chloride overload or restriction during pregnancy: cardiac and renal structural alterations in the neonate

Grant number: 13/00458-7
Support Opportunities:Regular Research Grants
Duration: April 01, 2013 - March 31, 2016
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Joel Claudio Heimann
Grantee:Joel Claudio Heimann
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Several epidemiological studies show that hypertension in adulthood is associated with the mother's diet during pregnancy. In humans, the reduced number of glomeruli is related to hypertension, cardiovascular disease and kidney disease in adulthood. In our laboratory, Alves-Rodrigues Jr. studied the adult male offspring from Wistar rats which were fed a low salt diet (HO- 0,15% NaCl), normal salt diet ( NR-1,3% NaCl) or high salt diet (HR-8% NaCl) during pregnancy. In this study we observed that the adult male offspring from mothers who received high salt diet during pregnancy have developed left ventricular hypertrophy in adulthood in response to chronic salt diet intake, independent of high blood pressure. Using the same experimental model, this project aims to study the structure of the heart and kidney of the offspring at birth . It will also be evaluate the expression of components rennin- angiotensin system in the heart and kidney by the method of immunohistochemistry. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SERAVALLI, PRISCILA; ZAGO, BRENO CALAZANS; DE OLIVEIRA, IVONE BRAGA; VERAS, MARIANA MATERA; HEIMANN, JOEL. Newborn cardiac structural alterations in response to salt restriction or overload during pregnancy. FASEB JOURNAL, v. 30, p. 2-pg., . (13/00458-7)
SERAVALLI, PRISCILA; DE OLIVEIRA, IVONE BRAGA; ZAGO, BRENO CALAZANS; DE CASTRO, ISAC; VERAS, MARIANA MATERA; ALVES-RODRIGUES, EDSON NOGUEIRA; HEIMANN, JOEL C.. High and Low Salt Intake during Pregnancy: Impact on Cardiac and Renal Structure in Newborns. PLoS One, v. 11, n. 8, . (13/00458-7)

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