Research Grants 12/13411-6 - Patologia bucal, Neoplasias bucais - BV FAPESP
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The role of podoplanin in the process of cellular remodelling in benign odontogenic tumors and oral malignant epithelial tumors

Abstract

The association of podoplanin with ezrin, moesin, and RhoA in the process of cellular remodeling has been suggested but has not been investigated.The aim of this study is to verify the possible correlation between the expression of podoplanin with ezrin, moesin, and RhoA's in two distinct types of oral neoplasias: benign odontogenic tumors (ameloblastomas, keratocystic odontogenic tumors, adenomatoid odontogenic tumors,calcifying epithelial odontogenic tumors, ameloblastic fibromas,ameloblastic fibro-odontomas, and calcifying cystic odontogenic tumors) and lip squamous cell carcinomas. The sample will be constituted by odontogenic tumors stored in the Pathologic Anatomy Service of the Department of Stomatology from Bauru School of Dentistry and by lip squamous cell carcinomas treated in the Department of Head and Neck Surgery and Otorhinolaryngology of the A.C. Camargo Hospital, São Paulo. The tumoral specimens will be immunohistochemically analyzed with anti-podoplanin, anti-ezrin, anti-moesin, and anti-RhoA antibodies by a semi-quantitative scoring method. The association between the staining of the proteins with demographic, clinic and microscopic variables will be analyzed by the Chi-square or Fischer's test. To verify the association between podoplanin expression with ezrin, moesin and RhoA expression, Mann-Whitney or Kruskal-Wallis test will be performed. The survival rates (overall and disease-free survival) will be calculated by the Kaplan-Meier method and the comparison of the survival curves will be performed using log-rank test. In all tests, p values lesser than 0.05 will be considered statistically significant. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ASSAO, AGNES; NONOGAKI, SUELY; PEREIRA LAURIS, JOSE ROBERTO; CARVALHO, ANDRE LOPES; LOPES PINTO, CLOVIS ANTONIO; SOARES, FERNANDO AUGUSTO; KOWALSKI, LUIZ PAULO; OLIVEIRA, DENISE TOSTES. Podoplanin, ezrin, and Rho-A proteins may have joint participation in tumor invasion of lip cancer. CLINICAL ORAL INVESTIGATIONS, v. 21, n. 5, p. 1647-1657, . (12/13411-6, 13/16999-7)
OLIVEIRA, DENISE TOSTES; DE SANTIS, LAIS PRISCILA; ASSAO, AGNES; TJIOE, KELLEN CRISTINE; NONOGAKI, SUELY; PEREIRA LAURIS, JOSE ROBERTO; SOARES, FERNANDO AUGUSTO. The relationship between ezrin and podoplanin expressions in keratocystic odontogenic tumors. BMC ORAL HEALTH, v. 14, . (12/13411-6, 13/16999-7)
COSTA, Y. F.; TJIOE, K. C.; NONOGAKI, S.; SOARES, F. A.; LAURIS, J. R. PEREIRA; OLIVEIRA, D. TOSTES. Are podoplanin and ezrin involved in the invasion process of the ameloblastomas?. EUROPEAN JOURNAL OF HISTOCHEMISTRY, v. 59, n. 1, p. 39-44, . (12/08278-5, 12/13411-6)
ABREU BARROS, FRANCISCO BARBARA; ASSAO, AGNES; GARCIA, NATALIA GALVAO; NONOGAKI, SUELY; CARVALHO, ANDRE LOPES; SOARES, FERNANDO AUGUSTO; KOWALSKI, LUIZ PAULO; OLIVEIRA, DENISE TOSTES. Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer. BMC CANCER, v. 18, . (12/13411-6)
ANTONIO, PAULA NASCIMENTO; GARCIA, NATALIA GALVAO; ASSAO, AGNES; PEREIRA LAURIS, JOSE ROBERTO; SOARES, FERNANDO AUGUSTO; OLIVEIRA, DENISE TOSTES. Immunoexpression of proteins involved in cytoskeleton remodeling in benign odontogenic lesions. ARCHIVES OF ORAL BIOLOGY, v. 87, p. 151-156, . (12/13411-6)
ASSAO, AGNES; YOSHINO, PAULA MIDORI; MALTA MEDEIROS, MARIA CAROLINA; CARVALHO, ANDRE LOPES; SOARES, FERNANDO AUGUSTO; KOWALSKI, LUIZ PAULO; OLIVEIRA, DENISE TOSTES. Moesin Involvement in Oral Carcinogenesis of the Lower Lip. ANTICANCER RESEARCH, v. 38, n. 5, p. 2755-2760, . (14/23236-2, 12/13411-6)
GARCIA, ALEXANDRE SIMOES; ASSAO, AGNES; CARVALHO, ANDRE LOPES; SOARES, FERNANDO AUGUSTO; KOWALSKI, LUIZ PAULO; OLIVEIRA, DENISE TOSTES. The stem cell markers expression CD44v6 and podoplanin in lip cancer: clinical significance. Virchows Archiv, v. 474, n. 6, p. 745-754, . (12/13411-6)

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