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Th17 response and apoptosis in the evolution of Sporothrix schenckii-induced infection

Abstract

Sporotrichosis is commonly caused by traumatic inoculation of thermo-dimorphic fungus Sporothrix schenckii in the skin or subcutaneous tissues, as a zoonosis from animal scratches or injuries involving soil. Previous studies on a sporotrichosis animal model showed an increased host susceptibility period during infection's acute phase with depressed immune response. This susceptibility has been associated to the inflammatory process exacerbation and apoptosis induction on immune cells by the invading pathogen. Apoptosis has probably evolved as a host protection mechanism, exposing the intracellular pathogen to the immune system and preventing the pathogen to use the cell as a way to evade the response. Adding to that, there's evidence that the simultaneous recognition of PAMPs (pathogen-associated molecular patterns) and apoptotic cell debris generate a cytokine profile capable of promoting Th17 cells differentiation, whose primary function seems to be the elimination of pathogens not adequately handled by Th1 and Th2 cells. Recently we showed that dendritic cells exposed to S. schenckii antigens are able to promote a Th1/Th17 in vitro response. That said, we propose to evaluate the Th17 response and apoptosis involvement during S. schenckii infection, for these are important mechanisms, strategic to this disease understanding and to the establishment of an effective treatment. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JELLMAYER, JULIANA APARECIDA; FERREIRA, LUCAS SOUZA; MANENTE, FRANCINE ALESSANDRA; GONCALVES, AMANDA COSTA; POLESI, MARISA CAMPOS; BATISTA-DUHARTE, ALEXANDER; CARLOS, IRACILDA ZEPPONE. Dectin-1 expression by macrophages and related antifungal mechanisms in a murine model of Sporothrix schenckii sensu stricto systemic infection. Microbial Pathogenesis, v. 110, p. 78-84, SEP 2017. Web of Science Citations: 11.
PORTUONDO, DEIVYS LEANDRO; BATISTA-DUHARTE, ALEXANDER; FERREIRA, LUCAS SOUZA; MARTINEZ, DAMIANA TELLEZ; POLESI, MARISA CAMPOS; DUARTE, ROBERTA APARECIDA; ALVES DE PAULA E SILVA, ANA CAROLINA; MARCOS, CAROLINE MARIA; FUSCO DE ALMEIDA, ANA MARISA; CARLOS, IRACILDA ZEPPONE. A cell wall protein-based vaccine candidate induce protective immune response against Sporothrix schenckii infection. Immunobiology, v. 221, n. 2, p. 300-309, FEB 2016. Web of Science Citations: 27.
FERREIRA, LUCAS SOUZA; GONCALVES, AMANDA COSTA; PORTUONDO, DEIVYS LEANDRO; GERALDO MAIA, DANIELLE CARDOSO; POLESI PLACERES, MARISA CAMPOS; BATISTA-DUHARTE, ALEXANDER; CARLOS, IRACILDA ZEPPONE. Optimal clearance of Sporothrix schenckii requires an intact Th17 response in a mouse model of systemic infection. Immunobiology, v. 220, n. 8, p. 985-992, AUG 2015. Web of Science Citations: 24.

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