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Analysis of miRNAs involved in regulation of MMP2 and MMP9 and its implication of this regulators and regulating the process of cell migration and invasion of the prostate adenocarcinoma

Grant number: 12/21833-8
Support type:Regular Research Grants
Duration: March 01, 2013 - February 28, 2015
Field of knowledge:Health Sciences - Medicine - Surgery
Principal researcher:Sabrina Thalita dos Reis Faria
Grantee:Sabrina Thalita dos Reis Faria
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Kátia Ramos Moreira Leite


Prostate cancer displays a peculiar biology with a high prevalence and low incidence clinic. The discovery and use of tumor markers have positively influenced early detection, diagnosis and staging of a number of neoplasias. The search and identification of new markers in PCa has been reason research in several laboratories, including ours (LIM 55), and promising results have been reported. Among the promising markers are the genes belonging to the family of matrix metalloproteinase. Matrix metalloproteinase (MMP) are proteins belonging to a family of about thirty endoproteinases or proteolytic enzymes that degrade several extracellular matrix components. Recently, a new class of regulatory molecules were described, micro RNA. miRNA is endogenous small molecule, non-protein coding, single-stranded, consisting of 19-25 nucleotides which belong to a new class of potent post-transcriptional regulators of gene expression. In our previous work group identified changes in gene expression MMP-2, MMP-9, TIMP-1, TIMP-2, RECK, MMP-14, and moreover, an association of expression with classical prognosis factors of prostate cancer. Knowing the importance of these genes in prostate carcinogenesis, we decided to evaluate the role of microRNAs in regulating these genes and the implication of this regulation in cell migration and invasion. We emphasize that there are no studies in the literature involving MMP and miRNAs in prostate carcinoma, demonstrating the originality of this study. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
IVANOVIC, RENATO F.; VIANA, NAYARA I.; MORAIS, DENIS R.; SILVA, IRAN A.; LEITE, KATIA R.; PONTES-JUNIOR, JOSE; INOUE, GUSTAVO; NAHAS, WILLIAM C.; SROUGI, MIGUEL; REIS, SABRINA T.. miR-29b enhances prostate cancer cell invasion independently of MMP-2 expression. CANCER CELL INTERNATIONAL, v. 18, . (15/00845-6, 12/21833-8)
IVANOVIC, RENATO F.; VIANA, NAYARA I.; MORAIS, DENIS R.; MOURA, CAIO; SILVA, IRAN A.; LEITE, KATIA R.; PONTES-JUNIOR, JOSE; NAHAS, WILLIAM C.; SROUGI, MIGUEL; REIS, SABRINA T.. miR-618: possible control over TIMP-1 and its expression in localized prostate cancer. BMC CANCER, v. 18, . (15/00845-6, 12/21833-8)

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