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Vouacapans and geranilgeraniol synergic effect evaluation on nociceptive pain, pharmacokinetic and preclinical toxicological studies

Grant number: 12/19661-4
Support Opportunities:Regular Research Grants
Duration: March 01, 2013 - February 28, 2015
Field of knowledge:Health Sciences - Pharmacy - Medicines Analysis and Control
Principal Investigator:Mary Ann Foglio
Grantee:Mary Ann Foglio
Host Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil
Associated researchers:João Ernesto de Carvalho

Abstract

This proposal is a continuation of our previous research work that identified geranylgeraniol and voucapan compounds as the major active principles involved with the antinociceptive activity. The studies proposed herein will permit to establish the sinergic relationships that take place, undergo pharmacokinetic studies of the pure compounds to further establish conditions to study the pharmakcokinetics of the standarized extract. Also preclinical cronic toxicity studies will be undertaken to establish safety doses to be employed. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE PAIVA, PAULA P.; NUNES, JULIA H. B.; NONATO, FABIANA R.; RUIZ, ANA L. T. G.; ZAFRED, RAFAEL R. T.; SOUSA, ILZA M. O.; OKUBO, MARCIA Y.; KAWANO, DANIEL F.; MONTEIRO, PAULA A.; FOGLIO, MARY A.; et al. In Silico, In Vitro, and In Vivo Antitumor and Anti-Inflammatory Evaluation of a Standardized Alkaloid-Enriched Fraction Obtained fromBoehmeria caudataSw. Aerial Parts. Molecules, v. 25, n. 17, . (17/21801-2, 12/19661-4, 11/22458-3, 14/06636-7, 11/22457-7)
DE PAIVA, PAULA P.; NUNES, JULIA H. B.; NONATO, FABIANA R.; RUIZ, ANA L. T. G.; ZAFRED, RAFAEL R. T.; SOUSA, ILZA M. O.; OKUBO, MARCIA Y.; KAWANO, DANIEL F.; MONTEIRO, PAULA A.; FOGLIO, MARY A.; et al. In Silico, In Vitro, and In Vivo Antitumor and Anti-Inflammatory Evaluation of a Standardized Alkaloid-Enriched Fraction Obtained fromBoehmeria caudataSw. Aerial Parts. Molecules, v. 25, n. 17, p. 20-pg., . (12/19661-4, 17/21801-2, 11/22457-7, 11/22458-3, 14/06636-7)
SPINDOLA, HUMBERTO M.; GRANDO, ROGERIO; FIGUEIREDO, MARIANA C.; BASTING, ROSANA; QUEIROZ, N. C. A.; DE FATIMA, ANGELO; DE CARVALHO, JOAO E.; WANG, ZAIJIE J.; FOGLIO, M. A.. Derivatives of furanditerpenes from Pterodon genus: Pharmacological studies disclose their potential as chronic pain relief in mice. European Journal of Pharmacology, v. 804, p. 68-77, . (10/09287-2, 12/19661-4, 12/03652-6)
DA SILVA SOUZA, VANESSA HELENA; BASTING, ROSANNA TARKANY; DE OLIVEIRA SOUSA, ILZA MARIA; ALMEIDA QUEIROZ, NUBIA DE CASSIA; DE CARVALHO, JOAO ERNESTO; FOGLIO, MARY ANN. Evaluation of non-clinical toxicity of extract and vouacapans from fruits ofPterodon pubescensBenth. DRUG AND CHEMICAL TOXICOLOGY, v. 45, n. 3, p. 14-pg., . (12/19661-4)

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Filed patent(s) as a result of this research project

PROCESSO PARA OBTENÇÃO DE MEMBRANAS POLIMÉRICAS POR ELECTROSPINNING, MEMBRANAS POLIMÉRICAS CONTENDO EXTRATOS DE PTERODON PUBESCENS BENTH E ARRABIDAEA CHICA VERLOT E SEUS USOS. BR1020160285062 - Universidade Estadual de Campinas (UNICAMP) . Tais Helena Costa Salles ; Mary Ann Foglio ; Fabiana Volpe Zanutto ; Ilza Maria Oliveira Souza ; Marcos Akira D'ávila - December 2016, 05

COMPOSIÇÃO FARMACÊUTICA À BASE DE EXTRATO DICLOROMETANO DE PTERODON PUBESCENS BENTH., SUA COMBINAÇÃO SINÉRGICA, FORMULAÇÃO E USO. BR1320180763783 - Universidade Estadual de Campinas (UNICAMP) . ROSANNA TARKANY BASTING / MARY ANN FOGLIO / JOÃO ERNESTO DE CARVALHO / ROGÉRIO GRANDO / HUMBERTO MOREIRA SPINDOLA / MARIANA CECCHETTO FIGUEIREDO / KARIN MAIA MONTEIRO / ILZA MARIA DE OLIVEIRA SOUSA / VANESSA HELENA DA SILVA SOUZA / NUBIA DE CASSIA ALMEIDA QUEIROZ / MICHELLE PEDROSA JORGE - December 2018, 18

COMPOSIÇÃO A BASE DE EXTRATO DE PTERODON PUBESCENS BENTH., SUA FORMULAÇÃO E USOS BR1320200262881 - Universidade Estadual de Campinas (UNICAMP) ; Universidade Estadual Paulista Julio de Mesquita Filho (Unesp - Araraquara) . Ilza Maria Oliveria Sousa ; Mary Ann Foglio ; Rosanna Tarkany Basting ; Mariana Cecchetto Figueiredo ; Fabiana Volpe Zanutto ; Leila Servat Medina ; Bruno Da Fonseca Santos ; Marlus Chorilli - December 2020, 21