Advanced search
Start date
Betweenand

Effect of melatonin on angiogenesis of granulosa cells in infertile women submitted to program of in vitro fertilization

Grant number: 12/50489-3
Support Opportunities:Regular Research Grants
Duration: March 01, 2013 - February 29, 2016
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:José Maria Soares Junior
Grantee:José Maria Soares Junior
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Melatonin is responsible for carrying the photoperiodic information to the body. This hormone passes this information on variations in the length of the night during the year (seasonal variations) to the body, allowing it to determine appropriate responses to environmental changes. Therefore, regulates various cellular functions, including the regulation of reproductive function. In addition, the concentration of melatonin is three times higher in follicular fluid than in blood circulation, which may generate a speculation on the melatonin action during ovulation. More recent studies have identified melatonin receptors type I and II in granulosa cells, as well as this hormone acts through cyclic AMP and interacts with the estrogen in rat cell culture. However, little is known about the gene and molecular mechanisms that melatonin influence the function of granulosa cells that may impact the fertility. For this reason, we propose the functional study to assess the molecular pathways and gene action of melatonin on ovarian granulosa cells of women with infertility and submitted to treatment in vitro fertilization program (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.