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The project for new diagnostic approaches in the management of fungal infections in AIDS and other immunocompromised patients

Grant number: 12/51158-0
Support Opportunities:Regular Research Grants
Duration: February 01, 2013 - July 31, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Maria Luiza Moretti
Grantee:Maria Luiza Moretti
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The project is based on the development and application of new technologies for the diagnosis of fungal infections in patients with AIDS and other immunosupressive conditions. The following methods are being studied and applied in three different projects that correspond to three thesis of post graduated students under my supervision: a) development of specific DNA chips for microarray in order to diagnosis fungal infections in patients living in Brazil, b) DNA sequencing will be the gold standard for fungal identification, c) detection of galactomanan and (1,3)beta-D-glucan in serum and BAL of patients with systemic fungal infection, d) application of the fast diagnosis system of real time PCR, e) antifungal susceptibility testing using microdilution and e-test. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MORSCH PASSOS, ANA ISABELA; DERTKIGIL, RACHEL POLO; RAMOS, MARCELO DE CARVALHO; BUSSO-LOPES, ARIANE FIDELIS; TARARAN, CIBELE; RIBEIRO, ERIVAN OLINDA; SCHREIBER, ANGELICA ZANINELLI; TRABASSO, PLINIO; RESENDE, MARIANGELA RIBEIRO; MORETTI, MARIA LUIZA. Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients. Brazilian Journal of Infectious Diseases, v. 21, n. 6, p. 606-612, . (12/51158-0)
MORSCH PASSOS, ANA ISABELA; DERTKIGIL, RACHEL POLO; RAMOS, MARCELO DE CARVALHO; BUSSO-LOPES, ARIANE FIDELIS; TARARAN, CIBELE; RIBEIRO, ERIVAN OLINDA; SCHREIBER, ANGELICA ZANINELLI; TRABASSO, PLINIO; RESENDE, MARIANGELA RIBEIRO; MORETTI, MARIA LUIZA. Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients. Brazilian Journal of Infectious Diseases, v. 21, n. 6, p. 7-pg., . (12/51158-0)
STURARO, LAIS LOVISON; GONOI, TOHRU; BUSSO-LOPES, ARIANE FIDELIS; TARARAM, CIBELE APARECIDA; LEVY, CARLOS EMILIO; LYRA, LUZIA; TRABASSO, PLINIO; SCHREIBER, ANGELICA ZANINELLI; KAMEI, KATSUHIKO; MORETTI, MARIA LUIZA. Visible DNA Microarray System as an Adjunctive Molecular Test in Identification of Pathogenic Fungi Directly from a Blood Culture Bottle. Journal of Clinical Microbiology, v. 56, n. 5, . (12/51158-0)
MORETTI, MARIA LUIZA; BUSSO-LOPES, ARIANE FIDELIS; TARARAM, CIBELE APARECIDA; MORAES, RENATO; MURAOSA, YASUNORI; MIKAMI, YUZURU; GONOI, TOHRU; TAGUCHI, HIDEAKI; LYRA, LUZIA; REICHERT-LIMA, FRANQUELINE; et al. Airborne transmission of invasive fusariosis in patients with hematologic malignancies. PLoS One, v. 13, n. 4, . (12/51158-0)

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