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GIFT: genomic improvement of fertilization traits in Danish and Brazilian cattle

Grant number: 12/50533-2
Support Opportunities:Research Projects - Thematic Grants
Duration: February 01, 2013 - May 31, 2018
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Reproduction
Convênio/Acordo: Innovation Fund Denmark
Principal Investigator:Marcelo Fábio Gouveia Nogueira
Grantee:Marcelo Fábio Gouveia Nogueira
Principal researcher abroad: Haja Kadarmideen
Institution abroad: University of Copenhagen, Copenhagen, Denmark
Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil
Associated scholarship(s):16/16951-2 - Effect of TUDCA on meiosis progression, reactive oxygen species concentration and gene expression on in vitro maturation of bovine cumulus-oocyte complexes, BP.IC
13/20571-2 - Functional genomics of feed intake and efficiency in Nellore cattle, BP.PD
13/07730-4 - Use of NPPC, folicular fluid and BMP15 to modulate oocyte meiotic arrest on in vitro maturation: effects on cumulus-oocyte complexes and bovine embryo production, BP.MS
 + associated scholarships 13/12097-9 - Genome-wide association studies (GWAS) applied to reproductive traits in Nellore heifers, BP.DR
13/10473-3 - Role of cell-secreted vesicles in ovarian follicular fluid during oocyte maturation and their involvement in controlling epigenetic changes, BP.PD
12/23409-9 - Differential gene expression, ultrastructural analysis and evaluation of the lipid profile of in vitro produced bovine blastocysts from oocytes matured conventionally or via SPOM system, BP.DR - associated scholarships

Abstract

Reproductive technologies are important tools in cattle breeding with Artificial Insemination (AI) used for more than 50 years and Embryo Transfer (ET) used since the mid-1980s. More recently, ET of in vitro produced (IVP) embryos derived from ultrasound-guided collection of oocytes (Ovum Pick-Up, OPU) from superior donor cows has been introduced. This technique is used increasingly worldwide, but there are needs for improved understanding of the biology as well as the associated quantitative genetics in order to exploit the full benefits. The aims of the GIFT project are to form a bridge between embryo technology and genetics/genomics in order to address complex biological mechanisms for OPU-IVP traits as well as heifer pregnancy rates, find key genes and genetic markers, and develop genomic selection programs for identification of superior donors and recipients. The GIFT partners (Brazil and Denmark) represent in collaboration a unique set of competences, which synergistically support each other in strong basic genomics and embryological experiences, extensive practical use of the techniques, access to both beef and dairy cattle and two breeds (Bos taurus and Bos indicus), as well as two environments (tropical and temperate climate). Hence, the GIFT project allows for a novel assessment of biological and genetic dimensions of the OPU-IVP technology in a contemporary breeding context. Overall, the GIFT project combines two practical embryo and genomic technologies to make a direct contribution to quality and quantity of meat and milk produced from cattle and used for human consumption. (AU)

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Scientific publications (56)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA JUNIOR, GERSON A.; PINHEIRO, VINICIUS G.; FONSECA, PABLO A. S.; COSTA, CAMILA B.; PIOLTINE, ELISA M.; BOTIGELLI, RAMON C.; RAZZA, EDUARDO M.; ERENO, RONALDO L.; FERRAZ, JOSE B. S.; SENEDA, MARCELO M.; et al. enomic and phenotypic analyses of antral follicle count in Aberdeen Angus cow. LIVESTOCK SCIENCE, v. 249, . (14/26354-6, 14/07566-2, 19/10732-5, 12/50533-2, 12/23409-9, 16/16841-2, 13/12097-9)
OLIVEIRA JUNIOR, GERSON A.; SANTOS, DANIEL J. A.; CESAR, ALINE S. M.; BOISON, SOLOMON A.; VENTURA, RICARDO V.; PEREZ, BRUNO C.; GARCIA, JOSE F.; FERRAZ, JOSE BENTO S.; GARRICK, DORIAN J.. Fine mapping of genomic regions associated with female fertility in Nellore beef cattle based on sequence variants from segregating sires. JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, v. 10, n. 1, . (13/12097-9, 12/50533-2, 15/12396-1, 14/07566-2)
DA SILVEIRA, JULIANO C.; ANDRADE, GABRIELLA M.; DEL COLLADO, MAITE; SAMPAIO, RAFAEL V.; SANGALLI, JULIANO R.; SILVA, LUCIANO A.; PINAFFI, FABIO V. L.; JARDIM, IZABELLE B.; CESAR, MARCELO C.; NOGUEIRA, MARCELO F. G.; et al. Supplementation with small-extracellular vesicles from ovarian follicular fluid during in vitro production modulates bovine embryo development. PLoS One, v. 12, n. 6, . (13/10473-3, 13/08135-2, 12/50533-2, 14/22887-0, 14/21034-3)
BATISTA, EMILIANA O. S.; VIEIRA, LAIS M.; FREITAS, BRUNO G.; GUERREIRO, BRUNA M.; CARVALHO, J. G. S.; MINGOTI, RODOLFO D.; VASCONCELLOS, GUILHERME; SOUZA, ALEXANDRE H.; BENTO STERMAN FERRAZ, JOSE; SAMPAIO BARUSELLI, PIETRO. Anti-Mullerian hormone and its relationship to ovulation response and fertility in timed AI Bos indicus heifers. REPRODUCTION IN DOMESTIC ANIMALS, v. 55, n. 6, . (12/50533-2)
VALENTE, RONIELE SANTANA; DE ALMEIDA, TAMIE GUIBU; ALVES, MAYRA FERNANDA; DE CAMARGO, JANINE; BASSO, ANDREA CRISTINA; ANACLETO BELAZ, KATIA ROBERTA; EBERLIN, MARCOS NOGUEIRA; DA CRUZ LANDIM-ALVARENGA, FERNANDA; FONTES, PATRICIA KUBO; GOUVEIA NOGUEIRA, MARCELO FABIO; et al. Modulation of long-chain Acyl-CoA synthetase on the development, lipid deposit and cryosurvival of in vitro produced bovine embryos. PLoS One, v. 14, n. 8, . (12/50533-2)
DE ROSSI, HUGO; BORTOLIERO COSTA, CAMILA; RODRIGUES-ROSSI, LUANA TEIXEIRA; BARROS NUNES, GIOVANA; SPINOSA CHELES, DORIS; MARAN PEREIRA, ISABELLA; ROCHA, DANIELE F. O.; FEITOSA, ELOI; COLNAGHI SIMIONATO, ANA VALERIA; ZOCCAL MINGOTI, GISELE; et al. Modulating the lipid profile of blastocyst cell membrane with DPPC multilamellar vesicles. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, v. 50, n. 1, p. 10-pg., . (20/07634-9, 20/11596-5, 12/50533-2, 19/10732-5)
FRANCHI, FERNANDA FAGALI; SATRAPA, RAFAEL AUGUSTO; FONTES, PATRICIA KUBO; SANTOS, PRISCILA HELENA; RAZZA, EDUARDO MONTANARI; EMANUELLI, ISABELE PICADA; ERENO, RONALDO LUIZ; MARECO, EDSON ASSUNCAO; GOUVEIA NOGUEIRA, MARCELO FABIO; BARROS, CIRO MORAES; et al. Equine chorionic gonadotropin drives the transcriptional profile of immature cumulus-oocyte complexes and in vitro-produced blastocysts of superstimulated Nelore cows. Molecular Reproduction and Development, v. 86, n. 11, . (13/11480-3, 12/50533-2)
FONTES, PATRICIA KUBO; SOUZA CASTILHO, ANTHONY CESAR; RAZZA, EDUARDO MONTANARI; GOUVEIA NOGUEIRA, MARCELO FABIO. Bona fide gene expression analysis of samples from the bovine reproductive system by microfluidic platform. Analytical Biochemistry, v. 596, . (12/50533-2)
ROCHA, JOSE CELSO; PASSALIA, FELIPE JOSE; MATOS, FELIPE DELESTRO; TAKAHASHI, MARIA BEATRIZ; MASERATI, JR., MARC PETER; ALVES, MAYRA FERNANDA; DE ALMEIDA, TAMIE GUIBU; CARDOSO, BRUNA LOPES; BASSO, ANDREA CRISTINA; GOUVEIA NOGUEIRA, MARCELO FABIO. Automatized image processing of bovine blastocysts produced in vitro for quantitative variable determination. SCIENTIFIC DATA, v. 4, . (16/19004-4, 11/06179-7, 06/06491-2, 13/05083-1, 12/50533-2, 12/20110-2)
ANDRADE, G. M.; MEIRELLES, F. V.; PERECIN, F.; DA SILVEIRA, J. C.. Cellular and extracellular vesicular origins of miRNAs within the bovine ovarian follicle. REPRODUCTION IN DOMESTIC ANIMALS, v. 52, n. 6, p. 1036-1045, . (13/10473-3, 13/08135-2, 12/50533-2, 14/22887-0, 14/21034-3)
DE ALMEIDA, TAMIE GUIBU; MINGOTI, RODOLFO DANIEL; DE CASTRO, LETICIA SIGNORI; PEREZ SIQUEIRA, ADRIANO FELIPE; DOS SANTOS HAMILTON, THAIS ROSE; FONTES, PATRICIA KUBO; GOUVEIA NOGUEIRA, MARCELO FABIO; ALVES, MAYRA FERNANDA; BASSO, ANDREA CRISTINA; MILAZZOTTO, MARCELLA PECORA; et al. Paternal effect does not affect in vitro embryo morphokinetics but modulates molecular profile. Theriogenology, v. 178, p. 30-39, . (16/15147-5, 12/50533-2)
OLIVEIRA JUNIOR, G. A.; PEREZ, B. C.; COLE, J. B.; SANTANA, M. H. A.; SILVEIRA, J.; MAZZONI, G.; VENTURA, R. V.; SANTANA JUNIOR, M. L.; KADARMIDEEN, H. N.; GARRICK, D. J.; et al. Genomic study and Medical Subject Headings enrichment analysis of early pregnancy rate and antral follicle numbers in Nelore heifers. JOURNAL OF ANIMAL SCIENCE, v. 95, n. 11, p. 4796-4812, . (12/50533-2, 13/12097-9, 14/26354-6, 14/07566-2)
VENTURA, RICARDO V.; BRITO, LUIZ F.; OLIVEIRA, JR., GERSON A.; DAETWYLER, HANS D.; SCHENKEL, FLAVIO S.; SARGOLZAEI, MEHDI; VANDERVOORT, GORDON; FONSECA E SILVA, FABYANO; MILLER, STEPHEN P.; CARVALHO, MINOS E.; et al. A comprehensive comparison of high-density SNP panels and an alternative ultra-high-density panel for genomic analyses in Nellore cattle. ANIMAL PRODUCTION SCIENCE, v. 60, n. 3, p. 333-346, . (16/19514-2, 12/50533-2)
PIOLTINE, ELISA M.; MACHADO, MARIANA F.; DA SILVEIRA, JULIANO C.; FONTES, PATRICIA K.; BOTIGELLI, RAMON C.; QUAGLIO, V, ANA ELISA; COSTA, CAMILA B.; NOGUEIRA, MARCELO F. G.. Can extracellular vesicles from bovine ovarian follicular fluid modulate the in-vitro oocyte meiosis progression similarly to the CNP-NPR2 system?. Theriogenology, v. 157, p. 210-217, . (12/50533-2, 13/07730-4)
SANGALLI, JULIANO RODRIGUES; SAMPAIO, RAFAEL VILAR; DEL COLLADO, MAITE; DA SILVEIRA, JULIANO COELHO; CAMARA DE BEM, TIAGO HENRIQUE; PERECIN, FELIPE; SMITH, LAWRENCE CHARLES; MEIRELLES, FLAVIO VIEIRA. Metabolic gene expression and epigenetic effects of the ketone body beta-hydroxybutyrate. SCIENTIFIC REPORTS, v. 8, . (13/08135-2, 16/13416-9, 13/06673-7, 12/50533-2, 14/21097-5, 14/22887-0, 14/21034-3)
RAZZA, EDUARDO M.; SUDANO, MATEUS J.; FONTES, PATRICIA K.; FRANCHI, FERNANDA F.; BELAZ, KATIA ROBERTA A.; SANTOS, PRISCILA H.; CASTILHO, ANTHONY C. S.; ROCHA, DANIELE F. O.; EBERLIN, MARCOS N.; MACHADO, MARIANA F.; et al. Treatment with cyclic adenosine monophosphate modulators prior to in vitro maturation alters the lipid composition and transcript profile of bovine cumulus-oocyte complexes and blastocysts. REPRODUCTION FERTILITY AND DEVELOPMENT, v. 30, n. 10, p. 1314-1328, . (13/05083-1, 12/23409-9, 12/50533-2, 12/10737-8)
DALL'ACQUA, PRISCILA CHEDIEK; NUNES, GIOVANA BARROS; DA SILVA, CINTIA RODRIGUES; FONTES, PATRICIA KUBO; GOUVEIA NOGUEIRA, MARCELO FABIO; LOPES, FLAVIA LOMBARDI; MARINHO, MARCIA; MINGOTI, GISELE ZOCCAL. Differences in embryonic gene expression and quality indicate the benefit of epidermal growth factor receptor inhibitor during prematuration to improve competence in bovine oocytes. REPRODUCTION IN DOMESTIC ANIMALS, v. 54, n. 4, p. 666-677, . (12/50533-2, 15/06733-5)
DA SILVEIRA, JULIANO C.; DE AVILA, ANA CLARA F. C. M.; GARRETT, HANNAH L.; BRUEMMER, JASON E.; WINGER, QUINTON A.; BOUMA, GERRIT J.. Cell-secreted vesicles containing microRNAs as regulators of gamete maturation. Journal of Endocrinology, v. 236, n. 1, p. R15-R27, . (13/10473-3, 15/16985-1, 12/50533-2, 17/02037-0, 14/22887-0)
MAZZONI, GIANLUCA; RAZZA, EDUARDO; PEDERSEN, HANNE S.; SECHER, JAN; KADARMIDEEN, HAJA N.; CALLESEN, HENRIK; STROEBECH, LOTTE; FREUDE, KRISTINE; HYTTEL, POUL. In vitro production of bovine embryos: cumulus/granulosa cell gene expression patterns point to early atresia as beneficial for oocyte competence. ANIMAL REPRODUCTION, v. 14, n. 3, p. 482-489, . (12/50533-2)
MAZZONI, GIANLUCA; PEDERSEN, HANNE S.; DE OLIVEIRA JUNIOR, GERSON A.; ALEXANDRE, PAMELA; RAZZA, EDUARDO M.; CALLESEN, HENRIK; HYTTEL, POUL; NOGUEIRA, MARCELO F. G.; FERRAZ, JOSE BENTO S.; KADARMIDEEN, HAJA N.. Application of integrative genomics and systems biology to conventional and in vitro reproductive traits in cattle. ANIMAL REPRODUCTION, v. 14, n. 3, p. 507-513, . (12/50533-2, 14/07566-2)
PEDERSEN, HANNE SKOVSGAARD; MAZZONI, GIANLUCA; STROEBECH, LOTTE; KADARMIDEEN, HAJA N.; HYTTEL, POUL; CALLESEN, HENRIK. Basic and practical aspects of pregnancy establishment in cattle. ANIMAL REPRODUCTION, v. 14, n. 3, p. 581-588, . (12/50533-2)
ROCHA, JOSE CELSO; PASSALIA, FELIPE JOSE; MATOS, FELIPE DELESTRO; TAKAHASHI, MARIA BEATRIZ; CINICIATO, DIEGO DE SOUZA; MASERATI, MARC PETER; ALVES, MAYRA FERNANDA; DE ALMEIDA, TAMIE GUIBU; CARDOSO, BRUNA LOPES; BASSO, ANDREA CRISTINA; et al. A Method Based on Artificial Intelligence To Fully Automatize The Evaluation of Bovine Blastocyst Images. SCIENTIFIC REPORTS, v. 7, . (11/06179-7, 06/06491-2, 13/05083-1, 12/50533-2, 12/20110-2)
ANDRADE, GABRIELLA MAMEDE; DA SILVEIRA, JULIANO COELHO; PERRINI, CLAUDIA; DEL COLLADO, MAITE; GEBREMEDHN, SAMUEL; TESFAYE, DAWIT; MEIRELLES, FLAVIO VIEIRA; PERECIN, FELIPE. The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes. PLoS One, v. 12, n. 9, . (12/50533-2, 13/08135-2, 14/22887-0, 14/21034-3)
CHELES, DORIS SPINOSA; DAL MOLIN, ELOIZA ADRIANE; ROCHA, JOSE CELSO; GOUVEIA NOGUEIRA, MARCELO FABIO. Mining of variables from embryo morphokinetics, blastocyst's morphology and patient parameters: an approach to predict the live birth in the assisted reproduction service. JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA, v. 24, n. 4, p. 470-479, . (12/50533-2, 17/19323-5)
GIROTO, ALAN B.; FONTES, PATRICIA K.; FRANCHI, FERNANDA F.; DOS SANTOS, PRISCILA H.; RAZZA, EDUARDO M.; NOGUEIRA, MARCELO F. G.; MAIOLI, MARCOS A.; NOGUEIRA, GUILHERME P.; NUNES, GIOVANA B.; MINGOTI, GISELE Z.; et al. Use of pregnancy-associated plasma protein-A during oocyte in vitro maturation increases IGF-1 and affects the transcriptional profile of cumulus cells and embryos from Nelore cows. Molecular Reproduction and Development, v. 86, n. 11, p. 1694-1704, . (16/22812-5, 15/04505-5, 12/50533-2, 13/11480-3)
DE FIGUEIREDO PESSOA, LAIS VICARI; LISBOA PIRES, PEDRO RATTO; DEL COLLADO, MAITE; GODOY PIERI, NAIRA CAROLINE; RECCHIA, KAIANA; SOUZA, ALINE FERNANDA; PERECIN, FELIPE; DA SILVEIRA, JULIANO COELHO; CESAR DE ANDRADE, ANDRE FURUGEN; AMBROSIO, CARLOS EDUARDO; et al. Generation and miRNA Characterization of Equine Induced Pluripotent Stem Cells Derived from Fetal and Adult Multipotent Tissues. STEM CELLS INTERNATIONAL, v. 2019, p. 15-pg., . (14/22887-0, 08/57877-3, 12/50533-2, 15/26818-5, 13/17955-3, 13/08135-2)
ISPADA, JESSICA; DA FONSECA JUNIOR, ALDCEJAM MARTINS; DE LIMA, CAMILA BRUNA; DOS SANTOS, ERIKA CRISTINA; FONTES, PATRICIA KUBO; GOUVEIA NOGUEIRA, MARCELO FABIO; DA SILVA, VINICIUS LOURENCO; ALMEIDA, FERNANDA NASCIMENTO; LEITE, SAUL DE CASTRO; CHITWOOD, JAMES LEE; et al. Tricarboxylic Acid Cycle Metabolites as Mediators of DNA Methylation Reprogramming in Bovine Preimplantation Embryos. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 18, p. 16-pg., . (12/50533-2, 18/11668-6, 17/18384-0, 15/03381-0)
ROCHA, J. C.; MATOS, F. D.; BASSO, A. C.; HICKMAN, C. F. L.; LAVERY, S.; NOGUEIRA, M. F. G.. Using artificial intelligence to improve blastocyst morphology evaluation. Human Reproduction, v. 32, p. 2-pg., . (12/50533-2, 06/06491-2, 13/05083-1, 12/20110-2)
DA SILVEIRA, JULIANO COELHO; ANDRADE, GABRIELLA MAMEDE; SIMAS, ROSINEIDE COSTA; MARTINS-JUNIOR, HELIO ALVES; EBERLIN, MARCOS NOGUEIRA; SMITH, LAWRENCE CHARLES; PERECIN, FELIPE; MEIRELLES, FLAVIO VIEIRA. Lipid profile of extracellular vesicles and their relationship with bovine oocyte developmental competence: New players in intra follicular cell communication. Theriogenology, v. 174, p. 1-8, . (11/15416-2, 19/15491-6, 15/21829-9, 12/50533-2, 13/08135-2, 14/22887-0, 14/21034-3)
PIOLTINE, ELISA MARIANO; COSTA, CAMILA BORTOLIERO; BARBOSA LATORRACA, LAIS; FRANCHI, FERNANDA FAGALI; DOS SANTOS, PRISCILA HELENA; MINGOTI, GISELE ZOCCAL; PAULA-LOPES, FABIOLA FREITAS DE; NOGUEIRA, MARCELO FABIO GOUVEIA. Treatment of in vitro-Matured Bovine Oocytes With Tauroursodeoxycholic Acid Modulates the Oxidative Stress Signaling Pathway. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 9, . (12/50533-2)
BOTIGELLI, RAMON CESAR; PIERI, NAIRA CAROLINA GODOY; BESSI, BRENDON WILLIAM; MACHADO, LUCAS SIMOES; BRIDI, ALESSANDRA; DE SOUZA, ALINE FERNANDA; RECCHIA, KAIANA; NETO, PAULO FANTINATO; ROSS, PABLO JUAN; BRESSAN, FABIANA FERNANDES; et al. Acquisition and maintenance of pluripotency are influenced by fibroblast growth factor, leukemia inhibitory factor, and 2i in bovine-induced pluripotent stem cells. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 10, p. 12-pg., . (19/10751-0, 13/08135-2, 16/16841-2, 15/26818-5, 12/50533-2)
GRIGOLETTO, LAIS; ALMEIDA SANTANA, MIGUEL HENRIQUE; BRESSAN, FABIANA FERNANDES; ELER, JOANIR PEREIRA; GOUVEIA NOGUEIRA, MARCELO FABIO; KADARMIDEEN, HAJA N.; BARUSELLI, PIETRO SAMPAIO; STERMAN FERRAZ, JOSE BENTO; BRITO, LUIZ F.. Genetic Parameters and Genome-Wide Association Studies for Anti-Mullerian Hormone Levels and Antral Follicle Populations Measured After Estrus Synchronization in Nellore Cattle. ANIMALS, v. 10, n. 7, . (12/50533-2, 14/07566-2, 17/11919-6)
DE FIGUEIREDO PESSOA, LAIS VICARI; LISBOA PIRES, PEDRO RATTO; DEL COLLADO, MAITE; GODOY PIERI, NAIRA CAROLINE; RECCHIA, KAIANA; SOUZA, ALINE FERNANDA; PERECIN, FELIPE; DA SILVEIRA, JULIANO COELHO; CESAR DE ANDRADE, ANDRE FURUGEN; AMBROSIO, CARLOS EDUARDO; et al. Generation and miRNA Characterization of Equine Induced Pluripotent Stem Cells Derived from Fetal and Adult Multipotent Tissues. STEM CELLS INTERNATIONAL, . (08/57877-3, 13/17955-3, 15/26818-5, 13/08135-2, 12/50533-2, 14/22887-0)
BESSI, BRENDON WILLIAN; BOTIGELLI, RAMON CESAR; PIERI, NAIRA CAROLINE GODOY; MACHADO, LUCAS SIMOES; CRUZ, JESSICA BRUNHARA; DE MORAES, PAMELA; DE SOUZA, ALINE FERNANDA; RECCHIA, KAIANA; BARBOSA, GABRIELA; DE CASTRO, RAQUEL VASCONCELOS GUIMARAES; et al. Cattle In Vitro Induced Pluripotent Stem Cells Generated and Maintained in 5 or 20% Oxygen and Different Supplementation. CELLS, v. 10, n. 6, . (15/26818-5, 19/10751-0, 16/16841-2, 12/50533-2, 18/24520-7)
DE BEM, T. H. C.; DA SILVEIRA, J. C.; SAMPAIO, R. V.; SANGALLI, J. R.; OLIVEIRA, M. L. F.; FERREIRA, R. M.; SILVA, L. A.; PERECIN, F.; KING, W. A.; MEIRELLES, F. V.; et al. Low levels of exosomal-miRNAs in maternal blood are associated with early pregnancy loss in cloned cattle. SCIENTIFIC REPORTS, v. 7, . (13/08135-2, 12/50533-2, 14/22887-0)
DA SILVEIRA, JULIANO C.; DE ANDRADE, GABRIELLA M.; NOGUEIRA, MARCELO F. G.; MEIRELLES, FLAVIO V.; PERECIN, FELIPE. Involvement of miRNAs and Cell-Secreted Vesicles in Mammalian Ovarian Antral Follicle Development. REPRODUCTIVE SCIENCES, v. 22, n. 12, p. 1474-1483, . (13/10473-3, 12/50533-2, 13/08135-2)
ALVES, GLAUCIA PEREIRA; BERTUCCEZ CORDEIRO, FERNANDA; DE LIMA, CAMILA BRUNA; ANNES, KELLY; DOS SANTOS, ERIKA CRISTINA; ISPADA, JESSICA; FONTES, PATRICIA KUBO; GOUVEIA NOGUEIRA, MARCELO FABIO; NICHI, MARCILIO; MILAZZOTTO, MARCELLA PECORA. Follicular environment as a predictive tool for embryo development and kinetics in cattle. REPRODUCTION FERTILITY AND DEVELOPMENT, v. 31, n. 3, p. 451-461, . (12/10351-2, 12/50533-2, 15/03381-0)
ANDRADE, GABRIELLA MAMEDE; BOMFIM, MONALISA MEDRADO; DEL COLLADO, MAITE; MEIRELLES, FLAVIO VIEIRA; PERECIN, FELIPE; DA SILVEIRA, JULIANO COELHO. Oxygen tension modulates extracellular vesicles and its miRNA contents in bovine embryo culture medium. Molecular Reproduction and Development, v. 86, n. 8, p. 1067-1080, . (12/50533-2, 14/21034-3, 15/21829-9, 14/22887-0, 14/21042-6, 13/08135-2)
DE LIMA, CAMILA BRUNA; DOS SANTOS, ERIKA CRISTINA; ISPADA, JESSICA; FONTES, PATRICIA KUBO; GOUVEIA NOGUEIRA, MARCELO FABIO; DIAS DOS SANTOS, CHARLES MORPHY; MILAZZOTTO, MARCELLA PECORA. The dynamics between in vitro culture and metabolism: embryonic adaptation to environmental changes. SCIENTIFIC REPORTS, v. 10, n. 1, . (12/50533-2, 17/18384-0, 15/03381-0, 17/11768-8)
DE LIMA, MARINA AMARO; MOROTTI, FABIO; BAYEUX, BERNARDO MARCOZZI; DE REZENDE, ROMULO GERMANO; BOTIGELLI, RAMON CESAR; CAMARA DE BEM, TIAGO HENRIQUE; FONTES, PATRICIA KUBO; GOUVEIA NOGUEIRA, MARCELO FABIO; MEIRELLES, FLAVIO VIEIRA; BARUSELLI, PIETRO SAMPAIO; et al. Ovarian follicular dynamics, progesterone concentrations, pregnancy rates and transcriptional patterns in Bos indicus females with a high or low antral follicle count. SCIENTIFIC REPORTS, v. 10, n. 1, . (12/50533-2, 18/13155-6, 14/22887-0)
SAMPAIO, RAFAEL VILAR; SANGALLI, JULIANO RODRIGUES; CAMARA DE BEM, TIAGO HENRIQUE; AMBRIZI, DEWISON RICARDO; DEL COLLADO, MAITE; BRIDI, ALESSANDRA; CAVALCANTE MENDES DE AVILA, ANA CLARA FAQUINELI; MACABELLI, CAROLINA HABERMANN; OLIVEIRA, LILIAN DE JESUS; DA SILVEIRA, JULIANO COELHO; et al. Catalytic inhibition of H3K9me2 writers disturbs epigenetic marks during bovine nuclear reprogramming. SCIENTIFIC REPORTS, v. 10, n. 1, . (15/08807-6, 14/22887-0, 13/08135-2, 14/50947-7, 14/21034-3, 15/25111-5, 12/50533-2, 13/07160-3)
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MÉTODO PARA MODIFICAÇÃO DA COMPOSIÇÃO DE LIPÍDEOS DE SUPERFÍCIE EM CÉLULAS DE BLASTOCISTO DE MAMÍFEROS BR102019016477-8 - Universidade Estadual Paulista Júlio de Mesquita Filho (Unesp) . GISELE ZOCCAL MINGOTI / MARCELO FÁBIO GOUVEIA NOGUEIRA / PEDRO HENRIQUE BENITES AOKI - August 2019, 08