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A new strategy to analyze gene-nutrient interaction in children and adolescents

Abstract

Despite the increasing rate of overweight and obesity among children and adolescents in Brazil, nutritional deficiencies are still a concern. Although seemingly paradoxical, micronutrient deficiencies are linked to risk of being overweight or obese. Objectives: Analyze the response (SAM/SAH ratio) to vitamins supplementation (vitamin A, thiamine, riboflavin, pyridoxine, folic acid, vitamin B12, vitamin D, vitamin E, niacin)in children and adolescents; correlate the response to genes involved in metabolism of the vitamins with SAM/SAH ratio; analyze the sequence of genes that interact with, are regulated by, or metabolize micronutrients mapping to quantitative trait loci (QTL) involved in obesity; analyze energy and nutrient intake; associate metabolic clusters based on SAM/SAH ratio to clusters of genotypic. Methods:We propose an intervention cross-over study to examine how a child or an adolescent will respond to vitamins supplementation regarding SAM/SAH ratio. The subjects have routine wellness check-ups at a public basic pediatric clinic on the outskirts of Ribeirão Preto (São Paulo, Brazil). The study design is based on measuring metabolites at baseline, after 6 weeks of a vitamin daily supplement, and following 6 weeks without the daily supplement. Comparing across the three time points will determine how an individual responds to changes in nutrient intakes. Genomic analyses using 5 M feature arrays will be used to associate changes in SAM/SAH levels to clusters of gene variants involved in nutrient metabolism. Expected Results: Our overall working hypotheses are that (i) the SAM/SAH ratio is a marker of nutritional status and(ii) individuals with different genetic make-ups will require different interventions to improve their methylation potential. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO DO VALE ALMADA, MARIA OLIMPIA; FAYAO ALMEIDA, ANE CRISTINA; UED, FABIO DA VEIGA; MATHIAS, MARIANA GIARETTA; COELHO-LANDELL, CAROLINA DE ALMEIDA; SALOMAO, ROBERTA GARCIA; DONEGA TOFFANO, ROSELI BORGES; CAMARNEIRO, JOYCE MORAES; HILLESHEIM, ELAINE; DE BARROS, TAMIRIS TREVISAN; et al. Metabolic Groups Related to Blood Vitamin Levels and Inflammatory Biomarkers in Brazilian Children and Adolescents. JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, v. 66, n. 6, p. 515-525, . (12/20421-8)
COELHO-LANDELL, CAROLINA ALMEIDA; SALOMAO, ROBERTA GARCIA; RIBEIRO DO VALE ALMADA, MARIA OLIMPIA; MATHIAS, MARIANA GIARETTA; DONEGA TOFFANO, ROSELI BORGES; HILLESHEIM, ELAINE; BARROS, TAMIRIS TREVISAN; CAMARNEIRO, JOYCE MORAES; CAMELO-JUNIOR, JOSE SIMON; ROSA, JOSE CESAR; et al. Metabo groups in response to micronutrient intervention: Pilot study. FOOD SCIENCE & NUTRITION, v. 8, n. 1, . (12/20421-8)
HILLESHEIM, ELAINE; DONEGA TOFFANO, ROSELI BORGES; DE BARROS, TAMIRIS TREVISAN; SALOMAO, ROBERTA GARCIA; MATHIAS, MARIANA GIARETTA; COELHO-LANDELL, CAROLINA DE ALMEIDA; RIBEIRO DO VALE ALMADA, MARIA OLIMPIA; CAMARNEIRO, JOYCE MORAES; SIMON CAMELO-JUNIOR, JOSE; UED, FABIO DA VEIGA; et al. Biomarker-based validity of a food frequency questionnaire estimating intake in Brazilian children and adolescents. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, v. 72, n. 2, . (12/20421-8)
BARROS, TAMIRIS TREVISAN DE; VENANCIO, VINICIUS DE PAULA; HERNANDES, LIVIA CRISTINA; GREGGI ANTUNES, LUSANIA MARIA; HILLESHEIM, ELAINE; SALOMAO, ROBERTA GARCIA; MATHIAS, MARIANA GIARETTA; COELHO-LANDELL, CAROLINA ALMEIDA; DONEGA TOFFANO, ROSELI BORGES; RIBEIRO DO VALE ALMADA, MARIA OLIMPIA; et al. DNA damage is inversely associated to blood levels of DHA and EPA fatty acids in Brazilian children and adolescents. FOOD & FUNCTION, v. 11, n. 6, p. 5115-5121, . (12/20421-8)
DE BARROS, TAMIRIS TREVISAN; VENANCIO, VINICIUS DE PAULA; HERNANDES, LIVIA CRISTINA; GREGGI ANTUNES, LUSANIA MARIA; HILLESHEIM, ELAINE; SALOMAO, ROBERTA GARCIA; MATHIAS, MARIANA GIARETTA; COELHO-LANDELL, CAROLINA ALMEIDA; DONEGA TOFFANO, ROSELI BORGES; RIBEIRO DO VALE ALMADA, MARIA OLIMPIA; et al. DNA Damage, n-3 Long-Chain PUFA Levels and Proteomic Profile in Brazilian Children and Adolescents. NUTRIENTS, v. 13, n. 8, . (12/20421-8)
UED, FABIO V.; MATHIAS, MARIANA G.; TOFFANO, ROSELI B. D.; BARROS, TAMIRIS T.; ALMADA, MARIA OLIMPIA R. V.; SALOMAO, ROBERTA G.; COELHO-LANDELL, CAROLINA A.; HILLESHEIM, ELAINE; CAMARNEIRO, JOYCE M.; CAMELO-JUNIOR, JOSE SIMON; et al. Vitamin B2 and Folate Concentrations are Associated with ARA, EPA and DHA Fatty Acids in Red Blood Cells of Brazilian Children and Adolescents. NUTRIENTS, v. 11, n. 12, . (12/20421-8)
FUZO, CARLOS ALESSANDRO; UED, FABIO DA VEIGA; MOCO, SOFIA; COMINETTI, ORNELLA; METAIRON, SYLVIANE; PRUVOST, SOLENN; CHARPAGNE, ALINE; CARAYOL, JEROME; TORRIERI, RAUL; SILVA JR, WILSON ARAUJO; et al. Contribution of genetic ancestry and polygenic risk score in meeting vitamin B12 needs in healthy Brazilian children and adolescents. SCIENTIFIC REPORTS, v. 11, n. 1, . (12/20421-8)

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