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Adipose tissue and bone: metabolic pathway between vitamin D, osteocalcin and adipokines in adolescents

Grant number: 12/11061-8
Support type:Regular Research Grants
Duration: January 01, 2013 - December 31, 2014
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal researcher:Lígia Araújo Martini
Grantee:Lígia Araújo Martini
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The endocrine actions of vitamin D could be genomic or non genomic. From a series of in vitro studies, it was described an elegant mechanism linking adipose tissue and the bone that involves factors (osteocalcin and leptin) secreted by both cells types. It has been observed that the gain in bone content and density, typical of adolescence could be higher in obese adolescents. By other hand, others investigators observed a decrease when adjusted by height. Adipokines seems to have an important role in the bone metabolism during adolescence. Objectives: To investigate the relationship between 25(OH)D with adipokines and osteocalcin in obese and normal weight adolescents. Methods: This is a cross sectional study with 400 adolescents between 15 to 19 years old. All of them will complete a socio demographic questionnaire and a 24h food recall. Anthropometric data and a bone densitometry will be obtained by DXA (Dual Energy X-Ray Absorptiometry). Blood collection will be taken after 12 h fasten and it will be measured by standardized techniques 25(OH)D, PTH, glicose, insulin, carboxilated and non-carboxilated ostecalcin, leptin, adiponectin, blood lipids and creatinine. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GIUDICI, K. V.; FISBERG, R. M.; MARCHIONI, D. M.; MARTINI, L. A.. Comparisons of physical activity, adipokines, vitamin D status and dietary vitamin D intake among adolescents. JOURNAL OF HUMAN NUTRITION AND DIETETICS, v. 30, n. 3, p. 369-377, . (12/11061-8, 11/22768-2)
GIUDICI, KELLY VIRECOULON; MARTINI, LIGIA ARAUJO. Comparison between body mass index and a body shape index with adiponectin/leptin ratio and markers of glucose metabolism among. ANNALS OF HUMAN BIOLOGY, v. 44, n. 6, p. 489-494, . (12/11061-8, 11/22768-2)
LOPES, MARIANA P.; GIUDICI, KELLY V.; MARCHIONI, DIRCE M.; FISBERG, REGINA M.; MARTINI, LIGIA A.. Relationships between n-3 polyunsaturated fatty acid intake, serum 25 hydroxyvitamin D, food consumption, and nutritional status among adolescents. Nutrition Research, v. 35, n. 8, p. 681-688, . (12/11061-8, 11/22768-2, 12/21130-7)
GIUDICI, KELLY VIRECOULON; FISBERG, REGINA MARA; LOBO MARCHIONI, DIRCE MARIA; EMO PETERS, BARBARA SANTAROSA; MARTINI, LIGIA ARAUJO. Crosstalk Between Bone and Fat Tissue: Associations Between Vitamin D, Osteocalcin, Adipokines, and Markers of Glucose Metabolism Among Adolescents. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, v. 36, n. 4, p. 273-280, . (12/11061-8, 11/22768-2)

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