Advanced search
Start date
Betweenand

Stem cells: from basic studies of kinin and purinergic receptor roles towards therapeutical applications

Grant number: 12/50880-4
Support Opportunities:Research Projects - Thematic Grants
Duration: December 01, 2012 - February 28, 2019
Field of knowledge:Biological Sciences - Biophysics - Cellular Biophysics
Principal Investigator:Alexander Henning Ulrich
Grantee:Alexander Henning Ulrich
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Pesquisadores principais:
Luiz Roberto Giorgetti de Britto ; Marimélia Aparecida Porcionatto
Associated scholarship(s):18/03607-7 - Culture and differentiation of dopaminergic neurons from embryonic stem cells, BP.TT
18/05543-6 - GABAergic neurons differentiation from mouse embryonic stem cells, BP.TT
17/17972-6 - Silencing of CaMKII-alpha in a hippocampal cell line as an in vitro model for the immature dentate gyrus neuropsychiatric endophenotype, BP.IC
+ associated scholarships 15/14343-2 - Dental pulp derived mesenchymal stem cells and its conditioned medium: a novel therapeutic approach for ALS, BP.PD
15/18730-0 - Lung cancer stem cells by DNA aptamers identification / purification and kallikrein-kinin system study on tumor progression, BP.PD
15/14342-6 - Identification of aptamers binding to human glioblastoma cells, BP.IC
14/26637-8 - Enrichment of cancer stem-like cells in glioblastoma multiforme, BP.IC
14/00462-7 - Identification of DNA aptamers to human glioblastoma stem-like cells, BP.DR
13/12786-9 - Participation of bradykinin in adult mouse neurogenesis, BP.MS
13/06044-0 - Parkinson disease: possible involvement of kinin, purinergic and transient potential receptors., BP.DR
13/02293-5 - Aptamers inhibiting the protein CD73 as possible antitumoral agents, BP.PD
12/24205-8 - Investigation on the role of P2X4 purinergic receptor during neuronal differentiation of P19 cells through interference RNA, BP.IC - associated scholarships

Abstract

Stem cells (SC) are unspecialized cells withself renewal capacity and with the ability to originate different cell types | of the body. In recent years, SC nave emerged as a significant therapeutic promise for several diseases. Furthermore, cancer stem cells (CSC ) have been implicated in initiation and growth of tumors, resistance to conventional therapies and, consequently, in recurrence of the disease, becoming a potential target for therapy. The basic structure of a SC depends on its genetic constitution, however the determination of a specific phenotype also depends on cell exposure to intrinsic and extrinsic factors in their microenvironment. Our laboratory has been studying the role of bradykinin (BK) and purines in induction, progression and phenotype determination in neural differentiation of different types of SC. As one of the main findings of our group, BK increased neurogenesis in several models of SC and also showed a neuroprotective effect, reversing the induction of apoptosis. Based on these data, in this project, we propose to study the interrelationship between purinergic and kininergic systems as a target for therapies using SC. For this purpose, we will evaluate the effect of BK and its stable analogs as potential tools for cell therapy in a preclinical model of Parkinson's disease, together with neural stem cell transplantation. Somatic cells of Parkinson's disease patients will be reprogrammed to pluripotent cells (iPS) to study possible alterations in the kininergic and purinergic systems and in their effects on the modulation of neural differentiation. We will develop DNA aptamers in order to obtain specific markers for different types of SC, such as mesenchymal and cancer SC. These aptamers have possible therapeutic applications, in the purification of mesenchymal SC for cell therapy and, in the case of tumor SC, have a diagnostic value in detection of those cells in biological fluids. To define new therapeutic targets and regarding the anti-proliferative effect of BK on neural stem cells (NSC), we will study the expression of kinin system and the involvement of their receptors on tumor progression in cells derived from lung tumors and glioblastoma with high malignancy. Furthermore, we will study P2X7 receptor in a mouse model of epilepsy, providing a second pre-clinical model in addition to the rat model for Parkinson's disease. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (80)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NERY, ARTHUR A.; PEREIRA, RICARDO L.; BASSANEZE, VINICIUS; NASCIMENTO, ISIS C.; SHERMAN, LAUREN S.; RAMESHWAR, PRANELA; LAMEU, CLAUDIANA; ULRICH, HENNING. Combination of Chemical and Neurotrophin Stimulation Modulates Neurotransmitter Receptor Expression and Activity in Transdifferentiating Human Adipose Stromal Cells. STEM CELL REVIEWS AND REPORTS, v. 15, n. 6, p. 851-863, . (12/50880-4, 15/19128-2, 15/18730-0)
ZAPARTE, ALINE; CAPPELLARI, ANGELICA R.; BRANDAO, CAROLINE A.; DE SOUZA, JULIA B.; BORGES, THIAGO J.; KIST, LUIZA W.; BOGO, MAURICIO R.; ZERBINI, LUIZ F.; RIBEIRO PINTO, LUIS FELIPE; GLASER, TALITA; et al. P2Y(2) receptor activation promotes esophageal cancer cells proliferation via ERK1/2 pathway. European Journal of Pharmacology, v. 891, . (12/50880-4)
PILLAT, MICHELI MAINARDI; OLIVEIRA-GIACOMELLI, AGATHA; DAS NEVES OLIVEIRA, MONA; ANDREJEW, ROBERTA; TURRINI, NATALIA; BARANOVA, JULIANA; LAH TURNSEK, TAMARA; ULRICH, HENNING. Mesenchymal stem cell-glioblastoma interactions mediated via kinin receptors unveiled by cytometry. Cytometry Part A, v. 99, n. 2, SI, . (18/07366-4, 20/10725-6, 12/50880-4, 19/24553-5, 19/26852-0)
VIVIANI, LUCAS G.; PICCIRILLO, ERIKA; ULRICH, HENNING; AMARAL, ANTONIA T-DO. Virtual Screening Approach for the Identification of Hydroxamic Acids as Novel Human Ecto-5 `-Nucleotidase Inhibitors. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 60, n. 2, p. 621-630, . (14/07248-0, 12/50880-4, 18/24678-0, 12/06633-2, 18/07366-4, 13/07937-8, 18/06381-0)
HIRSCH, MAURO MOZAEL; DECKMANN, IOHANNA; SANTOS-TERRA, JULIO; STAEVIE, GABRIELA ZANOTTO; FONTES-DUTRA, MELLANIE; CARELLO-COLLAR, GIOVANNA; KORBES-ROCKENBACH, MARILIA; SCHWINGEL, GUSTAVO BRUM; BAUER-NEGRINI, GUILHERME; RABELO, BRUNA; et al. Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism. Neuropharmacology, v. 167, . (12/50880-4, 15/14343-2)
GONCALVES, MARIA CAROLINA BITTENCOURT; CORREA-VELLOSO, JULIANA; NAALDIJK, YAHAIRA; CHEFFER, ARQUIMEDES; ULRICH, HENNING. Purinergic modulation of pathways associated to suicidal behavior. MOLECULAR PSYCHIATRY, v. 25, n. 3, p. 514-516, . (12/50880-4, 13/02293-5, 15/14343-2)
RIBEIRO, D. E.; GLASER, T.; OLIVEIRA-GIACOMELLI, A.; ULRICH, H.. Purinergic receptors in neurogenic processes. Brain Research Bulletin, v. 151, n. SI, p. 3-11, . (12/50880-4, 15/13345-1)
ADAMIAK, MATEUSZ; BUJKO, KAMILA; CYMER, MONIKA; PLONKA, MONIKA; GLASER, TALITA; KUCIA, MAGDA; RATAJCZAK, JANINA; ULRICH, HENNING; ABDEL-LATIF, AHMED; RATAJCZAK, MARIUSZ Z.. Novel evidence that extracellular nucleotides and purinergic signaling induce innate immunity-mediated mobilization of hematopoietic stem/progenitor cells. LEUKEMIA, v. 32, n. 9, p. 1920-1931, . (12/50880-4)
BALDISSARELLI, JUCIMARA; MANICA, ALINE; PILLAT, MICHELI MAINARDI; BAGATINI, MARGARETE DULCE; ROSA LEAL, DANIELA BITENCOURT; ABDALLA, FATIMA HUSEIN; MORSCH, VERA M.; ULRICH, HENNING; BORNEMANN, CLARISSA PEREIRA; CHITOLINA SCHETINGER, MARIA R.. Increased cytokines production and oxidative stress are related with purinergic signaling and cell survival in post-thyroidectomy hypothyroidism. Molecular and Cellular Endocrinology, v. 499, . (12/50880-4)
FRACASSO, MATEUS; PILLAT, MICHELI M.; BOTTARI, NATHIELI B.; DA SILVA, ANIELEN D.; GRANDO, THIRSSA H.; MATOS, ANTONIO F. I. M.; PETRY, LETICIA S.; ULRICH, HENNING; DE ANDRADE, CINTHIA M.; MONTEIRO, SILVIA G.; et al. Trypanosoma evansi impacts on embryonic neural progenitor cell functions. Microbial Pathogenesis, v. 136, . (12/50880-4)
OLIVEIRA-GIACOMELLI, AGATHA; ALBINO, CAROLINA M.; NOBREGA DE SOUZA, HELLIO DANNY; CORREA-VELLOSO, JULIANA; DE JESUS SANTOS, ANA PAULA; BARANOVA, JULIANA; ULRICH, HENNING. P2Y6 and P2X7 Receptor Antagonism Exerts Neuroprotective/ Neuroregenerative Effects in an Animal Model of Parkinson's Disease. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 13, . (12/50880-4, 18/07366-4, 17/24400-9)
BOTTARI, NATHIELI B.; SCHETINGER, MARIA ROSA C.; PILLAT, MICHELI M.; PALMA, THAIS V.; ULRICH, HENNING; ALVES, MARIANA S.; MORSCH, VERA M.; MELAZZO, CINTHIA; DE BARROS, LUIZ DANIEL; GARCIA, JOAO LUIS; et al. Resveratrol as a Therapy to Restore Neurogliogenesis of Neural Progenitor Cells Infected by Toxoplasma gondii. Molecular Neurobiology, v. 56, n. 4, p. 2328-2338, . (12/50880-4, 15/19478-3)
VIEIRA, JULIANO MARCHI; GUTIERRES, JESSIE MARTINS; CARVALHO, FABIANO BARBOSA; STEFANELLO, NAIARA; OLIVEIRA, LIZIELLE; CARDOSO, ANDREIA MACHADO; MORSCH, VERA MARIA; PILLAT, MICHELI MAINARDI; ULRICH, HENNING; FRESCURA DUARTE, MARTA MEDEIROS; et al. Caffeine and high intensity exercise: Impact on purinergic and cholinergic signalling in lymphocytes and on cytokine levels. BIOMEDICINE & PHARMACOTHERAPY, v. 108, p. 1731-1738, . (12/50880-4, 15/19478-3)
VIEIRA, MARIANA S.; SANTOS, ANDERSON K.; VASCONCELLOS, REBECCA; GOULART, VANIA A. M.; PARREIRA, RICARDO C.; KIHARA, ALEXANDRE H.; ULRICH, HENNING; RESENDE, RODRIGO R.. Neural stem cell differentiation into mature neurons: Mechanisms of regulation and biotechnological applications. BIOTECHNOLOGY ADVANCES, v. 36, n. 7, p. 1946-1970, . (12/50880-4)
DE ALMEIDA-PEREIRA, LUANA; REPOSSI, MARINNA GARCIA; MAGALHAES, CAMILA FEITOSA; AZEVEDO, RAFAEL DE FREITAS; CORREA-VELLOSO, JULIANA DA CRUZ; ULRICH, HENNING; MARQUES VENTURA, ANA LUCIA; FRAGEL-MADEIRA, LUCIANNE. P2Y(12) but not P2Y(13) Purinergic Receptor Controls Postnatal Rat Retinogenesis In Vivo. Molecular Neurobiology, v. 55, n. 11, p. 8612-8624, . (12/50880-4)
OLIVEIRA, AGATHA; ILLES, PETER; ULRICH, HENNING. Purinergic receptors in embryonic and adult neurogenesis. Neuropharmacology, v. 104, n. SI, p. 272-281, . (12/50880-4)
SIGNOR, CRISTIANE; GIRARDI, BRUNA AMANDA; WENDEL, ARITHANE LORENA; SANTANA FRUHAUF, PAMELLA KARINA; PILLAT, MICHELI M.; ULRICH, HENNING; MELLO, CARLOS F.; RUBIN, MARIBEL A.. Spermidine improves the persistence of reconsolidated fear memory and neural differentiation in vitro: Involvement. NEUROBIOLOGY OF LEARNING AND MEMORY, v. 140, p. 82-91, . (12/50880-4)
BERGAMIN, LETICIA SCUSSEL; FIGUEIRO, FABRICIO; DIETRICH, FABRICIA; MANICA, FABIANA DE MATTOS; FILIPPI-CHIELA, EDUARDO C.; MENDES, FRANCIANE BRACKMAN; FARIAS JANDREY, ELISA HELENA; LOPES, DANIELA VASCONCELOS; OLIVEIRA, FRANCINE H.; NASCIMENTO, ISIS C.; et al. Interference of ursolic acid treatment with glioma growth: An in vitro and in vivo study. European Journal of Pharmacology, v. 811, p. 268-275, . (15/18730-0, 12/50880-4)
TAKADA, SILVIA HONDA; IKEBARA, JULIANE MIDORI; DE SOUSA, ERICA; CARDOSO, DEBORA STERZECK; RESENDE, RODRIGO RIBEIRO; ULRICH, HENNING; RUECKL, MARTIN; RUEDIGER, STEN; KIHARA, ALEXANDRE HIROAKI. Determining the Roles of Inositol Trisphosphate Receptors in Neurodegeneration: Interdisciplinary Perspectives on a Complex Topic. Molecular Neurobiology, v. 54, n. 9, p. 6870-6884, . (12/50880-4, 11/50151-0, 15/50122-0, 14/16711-6)
MARTINEZ-RAMIREZ, A. S.; DIAZ-MUNOZ, M.; BATTASTINI, A. M.; CAMPOS-CONTRERAS, A.; OLVERA, A.; BERGAMIN, L.; GLASER, T.; MORITZ, C. E. JACINTHO; ULRICH, H.; VAZQUEZ-CUEVAS, F. G.. Cellular Migration Ability Is Modulated by Extracellular Purines in Ovarian Carcinoma SKOV-3 Cells. Journal of Cellular Biochemistry, v. 118, n. 12, p. 4468-4478, . (15/13345-1, 12/50880-4, 16/07659-6)
CORREA-VELLOSO, JULIANA C.; GONCALVES, MARIA C. B.; NAALDIJK, YAHAIRA; OLIVEIRA-GIACOMELLI, AGATHA; PILLAT, MICHELI M.; ULRICH, HENNING. Pathophysiology in the comorbidity of Bipolar Disorder and Alzheimer's Disease: pharmacological and stem cell approaches. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 80, n. A, p. 34-53, . (15/14343-2, 15/19478-3, 12/50880-4)
NASCIMENTO, ISIS C.; GLASER, TALITA; NERY, ARTHUR A.; PILLAT, MICHELI M.; PESQUERO, JOAO B.; ULRICH, HENNING. Kinin-B1 and B2 receptor activity in proliferation and neural phenotype determination of mouse embryonic stem cells. Cytometry Part A, v. 87A, n. 11, p. 989-1000, . (12/50880-4)
PILLAT, MICHELI M.; OLIVEIRA, MONA N.; MOTALN, HELENA; BREZNIK, BARBARA; GLASER, TALITA; LAH, TAMARA T.; ULRICH, HENNING. Glioblastoma-Mesenchymal Stem Cell Communication Modulates Expression Patterns of Kinin Receptors: Possible Involvement of Bradykinin in Information Flow. Cytometry Part A, v. 89A, n. 4, p. 365-375, . (12/50880-4)
ALVES, JANAINA M.; MARTINS, ANTONIO H.; LAMEU, CLAUDIANA; GLASER, TALITA; BOUKLI, NAWAL M.; BASSANEZE, VINICIUS; DARIOLLI, RAFAEL; NASCIMENTO, ISIS C.; MARTINS, POLIANA C. M.; DE SOUZA, HELLIO D. N.; et al. Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation. STEM CELL REVIEWS AND REPORTS, v. 15, n. 1, p. 11-pg., . (12/50880-4, 15/19128-2)
GLASER, TALITA; SHIMOJO, HIROMI; RIBEIRO, DEIDIANE ELISA; MARTINS, PATRICIA PEREIRA LOPES; BECO, RENATA PEREIRA; KOSINSKI, MICHAL; SAMPAIO, VANESSA FERNANDES ARNAUD; CORREA-VELLOSO, JULIANA; OLIVEIRA-GIACOMELLI, AGATHA; LAMEU, CLAUDIANA; et al. ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. MOLECULAR PSYCHIATRY, . (18/07366-4, 12/50880-4, 15/13345-1)
ANDREJEW, ROBERTA; GLASER, TALITA; OLIVEIRA-GIACOMELLI, AGATHA; RIBEIRO, DEIDIANE; GODOY, MARIANA; GRANATO, ALESSANDRO; ULRICH, HENNING; RATAJCZAK, MZ. Targeting Purinergic Signaling and Cell Therapy in Cardiovascular and Neurodegenerative Diseases. STEM CELLS: THERAPEUTIC APPLICATIONS, v. 1201, p. 79-pg., . (18/08426-0, 19/05384-8, 15/13345-1, 12/50880-4)
VIDIC, MATEJA; SMUC, TINA; JANEZ, NIKA; BLANK, MICHAEL; ACCETTO, TOMAZ; MAVRI, JAN; NASCIMENTO, ISIS C.; NERY, ARTHUR A.; ULRICH, HENNING; LAH, TAMARA T.. In silico selection approach to develop DNA aptamers for a stem-like cell subpopulation of non-small lung cancer adenocarcinoma cell line A549. RADIOLOGY AND ONCOLOGY, v. 52, n. 2, p. 8-pg., . (15/18730-0, 12/50880-4)
ZAPARTE, ALINE; CAPPELLARI, ANGELICA R.; BRANDAO, CAROLINE A.; DE SOUZA, JULIA B.; BORGES, THIAGO J.; KIST, LUIZA W.; BOGO, MAURICIO R.; ZERBINI, LUIZ F.; RIBEIRO PINTO, LUIS FELIPE; GLASER, TALITA; et al. P2Y2 receptor activation promotes esophageal cancer cells proliferation via ERK1/2 pathway. European Journal of Pharmacology, v. 891, p. 12-pg., . (12/50880-4)
GIACOMELLI, AGATHA OLIVEIRA; ALBINO, CAROLINA DE MOURA; NOBREGA DE SOUZA, HELLIO DANNY; ULRICH, HENNING. EFFECT OF P2Y6 RECEPTOR ANTAGONISM IN AN ANIMAL MODEL OF PARKINSON'S DISEASE. PURINERGIC SIGNALLING, v. 14, p. 2-pg., . (12/50880-4)
PILLAT, MICHELI MAINARDI; OLIVEIRA-GIACOMELLI, AGATHA; DAS NEVES OLIVEIRA, MONA; ANDREJEW, ROBERTA; TURRINI, NATALIA; BARANOVA, JULIANA; LAH TURNSEK, TAMARA; ULRICH, HENNING. Mesenchymal stem cell-glioblastoma interactions mediated via kinin receptors unveiled by cytometry. Cytometry Part A, v. 99, n. 2, p. 12-pg., . (12/50880-4, 20/10725-6, 19/24553-5, 19/26852-0, 18/07366-4)
CORREA-VELLOSO, JULIANA C.; GONCALVES, MARIA C. B.; NAALDIJK, YAHAIRA; OLIVEIRA-GIACOMELLI, AGATHA; PILLAT, MICHELI M.; ULRICH, HENNING. Pathophysiology in the comorbidity of Bipolar Disorder and Alzheimer's Disease: pharmacological and stem cell approaches. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 80, p. 20-pg., . (15/19478-3, 15/14343-2, 12/50880-4)
VIVIANI, LUCAS G.; PICCIRILLO, ERIKA; CHEFFER, ARQUIMEDES; DE REZENDE, LEANDRO; ULRICH, HENNING; CARMONA-RIBEIRO, ANA MARIA; T-DO AMARAL, ANTONIA. Be Aware of Aggregators in the Search for Potential Human ecto-5 '-Nucleotidase Inhibitors. Molecules, v. 23, n. 8, p. 15-pg., . (16/12392-9, 13/07937-8, 12/50880-4, 18/14871-7, 12/06633-2, 14/07248-0)
RIBEIRO, D. E.; GLASER, T.; OLIVEIRA-GIACOMELLI, A.; ULRICH, H.. Purinergic receptors in neurogenic processes. Brain Research Bulletin, v. 151, p. 9-pg., . (15/13345-1, 12/50880-4)
LINZKE, MARLEEN; YAN, SUN LIU REI; TARNOK, ATTILA; ULRICH, HENNING; GROVES, MATTHEW R.; WRENGER, CARSTEN. Live and Let Dye: Visualizing the Cellular Compartments of the Malaria Parasite Plasmodium falciparum. Cytometry Part A, v. 97, n. 7, p. 12-pg., . (17/03966-4, 12/50880-4, 14/23330-9, 12/50393-6, 17/26358-0, 15/26722-8)
VIVIANI, LUCAS G.; PICCIRILLO, ERIKA; ULRICH, HENNING; AMARAL, ANTONIA T-DO. Virtual Screening Approach for the Identification of Hydroxamic Acids as Novel Human Ecto-5 '-Nucleotidase Inhibitors. JOURNAL OF CHEMICAL INFORMATION AND MODELING, v. 60, n. 2, p. 10-pg., . (13/07937-8, 12/50880-4, 18/06381-0, 18/24678-0, 12/06633-2, 18/07366-4, 14/07248-0)
PILLAT, MICHELI M.; OLIVEIRA, MONA N.; MOTALN, HELENA; BREZNIK, BARBARA; GLASER, TALITA; LAH, TAMARA T.; ULRICH, HENNING. Glioblastoma-Mesenchymal Stem Cell Communication Modulates Expression Patterns of Kinin Receptors: Possible Involvement of Bradykinin in Information Flow. Cytometry Part A, v. 89A, n. 4, p. 11-pg., . (12/50880-4)
OLIVEIRA, AGATHA; ILLES, PETER; ULRICH, HENNING. Purinergic receptors in embryonic and adult neurogenesis. Neuropharmacology, v. 104, p. 10-pg., . (12/50880-4)
CAPPELLARI, ANGELICA R.; PILLAT, MICHELI M.; SOUZA, HELLIO D. N.; DIETRICH, FABRICIA; OLIVEIRA, FRANCINE H.; FIGUEIRO, FABRICIO; ABUJAMRA, ANA L.; ROESLER, RAFAEL; LECKA, JOANNA; SEVIGNY, JEAN; et al. Ecto-5 '-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model. PLoS One, v. 10, n. 10, p. 18-pg., . (12/50880-4)
VIDIC, MATEJA; SMUC, TINA; JANEZ, NIKA; BLANK, MICHAEL; ACCETTO, TOMAZ; MAVRI, JAN; NASCIMENTO, ISIS C.; NERY, ARTHUR A.; ULRICH, HENNING; LAH, TAMARA T.. In silico selection approach to develop DNA aptamers for a stem-like cell subpopulation of non-small lung cancer adenocarcinoma cell line A549. RADIOLOGY AND ONCOLOGY, v. 52, n. 2, p. 152-159, . (15/18730-0, 12/50880-4)
CHEFFER, A.; CASTILLO, A. R. G.; CORREA-VELLOSO, J.; GONCALVES, M. C. B.; NAALDIJK, Y.; NASCIMENTO, I. C.; BURNSTOCK, G.; ULRICH, H.. Purinergic system in psychiatric diseases. MOLECULAR PSYCHIATRY, v. 23, n. 1, p. 94-106, . (15/14343-2, 13/02293-5, 15/18730-0, 12/50880-4)
SCHNEIDER, GABRIELA; GLASER, TALITA; LAMEU, CLAUDIANA; ABDELBASET-ISMAIL, AHMED; SELLERS, ZACHARIAH PAYNE; MONIUSZKO, MARCIN; ULRICH, HENNING; RATAJCZAK, MARIUSZ Z.. Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Molecular Cancer, v. 14, . (12/50880-4)
MENCIN, NINA; SMUC, TINA; VRANICAR, MARKO; MAVRI, JAN; HREN, MATJAZ; GALESA, KATJA; KRKOC, PETER; ULRICH, HENNING; SOLAR, BORUT. Optimization of SELEX: Comparison of different methods for monitoring the progress of in vitro selection of aptamers. Journal of Pharmaceutical and Biomedical Analysis, v. 91, p. 151-159, . (12/50393-6, 12/50880-4)
ULRICH, HENNING; RATAJCZAK, MARIUSZ Z.; SCHNEIDER, GABRIELA; ADINOLFI, ELENA; ORIOLI, ELISA; FERRAZOLI, ENEAS G.; GLASER, TALITA; CORREA-VELLOSO, JULIANA; MARTINS, POLIANA C. M.; COUTINHO, FERNANDA; et al. Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis. FRONTIERS IN PHARMACOLOGY, v. 9, . (12/50880-4, 15/19128-2)
DATI, L. M.; ULRICH, H.; REAL, C. C.; FENG, Z. P.; SUN, H. S.; BRITTO, L. R.. CARVACROL PROMOTES NEUROPROTECTION IN THE MOUSE HEMIPARKINSONIAN MODEL. Neuroscience, v. 356, p. 176-181, . (12/50880-4)
SMUC, TINA; AHN, IL-YOUNG; ULRICH, HENNING. Nucleic acid aptamers as high affinity ligands in biotechnology and biosensorics. Journal of Pharmaceutical and Biomedical Analysis, v. 81-82, p. 210-217, . (12/50393-6, 06/61285-9, 12/50880-4)
NERY, ARTHUR A.; MAGDESIAN, MARGARET H.; TRUJILLO, CLEBER A.; SATHLER, LUCIANA B.; JULIANO, MARIA A.; JULIANO, LUIZ; ULRICH, HENNING; FERREIRA, SERGIO T.. Rescue of Amyloid-Beta-Induced Inhibition of Nicotinic Acetylcholine Receptors by a Peptide Homologous to the Nicotine Binding Domain of the Alpha 7 Subtype. PLoS One, v. 8, n. 7, . (06/61285-9, 12/50880-4)
GLASER, TALITA; RESENDE, RODRIGO R.; ULRICH, HENNING. Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation. CELL COMMUNICATION AND SIGNALING, v. 11, . (06/61285-9, 12/50880-4)
OLIVEIRA-GIACOMELLI, AGATHA; NAALDIJK, YAHAIRA; SARDA-ARROYO, LAURA; GONCALVES, MARIA C. B.; CORREA-VELLOSO, JULIANA; PILLAT, MICHELI M.; DE SOUZA, HELLIO D. N.; ULRICH, HENNING. Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy. FRONTIERS IN PHARMACOLOGY, v. 9, . (12/20685-5, 12/50880-4, 15/14343-2, 13/25338-4)
REICHERT, KARINE P.; SCHETINGER, MARIA ROSA C.; PILLAT, MICHELI M.; BOTTARI, NATHIELI B.; PALMA, TAIS V.; GUTIERRES, JESSIE M.; ULRICH, HENNING; ANDRADE, CINTHIA M.; EXLEY, CHRISTOPHER; MORSCH, VERA M. M.. Aluminum affects neural phenotype determination of embryonic neural progenitor cells. ARCHIVES OF TOXICOLOGY, v. 93, n. 9, p. 2515-2524, . (12/50880-4, 15/19478-3)
GLASER, TALITA; ARNAUD SAMPAIO, VANESSA FERNANDES; LAMEU, CLAUDIANA; ULRICH, HENNING. Calcium signalling: A common target in neurological disorders and neurogenesis. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, v. 95, n. SI, p. 25-33, . (12/50880-4, 15/13345-1, 15/19128-2)
BAGATINI, MARGARETE DULCE; BERTOLIN, KALYNE; BRIDI, ALESSANDRA; PELINSON, LUANA PAULA; ROSA BONADIMAN, BEATRIZ DA SILVA; PILLAT, MICHELE MAINARDI; DIAS GONCALVES, PAULO BAYARD; ULRICH, HENNING; CHITOLINA SCHETINGER, MARIA ROSA; MORSCH, VERA MARIA. 1, 25-Dihydroxyvitamin D3 alters ectonucleotidase expression and activity in human cutaneous melanoma cells. Journal of Cellular Biochemistry, v. 120, n. 6, p. 9992-10000, . (12/50880-4)
TENG, YANG D.; WANG, LEI; KABATAS, SERDAR; ULRICH, HENNING; ZAFONTE, ROSS D.. Cancer Stem Cells or Tumor Survival Cells?. STEM CELLS AND DEVELOPMENT, v. 27, n. 21, . (12/50880-4)
VIVIANI, LUCAS G.; PICCIRILLO, ERIKA; CHEFFER, ARQUIMEDES; DE REZENDE, LEANDRO; ULRICH, HENNING; CARMONA-RIBEIRO, ANA MARIA; T-DO AMARAL, ANTONIA. Be Aware of Aggregators in the Search for Potential Human ecto-5 `-Nucleotidase Inhibitors. Molecules, v. 23, n. 8, . (12/50880-4, 14/07248-0, 16/12392-9, 12/06633-2, 18/14871-7, 13/07937-8)
LINZKE, MARLEEN; YAN, SUN LIU REI; TARNOK, ATTILA; ULRICH, HENNING; GROVES, MATTHEW R.; WRENGER, CARSTEN. Live and Let Dye: Visualizing the Cellular Compartments of the Malaria Parasite Plasmodium falciparum. Cytometry Part A, v. 97, n. 7, SI, . (12/50880-4, 17/03966-4, 15/26722-8, 14/23330-9, 17/26358-0, 12/50393-6)
RIBEIRO, DEIDIANE ELISA; RONCALHO, ALINE LULHO; GLASER, TALITA; ULRICH, HENNING; WEGENER, GREGERS; JOCA, SAMIA. P2X7 Receptor Signaling in Stress and Depression. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 11, . (15/13345-1, 12/50880-4, 18/08426-0)
FRACASSO, MATEUS; BOTTARI, NATHIELI B.; DA SILVA, ANIELEN D.; GRANDO, THIRSSA H.; PILLAT, MICHELI M.; ULRICH, HENNING; VIDAL, TAIS; DE ANDRADE, CINTHIA M.; MONTEIRO, SILVIA G.; NASCIMENTO, LUIZ FLAVIO N.; et al. Effects of resveratrol on the differentiation fate of neural progenitor cells of mouse embryos infected with Trypanosoma cruzi. Microbial Pathogenesis, v. 132, p. 156-161, . (12/50880-4)
TROMBETTA-LIMA, MARINA; ASSIS-RIBAS, THAIS; CINTRA, RICARDO C.; CAMPEIRO, JOANA D.; GUERREIRO, JULIANO R.; WINNISCHOFER, SHEILA M. B.; NASCIMENTO, ISIS C. C.; ULRICH, HENNING; HAYASHI, MIRIAN A. F.; SOGAYAR, MARI C.. Impact of Reck expression and promoter activity in neuronal in vitro differentiation. MOLECULAR BIOLOGY REPORTS, v. 48, n. 2, . (18/20014-0, 16/05311-2, 18/07366-4, 14/50891-1, 19/13112-8, 15/26328-8, 16/18277-7, 12/50880-4, 17/02413-1)
RAJPUROHIT, CHETAN SINGH; KUMAR, VIVEK; CHEFFER, ARQUIMEDES; OLIVEIRA, DANYLLO; ULRICH, HENNING; OKAMOTO, OSWALDO KEITH; ZATZ, MAYANA; ANSARI, UZAIR AHMAD; KHANNA, VINAY KUMAR; PANT, ADITYA BHUSHAN. Mechanistic Insights of Astrocyte-Mediated Hyperactive Autophagy and Loss of Motor Neuron Function in SOD1(L39R)Linked Amyotrophic Lateral Sclerosis. Molecular Neurobiology, . (13/08028-1, 12/50880-4)
ALVES, JANAINA M.; MARTINS, ANTONIO H.; LAMEU, CLAUDIANA; GLASER, TALITA; BOUKLI, NAWAL M.; BASSANEZE, VINICIUS; DARIOLLI, RAFAEL; NASCIMENTO, ISIS C.; MARTINS, POLIANA C. M.; DE SOUZA, HELLIO D. N.; et al. Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation. STEM CELL REVIEWS AND REPORTS, v. 15, n. 1, p. 48-58, . (12/50880-4, 15/19128-2)
GLASER, TALITA; SHIMOJO, HIROMI; RIBEIRO, DEIDIANE ELISA; MARTINS, PATRICIA PEREIRA LOPES; BECO, RENATA PEREIRA; KOSINSKI, MICHAL; SAMPAIO, VANESSA FERNANDES ARNAUD; CORREA-VELLOSO, JULIANA; OLIVEIRA-GIACOMELLI, AGATHA; LAMEU, CLAUDIANA; et al. ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. MOLECULAR PSYCHIATRY, v. 26, n. 6, p. 2633-2650, . (18/07366-4, 15/13345-1, 12/50880-4)
NASCIMENTO, ISIS C.; GLASER, TALITA; NERY, ARTHUR A.; PILLAT, MICHELI M.; PESQUERO, JOAO B.; ULRICH, HENNING. Kinin-B1 and B2 receptor activity in proliferation and neural phenotype determination of mouse embryonic stem cells. Cytometry Part A, v. 87A, n. 11, p. 12-pg., . (12/50880-4)
DA SILVA, ARUA C.; HIGGINS, MICHAEL J.; CORDOBA DE TORRESI, SUSANA I.. The effect of nanoscale surface electrical properties of partially biodegradable PEDOT-co-PDLLA conducting polymers on protein adhesion investigated by atomic force microscopy. Materials Science & Engineering C-Materials for Biological Applications, v. 99, p. 468-478, . (14/09353-6, 12/50880-4, 17/00705-5, 15/26308-7)
BOTTARI, NATHIELI B.; PILLAT, MICHELI M.; SCHETINGER, MARIA R. C.; REICHERT, KARINE P.; MACHADO, VANESSA; ASSMANN, CHARLES E.; ULRICH, HENNING; DUTRA, ANIELEN; MORSCH, VERA M.; VIDAL, TAIS; et al. Resveratrol-mediated reversal of changes in purinergic signaling and immune response induced by Toxoplasma gondii infection of neural progenitor cells. PURINERGIC SIGNALLING, v. 15, n. 1, p. 77-84, . (12/50880-4, 15/19478-3)
BALDISSARELLI, JUCIMARA; PILLAT, MICHELI M.; SCHMATZ, ROBERTA; CARDOSO, ANDREIA M.; ABDALLA, FATIMA H.; DE OLIVEIRA, JULIANA S.; POLACHINI, CARLA R. N.; CASALI, EMERSON; BORNEMANN, CLARISSA PEREIRA; ULRICH, HENNING; et al. Post-thyroidectomy hypothyroidism increases the expression and activity of ectonucleotidases in platelets: Possible involvement of reactive oxygen species. PLATELETS, v. 29, n. 8, p. 801-810, . (12/50880-4)
FRANCA, RAQUELI TERESINHA; PILLAT, MICHELI MAINARDI; DA SILVA, CASSIA BAGOLIN; SCHAFER, ANDRESSA SALVADORI; DORNELLES, GUILHERME LOPES; COSTA, MARCIO MACHADO; CHAVES, RAFAEL OLIVEIRA; DE ANDRADE, CINTHIA MELAZZO; ERHARDT, MAGNOLIA MARTINS; ANTOZIAZZI, ALFREDO QUITES; et al. Surface immunoglobulins of erythrocytes and platelets in dogs naturally infected by Rangelia vitalii. Microbial Pathogenesis, v. 121, p. 245-251, . (12/50880-4, 15/19478-3)
FERRAZOLI, ENEAS G.; DE SOUZA, HELLIO D. N.; NASCIMENTO, ISIS C.; OLIVEIRA-GIACOMELLI, AGATHA; SCHWINDT, TELMA T.; BRITTO, LUIZ R.; ULRICHT, HENNING. Brilliant Blue G, But Not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease. CELL TRANSPLANTATION, v. 26, n. 4, SI, p. 669-677, . (15/18730-0, 11/09852-4, 12/20685-5, 12/50880-4)
PINTO FILHO, SAULO T. L.; PILLAT, MICHELI M.; ROSA, MATHEUS P.; DALMOLIN, FABIOLA; ULRICH, HENNING; PIPPI, NEY L.. Padrão de expressão de proteínas específicas das células-tronco mesenquimais derivadas de tecido adiposo: possível agente imunossupressor em aloenxerto parcial para restauração de vesícula urinária de coelhos. Pesquisa Veterinária Brasileira, v. 38, n. 12, p. 2183-2189, . (15/19478-3, 12/50880-4)
RIBEIRO, DEIDIANE ELISA; RONCALHO, ALINE LULHO; GLASER, TALITA; ULRICH, HENNING; WEGENER, GREGERS; JOCA, SAMIA. P2X7 Receptor Signaling in Stress and Depression. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 11, p. 26-pg., . (18/08426-0, 15/13345-1, 12/50880-4)
RAJPUROHIT, CHETAN SINGH; KUMAR, VIVEK; CHEFFER, ARQUIMEDES; OLIVEIRA, DANYLLO; ULRICH, HENNING; OKAMOTO, OSWALDO KEITH; ZATZ, MAYANA; ANSARI, UZAIR AHMAD; KHANNA, VINAY KUMAR; PANT, ADITYA BHUSHAN. Mechanistic Insights of Astrocyte-Mediated Hyperactive Autophagy and Loss of Motor Neuron Function in SOD1(L39R)Linked Amyotrophic Lateral Sclerosis. Molecular Neurobiology, v. 57, n. 10, p. 17-pg., . (13/08028-1, 12/50880-4)
BAGATINI, M. D.; BERTOLIN, K.; BRIDI, A.; PELISON, L. P.; BONADIMAN, B. S. R.; PILLAT, M. M.; GONCALVES, P. B. D.; ULRICH, H.; SCHETINGER, M. R. C.; MORSCH, V. M. M.. 1 alpha,25-dihydroxyvitamin D3 alters ectonucleotidase expression and activity in human cutaneous melanoma cells.. PURINERGIC SIGNALLING, v. 14, p. 1-pg., . (12/50880-4)
SANTOS, ANDERSON K.; SCALZO, SERGIO; DE SOUZA, RAYSA T. V.; SANTANA, PEDRO H. G.; MARQUES, BRUNO L.; OLIVEIRA, LUCAS F.; FILHO DANIEL, M.; KIHARA, ALEXANDRE HIROAKI; SANTIAGO, HELTON DA COSTA; PARREIRA, RICARDO C.; et al. Strategic use of organoids and organs-on-chip as biomimetic tools. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, v. 144, p. 8-pg., . (18/07366-4, 20/11667-0, 12/50880-4)
FERRAZOLI, ENEAS G.; DE SOUZA, HELLIO D. N.; NASCIMENTO, ISIS C.; OLIVEIRA-GIACOMELLI, AGATHA; SCHWINDT, TELMA T.; BRITTO, LUIZ R.; ULRICHT, HENNING. Brilliant Blue G, But Not Fenofibrate, Treatment Reverts Hemiparkinsonian Behavior and Restores Dopamine Levels in an Animal Model of Parkinson's Disease. CELL TRANSPLANTATION, v. 26, n. 4, p. 9-pg., . (12/20685-5, 15/18730-0, 11/09852-4, 12/50880-4)
GLASER, TALITA; ARNAUD SAMPAIO, VANESSA FERNANDES; LAMEU, CLAUDIANA; ULRICH, HENNING. Calcium signalling: A common target in neurological disorders and neurogenesis. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, v. 95, p. 9-pg., . (15/19128-2, 15/13345-1, 12/50880-4)
LIANG, NICHOLAS; TRUJILLO, CLEBER A.; NEGRAES, PRISCILLA D.; MUOTRI, ALYSSON R.; LAMEU, CLAUDIANA; ULRICH, HENNING. Stem cell contributions to neurological disease modeling and personalized medicine. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 80, p. 9-pg., . (16/26189-0, 12/50880-4)
OLIVEIRA, MONA N.; PILLAT, MICHELI M.; MOTALN, HELENA; ULRICH, HENNING; LAH, TAMARA T.. Kinin-B1 Receptor Stimulation Promotes Invasion and is Involved in Cell-Cell Interaction of Co-Cultured Glioblastoma and Mesenchymal Stem Cells. SCIENTIFIC REPORTS, v. 8, . (12/50880-4)
PILLAT, MICHELI M.; LAMEU, CLAUDIANA; TRUJILLO, CLEBER A.; GLASER, TALITA; CAPPELLARI, ANGELICA R.; NEGRAES, PRISCILLA D.; BATTASTINI, ANA M. O.; SCHWINDT, TELMA T.; MUOTRI, ALYSSON R.; ULRICH, HENNING. Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation. Journal of Cell Science, v. 129, n. 18, p. 3437-3448, . (12/50880-4)
CAPPELLARI, ANGELICA R.; PILLAT, MICHELI M.; SOUZA, HELLIO D. N.; DIETRICH, FABRICIA; OLIVEIRA, FRANCINE H.; FIGUEIRO, FABRICIO; ABUJAMRA, ANA L.; ROESLER, RAFAEL; LECKA, JOANNA; SEVIGNY, JEAN; et al. Ecto-5 `-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model. PLoS One, v. 10, n. 10, . (12/50880-4)
GLASER, TALITA; BUENO, VANIA B.; CORNEJO, DANIEL R.; PETRI, DENISE F. S.; ULRICH, HENNING. Neuronal adhesion, proliferation and differentiation of embryonic stem cells on hybrid scaffolds made of xanthan and magnetite nanoparticles. Biomedical Materials, v. 10, n. 4, . (10/13034-2, 12/50880-4)
DA SILVA, ARUA C.; SEMEANO, ANA TERESA S.; DOURADO, ANDRE H. B.; ULRICH, HENNING; CORDOBA DE TORRESI, I, SUSANA. Novel Conducting and Biodegradable Copolymers with Noncytotoxic Properties toward Embryonic Stem Cells. ACS OMEGA, v. 3, n. 5, p. 5593-5604, . (14/09353-6, 13/25592-8, 12/50880-4, 15/26308-7)
LIANG, NICHOLAS; TRUJILLO, CLEBER A.; NEGRAES, PRISCILLA D.; MUOTRI, ALYSSON R.; LAMEU, CLAUDIANA; ULRICH, HENNING. Stem cell contributions to neurological disease modeling and personalized medicine. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 80, n. A, p. 54-62, . (16/26189-0, 12/50880-4)

Please report errors in scientific publications list using this form.
Filed patent(s) as a result of this research project

MÉTODO DE IDENTIFICAÇÃO DE COMPOSTOS INIBIDORES DE ECTO-5`-NUCLEOTIDASE HUMANA (CD73) E USO DOS COMPOSTOS IDENTIFICADOS BR1020180071661 - Universidade de São Paulo (USP) . ANTONIA TAVARES DO AMARAL / ALEXANDER HENNING ULRICH / ARQUIMEDES CHEFFER / LUCAS GASPARELLO VIVIANI - April 2018, 09