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Pd(II) compounds: synthesis, cytotoxicity, and DNA binding studies

Abstract

This work deals with the synthesis, characterization, cytotoxicity evaluation and DNA binding studies involving chelated compounds of the type [Pd(N-C)(X)(L)] and [PdX2(N-S)] {N-C = C2,N-bzox, C2,N-mbz, C2,N-bzan (bzox=benzaldehydeoxime, mbz = N-benzylidenemethylamine, bzan = N-Benzylideneaniline); N-S = 1-thiocarbamoylpyrazoles; L = thiourea-type ligands, X=Cl, Br, I, SCN}. The compounds will be characterized by elemental analysis, IR and NMR spectroscopies, ESI/MS mass spectrometry, thermogravimetry (TG) and single crystal X-ray diffraction methods. The citotoxicity of compounds towards normal cells and tumor cell sensitive and resistant to cisplatin will be determined by M.T.T. assay. DNA binding studies will be carried out involving the compounds with promising Resistance Factor (RF) and Therapeutic Index (TI) values aimimg at gaining information about the intensity and kinectics of such interaction. The influence of the compounds on the tertiary structure of DNA will be determined by their ability to modify the electrophoretic mobility of the plasmid DNA. Viscosity experiments and thermal denaturation of DNA will be also carried out depending on the acquisition of the described instruments in this project. (AU)

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Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARRA, CAROLINA V.; ROCHA, FILLIPE V.; GAUTIER, ARNAUD; MOREL, LAURENT; QUILLES, MARCELA B.; CARLOS, IRACILDA Z.; TREU-FILHO, OSWALDO; FREM, REGINA C. G.; MAURO, ANTONIO E.; NETTO, ADELINO V. G.. Synthesis, cytotoxic activity and DNA interaction of Pd(II) complexes bearing N `-methyl-3,5-dimethyl-1-thiocarbamoylpyrazole. Polyhedron, v. 65, p. 214-220, . (12/15486-3)
DE SOUZA, RONAN F. F.; DA CUNHA, GISLAINE A.; PEREIRA, JOSE C. M.; GARCIA, DANIEL M.; BINCOLETTO, CLAUDIA; GOTO, RENATA N.; LEOPOLDINO, ANDREIA M.; DA SILVA, ISABEL C.; PAVAN, FERNANDO R.; DEFLON, VICTOR M.; et al. Orthopalladated acetophenone oxime compounds bearing thioamides as ligands: Synthesis, structure and cytotoxic evaluation. Inorganica Chimica Acta, v. 486, p. 617-624, . (16/17711-5, 12/15486-3)
NATHÁLIA A. THOMAZELLA; SAHRA C. LEMOS; RONAN F. F. DE SOUZA; RODRIGO A. DE SOUZA; ANTONIO E. MAURO; IRACILDA Z. CARLOS; ADELINO V. G. NETTO. SÍNTESE, CARACTERIZAÇÃO E AVALIAÇÃO DA ATIVIDADE CITOTÓXICA DE COMPOSTOS CICLOPALADADOS CONTENDO COMO LIGANTES BENZALDEIDOXIMA ORTOMETALADA E ETILENOTIOURÉIA. Química Nova, v. 41, n. 10, p. 1150-1155, . (12/15486-3)
DA SILVA, C.; FERREIRA, J. G.; MAURO, A. E.; FREM, R. C. G.; SANTOS, R. H. A.; DA SILVA, P. B.; PAVAN, F. R.; MARINO, L. B.; LEITE, C. Q. F.; NETTO, A. V. G.. Synthesis and antimycobacterial activity of new pyrazolate-bridged dinuclear complexes of the type [Pd(mu-L)(N-3)(PPh3)](2) (PPh3 = triphenylphosphine; L = pyrazolates). Inorganic Chemistry Communications, v. 48, p. 153-155, . (12/15486-3)
DE MOURA, THALES R.; CAVALCANTI, SAHRA L.; DE GODOY, PAULO R. D. V.; SAKAMOTO-HOJO, ELZA T.; ROCHA, FILLIPE V.; DE ALMEIDA, EDUARDO T.; DEFLON, VICTOR M.; MAURO, ANTONIO E.; NETTO, ADELINO V. G.. Synthesis, characterization and antitumor activity of palladium(II) complexes of imidazolidine-2-thione. TRANSITION METAL CHEMISTRY, v. 42, n. 6, p. 565-574, . (09/54011-8, 16/17711-5, 12/15486-3)
BOZZA, GABRIELA F.; DE FARIAS, RENAN L.; DE SOUZA, RONAN F. F.; ROCHA, V, FILLIPE; BARRA, V, CAROLINA; DEFLON, VICTOR M.; DE ALMEIDA, EDUARDO T.; MAURO, ANTONIO E.; NETTO, ADELINO V. G.. Palladium orthometallated complexes containing acetophenoneoxime: Synthesis, crystal structures and hirshfeld surface analysis. Journal of Molecular Structure, v. 1175, p. 195-207, . (16/17711-5, 12/15486-3, 14/11340-0)
ROCHA, FILLIPE V.; FARIAS, RENAN L.; LIMA, MAURO A.; BATISTA, VICTOR S.; NASCIMENTO-JUNIOR, NAILTON M.; GARRIDO, SAULO S.; LEOPOLDINO, ANDREA M.; GOTO, RENATA N.; OLIVEIRA, ADRIANO B.; BECK, JOHANNES; et al. Computational studies, design and synthesis of Pd(II)-based complexes: Allosteric inhibitors of the Human Topoisomerase-II alpha. Journal of Inorganic Biochemistry, v. 199, . (16/04201-9, 16/17711-5, 13/20156-5, 12/15486-3)
DA CUNHA, GISLAINE A.; DE SOUZA, RONAN F. F.; DE FARIAS, RENAN L.; MOREIRA, MARIETE B.; SILVA, DEBORA E. S.; ZANETTI, RENAN D.; GARCIA, DANIEL M.; SPINDOLA, DANIEL G.; MICHELIN, LUIS F. G.; BINCOLETTO, CLAUDIA; et al. Cyclopalladated compounds containing 2,6-lutidine: Synthesis, spectral and biological studies. Journal of Inorganic Biochemistry, v. 203, . (14/02205-1, 16/25112-4, 09/54011-8, 12/15486-3)
ROCHA, FILLIPE VIEIRA; BARRA, CAROLINA VALERIO; MAURO, ANTONIO EDUARDO; CARLOS, IRACILDA Z.; NAUTON, LIONEL; EL GHOZZI, MALIKA; GAUTIER, ARNAUD; MOREL, LAURENT; GODOY NETTO, ADELINO VIEIRA. Synthesis, Characterization, X-ray Structure, DNA Cleavage, and Cytotoxic Activities of Palladium(II) Complexes of 4-Phenyl-3-thiosemicarbazide and Triphenylphosphane. European Journal of Inorganic Chemistry, v. 2013, n. 25, p. 4499-4505, . (12/15486-3)
DA SILVA, CRISTIANA; RIBEIRO, LEONARDO B.; FURUNO, CAIO C.; DA CUNHA, GISLAINE A.; DE SOUZA, RONAN F. F.; NETTO, ADELINO V. G.; MAURO, ANTONIO E.; FREM, REGINA C. G.; FERNANDES, JOSE A.; ALMEIDA PAZ, FILIPE A.; et al. Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity. Polyhedron, v. 100, p. 10-16, . (12/15486-3)
VELASQUES, JECIKA M.; DE SOUZA, RONAN F. F.; SILVA, DEBORA E. S.; FARIAS, RENAN L.; ZANETTI, RENAN D.; MOREIRA, MARIETE B.; ELLENA, JAVIER; PEREIRA, JOSE C. M.; MAURO, ANTONIO E.; OLIVEIRA, ADRIANO B.; et al. Orthopalladated tetralone oxime compounds bearing tertiary phosphines: Synthesis, structure, biological and in silico studies. JOURNAL OF ORGANOMETALLIC CHEMISTRY, v. 958, . (12/15486-3, 16/17711-5)

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