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Cardiometabolic evaluation and pancreatic beta cell secretion pattern in congenital adrenal hyperplasia patients

Grant number: 12/16778-8
Support Opportunities:Regular Research Grants
Duration: November 01, 2012 - October 31, 2014
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Gil Guerra Júnior
Grantee:Gil Guerra Júnior
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated researchers:Bruno Geloneze Neto ; Sofia Helena Valente de Lemos-Marini

Abstract

The deficiency of 21-hydroxylase (D21OH) is the most common form of congenital adrenal hyperplasia (CAH), responsible for more than 90% of cases with its classical form. With the improvement of diagnosis and the introduction of replacement therapy with corticosteroids, there was significant increment in patient survival. However, studies on the long-term effects of this treatment, mainly about cardiometabolic risk, are still rare and partly controversial. Therefore, the aim of this study will be evaluate the cardiometabolic risk, including insulin sensitivity, in patients with the classical form of CAH-D21OH compared to a control group matched for age, sex and BMI. Also we will analyze the association of risk factors present in metabolic syndrome in patients with CAH-21OHD with age, sex, genotype, disease control, body composition, physical activity, serum laboratory parameters (leptin, adiponectin, C-reactive protein, IL-6, Il-1², and metanephrine in urine and serum), insulin resistance, thickness of carotid intima-media (TCIM), and indirect calorimetry. Patients aged over six years, of both sexes, with a diagnosis of HAC-D21H and monitored routinely for at least two years in our clinic, will be evaluated. For the determination of cardiometabolic risk evaluations about body composition (BMI, DXA, skinfold thickness, bioelectrical impedance analysis), blood pressure monitoring for 24 hours, blood parameters (lipid profile, hyperglycemic clamp, leptin, adiponectin, C-reactive protein and free metanephrine), physical activity by questionnaire, and TCIM by ultrasonography will take place. In the analysis of results, statistical tests (chi-square, Student's t and Mann-Whitney test, and multiple linear regression) with p less than 0.05 (AU)

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BORGES, JULIANO HENRIQUE; DE OLIVEIRA, DANIEL MINUTTI; DE LEMOS-MARINI, SOFIA HELENA VALENTE; GELONEZE, BRUNO; GUERRA-JUNIOR, GIL; GONCALVES, EZEQUIEL MOREIRA. ormal bone health in young adults with 21-hydroxylase enzyme deficiency undergoing glucocorticoid replacement therap. OSTEOPOROSIS INTERNATIONAL, v. 33, n. 1, . (12/16778-8, 11/23460-1)
DE OLIVEIRA, DANIEL MINUTTI; JUNQUEIRA VASQUES, ANA CAROLINA; GONCALVES, EZEQUIEL MOREIRA; VALENTE DE LEMOS-MARINI, SOFIA HELENA; GUERRA-JUNIOR, GIL; GELONEZE, BRUNO. ENERGY EXPENDITURE IN 21-HYDROXYLASE CONGENITAL ADRENAL HYPERPLASIA PATIENTS AND COMPARISON WITH PREDICTIVE EQUATIONS. ENDOCRINE PRACTICE, v. 26, n. 4, p. 388-398, . (12/16778-8, 11/23460-1)
GONCALVES, EZEQUIEL MOREIRA; RIBEIRO, ROBERTO REGIS; GOMES DE CARVALHO, WELLINGTON ROBERTO; DE MORAES, ANDERSON MARQUES; ROMAN, EVERTON PAULO; SANTOS, KEILA DONASSOLO; RODRIGUES MEDAETS, PEDRO AUGUSTO; VEIGA-JUNIOR, NELIO NEVES; LACE DE MORAES COELHO, ADRIELLE CAROLINE; KRAHENBUEHL, TATHYANE; et al. Brazilian Pediatric Reference Data for Quantitative Ultrasound of Phalanges According to Gender, Age, Height and Weight. PLoS One, v. 10, n. 6, . (12/16778-8, 06/01978-0, 11/23460-1)
JULIANO HENRIQUE BORGES; DANIELA ALBIERO CAMARGO; LETICIA ESPOSITO SEWAYBRICKER; RENATA ISA SANTORO; DANIEL MINUTTI DE OLIVEIRA; SOFIA HELENA VALENTE DE LEMOS-MARINI; BRUNO GELONEZE; GIL GUERRA-JÚNIOR; EZEQUIEL MOREIRA GONÇALVES. Normal ambulatory blood pressure in young adults with 21-hydroxylase enzyme deficiency undergoing glucocorticoid replacement therapy. ARCHIVES OF ENDOCRINOLOGY METABOLISM, . (12/16778-8, 14/20186-4, 11/23460-1, 17/00657-0)
BORGES, JULIANO HENRIQUE; CAMARGO, DANIELA ALBIERO; SEWAYBRICKER, LETICIA ESPOSITO; SANTORO, RENATA ISA; DE OLIVEIRA, DANIEL MINUTTI; DE LEMOS-MARINI, SOFIA HELENA VALENTE; GELONEZE, BRUNO; GUERRA-JUNIOR, GIL; GONCALVES, EZEQUIEL MOREIRA. Normal ambulatory blood pressure in young adults with 21-hydroxylase enzyme deficiency undergoing glucocorticoid replacement therapy. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 67, n. 1, p. 9-pg., . (11/23460-1, 17/00657-0, 12/16778-8, 14/20186-4)
BORGES, JULIANO HENRIQUE; DE OLIVEIRA, DANIEL MINUTTI; DE LEMOS-MARINI, SOFIA HELENA VALENTE; GELONEZE, BRUNO; GONCALVES, EZEQUIEL MOREIRA; GUERRA-JUNIOR, GIL. Fat Distribution and Lipid Profile of Young Adults with Congenital Adrenal Hyperplasia Due to21-HydroxylaseEnzyme Deficiency. LIPIDS, v. 56, n. 1, . (11/23460-1, 12/16778-8)
GONCALVES, EZEQUIEL M.; SEWAYBRICKER, LETICIA E.; BAPTISTA, FATIMA; SILVA, ANALIZA M.; CARVALHO, WELLINGTON R. G.; SANTOS, ALLAN O.; DE MELLO, MARICILDA P.; LEMOS-MARINI, SOFIA H. V.; GUERRA-JUNIOR, GIL. PERFORMANCE OF PHALANGEAL QUANTITATIVE ULTRASOUND PARAMETERS IN THE EVALUATION OF REDUCED BONE MINERAL DENSITY ASSESSED BY DX IN PATIENTS WITH 21 HYDROXYLASE DEFICIENCY. ULTRASOUND IN MEDICINE AND BIOLOGY, v. 40, n. 7, p. 1414-1419, . (12/16778-8, 11/23460-1)
DE OLIVEIRA, DANIEL MINUTTI; TURA, ANDREA; JUNQUEIRA VASQUES, ANA CAROLINA; CAMILO, DANIELLA FERNANDES; LIMA, MARCELO MIRANDA; VALENTE DE LEMOS-MARINI, SOFIA HELENA; GONCALVES, EZEQUIEL MOREIRA; GUERRA-JUNIOR, GIL; GELONEZE, BRUNO. Insulin Resistance in Congenital Adrenal Hyperplasia is Compensated for by Reduced Insulin Clearance. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v. 106, n. 4, p. E1574-E1585, . (12/16778-8, 11/23460-1)
BORGES, JULIANO HENRIQUE; SANTORO, RENATA ISA; DE OLIVEIRA, DANIEL MINUTTI; DE LEMOS-MARINI, SOFIA HELENA VALENTE; GELONEZE, BRUNO; GUERRA-JUNIOR, GIL; GONCALVES, EZEQUIEL MOREIRA. Cardiovascular dysfunction risk in young adults with congenital adrenal hyperplasia caused by 21-hydroxylase enzyme deficiency. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, v. 75, n. 7, . (11/23460-1, 12/16778-8)

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