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Folate status and psoriasis: prospective study

Grant number: 12/14278-8
Support Opportunities:Regular Research Grants
Duration: November 01, 2012 - April 30, 2015
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Principal Investigator:Luciana Yuki Tomita
Grantee:Luciana Yuki Tomita
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated researchers: Andréia Castanheiro da Costa ; Luiza Keiko Matsuka Oyafuso ; Solange Andreoni ; Vânia D'Almeida


Psoriasis is a chronic inflammatory disease. The incidence increased twice in the last decades, affecting 250 million people worldwide nowadays. The etiology is unknown, but genetic and environmental factors such as cigarette smoking, alcohol consumption, reduced fish intake, obesity and stressful life events have been suggested. Methotrexate (MTX) is a folic acid antagonist widely used for the treatment of psoriasis. Folic acid supplement is used in the belief that it reduces adverse effects of MTX - hyperhomocysteinemia, sickness, alopecia, lack of appetite and elevated liver enzymes - however, few studies on folate status in the MTX use showed that supplement intake reduced therapeutic effect. Until the present study, no study was conducted after folic acid fortification. The aim of the present study is to investigate folate status prospectively before and after MTX and clinical status among patients diagnosed with psoriasis attended in a teaching hospital in the ABC region close to São Paulo city. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TOMITA, LUCIANA Y.; DA COSTA, ANDREIA C.; ANDREONI, SOLANGE; OYAFUSO, LUIZA K. M.; D'ALMEIDA, VANIA; FONSECA, FERNANDO L. A.; ROCHA, ANA C. L.; KOBATA, CLARICE. Folate Nutritional Status among Psoriasis Patients not Exposed to Anti-folate Drug. CURRENT NUTRITION & FOOD SCIENCE, v. 16, n. 4, p. 543-553, . (12/14278-8)

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